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Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – A Europe Against Cancer Program

Gabert, J, Beillard, E, van der Velden, V H J, Bi, W, Grimwade, D, Pallisgaard, N, Barbany, G, Cazzaniga, G, Cayuela, J M, Cavé, H, Pane, F, Aerts, J L E, De Micheli, D, Thirion, X, Pradel, V, González, M, Viehmann, S, Malec, M, Saglio, G, van Dongen, J J M·2003·Leukemia
DOI 10.1038/sj.leu.2403135
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Abstract

Detection of minimal residual disease (MRD) has proven to provide independent prognostic information for treatment stratification in several types of leukemias such as childhood acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and acute promyelocytic leukemia. This report focuses on the accurate quantitative measurement of fusion gene (FG) transcripts as can be applied in 35-45% of ALL and acute myeloid leukemia, and in more than 90% of CML. A total of 26 European university laboratories from 10 countries have collaborated to establish a standardized protocol for TaqMan-based real-time quantitative PCR (RQ-PCR) analysis of the main leukemia-associated FGs within the Europe Against Cancer (EAC) program. Four phases were scheduled: (1) training, (2) optimization, (3) sensitivity testing and (4) patient sample testing. During our program, three quality control rounds on a large series of coded RNA samples were performed including a balanced randomized assay, which enabled final validation of the EAC primer and probe sets. The expression level of the nine major FG transcripts in a large series of stored diagnostic leukemia samples (n=278) was evaluated. After normalization, no statistically significant difference in expression level was observed between bone marrow and peripheral blood on paired samples at diagnosis. However, RQ-PCR revealed marked differences in FG expression between transcripts in leukemic samples at diagnosis that could account for differenti…

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Metadata

Authors
Gabert, J., Beillard, E., van der Velden, V. H. J., Bi, W., Grimwade, D., Pallisgaard, N., Barbany, G., Cazzaniga, G., Cayuela, J. M., Cavé, H., Pane, F., Aerts, J. L. E., De Micheli, D., Thirion, X., Pradel, V, González, M., Viehmann, S., Malec, M., Saglio, G., & van Dongen, J. J. M.
Venue
Leukemia
Publisher
Springer Science and Business Media LLC
Published
2003-10-09
Volume
17
Issue
12
Pages
2318-2357
ISSN
  • 0887-6924
  • 1476-5551
DOI
10.1038/sj.leu.2403135
Cited by
1,284
References
5
Language
en
Licence

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