The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc− cystine transporter: a new action for an old drug
Abstract
Although cyst(e)ine is nutritionally a non-essential amino acid, lymphoid cells cannot synthesize it, rendering their growth dependent on uptake of cyst(e)ine from their microenvironment. Accordingly, we previously suggested that the x(c)- plasma membrane cystine transporter provided a target for lymphoid cancer therapy. Its inhibition could lead to cyst(e)ine deficiency in lymphoma cells via reduction of both their cystine uptake and cysteine supply by somatic cells. In this study, using rat Nb2 lymphoma cultures, drugs were screened for growth arrest based on x(c)- inhibition. Sulfasalazine was fortuitously found to be a novel, potent inhibitor of the x(c)- transporter. It showed high rat lymphoma growth-inhibitory and lytic activity in vitro (IC50 = 0.16 mM), based specifically on inhibition of x(c)--mediated cystine uptake, in contrast to its colonic metabolites, sulfapyridine and 5-aminosalicylic acid. Sulfasalazine was even more effective against human non-Hodgkin's lymphoma (DoHH2) cultures. In rats (n = 13), sulfasalazine (i.p.) markedly inhibited growth of well-developed, rapidly growing rat Nb2 lymphoma transplants without apparent side-effects. Reduced, macrophage-mediated supply of cysteine was probably involved. In five rats, 90-100% tumor growth suppression, relative to controls, was obtained. The x(c)- cystine transporter represents a novel target for sulfasalazine-like drugs with high potential for application in therapy of lymphoblastic and other malignancies dependent on extracellular cyst(e)ine.
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“DLBCLs with low system xc− activity are more susceptible to ferroptosis”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [77]
In the citing paper
“sulfasalazine potently inhibited the growth of lymphomas with low-level expression of SLC7A11, a subunit of system xc− [77, 78].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [77]
In the citing paper
“Since some leukemias and lymphomas have a defective transsulfuration pathway [76, 77]”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [77]
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Additional file 8 of Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis
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Metadata
- Authors
- Gout, P., Buckley, A., Simms, C., & Bruchovsky, N.
- Affiliations
- BC Cancer Agency (CA)
- University of Cincinnati Medical Center (US)
- Venue
- Leukemia
- Published
- 2001-10-01
- Volume
- 15
- Issue
- 10
- Pages
- 1633-1640
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2137749199
- Cited by
- 640
- References
- 41
- Citations by year
- 2026: 32 · 2025: 47 · 2024: 62 · 2023: 63 · 2022: 74 · 2021: 93 · 2020: 46 · 2019: 41 · 2018: 23 · 2017: 28 · 2016: 23 · 2015: 22 · 2014: 14 · 2013: 10 · 2012: 18
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio Cancer Research Associates
- National Institutes of Health (5r01dk053452-05)
- BC Cancer Agency
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 53452)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- sulfasalazine, cystine uptake, lymphoma, cysteine deficiency, non-Hodgkin lymphoma, sulfapyridine, 5-aminosalicylic acid, tumor growth inhibition, drug repurposing
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Antineoplastic Agents, Carrier Proteins, Cell Division, Drug Evaluation, Preclinical, Humans, Injections, Intraperitoneal, Lymphoma, Neoplasm Transplantation, Rats, Inbred Strains, Sulfasalazine, Tumor Cells, Cultured, Inhibitory Concentration 50, Amino Acid Transport System y+, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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