The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Bone marrow mesenchymal stem cells are abnormal in multiple myeloma
Open accessAbstract
Recent literature suggested that cells of the microenvironment of tumors could be abnormal as well. To address this hypothesis in multiple myeloma (MM), we studied bone marrow mesenchymal stem cells (BMMSCs), the only long-lived cells of the bone marrow microenvironment, by gene expression profiling and phenotypic and functional studies in three groups of individuals: patients with MM, patients with monoclonal gamopathy of undefined significance (MGUS) and healthy age-matched subjects. Gene expression profile independently classified the BMMSCs of these individuals in a normal and in an MM group. MGUS BMMSCs were interspersed between these two groups. Among the 145 distinct genes differentially expressed in MM and normal BMMSCs, 46% may account for a tumor-microenvironment cross-talk. Known soluble factors implicated in MM pathophysiologic features (i.e. IL (interleukin)-6, DKK1) were revealed and new ones were found which are involved in angiogenesis, osteogenic differentiation or tumor growth. In particular, GDF15 was found to induce dose-dependent growth of MOLP-6, a stromal cell-dependent myeloma cell line. Functionally, MM BMMSCs induced an overgrowth of MOLP-6, and their capacity to differentiate into an osteoblastic lineage was impaired. Thus, MM BMMSCs are abnormal and could create a very efficient niche to support the survival and proliferation of the myeloma cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Secretion of elevated levels of IL-6 by MSC has been detected upon interaction with malignant cells in several epithelial, hematopoietic and mesenchymal cancers (Table 2) [43, 69, 76, 77, 82, 115–119].”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [77]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Notably, MM-MSCs have different gene profiles from their counterparts in normal MSCs [289, 290].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [289]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Attal, M., Harousseau, J.-L., Stoppa, A.-M., Sotto, J.-J., Fuzibet, J.-G., Rossi, J.-F., Casassus, P., Maisonneuve, H., Facon, T., Ifrah, N., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607113350204 · Cited by 2,548
Self-citationStromal fibroblasts in cancer initiation and progression
Bhowmick, N. A., Neilson, E. G., & Moses, H. L. (2004) · Nature · doi:10.1038/nature03096 · Cited by 2,354
The microenvironment of the tumour–host interface
Liotta, L. A., & Kohn, E. C. (2001) · Nature · doi:10.1038/35077241 · Cited by 2,330
Ttal, M. I. A., Ean, J., Dünne, A. A., Toppa, A. S., Ossi, R. G., Hilippe, P., Asassus, C., Acon, T. H. F., Orbert, N., Ayen, C. A. P., et al. (2013) · Cited by 2,161
Gregory, C. A., Gunn, W., Peister, A., & Prockop, D. J. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.02.002 · Cited by 1,568
Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,505
Molecular characterization of the tumor microenvironment in breast cancer
Allinen, M., Beroukhim, R., Cai, L., Brennan, C., Lahti-Domenici, J., Huang, H., Porter, D., Hu, M., Chin, L., Richardson, A., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.010 · Cited by 1,299
Single versus Double Autologous Stem-Cell Transplantation for Multiple Myeloma
Attal, M., Harousseau, J.-L., Facon, T., Guilhot, F., Doyen, C., Fuzibet, J.-G., Monconduit, M., Hulin, C., Caillot, D., Bouabdallah, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa032290 · Cited by 984
Self-citationSingle versus Double Autologous Stem-Cell Transplantation for Multiple Myeloma
(2004) · New England Journal of Medicine · doi:10.1056/nejm200406173502526 · Cited by 817
Gupta, D., Treon, S. P., Shima, Y., Hideshima, T., Podar, K., Tai, Y.-T., Lin, B. K., Lentzsch, S., Davies, F. E., Chauhan, D., et al. (2001) · Leukemia · doi:10.1038/sj.leu.2402295 · Cited by 555
Distinct epigenetic changes in the stromal cells of breast cancers
Hu, M., Yao, J., Cai, L., Bachman, K., van den Brûle, F., Velculescu, V. E., & Polyák, K. (2005) · Nature Genetics · doi:10.1038/ng1596 · Cited by 520
Interleukin-6 in human multiple myeloma
Klein, B., Zhang, X., Lu, Z., & Bataille, R. (1995) · Blood · doi:10.1182/blood.v85.4.863.bloodjournal854863 · Cited by 519
Self-citationRequirement for the lp A1 lysophosphatidic acid receptor gene in normal suckling behavior
Contos, J. J. A., Fukushima, N., Weiner, J. A., Kaushal, D., & Chun, J. J. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.24.13384 · Cited by 478
Analysis of high density expression microarrays with signed-rank call algorithms
Liu, W.-M., Mei, R., Di, X., Ryder, T. B., Hubbell, E. A., Dee, S., Webster, T. A., Harrington, C. A., Ho, M.-H., Baid, J., et al. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.12.1593 · Cited by 426
The stroma as a crucial target in rat mammary gland carcinogenesis
Maffini, M. V., Soto, A. M., Calabro, J. M., Ucci, A. A., & Sonnenschein, C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01000 · Cited by 425
Uchiyama, H., Barut, B., Mohrbacher, A., Chauhan, D., & Anderson, K. C. (1993) · Blood · doi:10.1182/blood.v82.12.3712.3712 · Cited by 421
Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
Oshima, T., Abe, M., Asano, J., Hara, T., Kitazoe, K.-I., Sekimoto, E., Tanaka, Y., Shibata, H., Hashimoto, T., Ozaki, S., et al. (2005) · Blood · doi:10.1182/blood-2004-12-4940 · Cited by 343
Jan, S. L., Amy, C., Cazes, A., Monnot, C., Lamandé, N., Favier, J., Philippe, J., Sibony, M., Gasc, J., Corvol, P. L., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64285-x · Cited by 342
Starnes, T., Broxmeyer, H. E., Robertson, M. J., & Hromas, R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.642 · Cited by 331
Gregory, C. A., Singh, H., Perry, A. S., & Prockop, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300373200 · Cited by 284
Zhang, X., Gaillard, J., Robillard, N., Lu, Z., Gu, Z., Jourdan, M., Boiron, J.-M., Bataille, R., & Klein, B. (1994) · Blood · doi:10.1182/blood.v83.12.3654.3654 · Cited by 277
Self-citationSerum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers
Koopmann, J., Buckhaults, P., Brown, D. A., ZAHURAK, M. L., Sato, N., Fukushima, N., Sokoll, L. J., Chan, D. W., Yeo, C. J., Hruban, R. H., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0165 · Cited by 274
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.
Brown, D. A., Ward, R. L., Buckhaults, P., Liu, T., Romans, K. E., Hawkins, N. J., Bauskin, A. R., Kinzler, K. W., Vogelstein, B., & Breit, S. N. (2003) · PubMed · Cited by 265
Gunn, W., Conley, A., Deininger, L., Olson, S. D., Prockop, D. J., & Gregory, C. A. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0220 · Cited by 260
'Role of bone marrow stromal cells in the growth of human multiple myeloma
Caligaris‐Cappio, F., Bergui, L., Gregoretti, M. G., Gaïdano, G., Gaboli, M. P., M., S., Zallone, A., & Marchisio, P. (1991) · Blood · doi:10.1182/blood.v77.12.2688.bloodjournal77122688 · Cited by 233
Tarte, K., Zhan, F., Vos, J. D., Klein, B., & Shaughnessy, J. D. (2003) · Blood · doi:10.1182/blood-2002-10-3161 · Cited by 215
Self-citationMichigami, T., Shimizu, N., Williams, P. J., Niewolna, M., Dallas, S. L., Mundy, G. R., & Yoneda, T. (2000) · Blood · doi:10.1182/blood.v96.5.1953.h8001953_1953_1960 · Cited by 213
Moore, A. G., Brown, D. A., Fairlie, W. D., Bauskin, A. R., Brown, P. K., Munier, M. L. C., Russell, P. K., Salamonsen, L. A., Wallace, E. M., & Breit, S. N. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7007 · Cited by 206
Zannettino, A. C. W., Farrugia, A. N., Kortesidis, A., Manavis, J., To, L. B., Martin, S. K., Diamond, P., Tamamura, H., Lapidot, T., Fujii, N., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1687 · Cited by 205
Bottner, M. B., Suter‐Crazzolara, C., Schober, A., & Unsicker, K. (1999) · Cell and Tissue Research · doi:10.1007/s004410051337 · Cited by 180
Liu, T., Bauskin, A. R., Zaunders, J. J., Brown, D. A., Pankhurst, S., Russell, P. J., Breit, S. N., & Panhurst, S. (2003) · PubMed · Cited by 174
Bajou, K., Maillard, C., Jost, M., Lijnen, R. H., Gils, A., Declerck, P. J., Carmeliet, P., Foidart, J.-M., & Noël, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207859 · Cited by 164
Ferlin, M., Noraz, N., Hertogh, C., Brochier, J., Taylor, N. N., & Klein, B. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02364.x · Cited by 156
Self-citationBauskin, A. R., Brown, D. A., Junankar, S. R., Rasiah, K., Eggleton, S. A., Hunter, M. I., Liu, T., Smith, D., Kuffner, T., Pankhurst, G. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3827 · Cited by 154
WISP-1 Is an Osteoblastic Regulator Expressed During Skeletal Development and Fracture Repair
French, D. M., Kaul, R. J., D’Souza, A. L., Crowley, C. W., Bao, M., Frantz, G. D., Filvaroff, E. H., & Desnoyers, L. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63348-2 · Cited by 152
Jaubert, J., Jaubert, F., Martín, N., Washburn, L. L., Lee, B. K., Eicher, E. M., & Guénet, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10278 · Cited by 146
Subramaniam, S., Strelau, J., & Unsicker, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210037200 · Cited by 135
Bassil, C. F., Zhao, Y., Zavaglia, K. M., Jin, P., Panelli, M. C., Voiculescu, S. E., Mandruzzato, S., Lee, H. M., Seliger, B., Freedman, R. S., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3433 · Cited by 127
Vincent, T., Jourdan, M., Sy, M., Klein, B., & Mechti, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m003965200 · Cited by 121
Self-citationAttraction of human monocytes by the neuropeptide secretoneurin
Reinisch, N., Kirchmair, R., Kähler, C. M., Hogue‐Angeletti, R., Fischer‐Colbrie, R., Winkler, H. J. S., & Wiedermann, C. J. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81676-q · Cited by 119
Grey, A. B., Chen, Q., Callon, K. E., Xu, X., Reid, I. R., & Cornish, J. (2002) · Endocrinology · doi:10.1210/en.2002-220347 · Cited by 114
Mahtouk, K., Hose, D., Reme, T. X., Vos, J. D., Jourdan, M., Moreaux, J., Fiol, G., Raab, M. S., Jourdan, É., Grau, V., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208536 · Cited by 109
Self-citationSilvestris, F., Cafforio, P., Calvani, N., & Dammacco, F. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.05084.x · Cited by 105
Advances in Biology and Therapy of Multiple Myeloma
Barillé‐Nion, S., Barlogie, B., Bataille, R., Bergsagel, P. L., Epstein, J., Fenton, R. G., Jacobson, J. L., Kuehl, W. M., Shaughnessy, J. D., & Tricot, G. J. K. (2003) · Hematology · doi:10.1182/asheducation-2003.1.248 · Cited by 91
Interleukin‐1 in multiple myeloma: producer cells and their role in the control of IL‐6 production
Costes, V., Portier, M., Lu, Z., Rossi, J., Bataille, R., & Klein, B. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.01101.x · Cited by 88
Self-citationLacy, M. Q., Donovan, K. A., Heimbach, J. K., Ahmann, G. J., & Lust, J. A. (1999) · Blood · doi:10.1182/blood.v93.1.300 · Cited by 81
Novel therapies for multiple myeloma
Hayashi, T., Hideshima, T., & Anderson, K. C. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.03929.x · Cited by 76
Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease
Silvestris, F., Cafforio, P., Tucci, M., Grinello, D., & Dammacco, F. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04374.x · Cited by 72
Calabro, A. R., Oken, M. M., Hascall, V., & Masellis-Smith, A. (2002) · Blood · doi:10.1182/blood-2002-01-0030 · Cited by 69
Microarray‐based understanding of normal and malignant plasma cells
Vos, J. D., Hose, D., Reme, T. X., Tarte, K., Moreaux, J., Mahtouk, K., Jourdan, M., Goldschmidt, H., Rossi, J., Cremer, F. W., et al. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00362.x · Cited by 65
Self-citationGrey, A. B., Banovic, T., Naot, D., Hill, B. L., Callon, K. E., Reid, I. R., & Cornish, J. (2001) · Endocrinology · doi:10.1210/endo.142.3.8011 · Cited by 61
Lack of IL‐1 secretion from human myeloma cells highly purified by immunomagnetic separation
Børset, M., Helseth, E., Naume, B., & Waage, A. (1993) · British Journal of Haematology · doi:10.1111/j.1365-2141.1993.tb03331.x · Cited by 58
Human recombinant dimeric IL-6 binds to its receptor as detected by anti-IL-6 monoclonal antibodies
Wijdenes, J., Clément, C., Klein, B., Morel-Fourrier, B., Vita, N., Ferrara, P., & Peters, A. (1991) · Molecular Immunology · doi:10.1016/0161-5890(91)90004-4 · Cited by 44
Self-citationMaillard, C., Jost, M., Rømer, M. U., Brünner, N., Houard, X., Lejeune, A., Munaut, C., Bajou, K., Mélen, L., Danø, K., et al. (2005) · Neoplasia · doi:10.1593/neo.04406 · Cited by 41
Schecroun, N., & Delloye, C. (2004) · Bone · doi:10.1016/j.bone.2004.03.029 · Cited by 38
Characterization of bone marrow stromal cells from multiple myeloma
Gregoretti, M. G., Gottardi, D., Ghia, P., Bergui, L., Merico, F., Marchisio, P. C., & Caligaris‐Cappio, F. (1994) · Leukemia Research · doi:10.1016/0145-2126(94)90067-1 · Cited by 35
Berenson, J. R. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2005.03.001 · Cited by 28
Angiogenic Switch in Multiple Myeloma
Giuliani, N., Colla, S., & Rizzoli, V. (2004) · Hematology · doi:10.1080/10245330400018524 · Cited by 24
Gessain, A., Caumes, É., Feyeux, C., Francoised'Agay, M., Capesius, C., Gentilini, M., & Morel, P. (1992) · Cancer · doi:10.1002/1097-0142(19920315)69:6 · Cited by 14
Self-citationHarashima, A., Matsuo, Y., Nishizaki, C., Kozuka, T., Fukuda, S., Sezaki, T., & Orita, K. (2000) · PubMed · Cited by 5
Berenson (2001) · doi:10.1002/1097-0142(20010401)91:7
Cited by
Sorted by citations
No place like home: anatomy and function of the stem cell niche
Jones, D. L., & Wagers, A. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2319 · Cited by 830
Raab, M. S., Podar, K., Breitkreutz, I., Richardson, P. G. G., & Anderson, K. C. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60221-x · Cited by 713
Targeting the bone marrow microenvironment in multiple myeloma
Kawano, Y., Moschetta, M., Manier, S., Glavey, S. V., Görgün, G., Roccaro, A. M., Anderson, K. C., & Ghobrial, I. M. (2014) · Immunological Reviews · doi:10.1111/imr.12233 · Cited by 394
Bone marrow microenvironment and the identification of new targets for myeloma therapy
Podar, K., Chauhan, D., & Anderson, K. C. (2008) · Leukemia · doi:10.1038/leu.2008.259 · Cited by 341
Treatment of Inflammatory Diseases with Mesenchymal Stem Cells
Newman, R., Yoo, D. S., LeRoux, M. A., & Danilkovitch‐Miagkova, A. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809788462635 · Cited by 309
Metadata
- Authors
- Corre, J., Mahtouk, K., Attal, M., Gadelorge, M., Huynh, A., Fleury-Cappellesso, S., Danho, C., Laharrague, P., Klein, B., Rème, T., & Bourin, P.
- Affiliations
- Établissement Français du Sang (FR)
- Inserm (FR)
- Hôpital Purpan (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Bourin, P
- Venue
- Leukemia
- Published
- 2007-03-08
- Volume
- 21
- Issue
- 5
- Pages
- 1079-1088
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- PMC
- PMC2346535
- OpenAlex
- W2048064990
- Cited by
- 328
- References
- 62
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 13 · 2023: 11 · 2022: 12 · 2021: 20 · 2020: 18 · 2019: 10 · 2018: 18 · 2017: 21 · 2016: 21 · 2015: 18 · 2014: 23 · 2013: 25 · 2012: 25
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- multiple myeloma, bone marrow mesenchymal stem cells, tumor microenvironment, monoclonal gammopathy of undetermined significance, gene expression profiling, interleukin-6, DKK1, GDF15, angiogenesis, osteogenic differentiation
- MeSH terms
- Adult, Aged, Bone Marrow Cells, Cell Differentiation, Female, Hematopoiesis, Humans, Male, Middle Aged, Multiple Myeloma, Osteoblasts, Cytokines, Gene Expression Profiling, Cell Proliferation, Growth Differentiation Factor 15, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
