Sunburn and p53 in the onset of skin cancer

p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864 · see citing works

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300 · see citing works

High burden and pervasive positive selection of somatic mutations in normal human skin

Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770 · see citing works

The Protective Role of Melanin Against UV Damage in Human Skin ^†

Brenner, M., & Hearing, V. J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00226.x · Cited by 1,741 · see citing works

Melanocyte biology and skin pigmentation

Lin, J. Y., & Fisher, D. E. (2007) · Nature · doi:10.1038/nature05660 · Cited by 1,379 · see citing works

Toxic effects of ultraviolet radiation on the skin

Matsumura, Y., & Ananthaswamy, H. N. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.08.019 · Cited by 1,270 · see citing works

Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms

Nichols, J. A., & Katiyar, S. K. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-009-1001-3 · Cited by 1,103 · see citing works

Oxidation events and skin aging

Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980 · see citing works

Frequent clones of p53-mutated keratinocytes in normal human skin

Jonason, A. S., Kunala, S., Price, G. J., Restifo, R. J., Spinelli, H. M., Persing, J. A., Leffell, D. J., Tarone, R. E., & Brash, D. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14025 · Cited by 685 · see citing works

Central role of p53 in the suntan response and pathologic hyperpigmentation

Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.045 · Cited by 657 · see citing works

Cutaneous photodamage, oxidative stress, and topical antioxidant protection

Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544 · see citing works

<scp>UV</scp> Signature Mutations

Brash, D. E. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12377 · Cited by 401 · see citing works

Sunlight and skin cancer: another link revealed

Kraemer, K. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.11 · Cited by 403 · see citing works

Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study

Yarosh, D., Klein, J., O'Connor, A., Hawk, J., Rafal, E., & Wolf, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04214-8 · Cited by 390 · see citing works

Natural products as photoprotection

Saewan, N., & Jimtaisong, A. (2015) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12123 · Cited by 306 · see citing works

Ultraviolet radiation and cutaneous malignant melanoma

Jhappan, C., Noonan, F. P., & Merlino, G. (2003) · Oncogene · doi:10.1038/sj.onc.1206450 · Cited by 283 · see citing works

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy

Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works

Fas Ligand: A Sensor for DNA Damage Critical in Skin Cancer Etiology

Hill, L. L., Ouhtit, A., Loughlin, S. M., Kripke, M. L., Ananthaswamy, H. N., & Owen-Schaub, L. B. (1999) · Science · doi:10.1126/science.285.5429.898 · Cited by 245 · see citing works

The Similarity of Action Spectra for Thymine Dimers in Human Epidermis and Erythema Suggests that DNA is the Chromophore for Erythema

Young, A. R., Harrison, G. I., Chadwick, C. A., Nikaido, O., Ramsden, J., & Potten, C. S. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00436.x · Cited by 235 · see citing works

α-Melanocyte-stimulating Hormone Protects from Ultraviolet Radiation-induced Apoptosis and DNA Damage

Böhm, M., Wolff, I., Scholzen, T. E., Robinson, S. J., Healy, E., Luger, T. A., Schwarz, T., & Schwarz, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m406334200 · Cited by 228 · see citing works

Macroscopic somatic clonal expansion in morphologically normal human urothelium

Li, R., Du, Y., Chen, Z., Xu, D., Lin, T., Jin, S., Wang, G., Liu, Z., Lu, M., Chen, X., et al. (2020) · Science · doi:10.1126/science.aba7300 · Cited by 206 · see citing works

Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis

Yamaguchi, Y., Takahashi, K., Zmudzka, B. Z., Kornhauser, A., Miller, S. A., Tadokoro, T., Berens, W., Beer, J. Z., Hearing, V. J., Yamaguchi, Y., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-5725fje · Cited by 205 · see citing works

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin

Takeuchi, S., Zhang, W., Wakamatsu, K., Ito, S., Hearing, V. J., Kraemer, K. H., & Brash, D. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403994101 · Cited by 196 · see citing works

Damage to Skin Extracellular Matrix Induced by UV Exposure

Watson, R. E. B., Gibbs, N. K., Griffiths, C. E. M., & Sherratt, M. J. (2014) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5653 · Cited by 179 · see citing works

Cellular aspects of photocarcinogenesis

Nishigori, C. (2006) · Photochemical &amp; Photobiological Sciences · doi:10.1039/b507471a · Cited by 161 · see citing works

Escaping the stem cell compartment: Sustained UVB exposure allows <i>p53</i> -mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

Zhang, W., Remenyik, E., Zelterman, D., Brash, D. E., & Wikonkal, N. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241353198 · Cited by 173 · see citing works

The consequences for human health of stratospheric ozone depletion in association with other environmental factors

Lucas, R. M., Norval, M., Neale, R. E., Young, A. R., de Gruijl, F. R., Takizawa, Y., & van der Leun, J. C. (2014) · Photochemical &amp; Photobiological Sciences · doi:10.1039/c4pp90033b · Cited by 158 · see citing works

Apoptosis regulators and responses in human melanocytic and keratinocytic cells

Bowen, A. R., Hanks, A. N., Allen, S. M., Alexander, A., Diedrich, M. J., & Grossman, D. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12010.x · Cited by 149 · see citing works

Photodamage to human skin by suberythemal exposure to solar ultraviolet radiation can be attenuated by sunscreens: a review: Suberythemal exposure of human skin

Seité, S., Fourtanier, A., Moyal, D., & Young, A. R. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10018.x · Cited by 142 · see citing works

Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma

Lee, C. S., Bhaduri, A., Mah, A., Johnson, W. L., Ungewickell, A., Aros, C. J., Nguyen, C. B., Rios, E. J., Siprashvili, Z., Straight, A., et al. (2014) · Nature Genetics · doi:10.1038/ng.3091 · Cited by 143 · see citing works

Immediate effects of UV radiation on the skin: Modification by an antioxidant complex containing carotenoids

Césarini, J. P., Michel, L., Maurette, J. M., Adhoute, H., & Béjot, M. (2003) · Photodermatology, Photoimmunology &amp; Photomedicine · doi:10.1034/j.1600-0781.2003.00044.x · Cited by 143 · see citing works

Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

Dinkova-Kostova, A. (2008) · Planta Medica · doi:10.1055/s-2008-1081296 · Cited by 136 · see citing works

The molecular determinants of sunburn cell formation

Murphy, G., Young, A. R., Wulf, H. C., Kulms, D., & Schwarz, T. (2001) · Experimental Dermatology · doi:10.1034/j.1600-0625.2001.010003155.x · Cited by 122 · see citing works

Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers

Rhodes, L. E. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg038 · Cited by 118 · see citing works

Calcium Plus Vitamin D Supplementation and the Risk of Nonmelanoma and Melanoma Skin Cancer: Post Hoc Analyses of the Women's Health Initiative Randomized Controlled Trial

Tang, J. Y., Fu, T., LeBlanc, E., Manson, J. E., Feldman, D., Linos, E., Vitolins, M. Z., Zeitouni, N. C., Larson, J., & Stefanick, M. L. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.5967 · Cited by 117 · see citing works

Human Melanocytes and Keratinocytes Exposed to UVB or UVA In Vivo Show Comparable Levels of Thymine Dimers

Young, A. R., Potten, C. S., Nikaido, O., Parsons, P. G., Boenders, J., Ramsden, J. M., & Chadwick, C. A. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00435.x · Cited by 117 · see citing works

The Melanocortin 1 Receptor and the UV Response of Human Melanocytes—A Shift in Paradigm^†

Abdel‐Malek, Z. A., Knittel, J., Kadekaro, A. L., Swope, V. B., & Starner, R. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00294.x · Cited by 111 · see citing works

UV-induced squamous cell carcinoma—a role for antiapoptotic signalling pathways

Rodust, P. M., Stockfleth, E., Ulrich, C., Leverkus, M., & Eberle, J. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09458.x · Cited by 105 · see citing works

Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light

Lou, Y.-R., Lu, Y.-P., Xie, J.-G., Huang, M.-T., & Conney, A. H. (1999) · Nutrition and Cancer · doi:10.1207/s15327914nc330205 · Cited by 105 · see citing works

Vitamin D receptor, a tumor suppressor in skin

Bikle, D. D. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0367 · Cited by 101 · see citing works

Cell type and DNA damage specific response of human skin cells to environmental agents

D’Errico, M., Lemma, T., Calcagnile, A., Santis, L. P. D., & Dogliotti, E. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.06.009 · Cited by 98 · see citing works

Molecular mechanisms involved in UV-induced apoptotic cell death

Kulms, D., & Schwarz, T. (2002) · Skin Pharmacology and Physiology · doi:10.1159/000064539 · Cited by 89 · see citing works

Loss of Fas-Ligand Expression in Mouse Keratinocytes during UV Carcinogenesis

Ouhtit, A., Gorny, A., Muller, H. K., Hill, L. L., Owen-Schaub, L., & Ananthaswamy, H. N. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64836-5 · Cited by 82 · see citing works

Differential role of transcription-coupled repair in UVB-induced G ₂ arrest and apoptosis in mouse epidermis

van Oosten, M., Rebel, H., Friedberg, E. C., van Steeg, H., van der Horst, G. T. J., van Kranen, H. J., Westerman, A., van Zeeland, A. A., Mullenders, L. H. F., & de Gruijl, F. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200226697 · Cited by 82 · see citing works

G2 phase cell cycle arrest in human skin following UV irradiation

Pavey, S., Russell, T., & Gabrielli, B. (2001) · Oncogene · doi:10.1038/sj.onc.1204707 · Cited by 80 · see citing works

The actinic keratosis: A perspective and update

SCHWARTZ, R. A. (1997) · Dermatologic Surgery · doi:10.1111/j.1524-4725.1997.tb00438.x · Cited by 80 · see citing works

IL-12 Prevents the Inhibitory Effects of <i>cis</i> -Urocanic Acid on Tumor Antigen Presentation by Langerhans Cells: Implications for Photocarcinogenesis

Beissert, S., Rühlemann, D., Mohammad, T., Grabbe, S., El-Ghorr, A., Norval, M., Morrison, H., Granstein, R. D., & Schwarz, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6232 · Cited by 77 · see citing works

Ultraviolet B-Sensitive Rice Cultivar Deficient in Cyclobutyl Pyrimidine Dimer Repair

Hidema, J., Kumagai, T., Sutherland, J. C., & Sutherland, B. M. (1997) · Plant Physiology · doi:10.1104/pp.113.1.39 · Cited by 76 · see citing works

Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation

Ikehata, H., & Yamamoto, M. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.038 · Cited by 73 · see citing works

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors

Martínez-Cruz, A. B., Santos, M., Lara, M. F., Segrelles, C., Ruiz, S., Moral, M., Lorz, C., García-Escudero, R., & Paramio, J. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3049 · Cited by 65 · see citing works

Somatic mutation theory, DNA repair rates, and the molecular epidemiology of p53 mutations

Holmquist, G. P., & Gao, S. (1997) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(96)00045-2 · Cited by 66 · see citing works

Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVB

D'Errico, M., Teson, M., Calcagnile, A., De Santis, L. P., Nikaido, O., Botta, E., Zambruno, G., Stefanini, M., & Dogliotti, E. (2003) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4401224 · Cited by 62 · see citing works

Solar ultraviolet radiation induces biological alterations in human skin in vitro: Relevance of a well-balanced UVA/UVB protection

Bernerd, F., Marionnet, C., & Duval, C. (2012) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/0378-6323.97351 · Cited by 54 · see citing works

Modulation of viability and apoptosis of UVB-exposed human keratinocyte HaCaT cells by aqueous methanol extract of laver (Porphyra yezoensis)

Kim, S., You, D. H., Han, T., & Choi, E.-M. (2014) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2014.10.012 · Cited by 49 · see citing works

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes

Brash, D. E., Wikonkal, N. M., Remenyik, E., van der Horst, G. T. J., Friedberg, E. C., Cheo, D. L., van Steeg, H., Westerman, A., & van Kranen, H. J. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01554.x · Cited by 47 · see citing works

Chemical excitation of electrons: A dark path to melanoma

Premi, S., & Brash, D. E. (2016) · DNA Repair · doi:10.1016/j.dnarep.2016.05.023 · Cited by 47 · see citing works

Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency

Nijhof, J. G. W., van Pelt, C., Mulder, A. A., Mitchell, D. L., Mullenders, L. H. F., & de Gruijl, F. R. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl213 · Cited by 44 · see citing works

Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum C

Stout, G. J., & Blasco, M. A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3125 · Cited by 35 · see citing works

Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling

Knezevic, D., Zhang, W., Rochette, P. J., & Brash, D. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701318104 · Cited by 34 · see citing works

Colonization of adjacent stem cell compartments by mutant keratinocytes

BRASH, D., ZHANG, W., GROSSMAN, D., & TAKEUCHI, S. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.08.006 · Cited by 32 · see citing works

A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis

Pradhan, S., Kim, H. K., Thrash, C. J., Cox, M. A., Mantena, S. K., Wu, J.-H., Athar, M., Katiyar, S. K., Elmets, C. A., & Timares, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3077 · Cited by 28 · see citing works

Pyrimidine (6–4) pyrimidone photoproduct mapping after sublethal UVC doses: nucleotide resolution using terminal transferase-dependent PCR

Rochette, P. J., Bastien, N., Todo, T., & Drouin, R. (2006) · Photochemistry and Photobiology · doi:10.1562/2004-12-01-ra-390 · Cited by 27 · see citing works

The Phototumorigenic Fluoroquinolone Lomefloxacin Photosensitizes Pyrimidine Dimer Formation in Human Keratinocytes <i>In Vitro</i>

Traynor, N. J., & Gibbs, N. K. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb08308.x · Cited by 26 · see citing works

Photoaging in skin of color

Bennett, M. F., & Cooper, K. D. (2009) · Light-Based Therapies for Skin of Color · doi:10.1007/978-1-84882-328-0_2 · Cited by 2 · see citing works