The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis
Open accessAbstract
A meta-analysis was conducted on studies reporting data on associations between candidate genes and human personality. Studies reporting data for psychiatric populations (including organic disease and substance abuse) were excluded. A total of 46 studies contributed to the analysis. Pooled data using a fixed-effects model suggested significant associations between the 5HTT LPR, DRD4 c>t, DRD4 length, DRD2 A1/A2, DRD3 A1/A2 polymorphisms and personality traits. A multivariate analysis using a mixed-effects model and including age, sex and predominant ethnicity as covariates was applied to the analyses of 5HTT LPR and DRD4 length polymorphism data. Only the association between the 5HTT LPR polymorphism and avoidance traits remained significant (P=0.038). However, sensitivity analyses excluding data from studies reporting allele frequencies not in Hardy–Weinberg equilibrium and unpublished data resulted in this association no longer being significant. Implications for the design of future association studies of human personality are discussed, including the likely sample sizes that will be required to achieve sufficient power and the potential role of moderating variables such as sex.
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Cites
A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal
Cloninger, C. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180093014 · Cited by 3,678
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Systematic Reviews in Health Care: Meta‐Analysis in Context
(2001) · doi:10.1002/9780470693926 · Cited by 1,693
Cited by
Personality Development: Stability and Change
Caspi, A., Roberts, B. W., & Shiner, R. L. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.141913 · Cited by 2,699
Public health significance of neuroticism
Lahey, B. B. (2009) · American Psychologist · doi:10.1037/a0015309 · Cited by 1,901
“A fourth meta-analysis initially did not find a significant association between 5-HTTLPR and neuroticism (Munafo et al., 2003), but a revised and updated report of this meta-analysis confirmed the significant association between 5-HTTLPR and neuroticism (Munafo, Clark, & Flint, 2005).”
ResultEmotion-based dispositions to rash action: positive and negative urgency
Cyders, M. A., & Smith, G. T. (2008) · Psychological Bulletin · doi:10.1037/a0013341 · Cited by 1,136
Connelly, B. S., & Ones, D. S. (2010) · Psychological Bulletin · doi:10.1037/a0021212 · Cited by 1,059
Desire to Acquire: Powerlessness and Compensatory Consumption
Rucker, D. D., & Galinsky, A. D. (2008) · Journal of Consumer Research · doi:10.1086/588569 · Cited by 925
Metadata
- Authors
- Munafò, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., & Flint, J.
- Venue
- Molecular Psychiatry
- Published
- 2003-05-01
- Volume
- 8
- Issue
- 5
- Pages
- 471-484
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2041186704
- Cited by
- 356
- References
- 3
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Munafò, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., & Flint, J. (2003). Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis. Molecular Psychiatry. https://doi.org/10.1038/sj.mp.4001326
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