Peroxisome Proliferator-Activated Receptors Increase Human Sebum Production
Open accessAbstract
Sebum production is key in the pathophysiology of acne, an extremely common condition, which when severe, may require treatment with isotretinoin, a known teratogen. Apart from isotretinoin and hormonal therapy, no agents are available to reduce sebum. Increasing our understanding of the regulation of sebum production is a milestone in identifying alternative therapeutic targets. Studies in sebocytes and human sebaceous glands indicate that agonists of peroxisome proliferator-activated receptors (PPARs) alter sebaceous lipid production. The goal of this study is to verify the expression and activity of PPARs in human skin and SEB-1 sebocytes and to assess the effects of PPAR ligands on sebum production in patients. To investigate the contribution of each receptor subtype to sebum production, lipogenesis assays were performed in SEB-1 sebocytes that were treated with PPAR ligands and isotretinoin. Isotretinoin significantly decreased lipogenesis, while the PPARalpha agonist-GW7647, PPARdelta agonist-GW0742, PPARalpha/delta agonist-GW2433, PPARgamma agonist rosiglitazone, and the pan-agonist-GW4148, increased lipogenesis. Patients treated with thiazolidinediones or fibrates had significant increases in sebum production (37 and 77%, respectively) when compared to age-, disease-, and sex-matched controls. These data indicate that PPARs play a role in regulating sebum production and that selective modulation of their activity may represent a novel therapeutic strategy for the trea…
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Linoleic and arachidonic acid activation of PPAR-δ and PPAR-γ leads to an increased intracellular lipid content of sebocytes.
“Previous studies showed that linoleic and arachidonic acid activation of PPAR-δ and PPAR-γ has led to an increased intracellular lipid content of sebocytes, while PPAR-α agonists blocked lipogenesis via inhibiting the leukotriene pathway.”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [73]
PPAR-α agonists block lipogenesis via inhibiting the leukotriene pathway.
“while PPAR-α agonists blocked lipogenesis via inhibiting the leukotriene pathway.”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [73]
PPAR-α seems to be related to β-oxidation of fatty acids and lipid catabolism.
“Furthermore, PPAR-α seems to be related to β-oxidation of fatty acids and lipid catabolism.73”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [73]
PPARs alter sebaceous lipid production and modulate acne formation.
“Androgen stimulation has been found to play a critical role in regulating sebocyte proliferation and driving the emergence of acne2, while PPARs have been shown to alter sebaceous lipid production and modulate acne formation34, 35.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [34]
Cites
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217 · see citing works
Acne and sebaceous gland function
Zouboulis, C. C. (2004) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2004.03.004 · Cited by 561 · see citing works
Peroxisome Proliferator-Activated Receptors and Skin Development
Rosenfield, R. L., Deplewski, D., & Greene, M. E. (2000) · Hormone Research in Paediatrics · doi:10.1159/000053270 · Cited by 69 · see citing works
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New developments in our understanding of acne pathogenesis and treatment
Kurokawa, I., Danby, F. W., Ju, Q., Wang, X., Xiang, L. F., Xia, L., Chen, W., Nagy, I., Picardo, M., Suh, D. H., et al. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00890.x · Cited by 584 · see citing works
Linking diet to acne metabolomics, inflammation, and comedogenesis: an update
Melnik, B. (2015) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s69135 · Cited by 259 · see citing works
More than one way to skin . . .
Fuchs, E., & Horsley, V. (2008) · Genes & Development · doi:10.1101/gad.1645908 · Cited by 224 · see citing works
Sebaceous-immunobiology is orchestrated by sebum lipids
Lovászi, M., Szegedi, A., Zouboulis, C. C., & Törőcsik, D. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1375636 · Cited by 151 · see citing works
“Furthermore, PPAR-a seems to be related to b-oxidation of fatty acids and lipid catabolism.(73)”
BackgroundDobrosi, N., Tóth, B. I., Nagy, G., Dózsa, A., Géczy, T., Nagy, L., Zouboulis, C. C., Paus, R., Kovács, L., & Bíró, T. (2008) · The FASEB Journal · doi:10.1096/fj.07-104877 · Cited by 142 · see citing works
Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro
Feldman, A., Mukha, D., Maor, I. I., Sedov, E., Koren, E., Yosefzon, Y., Shlomi, T., & Fuchs, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-10261-6 · Cited by 52 · see citing works
- Authors
- Trivedi, N. R., Cong, Z., Nelson, A. M., Albert, A. J., Rosamilia, L. L., Sivarajah, S., Gilliland, K. L., Liu, W., Mauger, D. T., Gabbay, R. A., & Thiboutot, D. M.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Thiboutot, Diane M.
- ORCID
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 126
- Issue
- 9
- Pages
- 2002-2009
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2072353008
- Cited by
- 184
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 6 · 2019: 12 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 13 · 2013: 7 · 2012: 11
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR047820)
- National Center for Research Resources (C06RR016499, M01RR010732)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- peroxisome proliferator-activated receptors, sebum production, acne, sebocytes, lipogenesis, PPAR agonists, isotretinoin, thiazolidinediones, fibrates, rosiglitazone, GW7647, GW0742, sebaceous glands, acne treatment
- MeSH terms
- Rosiglitazone, Pioglitazone, Adult, Hypolipidemic Agents, Cell Line, Transformed, Diabetes Mellitus, Female, Humans, Hyperlipidemias, Hypoglycemic Agents, Ligands, Male, Middle Aged, Fenofibrate, Sebaceous Glands, Sebum, Gemfibrozil, Isotretinoin, Thiazolidinediones, PPAR alpha, PPAR gamma, Lipogenesis
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