Cited by 83Neonatal and fetal brain pathologyCerebral Palsy and Movement DisordersInfant Development and Preterm Care

Movement, imaging and neurobehavioral assessment as predictors of cerebral palsy in preterm infants

Constantinou, J C, Adamson-Macedo, E N, Mirmiran, M, Fleisher, B E·2007·Journal of Perinatology

Abstract

Objective To study the relative efficacy of three early predictors of cerebral palsy.Method One Hundred and thirty infants with birth weight <1500 g were recruited. Video recordings of spontaneous general movements were made at 36 and 52 weeks postconceptional age. Magnetic resonance imaging and the neurobehavioral assessment of the preterm infant were done at 36 weeks postconceptional age. Follow-up neurological examination and Bayley assessments were made at 18 months corrected age to make early identification of cerebral palsy.Results Magnetic resonance imaging gave the best specificity and accuracy of 91 and 84% respectively. General movements at 52 weeks showed an improved specificity and accuracy over performance at 36 weeks postconceptional age. The negative predictive value for all methods tested was between 90 and 97%. Combining the results of magnetic resonance imaging and the neurobehavioral assessment improved the sensitivity of prediction to 80%, suggesting that a holistic approach to early detection of cerebral lesions is preferable to a single test.Conclusions The majority of infants who appeared to behave within normal limits and exhibit normal brain structure in the newborn period were classified as neurologically intact at follow-up.

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Crossref · 10.1038/sj.jp.7211664

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Authors
Constantinou, J. C., Adamson-Macedo, E. N., Mirmiran, M., & Fleisher, B. E.
Affiliations
  • Stanford Medicine (US)
  • University of Wolverhampton (GB)
Corresponding author
Constantinou, J C
Venue
Journal of Perinatology
Published
2007-02-15
Volume
27
Issue
4
Pages
225-229
ISSN
  • 0743-8346 (ISSN-L)
  • 1476-5543
OpenAlex
W1965873886
Cited by
83
References
21
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 5 · 2013: 2 · 2012: 3
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Perinatology (publishedVersion)
  • PubMed (publishedVersion)
  • Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton) (submittedVersion)
Funders
National Center for Research Resources (M01RR000070)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Psychiatry and Mental health › Cerebral Palsy and Movement Disorders
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Keywords
cerebral palsy, preterm infants, early prediction, general movements, magnetic resonance imaging, neurobehavioral assessment, Bayley Scales, brain lesions, neurodevelopmental outcomes, diagnostic accuracy
MeSH terms
Cerebral Palsy, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging, Male, Movement, Predictive Value of Tests, Respiration, Artificial, Sensitivity and Specificity, Video Recording, Early Diagnosis

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