Tight Junctions/Adherens Junctions: Basic Structure and Function

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

Farquhar, M. G., & Palade, G. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.375 · Cited by 3,637

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,537

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917

Regulation of cadherin-mediated adhesion in morphogenesis

Gumbiner, B. M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1699 · Cited by 1,523

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512

The tight junction: a multifunctional complex.

Schneeberger, E., & Lynch, R. D. (2004) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00558.2003 · Cited by 1,450

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195

Cadherins in development: cell adhesion, sorting, and tissue morphogenesisPreprint

Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,101

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation

Bertet, C., Sulak, L., & Lecuit, T. (2004) · Nature · doi:10.1038/nature02590 · Cited by 1,037

Deconstructing the Cadherin-Catenin-Actin Complex

Yamada, S., Pokutta, S., Drees, F., Weis, W. I., & Nelson, W. J. (2005) · Cell · doi:10.1016/j.cell.2005.09.020 · Cited by 1,022

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998

α-Catenin Is a Molecular Switch that Binds E-Cadherin-β-Catenin and Regulates Actin-Filament Assembly

Drees, F., Pokutta, S., Yamada, S., Nelson, W. J., & Weis, W. I. (2005) · Cell · doi:10.1016/j.cell.2005.09.021 · Cited by 986

Signalling to and from tight junctions

Matter, K., & Balda, M. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1055 · Cited by 926

ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation

Umeda, K., Ikenouchi, J., Katahira-Tayama, S., Furuse, K., Sasaki, H., Nakayama, M., Matsui, T., Tsukita, S., Furuse, M., & Tsukita, S. (2006) · Cell · doi:10.1016/j.cell.2006.06.043 · Cited by 825

Cadherin-catenin complex: Protein interactions and their implications for cadherin function

Aberle, H., Schwartz, H. T., & Kemler, R. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960616)61:4 · Cited by 806

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., & Tsukita, S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200510043 · Cited by 787

Tight Junctions and Cell Polarity

Shin, K., Fogg, V. C., & Margolis, B. L. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104219 · Cited by 774

High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells

Barrios‐Rodiles, M., Brown, K. R., Ozdamar, B., Bose, R., Liu, Z., Donovan, R. S., Shinjo, F., Liu, Y., Dembowy, J., Taylor, I. W., et al. (2005) · Science · doi:10.1126/science.1105776 · Cited by 726

Adaptation of core mechanisms to generate cell polarity

Nelson, W. J. (2003) · Nature · doi:10.1038/nature01602 · Cited by 716

Balancing cell adhesion and Wnt signaling, the key role of β-catenin

Brembeck, F. H., Rosário, M., & Birchmeier, W. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.007 · Cited by 677

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

Itoh, M., Nagafuchi, A., Moroi, S., & Tsukita, S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.1.181 · Cited by 677

Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability

Itallie, C. M. V., Rahner, C., & Anderson, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12464 · Cited by 593

Claudins create charge-selective channels in the paracellular pathway between epithelial cells

Colegio, O. R., Itallie, C. M. V., McCrea, H. J., Rahner, C., & Anderson, J. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00038.2002 · Cited by 545

Junctional adhesion molecules (JAMs): more molecules with dual functions?

Ebnet, K., Suzuki, A., Ohno, S., & Vestweber, D. (2004) · Journal of Cell Science · doi:10.1242/jcs.00930 · Cited by 530

Claudins in occluding junctions of humans and flies

Furuse, M., & Tsukita, S. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.02.006 · Cited by 525

E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

Tunggal, J. A., Helfrich, I., Schmitz, A., Schwarz, H., Günzel, D., Fromm, M., Kemler, R., Krieg, T., & Niessen, C. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600605 · Cited by 491 · cited 2×

p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho

Wildenberg, G. A., Dohn, M. R., Carnahan, R. H., Davis, M. A., Lobdell, N. A., Settleman, J. E., & Reynolds, A. B. (2006) · Cell · doi:10.1016/j.cell.2006.09.046 · Cited by 437

Hyperproliferation and Defects in Epithelial Polarity upon Conditional Ablation of α-Catenin in Skin

Vasioukhin, V., Bauer, C., Degenstein, L., Wise, B., & Fuchs, E. (2001) · Cell · doi:10.1016/s0092-8674(01)00246-x · Cited by 435

Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: A tight junction disease

Hadj-Rabia, S., Baala, L., Vabres, P., Hamel‐Teillac, D., Jacquemin, E., Fabrè, M., Lyonnet, S., Prost, Y. D., Münnich, A., Hadchouel, M., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.022 · Cited by 426

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

Clayburgh, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24970 · Cited by 419

Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables

Kobielak, A., Pasolli, H. A., & Fuchs, E. V. (2003) · Nature Cell Biology · doi:10.1038/ncb1075 · Cited by 401

Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants

Duguay, D., Foty, R. A., & Steinberg, M. S. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00016-7 · Cited by 397

The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules.

Nagafuchi, A., Ishihara, S., & Tsukita, S. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.1.235 · Cited by 386

Rap1: a key regulator in cell-cell junction formation

Kooistra, M. R. H., Dubé, N., & Bos, J. L. (2006) · Journal of Cell Science · doi:10.1242/jcs.03306 · Cited by 325

Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells

Yu, A. S. L., McCarthy, K. M., Francis, S. A., McCormack, J. M., Lai, J., Rogers, R. A., Lynch, R. D., & Schneeberger, E. E. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00581.2004 · Cited by 307

Desmoplakin is essential in epidermal sheet formation

Vasioukhin, V. I., Bowers, E., Bauer, C. R., Degenstein, L., & Fuchs, E. V. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-1076 · Cited by 304

Afadin

Ikeda, W., Nakanishi, H., Miyoshi, J., Mandai, K., Ishizaki, H., Tanaka, M., Togawa, A., Takahashi, K. P., Nishioka, H., Yoshida, H., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.1117 · Cited by 302

Isolation and functional characterization of the actin‐binding region in the tight junction protein ZO‐1

Fanning, A. S., Ma, T. Y., & Anderson, J. M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0121fje · Cited by 296

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

Qin, Y., Capaldo, C., Gumbiner, B. M., & Macara, I. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506094 · Cited by 285

Tricellulin is a tight-junction protein necessary for hearing

Riazuddin, S., Ahmed, Z. M., Fanning, A. S., Lagziel, A., Kitajiri, S.-I., Ramzan, K., Khan, S. N., Chattaraj, P., Friedman, P. L., Anderson, J. M., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/510022 · Cited by 283

The epidermal barrier function is dependent on the serine protease CAP1/Prss8

Leyvraz, C., Charles, R., Rubera, I., Guitard, M., Rotman, S., Breiden, B., Sandhoff, K., & Hümmler, E. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501038 · Cited by 272

p120-Catenin Mediates Inflammatory Responses in the Skin

Pérez‐Moreno, M., Davis, M. A., Wong, E., Pasolli, H. A., Reynolds, A. B., & Fuchs, E. V. (2006) · Cell · doi:10.1016/j.cell.2005.11.043 · Cited by 267

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

Prasad, R., Gu, Y., Alder, H., Nakamura, T., Canaani, O. D., Saito, H., Huebner, K., Gale, R. P., Nowell̀, P. C., & Kuriyama, K. (1993) · PubMed · Cited by 257

aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization

Suzuki, A., Ishiyama, C., Hashiba, K., Shimizu, M., Ebnet, K., & Ohno, S. (2002) · Journal of Cell Science · doi:10.1242/jcs.00032 · Cited by 251

Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C

Gliki, G., Ebnet, K., Aurrand‐Lions, M., Imhof, B. A., & Adams, R. H. (2004) · Nature · doi:10.1038/nature02877 · Cited by 241

Permeability barrier dysfunction in transgenic mice overexpressing claudin 6

Turksen, K., & Troy, T.-C. (2002) · Development · doi:10.1242/dev.129.7.1775 · Cited by 230

Binding of GEF-H1 to the Tight Junction-Associated Adaptor Cingulin Results in Inhibition of Rho Signaling and G1/S Phase Transition

Aijaz, S., D’Atri, F., Citi, S., Balda, M. S., & Matter, K. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.003 · Cited by 226

Setting up a selective barrier at the apical junction complex

Anderson, J. M., Van Itallie, C. M., & Fanning, A. S. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.01.005 · Cited by 215

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift.

Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J., Birchmeier, W., & Tsukita, S. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.6.1839 · Cited by 212

Absence of the tight junctional protein AF-6 disrupts epithelial cell–cell junctions and cell polarity during mouse development

Zhadanov, A. B., Provance, D. W., Speer, C. A., Coffin, J. D., Goss, D., Blixt, J. A., Reichert, C. M., & Mercer, J. A. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80392-3 · Cited by 208

p120-ctn: A nexus for contextual signaling via Rho GTPases

Anastasiadis, P. Z. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.040 · Cited by 201

Cadherin-mediated cell sorting not determined by binding or adhesion specificity

Niessen, C. M., & Gumbiner, B. M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108040 · Cited by 200

Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses

Tinkle, C. L., Lechler, T., Pasolli, H. A., & Fuchs, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307437100 · Cited by 193

Can 1000 Reviews Be Wrong? Actin, α-Catenin, and Adherens Junctions

Gates, J., & Peifer, M. A. (2005) · Cell · doi:10.1016/j.cell.2005.11.009 · Cited by 182

Regulation of E-cadherin Endocytosis by Nectin through Afadin, Rap1, and p120ctn

Hoshino, T., Sakisaka, T., Baba, T., Yamada, T., Kimura, T., & Takai, Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414447200 · Cited by 171

Arp2/3 Activity Is Necessary for Efficient Formation of E-cadherin Adhesive Contacts

Verma, S., Shewan, A. M., Scott, J. A., Helwani, F., den Elzen, N. R., Miki, H., Takenawa, T., & Yap, A. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404814200 · Cited by 161

E‐cadherin controls adherens junctions in the epidermis and the renewal of hair follicles

Young, P., Boussadia, O., Halfter, H., Grose, R., Berger, P., Leone, D. P., Robenek, H., Charnay, P., Kemler, R., & Suter, U. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg560 · Cited by 156

The challenges of abundance: epithelial junctions and small GTPase signalling

Braga, V. M. M., & Yap, A. S. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.012 · Cited by 146

Role of p120-catenin in cadherin trafficking

Xiao, K., Oas, R. G., Chiasson, C. M., & Kowalczyk, A. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.07.005 · Cited by 144

Links between α-catenin, NF-κB, and squamous cell carcinoma in skin

Kobielak, A., & Fuchs, E. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510422103 · Cited by 123

Role of aPKC Isoforms and Their Binding Partners Par3 and Par6 in Epidermal Barrier Formation

Helfrich, I., Schmitz, A., Zigrino, P., Michels, C., Haase, I., Bivic, A. L., Leitges, M., & Niessen, C. M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700621 · Cited by 115

Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery

Togashi, H., Miyoshi, J., Honda, T., Sakisaka, T., Takai, Y., & Takeichi, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200601089 · Cited by 110

Roles and modes of action of nectins in cell–cell adhesion

Irie, K., Shimizu, K., Sakisaka, T., Ikeda, W., & Takai, Y. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.09.002 · Cited by 109

Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion

Pacquelet, A., & Rørth, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506131 · Cited by 107

Tight Junction Proteins in the Skin

Brandner, J. M., Kief, S., Wladykowski, E., Houdek, P., & Moll, I. (2006) · Skin Pharmacology and Physiology · doi:10.1159/000091973 · Cited by 93

Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression

Guillemot, L., Hammar, E. B., Kaister, C., Ritz, J., Caille, D., Jond, L., Bauer, C. R., Meda, P., & Citi, S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01399 · Cited by 88

Microbial strategies to target, cross or disrupt epithelia

Sousa, S., Lecuit, M., & Cossart, P. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.013 · Cited by 86

Roles and modes of action of nectins in cell–cell adhesion

IRIE, K., Shimizu, K., Sakisaka, T., et al. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(04)00088-6 · Cited by 83

Sealing the live part of the skin: The integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis

Schlüter, H., Wepf, R. A., Moll, I., & Franke, W. W. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00434 · Cited by 80

Cinderella no longer: α-catenin steps out of cadherin's shadow

Scott, J. A., & Yap, A. S. (2006) · Journal of Cell Science · doi:10.1242/jcs.03267 · Cited by 57

Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton

Lorger, M., & Moelling, K. (2006) · Journal of Cell Science · doi:10.1242/jcs.03027 · Cited by 53

ZOning out Tight Junctions

Shin, K., & Margolis, B. L. (2006) · Cell · doi:10.1016/j.cell.2006.08.005 · Cited by 42

Postnatal Lethality of P-Cadherin/Desmoglein 3 Double Knockout Mice: Demonstration of a Cooperative Effect of these Cell Adhesion Molecules in Tissue Homeostasis of Stratified Squamous Epithelia

Lenox, J. M., Koch, P. J., Mahoney, M. G., Lieberman, M. K., Stanley, J. R., & Radice, G. L. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00976.x · Cited by 21

Collective cell migration in morphogenesis, regeneration and cancer

Friedl, P., & Gilmour, D. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,804

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

Boguniewicz, M., & Leung, D. Y. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01027.x · Cited by 1,100

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835

Tight junction defects in patients with atopic dermatitis

Benedetto, A. D., Rafaels, N. M., McGirt, L. Y., Ivanov, A. I., Georas, S. N., Cheadle, C., Berger, A. E., Zhang, K., Vidyasagar, S., Yoshida, T., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.018 · Cited by 750

Skin tissue generation by laser cell printing

Koch, L., Deiwick, A., Schlie, S., Michael, S., Gruene, M., Coger, V., Zychlinski, D., Schambach, A., Reimers, K., Vogt, P. M., et al. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24455 · Cited by 611

Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function

Brandner, J. M., Haftek, M., & Niessen, C. M. (2010) · The Open Dermatology Journal · doi:10.2174/1874372201004010014 · Cited by 43

Open Access Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function

Brandner, J. M., Haftek, M., & Niessen, C. M. (2016)

Cadherin‐Mediated Regulation of Tight Junctions in Stratifying Epithelia

Michels, C., Aghdam, S. Y., & Niessen, C. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04443.x · Cited by 20

Tight junctions in the skin

Morita, K., & Miyachi, Y. (2003) · Journal of Dermatological Science · doi:10.1016/s0923-1811(03)00038-0 · Cited by 65

Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function~!2009-10-24~!2009-12-10~!2010-04-23~!

Brandner, J. M., Haftek, M., & Niessen, C. M. (2010) · The Open Dermatology Journal · doi:10.2174/1874372201004020014 · Cited by 25