Current advances in local protein synthesis and synaptic plasticity
Open accessAbstract
Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation. Current research indicates that the specificity by which new proteins participate in either LTP or LTD may be determined in part by specific RNA-binding proteins as well as activity-dependent capture.
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Local translation of messenger RNAs at or near synapses is a critical mechanism for maintaining persistent changes in synaptic strength and for memory consolidation.
“This local translation of messenger RNAs (mRNAs) at or near synapses is a critical mechanism for maintaining persistent changes in synaptic strength and for memory consolidation (Figure 5).”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
The Abstract says local protein synthesis helps maintain long-term synaptic changes, and the section ‘Local protein synthesis is required for the persistence of synaptic change’ describes dendritic synthesis maintaining late-phase LTP. The paper connects persistent synaptic changes with information storage and reports memory deficits associated with altered translational control, but it does not establish that local translation itself is critical for memory consolidation. No page number is available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredLong-lasting forms of synaptic plasticity, including late-phase LTP (L-LTP) and LTD, require new local protein synthesis within dendrites, with specificity determined by RNA-binding proteins and activity-dependent capture.
“While early phases of LTP (E-LTP) are mediated by post-translational modifications in existing proteins and occur independently of protein synthesis, the long-lasting forms of synaptic plasticity, including late-phase LTP (L-LTP) and LTD, require new local protein synthesis within dendrites, a process where specificity is determined by RNA-binding proteins and activity-dependent capture [71,72].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
The sections “Local protein synthesis is required for the persistence of synaptic change” and “Summary and perspectives” support the roles of dendritic protein synthesis in persistent LTP and LTD, and of RNA-binding proteins and protein capture in specificity. But the paper says these mechanisms contribute to specificity and presents how they do so as partly tentative; the claim overstates this as definitively determined by both. Page numbers were not supplied in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredEarly phases of LTP (E-LTP) are mediated by post-translational modifications in existing proteins and occur independently of protein synthesis.
“While early phases of LTP (E-LTP) are mediated by post-translational modifications in existing proteins and occur independently of protein synthesis, the long-lasting forms of synaptic plasticity, including late-phase LTP (L-LTP) and LTD, require new local protein synthesis within dendrites, a process where specificity is determined by RNA-binding proteins and activity-dependent capture [71,72].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
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- Authors
- Pfeiffer, B. E., & Huber, K. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-07-05
- Volume
- 26
- Issue
- 27
- Pages
- 7147-7150
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673933
- OpenAlex
- W2011356607
- Cited by
- 168
- References
- 50
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 5
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- local protein synthesis, dendritic translation, synaptic plasticity, long-term potentiation, long-term depression, translation initiation, signal transduction, RNA-binding proteins
- MeSH terms
- Animals, Humans, Neuronal Plasticity, Synapses, Protein Biosynthesis, Long-Term Potentiation, Long-Term Synaptic Depression
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