The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ultraviolet Radiation Induced Signature Mutations in Photocarcinogenesis
Open accessAbstract
The photons of sunlight begin a series of genetic events in skin leading to cancer. UV signature mutations provide an alternative to inherited mutations as a way of identifying genes that are involved in cancer development. They augment epidemiologic and clinical data by serving as molecular evidence for the role of UV radiation in skin carcinogenesis. Signature mutations are present in TP53 and PTCH, two tumor suppressor genes responsible for non-melanoma skin cancer. We review evidence that clones of TP53-mutated cells are present in normal human and murine epidermis exposed to UVB and conclude that, in addition to being a tumorigenic mutagen, sunlight acts as a tumor promoter by favoring the clonal expansion of TP53 mutated cells. These combined actions of sunlight result in normal individuals' carrying a substantial burden of keratinocytes predisposed to cancer. Thus cancer involves both a single-cell problem and a multi-cell problem; in skin cancer, sunlight appears to drive both.
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Cites
Sunburn and p53 in the onset of skin cancer
Ziegler, A., Jonason, A. S., Leffellt, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T., & Brash, D. E. (1994) · Nature · doi:10.1038/372773a0 · Cited by 1,497
Self-citationp53-Dependent apoptosis suppresses tumor growth and progression in vivo
Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T., & Van Dyke, T. (1994) · Cell · doi:10.1016/0092-8674(94)90534-7 · Cited by 880 · cited 1×
“Work on DNA viruses has revealed that cells with an aberrant cell cycle undergo apoptosis (Morgenbesser et al, 1994; Symonds et al, 1994).”
Background
Cited by
The epidemiology of UV induced skin cancer
Armstrong, B. K., & Kricker, A. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00198-1 · Cited by 1,811
Solar and ultraviolet radiation
Gies, P., Roy, C., & Udelhofen, P. (2004) · Cancer Prevention — Cancer Causes · doi:10.1007/978-94-017-0511-0_3 · Cited by 354
Yamaguchi, Y., Takahashi, K., Zmudzka, B. Z., Kornhauser, A., Miller, S. A., Tadokoro, T., Berens, W., Beer, J. Z., Hearing, V. J., Yamaguchi, Y., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-5725fje · Cited by 205
Short- and Long-Wave UV Light (UVB and UVA) Induce Similar Mutations in Human Skin Cells
Kappes, U. P., Luo, D., Potter, M., Schulmeister, K., & Rünger, T. M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700093 · Cited by 200
Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)
Rünger, T. M., & Kappes, U. P. (2008) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2008.00319.x · Cited by 171
Metadata
- Authors
- Wikonkal, N. M., & Brash, D. E.
- Venue
- Journal of Investigative Dermatology Symposium Proceedings
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 4
- Issue
- 1
- Pages
- 6-10
- ISSN
- 1087-0024 (ISSN-L)
- OpenAlex
- W1968344694
- Cited by
- 208
- References
- 2
- FWCI
- 18.03
- Type
- conference paper
- Language
- en
- Open access
- hybrid
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- Wikonkal, N. M., & Brash, D. E. (1999). Ultraviolet Radiation Induced Signature Mutations in Photocarcinogenesis. Journal of Investigative Dermatology Symposium Proceedings. https://doi.org/10.1038/sj.jidsp.5640173
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