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Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis
Open accessAbstract
A meta-analysis was conducted on studies reporting data on associations between candidate genes and human personality. Studies reporting data for psychiatric populations (including organic disease and substance abuse) were excluded. A total of 46 studies contributed to the analysis. Pooled data using a fixed-effects model suggested significant associations between the 5HTT LPR, DRD4 c>t, DRD4 length, DRD2 A1/A2, DRD3 A1/A2 polymorphisms and personality traits. A multivariate analysis using a mixed-effects model and including age, sex and predominant ethnicity as covariates was applied to the analyses of 5HTT LPR and DRD4 length polymorphism data. Only the association between the 5HTT LPR polymorphism and avoidance traits remained significant (P=0.038). However, sensitivity analyses excluding data from studies reporting allele frequencies not in Hardy–Weinberg equilibrium and unpublished data resulted in this association no longer being significant. Implications for the design of future association studies of human personality are discussed, including the likely sample sizes that will be required to achieve sufficient power and the potential role of moderating variables such as sex.
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Cites
A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal
Cloninger, C. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180093014 · Cited by 3,678
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Systematic Reviews in Health Care: Meta‐Analysis in Context
(2001) · doi:10.1002/9780470693926 · Cited by 1,693
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Personality Development: Stability and Change
Caspi, A., Roberts, B. W., & Shiner, R. L. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.141913 · Cited by 2,699
Public health significance of neuroticism
Lahey, B. B. (2009) · American Psychologist · doi:10.1037/a0015309 · Cited by 1,901
“A fourth meta-analysis initially did not find a significant association between 5-HTTLPR and neuroticism (Munafo et al., 2003), but a revised and updated report of this meta-analysis confirmed the significant association between 5-HTTLPR and neuroticism (Munafo, Clark, & Flint, 2005).”
ResultEmotion-based dispositions to rash action: positive and negative urgency
Cyders, M. A., & Smith, G. T. (2008) · Psychological Bulletin · doi:10.1037/a0013341 · Cited by 1,136
Connelly, B. S., & Ones, D. S. (2010) · Psychological Bulletin · doi:10.1037/a0021212 · Cited by 1,059
Desire to Acquire: Powerlessness and Compensatory Consumption
Rucker, D. D., & Galinsky, A. D. (2008) · Journal of Consumer Research · doi:10.1086/588569 · Cited by 925
Personality Development: Continuity and Change Over the Life Course
McAdams, D. P., & Olson, B. D. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100507 · Cited by 931
Serotonin Transporter (5-HTTLPR) Genotype and Amygdala Activation: A Meta-Analysis
Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.016 · Cited by 789
Self-citationThe evolutionary genetics of personality
Penke, L., Denissen, J. J. A., & Miller, G. F. (2007) · European Journal of Personality · doi:10.1002/per.629 · Cited by 610
Munafò, M. R., Yalcin, B., Willis-Owen, S. A., & Flint, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.006 · Cited by 441
Self-citationThe development of anxiety disorders in childhood: an integrative review
Murray, L., Creswell, C., & Cooper, P. J. (2009) · Psychological Medicine · doi:10.1017/s0033291709005157 · Cited by 367
A phenotypic null hypothesis for the genetics of personality.
Turkheimer, E., Pettersson, E., & Horn, E. E. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143752 · Cited by 194
KORSTEN, P., MUELLER, J. C., HERMANNSTÄDTER, C., BOUWMAN, K. M., DINGEMANSE, N. J., DRENT, P. J., LIEDVOGEL, M., MATTHYSEN, E., Van OERS, K., Van OVERVELD, T., et al. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2009.04518.x · Cited by 123
Amygdala Function and 5-HTT Gene Variants in Adolescent Anxiety and Major Depressive Disorder
Lau, J. Y. F., Goldman, D., Buzas, B., Fromm, S. J., Guyer, A. E., Hodgkinson, C., Monk, C. S., Nelson, E. E., Shen, P.-H., Pine, D. S., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.037 · Cited by 113
Behavior Genetic Research Methods: Testing Quasi-Causal Hypotheses Using Multivariate Twin Data
Turkheimer, E., & Harden, K. P. (2014) · Handbook of Research Methods in Social and Personality Psychology · doi:10.1017/cbo9780511996481.012 · Cited by 111
Brezo, J., Bureau, A., Mérette, C., Jomphe, V, Barker, E. D., Vitaro, F., Hébert, M., Carbonneau, R., Tremblay, R. E., & Turecki, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.19 · Cited by 109
Neuroticism from the Top Down: Psychophysiology and Negative Emotionality
Matthews, G. (2004) · On the Psychobiology of Personality · doi:10.1016/b978-008044209-9/50015-4 · Cited by 93
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood
Nemoda, Z., Szekely, A., & Sasvari-Szekely, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.002 · Cited by 78
Nobile, M., Giorda, R., Marino, C., Carlet, O., Pastore, V., Vanzin, L., Bellina, M., Molteni, M., & Battaglia, M. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000594 · Cited by 72
The etiology of criminal onset: The enduring salience of nature and nurture
DeLisi, M., Beaver, K. M., Wright, J. P., & Vaughn, M. G. (2008) · Journal of Criminal Justice · doi:10.1016/j.jcrimjus.2008.04.001 · Cited by 64
Nobile, M., Rusconi, M., Bellina, M., Marino, C., Giorda, R., Carlet, O., Vanzin, L., Molteni, M., & Battaglia, M. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01958.x · Cited by 48
5-HTTLPR, anxiety and gender interaction moderates right amygdala volume in healthy subjects
Cerasa, A., Quattrone, A., Piras, F., Mangone, G., Magariello, A., Fagioli, S., Girardi, P., Muglia, M., Caltagirone, C., & Spalletta, G. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst144 · Cited by 35
Spark, A., & O'Connor, P. J. (2020) · Personality and Individual Differences · doi:10.1016/j.paid.2020.109934 · Cited by 15
Molecular Genetic Investigations of Personality: From Candidate Genes to Genome-wide Associations
Kazantseva, A., Malykh, S., & Khusnutdinova, E. (2016) · Behavioural Genetics for Education · doi:10.1057/9781137437327_8 · Cited by 2
Metadata
- Authors
- Munafò, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., & Flint, J.
- Venue
- Molecular Psychiatry
- Published
- 2003-05-01
- Volume
- 8
- Issue
- 5
- Pages
- 471-484
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2041186704
- Cited by
- 356
- References
- 3
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- green
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