Setting up a selective barrier at the apical junction complex
Abstract
Across the animal kingdom the apical junction complex of epithelial cells creates both a permeability barrier and cell polarity. Although based on overlapping and evolutionarily conserved proteins, the cell-cell contacts of nematodes, flies and mammals appear to differ in morphology and functional organization. Emerging evidence shows that the selective pore-like properties of vertebrate and invertebrate barriers are created by the claudin family. Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes.
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Tight junctions act as selective permeability barriers and form a fence separating the apical membrane domain from the basolateral domain in simple epithelial cells.
“Tight junctions act as selective permeability barriers but also form a fence that physically separates the apical membrane domain from the basolateral domain in simple epithelial cells (Anderson et al, 2004).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Anderson et al, 2004
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- Authors
- Anderson, J. M., Van Itallie, C. M., & Fanning, A. S.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Anderson, James Melvin
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 16
- Issue
- 2
- Pages
- 140-145
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2057869740
- Cited by
- 215
- References
- 46
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 14 · 2016: 8 · 2015: 12 · 2014: 7 · 2013: 9 · 2012: 11
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK34134, DK61397, R01DK061397)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- cell polarity, claudins, cell-cell contact, tight junctions
- MeSH terms
- Animals, Cell Membrane Permeability, Epithelial Cells, Humans, Membrane Proteins, Species Specificity, Cell Polarity, Tight Junctions, Evolution, Molecular, Adherens Junctions, Claudin-1
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