What is the biological significance of an age-related increase in IL-1β in hippocampus?
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Elevated IL-1β was reported in some studies and not others; aged Wistar and Fisher 344 rats were reported to show elevated brain IL-1β, whereas other strains did not exhibit increased baseline levels of brain IL-1β.
“For instance, aged (~22 month old) Wistar and Fisher 344 rats (Gemma et al, 2005;Lynch, 1999) were reported to show elevated brain IL-1β, whereas (23-26 month old) Fisher 344 × BN F1 and Fisher 344 rats (Barrientos et al, 2009;Gee, Ding, and Keller, 2006) and (18-22 month old) BALB/c and C57BL/6 mice did not exhibit increased baseline levels of brain IL-1β (Hascup et al, 2016;Huang et al, 2008;Wyn”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Lynch, 1999
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Microglia Priming with Aging and Stress
Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works
The immune system and memory consolidation: a role for the cytokine IL-1β
Pugh, C., Fleshner, M., Watkins, L. R., Maier, S. F., & Rudy, J. W. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00048-8 · Cited by 311 · see citing works
Kelly, A. M., Vereker, E., Nolan, Y. M., Brady, M., Barry, C. E., Loscher, C. E., Mills, K. H. G., & Lynch, M. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301938200 · Cited by 179 · see citing works
Self-citationSama, D. M., & Norris, C. M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.008 · Cited by 126 · see citing works
Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats
Mesches, M. H., Gemma, C., Veng, L., Allgeier, C. A., Young, D. A., Browning, M. D., & Bickford, P. C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00116-7 · Cited by 91 · see citing works
“The pro-inflammatory cytokine IL-1 is implicated in age-related deficits in both hippocampal-dependent memory [37] and LTP [17,33,62].”
BackgroundInfluentialSLEEP IMPAIRMENTS IN HEALTHY SENIORS: ROLES OF STRESS, CORTISOL, AND INTERLEUKIN-1 BETA
Prinz, P. N., Bailey, S. L., & Woods, D. L. (2000) · Chronobiology International · doi:10.1081/cbi-100101053 · Cited by 48 · see citing works
Mohammad, H. M. F., Sami, M. M., Makary, S., Toraih, E. A., Mohamed, A. O., & El-Ghaiesh, S. H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116588 · Cited by 36 · see citing works
Gu, J.-X., Cheng, X., Luo, X., Yang, X., Pang, Y., Zhang, X.-F., Zhang, Y.-Y., & Liu, Y. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2608-6 · Cited by 33 · see citing works
Rosiglitazone improves contextual fear conditioning in aged rats
Gemma, C., Stellwagen, H. M., Fister, M. C., Coultrap, S. J., Mesches, M. H., Browning, M. D., & Bickford, P. C. (2004) · Neuroreport · doi:10.1097/00001756-200410050-00023 · Cited by 24 · see citing works
“In aged rats, there is an increase in IL-1b, which has been implicated in a decline in synaptic plasticity in the hippocampus and performance on cognitive tasks [19].”
BackgroundRiddle, D. R., & Schindler, M. K. (2007) · Reviews in Clinical Gerontology · doi:10.1017/s0959259808002530 · Cited by 1 · see citing works
- Authors
- Lynch, M. A.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Lynch, M A
- ORCID
- Lynch, M A
- Venue
- Molecular Psychiatry
- Published
- 1999-01-01
- Volume
- 4
- Issue
- 1
- Pages
- 15-18
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2313318760
- Cited by
- 10
- References
- 0
- Citations by year
- 2019: 1 · 2018: 1 · 2016: 1 · 2013: 1
- Type
- other
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- IL-1β, hippocampus, aging, stress, long-term potentiation, synaptic plasticity, dentate gyrus, neuroinflammation
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