Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc− cystine transporter: a new action for an old drug

Goodman and Gilman's The Pharmacological Basis of Therapeutics

Hastings, R. C. (1996) · JAMA · doi:10.1001/jama.1996.03540120077042 · Cited by 2,375

Determination of subcutaneous tumor size in athymic (nude) mice

Tomayko, M. M., & Reynolds, C. P. (1989) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00300234 · Cited by 1,830

Cancer: Principles and Practice of Oncology

Gunn, W. G. (1994) · JAMA · doi:10.1001/jama.1994.03510350091047 · Cited by 1,803

Inhibition of NF-κB by Sodium Salicylate and Aspirin

Kopp, E. B., & Ghosh, S. (1994) · Science · doi:10.1126/science.8052854 · Cited by 1,744

Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

Sato, H., Tamba, M., Ishii, T., & Bannai, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11455 · Cited by 1,111

Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B

Wahl, C., Liptay, S., Adler, G., & Schmid, R. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci992 · Cited by 742

NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

Wang, C.-Y., Guttridge, D. C., Mayo, M. W., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.5923 · Cited by 594

Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

Back, S. A., Gan, X., Li, Y., Rosenberg, P. A., & Volpe, J. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06241.1998 · Cited by 586

Exchange of cystine and glutamate across plasma membrane of human fibroblasts.

Bannai, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35926-4 · Cited by 549

Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout

Insel, P. (1996) · Medical Entomology and Zoology · Cited by 416

The redox status of cystinotic fibroblasts

Vitvitsky, V., Witcher, M., Banerjee, R. V., & Thoene, J. G. (2009) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2009.12.010 · Cited by 16

The dynamic role of ferroptosis in cancer immunoediting: Implications for immunotherapy

Lan, J., Cai, D., Gou, S., Bai, Y., Lei, H., Li, Y., Chen, Y., Zhao, Y., Shen, J., Wu, S., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107674 · Cited by 16

cROSsing the Line: Between Beneficial and Harmful Effects of Reactive Oxygen Species in B-Cell Malignancies

Domka, K., Góral, A., & Firczuk, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01538 · Cited by 15

Potential applications of ferroptosis inducers and regulatory molecules in hematological malignancy therapy

Tang, X., Niu, Y., Jian, J., Guo, Y., Wang, Y., Zhu, Y. F., & Liu, B. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104203 · Cited by 15

Mechanisms of ferroptosis and targeted therapeutic approaches in lymphoma

Yu, T., Xu-Monette, Z. Y., Li, Y., Li, Y., & Young, K. H. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06295-w · Cited by 21

Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis

Wang, C., Zhao, Y., Peng, Y., Chen, W., Zhu, J., Gu, C., Huo, R., Ding, L., Liu, T., Liu, T., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156417 · Cited by 15

Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma

Ma, S., Adzavon, Y. M., Wen, X., Zhao, P., Xie, F., Liu, M., & Ma, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.873029 · Cited by 15

Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

Chintala, S., Tóth, K., Yin, M.-B., Bhattacharya, A., Smith, S. B., Ola, M. S., Cao, S., Durrani, F. A., Zinia, T. R., Dean, R., et al. (2010) · Chemotherapy · doi:10.1159/000316334 · Cited by 15

The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis

Wang, J., Hao, S., Song, G., Wang, Y., & Hao, Q. (2023) · PeerJ · doi:10.7717/peerj.14931 · Cited by 14

Role of ferroptosis in esophageal cancer and corresponding immunotherapy

Fan, X., Fan, Y.-T., Zeng, H., Dong, X.-Q., Lu, M., & Zhang, Z. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i7.1105 · Cited by 14

Electroacupuncture Inhibits Neural Ferroptosis in Rat Model of Traumatic Brain Injury via Activating System Xc − /GSH/GPX4 Axis

Li, N., Wang, R., Ai, X., Guo, J., Bai, Y., Guo, X., Zhang, R., Du, X., Chen, J., & Li, H. (2024) · Current Neurovascular Research · doi:10.2174/0115672026297775240405073502 · Cited by 14

Desaminotyrosine is a redox‐active microbial metabolite that bolsters macrophage antimicrobial functions while attenuating IL ‐6 production

Zhou, J., Han, J., Wei, Y., & Wang, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202400638r · Cited by 14

Programmed cell death and melatonin: A comprehensive review

Rafiyan, M., Reiter, R. J., Manesh, S. M. R., Asemi, R., Sharifi, M., Mohammadi, S., Mansournia, M. A., & Asemi, Z. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01454-4 · Cited by 14

Oxidative stress and cancer pain

Ungard, R. G., Seidlitz, E. P., & Singh, G. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0298 · Cited by 16

Metabolic Gatekeepers of Pathological B Cell Activation

Sadras, T., Chan, L. N., Xiao, G., & Müschen, M. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-061020-050135 · Cited by 17

Ferritinophagy‐Mediated ROS Production Contributed to Proliferation Inhibition, Apoptosis, and Ferroptosis Induction in Action of Mechanism of 2‐Pyridylhydrazone Dithiocarbamate Acetate

Li, L., Li, H., Li, Y., Feng, J., Guan, D., Zhang, Y., Fu, Y., Li, S., & Li, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5594059 · Cited by 14

Targeting Ferroptosis as the Achilles’ Heel of Breast Cancer: Mechanisms and Therapeutic Opportunities from a Comprehensive Systematic Review

Szulc, A., & Woźniak, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209902 · Cited by 17

Selenium nanoparticles decorated by fucoidan induce ferroptosis in HepG2 cells

Chen, Y., Liu, X., Chen, B., Zhu, F., Wang, Z., Cheong, K., Ye, S., Zhong, S., & Chen, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138841 · Cited by 13

Engineering Modular Peptide Nanoparticles for Ferroptosis‐Enhanced Tumor Immunotherapy

Wu, B., Yang, X., Kong, N., Liang, J., Li, S., & Wang, H. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202421703 · Cited by 13

Arylsulfonothioates: Thiol-Activated Donors of Hydropersulfides which are Excreted to Maintain Cellular Redox Homeostasis or Retained to Counter Oxidative Stress

Khodade, V. S., Liu, Q., Zhang, C., Keceli, G., Paolocci, N., & Toscano, J. P. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c17661 · Cited by 13

Identifying Prognostic Features by Bottom-Up Approach and Correlating to Drug Repositioning

Li, W., Yu, J., Lian, B., Sun, H., Li, J., Zhang, M., Li, L., Li, Y., Liu, Q., & Xie, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118672 · Cited by 13

Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H2O2-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45

Bauer, G. (2021) · Antioxidants · doi:10.3390/antiox10101585 · Cited by 13

Chemical hybridization of sulfasalazine and dihydroartemisinin promotes brain tumor cell death

Ackermann, A., Çapcı, A., Buchfelder, M., Tsogoeva, S. B., & Savaskan, N. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-99960-z · Cited by 13

A cascading-response fluorescent probe for real-time pH monitoring during cysteine-depletion process in pancreatic cancer cells

Qin, X., Zhang, S., Guo, X., Liu, X., & Shen, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1062781 · Cited by 12

Sulfasalazine attenuates ACL transection and medial menisectomy‐induced cartilage destruction by inhibition of cystine/glutamate antiporter

Tsai, W., Tsai, R., Liu, C., Wu, J., & Wong, C. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.23069 · Cited by 13

Reactive oxygen species and cancer

Kong, H., & Chandel, N. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00030-4 · Cited by 12

Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects

Verbruggen, L., Sprimont, L., Bentea, E., Janssen, P., Gharib, A., Deneyer, L., Pauw, L. D., Lara, O., Sato, H., Nicaise, C., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.625699 · Cited by 12

Regulators of system xc−–glutathione-glutathione peroxidase 4 antioxidant pathway: Recent advances and challenges in targeting ferroptosis for cancer treatment

Priyanka, Gupta, S., Vatsa, M., & Mondal, S. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104546 · Cited by 13

Breast cancer cells have an increased ferroptosis risk induced by system xc− blockade after deliberately downregulating CYTL1 to mediate malignancy

Xue, W., Yu, Y., Yao, Y., Zhou, L., Huang, Y., Wang, Y., Chen, Z., Wang, L., Li, X., Wang, X., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103034 · Cited by 11

Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions

Ali, A., Babar, Q., Saeed, A., Sergi, D., Naumovski, N., Ahmed, I. A. M., Shamlan, G. H., Hafiz, H., Manzoor, M. F., Trafiałek, J., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70385 · Cited by 14

Immuno-onco-metabolism and Therapeutic Resistance

Mir, M. A., Aisha, S., Nisar, S., Qayoom, H., & Mehraj, U. (2022) · Springer eBooks · doi:10.1007/978-981-16-6226-3_3 · Cited by 11

Progress in the study of ferroptosis in cancer treatment: State-of-the-Art

Wang, D. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110348 · Cited by 11

Amino acids in hematologic malignancies: Current status and future perspective

Wang, M., Zhao, A., Li, M., & Niu, T. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1113228 · Cited by 11

System χc- overexpression prevents 2-deoxy-d-ribose-induced β-cell damage

Yoo, S., Bae, J. Y., Moon, J., & Koh, G. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.012 · Cited by 11

Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats

Quintanilla, M. E., Morales, P., Ezquer, F. E., Ezquer, M., Herrera‐Marschitz, M., & Israel, Y. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.617418 · Cited by 11

Salubrinal Enhances Cancer Cell Death during Glucose Deprivation through the Upregulation of xCT and Mitochondrial Oxidative Stress

Chen, M., Hsu, L.-L., Wang, S., Pan, Y.-L., Lo, J., Yeh, T.-S., Tseng, L., & Lee, H. (2021) · Biomedicines · doi:10.3390/biomedicines9091101 · Cited by 12

Radioprotective effect of sulfasalazine on mouse bone marrow chromosomes

Mantena, S. K., Unnikrishnan, M. K., & Devi, P. U. (2008) · Mutagenesis · doi:10.1093/mutage/gen005 · Cited by 11

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

Amin, M. A., Zehravi, M., Sweilam, S. H., Jahnavi, P., Gupta, J. K., Rajashakar, V., Vodeti, R., Billah, A. A. M., Dharmamoorthy, G., Arjun, U. V. N. V., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70834 · Cited by 11

Intracellular self-aggregation of biomimetic Fe 3 O 4 nanoparticles for enhanced ferroptosis-inducing therapy of breast cancer

Zhang, Z., Xie, B., Lu, X., Xiong, L., Li, X., Zhang, Y., Li, C., & Wang, C. (2023) · Nanoscale · doi:10.1039/d3nr04305c · Cited by 10

Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain

Beckers, P., do Nascimento, I. B., Charlier, M., Desmet, N., Massie, A., & Hermans, E. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03112-9 · Cited by 13

Remodeling of sorafenib as an orally bioavailable ferroptosis inducer for Lung Cancer by chemical modification of adenine-binding motif

Kim, Y.-J., Lim, B., Kim, S. Y., Shin, Y.-Z., Yu, N., Shin, E.-K., Lee, J.-E., Jeon, Y. H., Kim, D., Lee, J., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116758 · Cited by 10

Pharmacologically Targeting Ferroptosis and Cuproptosis in Neuroblastoma

Liu, Y., Fleishman, J. S., Wang, H., & Huo, L. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04501-0 · Cited by 12

Ferroptosis Induction Enhances Photodynamic Therapy Efficacy for OLK

Yang, D., Yang, D., Song, Y. W., Liu, J., Wang, Y., Feng, X., Zeng, X., Chen, Q., Li, J., & Dan, H. (2024) · Journal of Dental Research · doi:10.1177/00220345241280257 · Cited by 10

Structure‐Activity‐Relationship‐Aided Design and Synthesis of xCT Antiporter Inhibitors

Cirillo, D., Sarowar, S., Enger, P. Ø., & Bjørsvik, H. (2021) · ChemMedChem · doi:10.1002/cmdc.202100204 · Cited by 10

Emerging roles of system antiporter and its inhibition in CNS disorders

Patel, D., Kharkar, P. S., & Nandave, M. (2015) · Molecular Membrane Biology · doi:10.3109/09687688.2015.1096972 · Cited by 10

Ferroptosis as a New Type of Cell Death and its Role in Cancer Treatment

Skoupilová, H., Michalová, E., & Hrstka, R. (2018) · Klinicka onkologie · doi:10.14735/amko20182s21 · Cited by 11

Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression

Ishii, T., Mimura, I., Nagaoka, K., Naito, A., Sugasawa, T., Kuroda, R., Yamada, D., Kanki, Y., Kume, H., Ushiku, T., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01255-3 · Cited by 10

FAdV-4-induced ferroptosis affects fat metabolism in LMH cells

Dong, W., Du, K., Ding, Y., Liu, Y., Peng, L., Wu, C., Sun, Y., Li, Z., & Niu, Y. (2024) · Veterinary Microbiology · doi:10.1016/j.vetmic.2024.110068 · Cited by 9

Targeting Ferroptosis: Small-molecule Inducers as Novel Anticancer Agents

Jin, S., Wang, H., Zhang, Z., & Yan, M. (2024) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/0118715206342278241008081126 · Cited by 9

Innovative Therapeutic Strategies Targeting the Network Architecture of Glioblastoma

Beichert, J., Hoffmann, D. C., Winkler, F., & Ratliff, M. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-0018 · Cited by 11

Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies

Song, L., Shu, Y., Zhou, T., Wang, Y., Zhang, H., Liao, Y., Zhu, C., Zhang, W., & Zou, Z. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00773-5 · Cited by 9

High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells

Valvo, V., Parietti, E., Deans, K., Ahn, S. W., Park, N. R., Ferland, B., Thompson, D., Dominas, C. A., Bhagavatula, S. K., Davidson, S. M., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1032360 · Cited by 9

Sulfasalazine and Mesalamine Modulate Beryllium-Specific Lymphocyte Proliferation and Inflammatory Cytokine Production

Dobis, D. R., Sawyer, R. T., Gillespie, M. M., Newman, L. S., Maier, L. A., & Day, B. J. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0150oc · Cited by 9

Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme

El-Dershaby, N. H., El-Hawash, S. A., Kassab, S. E., Daabees, H. G., Moneim, A. E. A., Wahab, I. A. A., Abd-Alhaseeb, M. M., & El-Miligy, M. M. M. (2022) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2022.2086868 · Cited by 9

Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc−

Gu, L., Hu, X., Xue, Z., Yang, J., LiShu, W., Ren, Y., Hertz, L., & Peng, L. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.10.010 · Cited by 9

Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception

Linher‐Melville, K., Sharma, M., Nakhla, P., Kum, E., Ungard, R. G., Park, J. E., Rosa, D. A., Gunning, P. T., & Singh, G. (2019) · Molecular Pain · doi:10.1177/1744806918823477 · Cited by 9

Effect of sulfasalazine on ferroptosis during intestinal injury in rats after liver transplantation

Wu, W., Bao, X., Bu, W., Wang, Y., Tan, Y., wei, J., & wang, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-58057-z · Cited by 10

Cystine/cysteine metabolism regulates the progression and response to treatment of triple‑negative breast cancer (Review)

Xiao, W., & Xu, C. (2024) · Oncology Letters · doi:10.3892/ol.2024.14654 · Cited by 8

Ferroptosis in tumor associated immune cells: A double-edged sword against tumors

Hu, J., Cui, L., Hou, B., Ding, X., Liu, H., Sun, W., Mi, Y., Chen, Y., & Zou, Z. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104818 · Cited by 8

Ferroptosis as an approach to leverage cancer metabolism

Jin, J., Hu, J., Li, M., Gu, W., Jiang, X., & Stockwell, B. R. (2026) · Trends in Cell Biology · doi:10.1016/j.tcb.2026.03.008 · Cited by 8

The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (Review)

Feng, Y., Li, X., Yang, B., Li, M., Du, Y., Wang, J., Liu, S., Gong, L., Li, L., & Gao, L. (2024) · Oncology Reports · doi:10.3892/or.2024.8738 · Cited by 9

Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease

Zhu, J., Zhang, Z., Chu, Y., Xie, Z., Zeng, D., Jin, L., & Li, L. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s496644 · Cited by 8

Ferroptosis in Cancer Immunotherapy—Implications for Hepatocellular Carcinoma

Kusnick, J., Bruneau, A., Tacke, F., & Hammerich, L. (2022) · Immuno · doi:10.3390/immuno2010014 · Cited by 9

Ferroptosis: A potential opportunity for intervention of pre-metastatic niche

Zhuo, S., Yang, L., Chen, S., Tang, C., Li, W., Gao, Z., Feng, J., & Yang, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.980620 · Cited by 8

Ferroptosis, a new form of cell death: mechanisms, biology and role in gynecological malignant tumor.

Mao, X., Liu, K., Shen, S.-Q., Meng, L., & Chen, S. (2023) · PubMed Central · Cited by 8

Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System x c −

Bridges, R. J., & Patel, S. A. (2008) · Topics in medicinal chemistry · doi:10.1007/7355_2008_026 · Cited by 8

Targeting ferroptosis in gastrointestinal tumors: Interplay of iron-dependent cell death and autophagy

Safari, M. H., Rahimzadeh, P., Alaei, E., Alimohammadi, M., Esfandiari, N., Daneshi, S., Malgard, N., Farahani, N., Taheriazam, A., & Hashemi, M. (2025) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2025.102013 · Cited by 8

The protective effect of N-acetylcysteine on hippocampal ferroptosis in an experimental obesity model

Tüfekci, K. K., & Tatar, M. (2023) · Journal of Cellular Neuroscience and Oxidative Stress · doi:10.37212/jcnos.1358141 · Cited by 7

Exploring the Updated Roles of Ferroptosis in Liver Diseases: Mechanisms, Regulators, and Therapeutic Implications

Ge, T., Wang, Y., Han, Y., Bao, X., & Chunfeng, L. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01611-3 · Cited by 7

Quantification and Metabolite Identification of Sulfasalazine in Mouse Brain and Plasma Using Quadrupole-Time-of-Flight Mass Spectrometry

Choi, J., Park, M., Shin, S., Byeon, J., Lee, B. I., Park, Y., & Shin, Y. G. (2021) · Molecules · doi:10.3390/molecules26041179 · Cited by 7

Oral Conventional Synthetic Disease-Modifying Antirheumatic Drugs with Antineoplastic Potential: a Review

Hsieh, C.-H., Huang, Y., & Tsai, T. (2022) · Dermatology and Therapy · doi:10.1007/s13555-022-00713-1 · Cited by 7

Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy

Cronin, S. J. F., Andrews, N. A., & Latrémolière, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1173599 · Cited by 7

Ferroptosis and its modulators: A raising target for cancer and Alzheimer’s disease

Singh, G., Kesharwani, P., Singh, G. K., Kumar, S., Putta, A., & Modi, G. P. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117564 · Cited by 7

Hodgkin s disease with nephrotic syndrome as a complication of ulcerative colitis: case report.

Bašić‐Jukić, N., Radman, I., Rončević, T., & Jakić‐Razumović, J. (2002) · PubMed · Cited by 7

Ferroptosis and its relationship with cancer

Su, C., Xue, Y., Fan, S., Sun, X., Si, Q., Gu, Z., Wang, J., & Deng, R. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1423869 · Cited by 6

LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance

Ramage, D. E., Wieske, L. H. E., Crowe, C., Christensen, J. B., von Wilmowski, T. A., Bannister, Z., Grant, D. W., Nakasone, M. A., Haubrich, K., Dorward, M., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.06.014 · Cited by 7

Ferroptosis in hematological malignancies: molecular mechanisms and therapeutic potential

Liu, J., Liu, R., Miao, J., & He, A. (2025) · Cellular Oncology · doi:10.1007/s13402-025-01142-w · Cited by 7

Defining a Water-Soluble Formulation of Arachidonic Acid as a Novel Ferroptosis Inducer in Cancer Cells

Day, Z. I., Mayfosh, A. J., Baxter, A. A., Williams, S. A., Hildebrand, J. M., Rau, T. F., Poon, I. K. H., & Hulett, M. D. (2024) · Biomolecules · doi:10.3390/biom14050555 · Cited by 6

Myeloid Derived Suppressor Cells: Subsets, Expansion, and Role in Cancer Progression

Abastado, J., & Zhi, L. (2012) · InTech eBooks · doi:10.5772/36409 · Cited by 6

Cysteine Metabolism in Cancer Progression and Therapy Resistance

Nin, D. S., Idres, S. B., & Deng, L. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_7 · Cited by 6

Small Molecule Regulators of Ferroptosis

Debieu, S., Solier, S., Colombeau, L., Versini, A., Sindikubwabo, F., Forrester, A. R., Müller, S., Cañeque, T., & Rodriguez, R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-62026-4_6 · Cited by 6

The Styryl Benzoic Acid Derivative DC10 Potentiates Radiotherapy by Targeting the xCT-Glutathione Axis

Sarowar, S., Cirillo, D., Játiva, P., Nilsen, M. H., Otragane, S.-M. A., Heggdal, J., Selheim, F., Ceña, V., Bjørsvik, H., & Enger, P. Ø. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.786739 · Cited by 6

Effect of early endometriosis on ovarian reserve and reproductive outcome

Kitaya, K. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/423 · Cited by 6

IDENTIFYING CANCER SPECIFIC METABOLIC SIGNATURES USING CONSTRAINT-BASED MODELS

Schultz, A., MEHTA, S., HU, C. W., Hoff, F. W., Horton, T. M., Kornblau, S. M., & Qutub, A. A. (2016) · Pacific Symposium on Biocomputing (PSB) · doi:10.1142/9789813207813_0045 · Cited by 6

Inhibition of xCT by sulfasalazine alleviates the depression-like behavior of adult male mice subjected to maternal separation stress

Wang, S., Liu, Y., Wu, Z., Jin, Y., Zhang, T., Yang, Z., & Liu, C. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114559 · Cited by 5

Iodine-131 induces ferroptosis and synergizes with sulfasalazine in differentiated thyroid cancer cells via suppressing SLC7A11

Li, L., Zhang, J., Zhang, X., Wang, P., Ma, M., & Yin, B. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1580828 · Cited by 7

Overview and SWOT analysis of nano-ferroptosis therapy for cancers

Qian, C., Zhu, J., Jiang, J., & Huang, Z. (2025) · Nanoscale Horizons · doi:10.1039/d5nh00170f · Cited by 5

Targeting ataxia-telangiectasia mutated and cystine/glutamate antiporter enhances radiotherapy efficacy and tumor suppression in glioblastoma

Seol, M. Y., Choi, S. H., & Yoon, H. I. (2025) · Journal of Neuro-Oncology · doi:10.1007/s11060-025-05128-4 · Cited by 5

SLC7A11 as a molecular nexus of prognosis, resistance, and therapeutic roadmap in cancer: A systematic review and meta-analysis

Sharma, A., Srivastava, Y., Prasad, S., Ghosh, S., Kumar, R. S., Bharti, A. C., Singh, R. P., & Nasare, V. D. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149257 · Cited by 7

Ferroptosis at the intersection of radiotherapy and immunotherapy

Wei, G.-X., Zhao, Y., Tang, R., Shi, H., & Li, Z. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10306-x · Cited by 7

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

Xu, X., Wang, X., Jiang, W., Kamaruddin, W. H. A., Fang, C., & Zhang, P. (2026) · BMEMat · doi:10.1002/bmm2.70080 · Cited by 5

CRL2FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer

Ahmed, B., Salaün, D., Jordan, J. B., Daulat, A. M., Pastorello, C., Brito, T., Yang, Y., Josselin, E., Byrne, D., Betzi, S., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.04.008 · Cited by 6

Deciphering Ferroptosis: From Molecular Pathways to Machine Learning-Guided Therapeutic Innovation

Mete, M., Ojha, A., Dhar, P., & Das, D. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01139-0 · Cited by 6

Gene expression profiling and pathway analysis in head and neck squamous cell carcinoma: focus on disulfidptosis

Tong, Y., Bai, S., Ou, L., Zhou, Q., Liu, S., Yin, L., Tang, K., Long, L., & Yin, Q. (2025) · Discover Oncology · doi:10.1007/s12672-025-02344-2 · Cited by 5

Ferroptosis in Haematological Malignancies: From Regulatory Networks to Novel Therapeutic Opportunities

Shayanmanesh, M., Ahmadi, S. E., & Amini, A. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70790 · Cited by 4

Ferroptosis Resistance in Cancer: An Emerging Crisis of New Hope

Xu, D., Yonghui, L., Li, Y., Li, S., Wang, Z., & Wang, J. (2021) · BIO Integration · doi:10.15212/bioi-2020-0039 · Cited by 5

Biological protein mediated ferroptotic tumor nanotherapeutics

Tao, J., Li, C., Zheng, Y., Wang, F., Zhang, M., Wu, X., Chen, Y., Zeng, Q., Chen, F., & Fei, W. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01289d · Cited by 5

Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems

Tan, Y., Dong, X., Zhuang, D., Cao, B., Jiang, H., He, Q., & Zhao, M. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04694-3 · Cited by 5

Starving cancer cells to enhances DNA damage and immunotherapy response

Shahi, A., & Kidane, D. (2024) · Oncotarget · doi:10.18632/oncotarget.28595 · Cited by 5

Implication of system xc− in complete Freund's adjuvant-induced peripheral inflammation and associated nociceptive sensitization

Beckers, P., Charlier, M., Azria-Richter, L., Braconnier, P., Desmet, N., Massie, A., & Hermans, E. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110340 · Cited by 5

In vitro studies on the lymphoma growth-inhibitory activity of sulfasalazine

Gout, P. W., Simms, C. R., & Robertson, M. C. (2003) · Anti-Cancer Drugs · doi:10.1097/00001813-200301000-00004 · Cited by 39

Potential use for sulfasalazine in lung cancer therapy

Gout, P. W., Guan, J., Wang, Y., Xue, H., Doxsee, D., Sutcliffe, M., Cutz, J., LeRiche, J., Bebb, G. D., Lam, S. C., et al. (2004) · Cancer Research · Cited by 1

Increased cystine uptake capability associated with malignant progression of Nb2 lymphoma cells

Gout, P., Kang, Y. J., Buckley, D., Bruchovsky, N., & Buckley, A. (1997) · Leukemia · doi:10.1038/sj.leu.2400739 · Cited by 53

210 Induction of apoptosis in chronic lymphocytic leukaemia by inhibition of NF-kB and novel sulfasalazine analogues

Packham, G., Habens, F., Mel, S. D., Srinivasan, N., Oakley, F., Mann, D. L., Potter, K. N., Stevenson, F. K., & Ganesan, A. (2004) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(04)80218-0

Abstract 1898: Regulation of cysteine supply for survival in hepatocellular carcinoma an breast cancer cell lines

Kim, D. H., & Lee, S. J. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-1898