Peroxisome Proliferator-Activated Receptors and Skin Development
Abstract
PPARs are nuclear hormone receptors. PPAR subtypes (α, γ, δ, the latter a xPPARβ homologue) were initially investigated in skin because of their known role in regulating lipid metabolism. Studies adding specific PPAR ligand activators to cultured skin or skin cells are compatible with the concepts that PPARα activation mediates early lipogenic steps common to the function of both skin epidermal cells (keratinocytes) and sebaceous cells (sebocytes), PPARγ activation plays a unique role in stimulating sebocyte lipogenesis, and PPARδ activation may contribute to lipid biosynthesis in both sebocytes and keratinocytes under certain circumstances. Epidermal keratinocytes appear to express small amounts of PPARα and PPARδ mRNA and a trace of PPARγ mRNA which is up-regulated with differentiation. Sebocytes express all subtypes; PPARγ gene expression excedes that in epidermis. The emerging data on PPAR protein expression suggests that epidermis normally expresses predominantly PPARα, while sebocytes express more PPARγ than PPARα. These expression patterns may change during hyperplasia, differentiation and inflammation. Gene disruption studies in mice are compatible with a contribution of PPARα to skin barrier function, suggest that PPARγ is necessary for sebocyte differentiation, and indicate that PPARδ can ameliorate inflammatory responses in skin. PPARs appear to play a role in keratinocyte synthesis of the lipids that they export to the intercellular space to form the skin permeability barrier. They also appear to be important for sebocyte formation of the intracellular fused lipid droplets that constitute the holocrine secretion of the sebaceous gland. In addition, they may play roles in keratinocyte growth and differentiation and the inhibition of skin inflammation by diverse mechanisms not necessarily related to fat metabolism.
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PPARs are prime members with varying effects on sebocyte proliferation and lipogenesis.
“are the prime members71 with varying effects on sebocyte proliferation and lipogenesis.72”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [72]
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Impaired Mitochondria Promote Aging-Associated Sebaceous Gland Dysfunction and Pathology
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Overview of Dermatological Diseases
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Diffuse sebaceous-gland hyperplasia
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Treatment of Sebaceous Hyperplasia with Pulsed Dye Laser
LAILA M. MOHAMMED, M. D. A. M. H., & Elshourbagy, E. (2019) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2019.54369
- Authors
- Rosenfield, R. L., Deplewski, D., & Greene, M. E.
- Affiliations
- University of Chicago (US)
- Northwestern University (US)
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 54
- Issue
- 5-6
- Pages
- 269-274
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W1982081547
- Cited by
- 69
- References
- 44
- Citations by year
- 2024: 1 · 2022: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research in Paediatrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7k08dk002309-02)
- U.S. Public Health Service
- National Institute of Diabetes and Digestive and Kidney Diseases (KO8-DK02309)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 06308, R01HD006308)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- peroxisome proliferator-activated receptors, PPARα, PPARγ, PPARδ, skin development, keratinocytes, sebocytes, sebocyte differentiation, lipogenesis, skin barrier function, lipid metabolism, holocrine secretion, skin inflammation, keratinocyte differentiation
- MeSH terms
- Epidermal Cells, Animals, Dermatitis, Epidermis, Humans, Lipids, Receptors, Cell Surface, Reference Values, Sebaceous Glands, Skin, Transcription Factors, Gene Expression, Receptors, Cytoplasmic and Nuclear, Mice, Knockout, Mice
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