Cited by 1,299Chemokine receptors and signalingBreast Cancer Treatment StudiesCancer Cells and Metastasis

Molecular characterization of the tumor microenvironment in breast cancer

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Allinen, Minna, Beroukhim, Rameen, Cai, Li, Brennan, Cameron, Lahti-Domenici, Jaana, Huang, Haiyan, Porter, Dale, Hu, Min +5 more·2004·Cancer Cell

Abstract

Here we describe the comprehensive gene expression profiles of each cell type composing normal breast tissue and in situ and invasive breast carcinomas using serial analysis of gene expression. Based on these data, we determined that extensive gene expression changes occur in all cell types during cancer progression and that a significant fraction of altered genes encode secreted proteins and receptors. Despite the dramatic gene expression changes in all cell types, genetic alterations were detected only in cancer epithelial cells. The CXCL14 and CXCL12 chemokines overexpressed in tumor myoepithelial cells and myofibroblasts, respectively, bind to receptors on epithelial cells and enhance their proliferation, migration, and invasion. Thus, chemokines may play a role in breast tumorigenesis by acting as paracrine factors.

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Crossref · 10.1016/j.ccr.2004.06.010

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Authors
Allinen, M., Beroukhim, R., Cai, L., Brennan, C., Lahti-Domenici, J., Huang, H., Porter, D., Hu, M., Chin, L., Richardson, A., Schnitt, S., Sellers, W. R., & Polyak, K.
Affiliations
  • Harvard University (US)
  • Dana-Farber Cancer Institute (US)
  • Brigham and Women's Hospital (US)
  • Beth Israel Deaconess Medical Center (US)
  • Broad Institute (US)
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2004-07
Volume
6
Issue
1
Pages
17-32
ISSN
1535-6108 (ISSN-L)
OpenAlex
W2049820772
Cited by
1,299
References
124
Citations by year
2026: 13 · 2025: 12 · 2024: 25 · 2023: 48 · 2022: 41 · 2021: 44 · 2020: 49 · 2019: 46 · 2018: 65 · 2017: 49 · 2016: 50 · 2015: 80 · 2014: 69 · 2013: 66 · 2012: 105
FWCI
28.72
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders
  • U.S. Department of Defense
  • National Institutes of Health (5f32ca094788-02)
  • Novartis Institutes for BioMedical Research
  • National Cancer Institute (CA 89393, P50 CA89393-01, P50 CA 89393, 5F32CA94788-02, P50CA089393, T32CA009172)
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
breast cancer, tumor microenvironment, gene expression profiling, serial analysis of gene expression, tumor progression, secreted proteins, receptors, myoepithelial cells, myofibroblasts, CXCL14, CXCL12, chemokines, paracrine signaling, tumor epithelial cells, cell proliferation, cell migration, tumor invasion
MeSH terms
Breast, Breast Neoplasms, Carcinoma in Situ, Cell Division, Cell Movement, Epithelium, Female, Humans, Muscle, Smooth, Neoplasm Invasiveness, Neoplasm Proteins, Tumor Cells, Cultured, Biomarkers, Tumor, Gene Library, Gene Expression Regulation, Neoplastic, Carcinoma, Ductal, Breast, Disease Progression, Chemokines, CXC, Gene Expression Profiling, Chemokine CXCL12

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