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Cited by 243Parathyroid Disorders and TreatmentsBone health and osteoporosis researchAlkaline Phosphatase Research Studies

Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men

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Nishida, Y., Taketani, Y., Yamanaka-Okumura, H., Imamura, F., Taniguchi, A., Sato, T., Shuto, E., Nashiki, K. +3 more·2006·Kidney International
DOI 10.1038/sj.ki.5002000
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Abstract

Serum fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor and important for the regulation of inorganic phosphate (Pi) homeostasis. In this study, we examined an acute effect of oral Pi loading on serum FGF23 levels to clarify the role in rapid adjustment of serum Pi level. We performed a randomized, double-blind, crossover study in eight healthy male volunteers. The subjects were alternately served one of three test meals containing different Pi amounts (400 mg (P400), 800 mg (P800), and 1200 mg (P1200)) as lunch at noon. The postprandial changes in serum levels of Pi, Ca, 1,25-dihydroxyvitamin D, intact-parathyroid hormone (iPTH), intact-FGF23 (iFGF23), and urinary excretion of Pi and Ca until 8 h after Pi loading were estimated. Serum Pi levels and urinary Pi excretion significantly increased within 1 h after P400 and P800 intake. Serum iPTH levels at 1-2 and 4-6 h after P1200 intake was significantly higher than those of P400 intake. Serum iFGF23 levels slightly decreased up to 8 h after P400 intake and up to 6 h after P800 intake, but not changed in P1200 intake. Significant increase of iFGF23 was observed at 8 h after P1200 intake compared with both P400 and P800 intake. Additionally, negative association was detected between iFGF23 and serum Pi, whereas positive association was observed between iPTH and serum Pi during the short period. We conclude that oral Pi loading cannot rapidly increase serum FGF23 level. FGF23 may be not associated with rapid adaptation of Pi homeostasis.

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Crossref · 10.1038/sj.ki.5002000

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  • Acute increases in dietary Pi intake as well as enteral or i.v. Pi loading cause a rapid increase in PTH and calcitriol, and timely delayed elevation of iFGF23.

    “Acute increases in dietary Pi intake as well as enteral or i.v. Pi loading cause a rapid increase in PTH and calcitriol, and timely delayed elevation of iFGF23 [44, 50, 59].”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [44]

    The Results section reports a rapid PTH increase after higher-phosphate meals, and the Discussion reports only a modest iFGF23 increase at 8 hours after the highest-phosphate meal. The Results found no phosphate-dose-dependent increase in calcitriol, and this study tested oral dietary loading, not intravenous loading. Page numbers are unavailable in our copy. (LLM, conf=0.91)

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  • Controlled experiments in healthy humans examined periods of either a few hours or several weeks, and often varied dietary calcium intake.

    “controlled experiments in healthy humans examined periods of either a few hours or several weeks, and often varied dietary calcium intake.”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [44]

    The Study design section (page not specified) describes a controlled experiment in eight healthy men, with measurements through eight hours after a meal. It does not describe a several-week human experiment, and the Discussion says calcium intake was standardized throughout this study rather than varied between test meals. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Short-term oral Pi loading in healthy subjects is sometimes accompanied by an increase in iFGF23.

    “This was accompanied by an increase in PTH and, in some studies, by an increase in intact FGF23 (iFGF23) [44, 59].”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [44]

  • Short-term oral Pi loading in healthy subjects is accompanied by an increase in PTH.

    “This was accompanied by an increase in PTH and, in some studies, by an increase in intact FGF23 (iFGF23) [44, 59].”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [44]

  • Short-term oral Pi loading in healthy subjects causes a post-prandial rise in serum Pi and urinary Pi excretion.

    “In short-term studies, where healthy subjects were orally loaded with Pi and followed up for eight hours, a post-prandial rise in serum Pi and urinary Pi excretion was observed.”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [44]

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Research works printed but not linked: 1

  1. Murer H, Biber J. Renal tubular phosphate transport. In: Seldin DW, Diebish G (eds). The Kidney, Physiology and Pathophysiology, 2nd edn. Raven press: New York, 1992, pp 2481-2509.

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Authors
Nishida, Y., Taketani, Y., Yamanaka-Okumura, H., Imamura, F., Taniguchi, A., Sato, T., Shuto, E., Nashiki, K., Arai, H., Yamamoto, H., & Takeda, E.
Affiliations
  • Tokushima University (JP)
  • Tufts University (US)
Corresponding author
Taketani, Y.
ORCID
Venue
Kidney International
Publisher
Elsevier BV
Published
2006-12
Volume
70
Issue
12
Pages
2141-2147
ISSN
0085-2538 (ISSN-L)
DOI
10.1038/sj.ki.5002000
OpenAlex
W2027418334
Cited by
243
References
27
Citations by year
2026: 6 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 9 · 2018: 15 · 2017: 8 · 2016: 12 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 21
FWCI
7.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Kidney International (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Uehara Memorial Foundation
  • Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Keywords
fibroblast growth factor 23, inorganic phosphate homeostasis, serum phosphorus, parathyroid hormone, 1,25-dihydroxyvitamin D, urinary phosphate excretion, urinary calcium excretion
MeSH terms
Fibroblast Growth Factor-23, Administration, Oral, Adult, Calcium, Fibroblast Growth Factors, Homeostasis, Humans, Male, Parathyroid Hormone, Phosphates, Vitamin D, Cross-Over Studies

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