Cited by 215Barrier Structure and Function StudiesCell Adhesion Molecules ResearchIon Transport and Channel Regulation

Setting up a selective barrier at the apical junction complex

Anderson, James Melvin, Van Itallie, Christina M, Fanning, Alan S·2004·Current Opinion in Cell Biology

Abstract

Across the animal kingdom the apical junction complex of epithelial cells creates both a permeability barrier and cell polarity. Although based on overlapping and evolutionarily conserved proteins, the cell-cell contacts of nematodes, flies and mammals appear to differ in morphology and functional organization. Emerging evidence shows that the selective pore-like properties of vertebrate and invertebrate barriers are created by the claudin family. Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes.

Integrity signals

Registry

Crossref · 10.1016/j.ceb.2004.01.005

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Tight junctions act as selective permeability barriers and form a fence separating the apical membrane domain from the basolateral domain in simple epithelial cells.

    “Tight junctions act as selective permeability barriers but also form a fence that physically separates the apical membrane domain from the basolateral domain in simple epithelial cells (Anderson et al, 2004).”

Cites

Flagged first, then by citations

3 of the 46 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Anderson, J. M., Van Itallie, C. M., & Fanning, A. S.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Anderson, James Melvin
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2004-04
Volume
16
Issue
2
Pages
140-145
ISSN
0955-0674 (ISSN-L)
OpenAlex
W2057869740
Cited by
215
References
46
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 14 · 2016: 8 · 2015: 12 · 2014: 7 · 2013: 9 · 2012: 11
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK34134, DK61397, R01DK061397)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
cell polarity, claudins, cell-cell contact, tight junctions
MeSH terms
Animals, Cell Membrane Permeability, Epithelial Cells, Humans, Membrane Proteins, Species Specificity, Cell Polarity, Tight Junctions, Evolution, Molecular, Adherens Junctions, Claudin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review