The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The MLL recombinome of acute leukemias
Abstract
Chromosomal rearrangements of the human MLL gene are a hallmark for aggressive (high-risk) pediatric, adult and therapy-associated acute leukemias. These patients need to be identified in order to subject these patients to appropriate therapy regimen. A recently developed long-distance inverse PCR method was applied to genomic DNA isolated from individual acute leukemia patients in order to identify chromosomal rearrangements of the human MLL gene. We present data of the molecular characterization of 414 samples obtained from 272 pediatric and 142 adult leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) was determined and several new TPGs were identified. The combined data of our study and published data revealed a total of 87 different MLL rearrangements of which 51 TPGs are now characterized at the molecular level. Interestingly, the four most frequently found TPGs (AF4, AF9, ENL and AF10) encode nuclear proteins that are part of a protein network involved in histone H3K79 methylation. Thus, translocations of the MLL gene, by itself coding for a histone H3K4 methyltransferase, are presumably not randomly chosen, rather functionally selected.
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Cites
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Zhang, Y., & Reinberg, D. (2001) · Genes & Development · doi:10.1101/gad.927301 · Cited by 1,530
The many faces of histone lysine methylation
Lachner, M., & Jenuwein, T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00335-6 · Cited by 819
hDOT1L Links Histone Methylation to Leukemogenesis
Okada, Y., Feng, Q., Lin, Y., Jiang, Q., Li, Y., Coffield, V. M., Su, L., Xu, G., & Zhang, Y. (2005) · Cell · doi:10.1016/j.cell.2005.02.020 · Cited by 804
Frequent chromosomal translocations induced by DNA double-strand breaks
Richardson, C., & Jasin, M. (2000) · Nature · doi:10.1038/35015097 · Cited by 517
Pui, C.-H., Gaynon, P. S., Boyett, J. M., Chessells, J. M., Baruchel, A., Kamps, W., Silverman, L. B., Biondi, A., Harms, D. O., Vilmer, E., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08782-2 · Cited by 399
Self-citationClinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
Pui, C.-H., Chessells, J. M., Camitta, B., Baruchel, A., Biondi, A., Boyett, J. M., Carroll, A., Eden, O. B., Evans, W. E., Gadner, H., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2402883 · Cited by 241
Self-citationALL-1 partial duplication in acute leukemia.
Schichman, S. A., Caligiuri, M. A., Gu, Y., Strout, M. P., Canaani, E., Bloomfield, C. D., & Croce, C. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6236 · Cited by 207
Caligiuri, M. A., Strout, M. P., Schichman, S. A., Mrózek, K., Arthur, D., Herzig, G. P., Baer, M., Schiffer, C. A., Heinonen, K., Knuutila, S., et al. (1996) · PubMed · Cited by 185
Diagnostic tool for the identification of MLL rearrangements including unknown partner genes
Meyer, C., Schneider, B., Reichel, M., Angermueller, S., Strehl, S., Schnittger, S., Schoch, C., Jansen, M. W. J. C., van Dongen, J. J., Pieters, R., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406994102 · Cited by 180
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Cited by
The impact of translocations and gene fusions on cancer causation
Mitelman, F., Johansson, B., & Mertens, F. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2091 · Cited by 1,400
MLL translocations, histone modifications and leukaemia stem-cell development
Krivtsov, A. V., & Armstrong, S. A. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2253 · Cited by 1,249
The MLL recombinome of acute leukemias in 2017
Meyer, C., Burmeister, T., Gröger, D., Tsaur, G., Fechina, L., Renneville, A., Sutton, R., Venn, N. C., Emerenciano, M., Pombo-de-Oliveira, M. S., et al. (2018) · Leukemia · doi:10.1038/leu.2017.213 · Cited by 676
Self-citationThe landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
for The St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project, Andersson, A. K., Ma, J., Wang, J., Chen, X., Gedman, A. L., Dang, J., Nakitandwe, J., Holmfeldt, L., Parker, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3230 · Cited by 490
Molecular genetics of B-precursor acute lymphoblastic leukemia
Mullighan, C. G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61203 · Cited by 247
Metadata
- Authors
- Meyer, C., Schneider, B., Jakob, S., Strehl, S., Attarbaschi, A., Schnittger, S., Schoch, C., Jansen, M. W. J. C., van Dongen, J. J. M., den Boer, M. L., Pieters, R., Ennas, M.-G., Angelucci, E., Koehl, U., Greil, J., Griesinger, F., zur Stadt, U., Eckert, C., Szczepański, T., Niggli, F. K., Schäfer, B. W., Kempski, H., Brady, H. J. M., Zuna, J., Trka, J., Nigro, L. L., Biondi, A., Delabesse, E., Macintyre, E., Stanulla, M., Schrappe, M., Haas, O. A., Burmeister, T., Dingermann, T., Klingebiel, T., & Marschalek, R.
- Venue
- Leukemia
- Published
- 2006-03-02
- Volume
- 20
- Issue
- 5
- Pages
- 777-784
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W1996600754
- Cited by
- 271
- References
- 18
- FWCI
- 24.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meyer, C., Schneider, B., Jakob, S., Strehl, S., Attarbaschi, A., Schnittger, S., Schoch, C., Jansen, M. W. J. C., van Dongen, J. J. M., den Boer, M. L., Pieters, R., Ennas, M.-G., Angelucci, E., Koehl, U., Greil, J., Griesinger, F., zur Stadt, U., Eckert, C., Szczepański, T., . . . Marschalek, R. (2006). The MLL recombinome of acute leukemias. Leukemia. https://doi.org/10.1038/sj.leu.2404150
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
