The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Tight Junctions/Adherens Junctions: Basic Structure and Function
Open accessAbstract
Adherens and tight junctions are intercellular junctions crucial for epithelial adhesion and barrier function in a wide variety of tissues and organisms. In stratifying epithelia, such as the epidermis, the role of adherens and tight junctions was considered less important owing to the abundance of desmosomes, mediating firm mechanical stability between the cells, and to the barrier function of the stratum corneum, respectively. This view has changed in recent years because of different studies that showed the importance of these structures for proper skin physiology and barrier function. The current review provides an overview of the crucial molecular constituents of these structures and highlights some recent results on their regulation. In particular, I will discuss their importance in skin biology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Enterocytes connect with each other in a continuous epithelial cell layer via adhesive junctional proteins that make up tight junction (TJ) proteins, adherens junction (AJ) proteins, gap junction proteins, and desmosomes (Table 2).31,32”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [31]
Citations
Cites
JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA
Farquhar, M. G., & Palade, G. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.375 · Cited by 3,637
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,537
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917
Regulation of cadherin-mediated adhesion in morphogenesis
Gumbiner, B. M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1699 · Cited by 1,523
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512
The tight junction: a multifunctional complex.
Schneeberger, E., & Lynch, R. D. (2004) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00558.2003 · Cited by 1,450
Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195
Cadherins in development: cell adhesion, sorting, and tissue morphogenesisPreprint
Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,101
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
Bertet, C., Sulak, L., & Lecuit, T. (2004) · Nature · doi:10.1038/nature02590 · Cited by 1,037
Deconstructing the Cadherin-Catenin-Actin Complex
Yamada, S., Pokutta, S., Drees, F., Weis, W. I., & Nelson, W. J. (2005) · Cell · doi:10.1016/j.cell.2005.09.020 · Cited by 1,022
Cited by
Sorted by citations
Items 701–765 of 765
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682889
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682904
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682886
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682892
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682868
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682895
Additional file 1 of Role of endothelial microRNA 155 on capillary leakage in systemic inflammation
Etzrodt, V., Idowu, T. O., Schenk, H., Seeliger, B., Prasse, A., Thamm, K., Pape, T., Müller‐Deile, J., van Meurs, M., Thum, T., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091597
Krajewski, D., Paul, D., Ge, S., Jellison, E. R., & Pachter, J. S. (2021) · Figshare · doi:10.6084/m9.figshare.17359140
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682910
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682913
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682874
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682907
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682883
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682901
Krajewski, D., Paul, D., Ge, S., Jellison, E. R., & Pachter, J. S. (2021) · Figshare · doi:10.6084/m9.figshare.17359137
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682862
Krajewski, D., Paul, D., Ge, S., Jellison, E. R., & Pachter, J. S. (2021) · Figshare · doi:10.6084/m9.figshare.17359134
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682880
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682865
Wang, F., Zou, P., Xu, S., Wang, Q., Zhou, Y., Li, X., Tang, L., Wang, B., Jin, Q., Yu, D., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321359
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682877
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682898
Krajewski, D., Paul, D., Ge, S., Jellison, E. R., & Pachter, J. S. (2021) · Figshare · doi:10.6084/m9.figshare.17359122
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682859
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., Bogin, Z. R., Bambi, S. A., Goldman, A. R., Azevedo, J. L. L. C., Orgaz, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26682916
Zhang, J., Jiang, W., Wu, P., Liu, Y., Ma, Y., Shi, H., Kuang, S., Li, S., Tang, L. Y., Zhou, X., et al. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.08.010
Yang, R.-J., Liu, J.-C., Liu, Y.-W., & He, F. (2026) · medRxiv · doi:10.64898/2026.01.20.26344459
Cavalcante, A. S., Lacerda, R. R. E., Campos, C. V., Capetini, V. C., da Conceição, Y. R. S., Bordin, S. A., Riffo‐Vasquez, Y., & Anhê, G. F. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110286
Kwankaew, N., Okuda, H., Ishikawa, T., Hori, K., & Ozaki, N. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102504
Haftek, M. (2026) · EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei · doi:10.1016/s1776-0313(26)51473-4
Guo, F., Littlepage, L. E., Stack, M. S., & Li, J. (2026) · npj Precision Oncology · doi:10.1038/s41698-026-01373-6
Rangappa, S., Thammanna Gowda, S. S., Hanumesh, P., & K., P. (2026) · Methods in molecular biology · doi:10.1007/7651_2026_695
Implication de la protéine Zonula Ocludens-2 (ZO-2) dans le processus d'invasion tumorale
Luczka, E. (2011) · theses.fr (ABES) · doi:10.70675/5f2ae623z9f56z45a9zba8ezef495445a69a
Etude des marqueurs de progression tumorale dans les cancers HPV-induits
Brochot-Dorigny, A. (2013) · theses.fr (ABES) · doi:10.70675/d6643687z76b0z4200zbfb2zfd4986de1fbc
Wu, G., Sougawa, N., Inoue, H., Tanimoto, H., Iwata, N., Goda, S., & Yamamoto, K. (2026) · Journal of Oral Biosciences · doi:10.1016/j.job.2026.100780
Paduano, V. (2015) · theses.fr (ABES) · doi:10.70675/c46f25cazdc6fz49bdzab03z6db400b54845
Rôle de la GTPase atypique RhoU dans l'homéostasie intestinale
Slaymi, C. (2014) · theses.fr (ABES) · doi:10.70675/6fbf53aez89c0z4815zbd1fz4a003ca52cad
Figueres, L. (2017) · theses.fr (ABES) · doi:10.70675/14fa9cc7z373bz419fz9cfez5f3f2e9cdf7f
Studying the formation of tricellular junction upon epithelial cell division in Drosophila
Wang, Z. (2017) · theses.fr (ABES) · doi:10.70675/7bf64dc6z7648z4185zbce1z11f7ddf7ee90
Rôle de l'oncostatine M et des interleukines 6 et 31 dans l'inflammation cutanée chez la souris
Pohin, M. (2017) · theses.fr (ABES) · doi:10.70675/6ee5de11z33c0z4d68z9887z2c7a7194291a
Jacqueroux, E. (2019) · theses.fr (ABES) · doi:10.70675/efb81441zf7d4z462ezb119z2027e0f494bc
Role of environmental factors on intestinal barrier dysfunctions reported in obesity
Postal, B. G. (2019) · theses.fr (ABES) · doi:10.70675/4b9e7a12ze552z46bez8767z3241d10852d3
Identification et caractérisation du lignage épithélial dans la glande mammaire bovine
Finot, L. (2019) · theses.fr (ABES) · doi:10.70675/68703960z3785z4794z886dz21f864ebec91
Twarog, C. (2020) · theses.fr (ABES) · doi:10.70675/64939fcdzc6d7z4c62z9ea5zd405e5379fb7 · Cited by 1
Weakly Supervised Segmentation and Context-Aware Classification in Computational Pathology
Lerousseau, M. (2022) · theses.fr (ABES) · doi:10.70675/8d10f89dz0f91z4e9dzb3a8zb5228b1172c1
Study of septin 9 in the cell polarity and development of cholangiocarcinoma
Cai, T. (2022) · theses.fr (ABES) · doi:10.70675/c3888784z575bz4056z8b60z98cb8e7e8719
Nanofitine, module de transport actif pour l'administration orale de biomédicaments
Masloh, S. (2022) · theses.fr (ABES) · doi:10.70675/84e28fcaz05c1z4135z82f9zdb218a7a4969
Martinier, I. (2023) · theses.fr (ABES) · doi:10.70675/c8872ff9z0aeez4facz9326zf565b159575d
Inferring the rheology of cellular materials through dedicated deep learning tools
Karnat, M. (2023) · theses.fr (ABES) · doi:10.70675/9a106b44z3811z4e25zaf6azfe4020dcb8b4
Imafuku, K., García‐Ponce, A., & Waschke, J. (2026) · Tissue Barriers · doi:10.1080/21688370.2026.2696758
Okamoto, S., Maruoka, S., Tsuya, K., Hikichi, M., Yamada, S., Kurosawa, Y., Kozu, Y., & Gon, Y. (2026) · BMC Molecular and Cell Biology · doi:10.21203/rs.3.rs-10722690/v1
Yang, R., Liu, J., Liu, Y., & He, F. (2026) · BioMed Research International · doi:10.1155/bmri/8727103
Bermejo, D. G., García-Pérez-de-Sevilla, G., & Molina-López, A. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1938370
Extreme temperatures and the epithelial barrier theory
Öğülür, İ., Babayev, H., Zeyneloglu, C., Zhao, B., Biçer, C., Liu, X., Zhang, Y., D’Avino, P., Li, M., Maldonado, A., et al. (2026) · Seminars in Immunopathology · doi:10.1007/s00281-026-01087-8
Frydrych, K., Wolak, D., & Hrabia, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219738
Metadata
- Authors
- Niessen, C. M.
- Affiliations
- University of Cologne (DE)
- Corresponding author
- Niessen, Carien M.
- ORCID
- Niessen, Carien M.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 127
- Issue
- 11
- Pages
- 2525-2532
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1980059877
- Cited by
- 756
- References
- 73
- Citations by year
- 2026: 21 · 2025: 44 · 2024: 58 · 2023: 36 · 2022: 48 · 2021: 54 · 2020: 40 · 2019: 34 · 2018: 42 · 2017: 46 · 2016: 37 · 2015: 47 · 2014: 48 · 2013: 42 · 2012: 45
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- tight junctions, adherens junctions, intercellular junctions, epithelial cell adhesion, epithelial barrier function, desmosomes, epidermis, skin physiology, junctional proteins
- MeSH terms
- Nectins, Animals, Epidermis, Humans, Skin Physiological Phenomena, Cell Adhesion Molecules, Cadherins, Tight Junctions, Adherens Junctions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review