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Cited by 61

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage

Scielzo, C, Camporeale, A, Geuna, M, Alessio, M, Poggi, A, Zocchi, M R, Chilosi, M, Caligaris-Cappio, F, Ghia, P·2006·Leukemia
DOI 10.1038/sj.leu.2404138
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Abstract

ZAP-70 tyrosine kinase is involved in signalling pathways following T-cell receptor stimulation and was originally described only in T cells and natural killer cells. ZAP-70 expression has been reported in normal mouse B lineage cells and in human malignant B lymphocytes, mainly in chronic lymphocytic leukemia (CLL) where it correlates with clinical outcome. We analyzed several B-cell lines and ex vivo malignant B cells, ranging from acute lymphoblastic leukemia to multiple myeloma and reflecting different stages of B-cell differentiation, and they showed ZAP-70 expression regardless their maturation stage. We then analyzed by Western blot and flow cytometry different human normal B-lymphocyte subpopulations: naïve, germinal center and memory B cells from tonsils, CD19+ CD5+ cells from cord blood and CD19+ lymphocytes from peripheral blood. All expressed ZAP-70 protein, though at different levels depending on their differentiation, activation and tissue localization. In addition, ZAP-70 expression levels could be modulated following stimulation via the B-cell receptor. These findings implicate a potential role of ZAP-70 in the signalling pathway of B lymphocytes at different maturational stages, indicate that ZAP-70 expression is not a CLL-specific feature among B-cell malignancies and suggest that the absence of ZAP-70 rather than its presence should be considered abnormal for malignant B lymphocytes.

Overview

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Crossref · 10.1038/sj.leu.2404138

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26 of 26 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Scielzo, C., Camporeale, A., Geuna, M., Alessio, M., Poggi, A., Zocchi, M. R., Chilosi, M., Caligaris-Cappio, F., & Ghia, P.
Venue
Leukemia
Publisher
Springer Science and Business Media LLC
Published
2006-02-16
Volume
20
Issue
4
Pages
689-695
ISSN
  • 0887-6924
  • 1476-5551
DOI
10.1038/sj.leu.2404138
Cited by
61
References
26
Language
en
Licence

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.