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Cited by 267Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue

Morganti-Kossman, M C, Lenzlinger, P M, Hans, V, Stahel, P, Csuka, E, Ammann, E, Stocker, R, Trentz, O, Kossmann, T·1997·Molecular Psychiatry
DOI 10.1038/sj.mp.4000227
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Abstract

A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with pro- and anti-inflammatory functions. In order to elucidate which cytokines are released in the human brain in response to injury as well as in the peripheral compartment, IL-1, IL-6, IL-8, IL-10, TNF-alpha and TGF-beta were monitored in CSF and serum of severely brain-injured patients. Furthermore, we investigated the possible modulation of systemic reactions by IL-6 and the ability of IL-6 and IL-8 to promote the synthesis of nerve growth factor.

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Crossref · 10.1038/sj.mp.4000227

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Metadata

Authors
Morganti-Kossman, M. C., Lenzlinger, P. M., Hans, V, Stahel, P., Csuka, E., Ammann, E., Stocker, R., Trentz, O., & Kossmann, T.
Affiliations
  • University Hospital Zurich (CH)
  • University of Alabama at Birmingham (US)
ORCID
Stocker, R
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
1997-03-01
Volume
2
Issue
2
Pages
133-136
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/sj.mp.4000227
OpenAlex
W1975908033
Cited by
267
References
0
Citations by year
2026: 3 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 16 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 9 · 2015: 5 · 2014: 12 · 2013: 11 · 2012: 15
FWCI
6.67
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
traumatic brain injury, cytokines, neuroinflammation, interleukin-6, interleukin-8, interleukin-1, IL-10, TNF-α, TGF-beta, cerebrospinal fluid, serum cytokines, systemic inflammatory response
MeSH terms
Animals, Blood-Brain Barrier, Brain Damage, Chronic, Brain Injuries, Cells, Cultured, Gene Expression Regulation, Humans, Inflammation, Nerve Growth Factors, Interleukin-6, Cytokines, Interleukin-8, Mice, Rats

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