Cited by 765Barrier Structure and Function StudiesSkin and Cellular Biology ResearchCell Adhesion Molecules Research

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Tight Junctions/Adherens Junctions: Basic Structure and Function

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Niessen, Carien M.·2007·Journal of Investigative Dermatology

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Abstract

Adherens and tight junctions are intercellular junctions crucial for epithelial adhesion and barrier function in a wide variety of tissues and organisms. In stratifying epithelia, such as the epidermis, the role of adherens and tight junctions was considered less important owing to the abundance of desmosomes, mediating firm mechanical stability between the cells, and to the barrier function of the stratum corneum, respectively. This view has changed in recent years because of different studies that showed the importance of these structures for proper skin physiology and barrier function. The current review provides an overview of the crucial molecular constituents of these structures and highlights some recent results on their regulation. In particular, I will discuss their importance in skin biology.

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Authors: Niessen, C. M.
Affiliations: University of Cologne (DE)
Corresponding author: Niessen, Carien M.
ORCID: Niessen, Carien M.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2007-11
Volume: 127
Issue: 11
Pages: 2525-2532
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/sj.jid.5700865
OpenAlex: W1980059877
Cited by: 756
References: 73
Citations by year: 2026: 21 · 2025: 44 · 2024: 58 · 2023: 36 · 2022: 48 · 2021: 54 · 2020: 40 · 2019: 34 · 2018: 42 · 2017: 46 · 2016: 37 · 2015: 47 · 2014: 48 · 2013: 42 · 2012: 45
FWCI: 2.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2953 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: tight junctions, adherens junctions, intercellular junctions, epithelial cell adhesion, epithelial barrier function, desmosomes, epidermis, skin physiology, junctional proteins
MeSH terms: Nectins, Animals, Epidermis, Humans, Skin Physiological Phenomena, Cell Adhesion Molecules, Cadherins, Tight Junctions, Adherens Junctions

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Tight Junctions/Adherens Junctions: Basic Structure and Function

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