Short- and Long-Wave UV Light (UVB and UVA) Induce Similar Mutations in Human Skin Cells

Kappes, Ulrike P.; Luo, Dan; Potter, Marisa; Schulmeister, Karl; Rünger, Thomas M.

doi:10.1038/sj.jid.5700093

Cited by 200Skin Protection and AgingDNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Short- and Long-Wave UV Light (UVB and UVA) Induce Similar Mutations in Human Skin Cells

Open access

Kappes, Ulrike P., Luo, Dan, Potter, Marisa, Schulmeister, Karl, Rünger, Thomas M.·2006·Journal of Investigative Dermatology

DOI 10.1038/sj.jid.5700093

Open this paper in CoChat — free account

Abstract

While the mutagenic and carcinogenic properties of longwave UV light (UVA) are well established, mechanisms of UVA mutagenesis remain a matter of debate. To elucidate the mechanisms of mutation formation with UVA in human skin, we determined the spectra of UVA- and UVB-induced mutations in primary human fibroblasts. As with UVB, we found the majority of mutations to be C-to-T transitions also with UVA. For both UVA and UVB, these transitions were found within runs of pyrimidines, at identical hotspots, and with the same predilection for the nontranscribed strand. They also included CC-to-TT tandem mutations. Therefore, these mutations point to a major role of pyrimidine dimers not only in UVB but also in UVA mutagenesis. While some differences were noted, the similarity between the spectra of UVA- and UVB-induced mutations further supports similar mechanisms of mutation formation. A non-dimer type of DNA damage does not appear to play a major role in either UVA or UVB mutagenesis. Therefore, the previously reported increasing mutagenicity per dimer with increasing wavelengths cannot be due to non-dimer DNA damage. Differences in the cellular response to UVA and UVB, such as the less prominent activation of p53 by UVA, might determine a different mutagenic outcome of UVA- and UVB-induced dimers.

Integrity signals

Registry

Crossref · 10.1038/sj.jid.5700093

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Most UVA-induced mutations in cultured cells are C to T transitions at bipyrimidine sites, the mutational hallmark of UV-induced CPDs.
“It was found that most mutations were C fi T transitions at bipyrimidine sites (11,90,91), in fact the mutational hallmark of UV-induced CPDs.”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [90]

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.
Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S., & Loeb, L. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48474-8 · Cited by 1,844 · see citing works
DNA repair: a laboratory manual of research procedures
(1981) · Annales de l Institut Pasteur Virologie · doi:10.1016/s0769-2617(81)80032-9 · Cited by 815 · see citing works
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Ziegler, A., Leffell, D. J., Kunala, S., Sharma, H. W., Gailani, M. R., Simon, J. A., Halperin, A. J., Baden, H. P., Shapiro, P. E., & Bale, A. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4216 · Cited by 739 · see citing works
Wavelength dependence of oxidative DNA damage induced by UV and visible light
Kielbassa, C. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.811 · Cited by 616 · see citing works
The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin carcinogenesis
Agar, N., Halliday, G. M., Barnetson, R. S., Ananthaswamy, H. N., Wheeler, M., & Jones, A. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401141101 · Cited by 530 · see citing works
Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice.
de Gruijl, F. R., Sterenborg, H. J. C. M., Forbes, P. D., Davies, R. E., Cole, C. A., Kelfkens, G., van Weelden, H., Slaper, H., & van der Leun, J. C. (1993) · PubMed · Cited by 471 · see citing works
Ultraviolet A and melanoma: A review
Wang, S. Q., Setlow, R. B., Berwick, M., Polsky, D., Marghoob, A. A., Kopf, A. W., & Bart, R. S. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.114594 · Cited by 454 · see citing works
Bipyrimidine Photoproducts Rather than Oxidative Lesions Are the Main Type of DNA Damage Involved in the Genotoxic Effect of Solar UVA Radiation
Douki, T., Reynaud-Angelin, A., Cadet, J., & Sage, E. (2003) · Biochemistry · doi:10.1021/bi034593c · Cited by 452 · see citing works
Free Radicals in Cutaneous Biology
Darr, D. J., & Fridovich, I. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12374036 · Cited by 402 · see citing works
Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.
Jolly, D. J., Okayama, H., Berg, P. R., Esty, A. C., Filpula, D. R., Böhlen, P., Johnson, G. G., Shively, J. E., Hunkapillar, T., & Friedmann, T. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.2.477 · Cited by 324 · see citing works
Ultraviolet B but not Ultraviolet A Radiation Initiates Melanoma
De Fabo, E. C., Noonan, F. P., Fears, T., & Merlino, G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1454 · Cited by 279 · see citing works
The ‘A rule’ of mutagen specificity: A consequence of DNA polymerase bypass of non‐instructional lesions?
Strauss, B. S. (1991) · BioEssays · doi:10.1002/bies.950130206 · Cited by 263 · see citing works
A role for ultraviolet A in solar mutagenesis.
Drobetsky, E. A., Turcotte, J., & Châteauneuf, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2350 · Cited by 255 · see citing works
Wavelength dependence of ultraviolet-induced DNA damage distribution: Involvement of direct or indirect mechanisms and possible artefacts
Kuluncsics, Z., Perdiz, D., Brulay, E., Muel, B., & Sage, E. (1999) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(99)00034-2 · Cited by 239 · see citing works
Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.
Brash, D. E., Seetharam, S., Kraemer, K. H., Seidman, M. M., & Bredberg, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3782 · Cited by 237 · see citing works
WAVELENGTH DEPENDENT FORMATION OF THYMINE DIMERS AND (6‐4)PHOTOPRODUCTS IN DNA BY MONOCHROMATIC ULTRAVIOLET LIGHT RANGING FROM 150 TO 365 nm
Matsunaga, T., Hieda, K., & Nikaido, O. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02034.x · Cited by 236 · see citing works
UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells
Rochette, P. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg402 · Cited by 231 · see citing works
Epidemiological Support for an Hypothesis for Melanoma Induction Indicating a Role for UVA Radiation
Moan, J. E., Dahlback, A., & Setlow, R. B. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb07995.x · Cited by 209 · see citing works
Ultraviolet Radiation Induced Signature Mutations in Photocarcinogenesis
Wikonkál, N. M., & Brash, D. E. (1999) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsp.5640173 · Cited by 207 · see citing works
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Basu, A. K., Loechler, E. L., Leadon, S. A., & Essigmann, J. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7677 · Cited by 202 · see citing works
Genotoxicity of singlet oxygen
Epe, B. (1991) · Chemico-Biological Interactions · doi:10.1016/0009-2797(91)90086-m · Cited by 185 · see citing works
Cell Cycle-Dependent Strand Bias for UV-Induced Mutations in the Transcribed Strand of Excision Repair-Proficient Human Fibroblasts but Not in Repair-Deficient Cells
McGregor, W. G., Chen, R., Лукаш, Л. Л., Maher, V. M., & McCormick, J. J. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.1927-1934.1991 · Cited by 175 · see citing works
INDUCTION OF DIRECT AND INDIRECT SINGLE‐STRAND BREAKS IN HUMAN CELL DNA BY FAR‐ AND NEAR‐ULTRAVIOLET RADIATIONS: ACTION SPECTRUM AND MECHANISMS
Peak, M. J., Peak, J. G., & Carnes, B. A. (1987) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1987.tb05390.x · Cited by 175 · see citing works
DNA repair: a laboratory manual of research procedures
(1982) · Annales de l Institut Pasteur Virologie · doi:10.1016/s0769-2617(82)80047-6 · Cited by 174 · see citing works
Mutagenesis and Cytotoxicity in Human Epithelial Cells by Far- and Near-Ultraviolet Radiations: Action Spectra
Jones, C., Huberman, E., Cunningham, M. L., & Peak, M. J. (1987) · Radiation Research · doi:10.2307/3576902 · Cited by 152 · see citing works
Larger yield of cyclobutane dimers than 8-oxo-7,8-dihydroguanine in the DNA of UVA-irradiated human skin cells
Courdavault, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2004) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.07.011 · Cited by 145 · see citing works
Replication of damaged DNA by translesion synthesis in human cells
Lehmann, A. R. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.029 · Cited by 142 · see citing works
Structure–function relationships in eukaryotic nuclei
Jackson, D. A. (1991) · BioEssays · doi:10.1002/bies.950130102 · Cited by 137 · see citing works
Amplification and direct nucleotide sequencing of cDNA from the lysate of low numbers of diploid human cells
Yang, J., Maher, V. M., & McCormick, J. J. (1989) · Gene · doi:10.1016/0378-1119(89)90121-2 · Cited by 135 · see citing works
Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role†
Douki, T., Perdiz, D., Grof, P., Kuluncsics, Z., Moustacchi, E., Cadet, J., & Sage, E. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb07988.x · Cited by 133 · see citing works
Role of UVA in the pathogenesis of melanoma and non‐melanoma skin cancer: A short review
Rünger, T. M. (1999) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1999.tb00090.x · Cited by 122 · see citing works
Self-citation
Cell Survival and Shuttle Vector Mutagenesis Induced by Ultraviolet A and Ultraviolet B Radiation in a Human Cell Line
Robert, C., Muel, B., Benoit, A., Dubertret, L., Sarasin, A. R., & Stary, A. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12345616 · Cited by 115 · see citing works
Mutations that alter RNA splicing of the human HPRT gene: a review of the spectrum
O’Neill, J. P., Rogan, P. K., Cariello, N. F., & Nicklas, J. A. (1998) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(98)00013-1 · Cited by 112 · see citing works
The wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts
Enninga, I. C., Groenendijk, R. T. L., Filon, A. R., van Zeeland, A. A., & Simons, J. W. I. M. (1986) · Carcinogenesis · doi:10.1093/carcin/7.11.1829 · Cited by 109 · see citing works
New structural and mechanistic insight into the A-rule and the instructional and non-instructional behavior of DNA photoproducts and other lesions
Taylor, J. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00252-x · Cited by 102 · see citing works
Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation.
Dahle, J., & Kvam, E. (2003) · PubMed · Cited by 96 · see citing works
G-to-T Transversions and Small Tandem Base Deletions Are the Hallmark of Mutations Induced by Ultraviolet A Radiation in Mammalian Cells
Nia, A. B., Synold, T. W., Xi, B., & Pfeifer, G. P. (2004) · Biochemistry · doi:10.1021/bi049761v · Cited by 83 · see citing works
Revisiting the rodent repairadox
Hanawalt, P. C. (2001) · Environmental and Molecular Mutagenesis · doi:10.1002/em.1057 · Cited by 82 · see citing works
The role of DNA polymerase η in UV mutational spectra
Choi, J., & Pfeifer, G. P. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.09.006 · Cited by 68 · see citing works
Production of Pyrimidine Dimers in DNA of Human Skin Exposed In Situ to UVA Radiation
Freeman, S. E., Gange, R. W., Sutherland, J. C., Matzinger, E. A., & Sutherland, B. M. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12469778 · Cited by 68 · see citing works
Protective effect of alpha-tocopherol in carrier liposomes on ultraviolet-mediated human epidermal cell damage in vitro.
Werninghaus, K., Rm, H., & Gilchrest, B. A. (1991) · PubMed · Cited by 66 · see citing works
Spectral comparison of solar simulators and sunlight.
Sayre, R. M., Cole, C. A., Billhimer, W. L., Stanfield, J. W., & Ley, R. D. (1990) · PubMed · Cited by 63 · see citing works
Low incidence of p53 mutations in UVA (365-nm)-induced skin tumors in hairless mice.
van Kranen, H. J., de Laat, A., van de Ven, J., Wester, P. W., de Vries, A., Berg, R. J. W., van Kreijl, C. F., & de Gruijl, F. R. (1997) · PubMed · Cited by 61 · see citing works
Action spectra for killing and mutation of Chinese hamster cells exposed to mid- and near-ultraviolet monochromatic light
Wells, R. L., & Han, A. (1984) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(84)90158-1 · Cited by 60 · see citing works
ULTRAVIOLET LIGHT INDUCES DOUBLE‐STRAND BREAKS IN DNA OF CULTURED HUMAN P3 CELLS AS MEASURED BY NEUTRAL FILTER ELUTION
Peak, J. G., & Peak, M. J. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb04194.x · Cited by 58 · see citing works
The mutagenic effect of ultraviolet‐A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes
Persson, Å. E., Edström, D. W., Bäckvall, H., Lundeberg, J., Pontén, F., Ros, A., & Williams, C. (2002) · Photodermatology Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2002.02781.x · Cited by 42 · see citing works
[Dosimetry of solar ultraviolet radiation. Daily and monthly changes in Paris].
Jeanmougin, M., & Civatte, J. (1987) · PubMed · Cited by 41 · see citing works
Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences
Tiemann, F., & Deppert, W. (1994) · Journal of Virology · doi:10.1128/jvi.68.5.2869-2878.1994 · Cited by 38 · see citing works
Ultraviolet-induced dimerization of non-adjacent pyrimidines
Nguyen, H. T., & Minton, K. W. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90480-9 · Cited by 34 · see citing works
Effect of donor age and prior sun exposure on growth inhibition of cultured human dermal fibroblasts by all trans‐retinoic acid
Stanulis‐Praeger, B. M., & Gilchrest, B. A. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041390117 · Cited by 34 · see citing works
[15] Ultraviolet A- and singlet oxygen-induced mutation spectra
Stary, A., & Sarasin, A. R. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19017-2 · Cited by 29 · see citing works
What the papers say: p53 Loss of Function: Implications for the Processes of Immortalization and Tumorigenesis
Finlay, C. A. (1992) · BioEssays · doi:10.1002/bies.950140811 · Cited by 24 · see citing works
UVAI-induced Edema and Pyrimidine Dimers in Murine Skin¶
Ley, R. D., & Fourtanier, A. M. (2000) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2000)0720485uieapd2.0.co2 · Cited by 14 · see citing works
Preparation and Characterization of DNA Containing a Site-Specific Nonadjacent Cyclobutane Thymine Dimer of the Type Implicated in UV-Induced −1 Frameshift Mutagenesis
Lingbeck, J. M., & Taylor, J. (1999) · Biochemistry · doi:10.1021/bi991035i · Cited by 13 · see citing works
Mutagenic specificity of alkylated and oxidized DNA bases as determined by site-specific mutagenesis.
Jm, E., Basu, A. K., & Loechler, E. L. (1989) · PubMed · Cited by 7 · see citing works
Isolation of Mutagen-Sensitive Chinese Hamster Cell Lines by Replica Plating
Zdzienicka, M. Z. (2003) · Humana Press eBooks · doi:10.1385/1-59259-675-4:49 · Cited by 1 · see citing works

Flagged first, then by citations

1 of the 57 references couldn’t be matched to a known paper.

Sorted by citations

Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility
Fairbanks, B. D., Schwartz, M. P., Bowman, C. N., & Anseth, K. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.055 · Cited by 1,206 · see citing works
Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation
Mouret, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604213103 · Cited by 684 · see citing works
Skin ageing and its treatment
Baumann, L. (2007) · The Journal of Pathology · doi:10.1002/path.2098 · Cited by 675 · see citing works
Epidemiology of Melanoma
Saginala, K., Barsouk, A. A., Aluru, J. S., Rawla, P., & Barsouk, A. (2021) · Medical Sciences · doi:10.3390/medsci9040063 · Cited by 637 · see citing works
The Mechanisms of UV Mutagenesis
Ikehata, H., & Ono, T. (2011) · Journal of Radiation Research · doi:10.1269/jrr.10175 · Cited by 515 · see citing works
UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
Pfeifer, G. P., & Besaratinia, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05144j · Cited by 473 · see citing works
Sunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works
Formation of UV-induced DNA damage contributing to skin cancer development
Cadet, J., & Douki, T. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00395a · Cited by 435 · see citing works
<scp>UV</scp> Signature Mutations
Brash, D. E. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12377 · Cited by 401 · see citing works
ULTRAVIOLET LIGHT INDUCED ALTERATION TO THE SKIN
Svobodová, A. R., Daniela Walterová, B., & Vostálová, J. (2006) · Biomedical Papers · doi:10.5507/bp.2006.003 · Cited by 359 · see citing works
Thiol–Ene Clickable Gelatin: A Platform Bioink for Multiple 3D Biofabrication Technologies
Bertlein, S., Lindberg, G. C. J., Lim, K. S., Jüngst, T., Boeck, T., Blunk, T., Teßmar, J., Hooper, G. J., Woodfield, T. B. F., & Gröll, J. (2017) · Advanced Materials · doi:10.1002/adma.201703404 · Cited by 332 · see citing works
Carcinogens and DNA damage
Barnes, J. L., Zubair, M., John, K., Poirier, M. C., & Martin, F. L. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180519 · Cited by 320 · see citing works
Blue-Light Irradiation Regulates Proliferation and Differentiation in Human Skin Cells
Liebmann, J., Born, M., & Kolb-Bachofen, V. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.194 · Cited by 311 · see citing works
Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup>
Cadet, J., Mouret, S., Ravanat, J., & Douki, T. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01200.x · Cited by 300 · see citing works
Photoresponsive molecular tools for emerging applications of light in medicine
Welleman, I. M., Hoorens, M. W. H., Feringa, B. L., Boersma, H. H., & Szymański, W. (2020) · Chemical Science · doi:10.1039/d0sc04187d · Cited by 274 · see citing works
Water-Soluble Photoinitiators in Biomedical Applications
Tomal, W., & Ortyl, J. (2020) · Polymers · doi:10.3390/polym12051073 · Cited by 253 · see citing works
Injectable scaffolds: Preparation and application in dental and craniofacial regeneration
Chang, B., Ahuja, N., Ma, C., & Liu, X. (2016) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2016.11.001 · Cited by 252 · see citing works
Photopolymerization of cell-laden gelatin methacryloyl hydrogels using a dental curing light for regenerative dentistry
Monteiro, N., Thrivikraman, G., Athirasala, A., Tahayeri, A., França, C. M., Ferracane, J. L., & Bertassoni, L. E. (2017) · Dental Materials · doi:10.1016/j.dental.2017.11.020 · Cited by 228 · see citing works
A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Murray, J. C., Burch, J. A., Streilein, R. D., Iannacchione, M. A., Hall, R. P., & Pinnell, S. R. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.05.004 · Cited by 212 · see citing works
Sunscreens - what's important to know
Antoniou, C., Kosmadaki, M., Stratigos, A. J., & Katsambas, A. D. (2008) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2007.02580.x · Cited by 172 · see citing works
Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)
Rünger, T. M., & Kappes, U. P. (2008) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2008.00319.x · Cited by 171 · see citing works
Self-citation
Unravelling UVA-induced mutagenesis
Sage, E., Girard, P.-M., & Francesconi, S. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05219e · Cited by 167 · see citing works
Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet‐induced photodamage in human skin
Oresajo, C. O., Stephens, T., Hino, P. D., Law, R. M., Yatskayer, M., Foltis, P., Pillai, S. G., & Pinnell, S. R. (2008) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2008.00408.x · Cited by 163 · see citing works
Wavelength dependence of ultraviolet radiation‐induced DNA damage as determined by laser irradiation suggests that cyclobutane pyrimidine dimers are the principal DNA lesions produced by terrestrial sunlight
Besaratinia, A., Yoon, J., Schroeder, C., Bradforth, S. E., Cockburn, M., & Pfeifer, G. P. (2011) · The FASEB Journal · doi:10.1096/fj.11-187336 · Cited by 155 · see citing works
Roles of UVA radiation and DNA damage responses in melanoma pathogenesis
Khan, A. Q., Travers, J. B., & Kemp, M. G. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22176 · Cited by 152 · see citing works
UVA-induced cyclobutane pyrimidine dimers in DNA: a direct photochemical mechanism?
Mouret, S., Philippe, C., Gracia-Chantegrel, J., Banyasz, A., Karpati, S., Markovitsi, D., & Douki, T. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/b924712b · Cited by 149 · see citing works
UVA1 induces cyclobutane pyrimidine dimers but not 6-4 photoproducts in human skin in vivo
Tewari, A., Sarkany, R. P., & Young, A. R. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.283 · Cited by 141 · see citing works
Highly efficient water-soluble visible light photoinitiators
Benedikt, S., Wang, J., Marković, M., Moszner, N., Dietliker, K., Ovsianikov, A., Grützmacher, H., & Liska, R. (2015) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.27903 · Cited by 139 · see citing works
Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective
Chiulan, I., Heggset, E. B., Voicu, Ș. I., & Chinga‐Carrasco, G. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.0c01745 · Cited by 137 · see citing works
An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases
Sani, E. S., Lara, R. P., Aldawood, Z. A., Bassir, S. H., Nguyen, D. H., Kantarcı, A., Intini, G., & Annabi, N. (2019) · Matter · doi:10.1016/j.matt.2019.07.019 · Cited by 135 · see citing works
Solar UV Radiation-Induced DNA Bipyrimidine Photoproducts: Formation and Mechanistic Insights
Cadet, J., Grand, A., & Douki, T. (2014) · Topics in current chemistry · doi:10.1007/128_2014_553 · Cited by 130 · see citing works
Solar radiation induced skin damage: Review of protective and preventive options
Svobodová, A. R., & Vostálová, J. (2010) · International Journal of Radiation Biology · doi:10.3109/09553002.2010.501842 · Cited by 131 · see citing works
Photoaging of the skin
Ichihashi, M., Ando, H., Yoshida, M., Niki, Y., & Matsui, M. S. (2009) · Anti-aging Medicine · doi:10.3793/jaam.6.46 · Cited by 121 · see citing works
An action spectrum for ultraviolet radiation-induced immunosuppression in humans
Damian, D. L., Matthews, Y. J., Phan, T. A., & Halliday, G. M. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10161.x · Cited by 115 · see citing works
Pre-Harvest UV-B Radiation and Photosynthetic Photon Flux Density Interactively Affect Plant Photosynthesis, Growth, and Secondary Metabolites Accumulation in Basil (Ocimum basilicum) Plants
Dou, H., Niu, G., & Gu, M. (2019) · Agronomy · doi:10.3390/agronomy9080434 · Cited by 112 · see citing works
Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C
Besaratinia, A., Kim, S.-I., Bates, S. E., & Pfeifer, G. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610534104 · Cited by 107 · see citing works
The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight
Schuch, A. P., & Menck, C. F. M. (2010) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2010.03.004 · Cited by 103 · see citing works
Ultraviolet A Radiation: Its Role in Immunosuppression and Carcinogenesis
Halliday, G. M., Byrne, S. N., & Damian, D. L. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.08.002 · Cited by 104 · see citing works
UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells
Cai-ling, L., Vojnovic, D., Kochevar, I. E., & Jurkunas, U. V. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19097 · Cited by 101 · see citing works
The role of ultraviolet radiation in melanomagenesis
Von Thaler, A., Kamenisch, Y., & Berneburg, M. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.01025.x · Cited by 100 · see citing works
Vitamin E inhibits the UVAI induction of “light” and “dark” cyclobutane pyrimidine dimers, and oxidatively generated DNA damage, in keratinocytes
Delinasios, G. J., Karbaschi, M., Cooke, M. S., & Young, A. R. (2018) · Scientific Reports · doi:10.1038/s41598-017-18924-4 · Cited by 95 · see citing works
The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts
Saini, N., Roberts, S. A., Klimczak, L. J., Chan, K., Grimm, S. A., Dai, S., Fargo, D. C., Boyer, J. C., Kaufmann, W. K., Taylor, J. A., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006385 · Cited by 94 · see citing works
UVA1 is skin deep: molecular and clinical implications
Tewari, A., Grage, M. M.-L., Harrison, G. I., Sarkany, R., & Young, A. R. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25323b · Cited by 93 · see citing works
Hybrid Tissue Engineering Scaffolds by Combination of Three-Dimensional Printing and Cell Photoencapsulation
Marković, M., Hoorick, J. V., Hölzl, K., Tromayer, M., Gruber, P., Nürnberger, S., Dubruel, P., Vlierberghe, S. V., Liska, R., & Ovsianikov, A. (2015) · Journal of Nanotechnology in Engineering and Medicine · doi:10.1115/1.4031466 · Cited by 90 · see citing works
DNA damage as a biological sensor for environmental sunlight
Schuch, A. P., Machado Garcia, C. C., Makita, K., & Menck, C. F. M. (2013) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp00004d · Cited by 90 · see citing works
Indoor Tanning and Melanoma Risk: Long-Term Evidence From a Prospective Population-Based Cohort Study
Ghiasvand, R., Rueegg, C. S., Weiderpass, E., Green, A. C., Lund, E., & Veierød, M. B. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww148 · Cited by 89 · see citing works
Understanding and Treating Various Skin Types: The Baumann Skin Type Indicator
Baumann, L. (2008) · Dermatologic Clinics · doi:10.1016/j.det.2008.03.007 · Cited by 91 · see citing works
Inflammatory Doses of UV May Not Be Necessary for Skin Carcinogenesis†
Halliday, G. M., & Lyons, J. G. (2007) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00247.x · Cited by 85 · see citing works
UVA Radiation, DNA Damage, and Melanoma
Jin, S., Padron, F., & Pfeifer, G. P. (2022) · ACS Omega · doi:10.1021/acsomega.2c04424 · Cited by 83 · see citing works
UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin
Ikehata, H., Kawai, K., Komura, J.-I., Sakatsume, K., Wang, L., Imai, M., Higashi, S., Nikaido, O., Yamamoto, K., Hieda, K., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.61 · Cited by 79 · see citing works
Rapid repair of UVA‐induced oxidized purines and persistence of UVB‐induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells
Nia, A. B., Kim, S.-I., & Pfeifer, G. P. (2008) · The FASEB Journal · doi:10.1096/fj.07-105437 · Cited by 78 · see citing works
Molecular Regulation of <scp>UV</scp> ‐Induced <scp>DNA</scp> Repair
Shah, P., & He, Y. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12406 · Cited by 75 · see citing works
Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins
Kumar, N., Moreno, N. C., Feltes, B. C., Menck, C. F. M., & Houten, B. V. (2020) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2019-0104 · Cited by 74 · see citing works
Watching the watcher: Regulation of p53 by mitochondria
Holley, A. K., & St Clair, D. K. (2009) · Future Oncology · doi:10.2217/14796694.5.1.117 · Cited by 75 · see citing works
How Different Wavelengths of the Ultraviolet Spectrum Contribute to Skin Carcinogenesis: The Role of Cellular Damage Responses
Rünger, T. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700988 · Cited by 74 · see citing works
Self-citation
Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy
Yu, Z.-W., Zheng, M. H., Fan, H., Liang, X., & Tang, Y. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00209-8 · Cited by 79 · see citing works
Comparison of DNA damage responses following equimutagenic doses of UVA and UVB: a less effective cell cycle arrest with UVA may render UVA-induced pyrimidine dimers more mutagenic than UVB-induced ones
Rünger, T. M., Farahvash, B., Hatvani, Z., & Rees, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05232b · Cited by 72 · see citing works
Self-citation
An overview of photopolymerization and its diverse applications
He, X., Zang, L., Xin, Y., & Zou, Y. (2023) · Applied Research · doi:10.1002/appl.202300030 · Cited by 72 · see citing works
Ultraviolet A within Sunlight Induces Mutations in the Epidermal Basal Layer of Engineered Human Skin
Huang, X., Bernerd, F., & Halliday, G. M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080318 · Cited by 72 · see citing works
Concurrent beneficial (vitamin D production) and hazardous (cutaneous DNA damage) impact of repeated low‐level summer sunlight exposures
Felton, S. J., Cooke, M. S., Kift, R., Berry, J., Webb, A. R., Lam, P. M. W., de Gruijl, F. R., Vail, A., & Rhodes, L. E. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14863 · Cited by 71 · see citing works
K-rasmutations in sinonasal cancers in relation to wood dust exposure
Bornholdt, J., Hansen, J., Steiniche, T., Dictor, M. R., Antonsen, A., Wolff, H. J., Schlünssen, V., Holmila, R. J., Luce, D., Vogel, U. B., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-53 · Cited by 71 · see citing works
Decreased DJ-1 Leads to Impaired Nrf2-Regulated Antioxidant Defense and Increased UV-A–Induced Apoptosis in Corneal Endothelial Cells
Cai-ling, L., Chen, Y.-M., Kochevar, I. E., & Jurkunas, U. V. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14580 · Cited by 70 · see citing works
Synthesis and characterization of photocrosslinkable albumin-based hydrogels for biomedical applications
Lantigua, D., Nguyen, M. A., Wu, X., Suvarnapathaki, S., Kwon, S., Gavin, W. E., & Camci‐Unal, G. (2020) · Soft Matter · doi:10.1039/d0sm00977f · Cited by 69 · see citing works
Safety Analysis for Laser-Based Optical Wireless Communications: A Tutorial
Soltani, M. D., Sarbazi, E., Bamiedakis, N., de Souza, P., Kazemi, H., Elmirghani, J. M. H., White, I. H., Penty, R. V., Haas, H., & Safari, M. (2022) · Proceedings of the IEEE · doi:10.1109/jproc.2022.3181968 · Cited by 71 · see citing works
Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells
Ryšavá, A., Vostálová, J., & Svobodová, A. R. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1962566 · Cited by 65 · see citing works
Characterization of a Human Skin Equivalent Model to Study the Effects of Ultraviolet B Radiation on Keratinocytes
Fernandez, T. L., Lonkhuyzen, D. R. V., Dawson, R., Kimlin, M. G., & Upton, Z. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0293 · Cited by 61 · see citing works
Photostability of Topical Agents Applied to the Skin: A Review
Kryczyk-Poprawa, A., Kwiecień, A., & Opoka, W. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics12010010 · Cited by 58 · see citing works
Longwave UV Light Induces the Aging-Associated Progerin
Takeuchi, H., & Rünger, T. M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.71 · Cited by 56 · see citing works
Self-citation
A Novel, Well‐Resolved Direct Laser Bioprinting System for Rapid Cell Encapsulation and Microwell Fabrication
Wang, Z., Jin, X., Tian, Z., Ménard, F., Holzman, J. F., & Kim, K. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701249 · Cited by 53 · see citing works
Inhibition of S-phase progression triggered by UVA-induced ROS does not require a functional DNA damage checkpoint response in mammalian cells
Girard, P.-M., Pozzebon, M. E., Delacôte, F., Douki, T., Smirnova, V., & Sage, É. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.05.004 · Cited by 50 · see citing works
No formation of DNA double-strand breaks and no activation of recombination repair with UVA
Rizzo, J. L., Dunn, J., Rees, A., & Rünger, T. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.365 · Cited by 50 · see citing works
Self-citation
EXPRESSION OF CONCERN: Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation‐induced inflammation in human skin ex vivo and cultured keratinocytes
Kleszczyński, K., Zwicker, S., Tukaj, S., Kasperkiewicz, M., Zillikens, D., Wolf, R., & Fischer, T. W. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12197 · Cited by 50 · see citing works
Engineering Microvascular Networks in LED Light-Cured Cell-Laden Hydrogels
Monteiro, N., He, W., França, C. M., Athirasala, A., & Bertassoni, L. E. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00502 · Cited by 50 · see citing works
Sun Exposure and Melanoma, Certainties and Weaknesses of the Present Knowledge
Arisi, M., Zane, C., Caravello, S., Rovati, C., Zanca, A., Venturini, M., & Calzavara‐Pinton, P. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00235 · Cited by 50 · see citing works
Wavelength dependency for UVA-induced suppression of recall immunity in humans
Matthews, Y. J., Halliday, G. M., Phan, T. A., & Damian, D. L. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.07.005 · Cited by 49 · see citing works
MEK inhibitors for the treatment of NRAS mutant melanoma
Sarkisian, S., & Davar, D. (2018) · Drug Design, Development and Therapy · doi:10.2147/dddt.s131721 · Cited by 40 · see citing works
Potential use of melatonin in skin cancer treatment: A review of current biological evidence
Pourhanifeh, M. H., Mahdavinia, M., Reiter, R. J., & Asemi, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28129 · Cited by 49 · see citing works
Feasibility of using multiphoton excited tissue autofluorescence for in vivo human histopathology
Cruz, J. M. D., McMullen, J. D., Williams, R. M., & Zipfel, W. R. (2010) · Biomedical Optics Express · doi:10.1364/boe.1.001320 · Cited by 48 · see citing works
Fibroblast encapsulation in gelatin methacryloyl (GelMA) versus collagen hydrogel as substrates for oral mucosa tissue engineering
Tabatabaei, F. S., Moharamzadeh, K., & Tayebi, L. (2020) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2020.08.015 · Cited by 47 · see citing works
Intracellular Degradation of Elastin by Cathepsin K in Skin Fibroblasts— A Possible Role in Photoaging
Codriansky, K. A., Quintanilla‐Dieck, M. J., Gan, S. D., Keady, M., Bhawan, J., & Rünger, T. M. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00592.x · Cited by 48 · see citing works
Self-citation
UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect
Kamenisch, Y., Baban, T., Schuller, W., von Thaler, A., Sinnberg, T. W., Metzler, G., Bauer, J. M., Schittek, B., Garbe, C., Röcken, M., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.02.815 · Cited by 45 · see citing works
Effect of Photoinitiation Process on Photo‐Crosslinking of Gelatin Methacryloyl Hydrogel Networks
Duymaz, D., Karaoğlu, İ. C., & Kızılel, S. (2025) · Macromolecular Rapid Communications · doi:10.1002/marc.202500376 · Cited by 45 · see citing works
Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis
Koreck, A., Széchenyi, A., Mórocz, M., Cîmpean, A. M., Bella, Z., Garaczi, E., Raica, M., Olariu, T. R., Raskó, I., & Kemény, L. V. (2007) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2007.09.013 · Cited by 44 · see citing works
Individual Photosensitivity of Human Skin and UVA-Induced Pyrimidine Dimers in DNA
Mouret, S., Leccia, M. ‐., Bourrain, J. ‐., Douki, T., & Béani, J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.47 · Cited by 43 · see citing works
Visible light-based stereolithography bioprinting of cell-adhesive gelatin hydrogels
Wang, Z., Tian, Z., Jin, X., Holzman, J. F., Ménard, F., & Kim, K. (2017) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2017.8037144 · Cited by 43 · see citing works
L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38/c-Fos signaling, and the proinflammatory cytokines
Salama, S. A., Arab, H. H., Omar, H. A., Gad, H. S., Abd‐Allah, G. M., Maghrabi, I. A., & Robaian, M. M. A. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.034 · Cited by 43 · see citing works
Activation of the Fanconi Anemia/BRCA Pathway and Recombination Repair in the Cellular Response to Solar Ultraviolet Light
Dunn, J., Potter, M., Rees, A., & Rünger, T. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0563 · Cited by 42 · see citing works
Self-citation
Ultra-violet B (UVB)-induced skin cell death occurs through a cyclophilin D intrinsic signaling pathway
Ji, C., Yang, B., Yang, Z. P., Tu, Y., Yang, Y., He, L., & Zhi-gang, B. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.160 · Cited by 40 · see citing works
The effects of sunlight on the skin
Halliday, G. M., Norval, M., Byrne, S. N., Huang, X., & Wolf, P. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.04.005 · Cited by 39 · see citing works
Dermatological Management of Aged Skin
Rostkowska, E., Poleszak, E., Wojciechowska, K., & Szewczyk, K. D. S. (2023) · Cosmetics · doi:10.3390/cosmetics10020055 · Cited by 41 · see citing works
[Ultraviolet A-induced DNA damage: role in skin cancer].
Béani, J. (2014) · PubMed · Cited by 38 · see citing works
Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation
Ikehata, H. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00360a · Cited by 38 · see citing works
Light emitting diodes technology-based photobiomodulation therapy (PBMT) for dermatology and aesthetics: Recent applications, challenges, and perspectives
Tran, V. V., Chae, M., Moon, J., & Lee, Y. (2020) · Optics & Laser Technology · doi:10.1016/j.optlastec.2020.106698 · Cited by 38 · see citing works
Effects and Mechanism of Nicotinamide Against <scp>UVA</scp>‐ and/or <scp>UVB</scp>‐mediated <scp>DNA</scp> Damages in Normal Melanocytes
Chhabra, G., Garvey, D. R., Singh, C. K., Mintie, C. A., & Ahmad, N. (2019) · Photochemistry and Photobiology · doi:10.1111/php.12994 · Cited by 36 · see citing works
Unravelling the molecular mechanism of mutagenic factors impacting human health
Goyal, K., Goel, H., Baranwal, P., Dixit, A., Khan, F., Jha, N. K., Kesari, K. K., Pandey, P., Pandey, A. K., Benjamin, M., et al. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-15442-9 · Cited by 34 · see citing works
Whole-exome sequencing reveals the impact of UVA light mutagenesis in xeroderma pigmentosum variant human cells
Moreno, N. C., de Souza, T. A., Garcia, C. C. M., Ruiz, N. Q., Corradi, C., Castro, L. P., Munford, V., Ienne, S., Alexandrov, L. B., & Menck, C. F. M. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1182 · Cited by 32 · see citing works
C→T Transition Mutations Are Not Solely UVB-Signature Mutations, Because They Are Also Generated by UVA
Rünger, T. M. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.165 · Cited by 33 · see citing works
Self-citation
New Agents for Prevention of Ultraviolet-Induced Nonmelanoma Skin Cancer
Camp, W. L., Turnham, J. W., Athar, M., & Elmets, C. A. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.01.003 · Cited by 32 · see citing works
Imaging of multiple fluorescent proteins in canopies enables synthetic biology in plants
Rigoulot, S. B., Schimel, T. M., Lee, J. H., Sears, R. G., Brabazon, H., Layton, J. S., Li, L., Meier, K. A., Poindexter, M. R., Schmid, M. J., et al. (2020) · Plant Biotechnology Journal · doi:10.1111/pbi.13510 · Cited by 32 · see citing works
Ultra-Violet Light Emission from HPV-G Cells Irradiated with Low Let Radiation from 90 Y; Consequences for Radiation Induced Bystander Effects
Ahmad, S., McNeill, F. E., Byun, S. H., Prestwich, W. V., Mothersill, C. E., Seymour, C. B., Armstrong, A. F., & Fernández-Palomo, C. (2013) · Dose-Response · doi:10.2203/dose-response.12-048.ahmad · Cited by 31 · see citing works

Short- and long-wave ultraviolet light (UVA and UVB) induce similar mutations in human skin cells
(2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.01.088 · Cited by 1 · see citing works
Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)
Rünger, T. M., & Kappes, U. P. (2008) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2008.00319.x · Cited by 171 · see citing works
Self-citation
Comparison of DNA damage responses following equimutagenic doses of UVA and UVB: a less effective cell cycle arrest with UVA may render UVA-induced pyrimidine dimers more mutagenic than UVB-induced ones
Rünger, T. M., Farahvash, B., Hatvani, Z., & Rees, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05232b · Cited by 72 · see citing works
Self-citation
Is UV‐induced mutation formation in melanocytes different from other skin cells?
Rünger, T. M. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00802.x · Cited by 9 · see citing works
Self-citation
Mutations induced by ultraviolet light
Pfeifer, G. P., You, Y., & Nia, A. B. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.057 · Cited by 770 · see citing works

Authors: Kappes, U. P., Luo, D., Potter, M., Schulmeister, K., & Rünger, T. M.
Affiliations: Boston University (US)
AIT Austrian Institute of Technology GmbH (AT)
Corresponding author: Rünger, Thomas M.
ORCID: Luo, Dan
Schulmeister, Karl
Rünger, Thomas M.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2006-03
Volume: 126
Issue: 3
Pages: 667-675
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/sj.jid.5700093
OpenAlex: W1983180437
Cited by: 200
References: 57
Citations by year: 2026: 4 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 14 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 7 · 2013: 10 · 2012: 8
FWCI: 13.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3563 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: pyrimidine dimers, C-to-T transitions, mutational hotspots, primary human fibroblasts, skin cancer, p53 activation, DNA damage
MeSH terms: Base Sequence, Cell Line, DNA Damage, Humans, Molecular Sequence Data, Mutation, Pyrimidine Dimers, Skin, Ultraviolet Rays, Genes, p53

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Short- and Long-Wave UV Light (UVB and UVA) Induce Similar Mutations in Human Skin Cells

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks