The DOI matches its Crossref record; 274 of the 283 references it cites were found in a registry or an index.
Autism as a disorder of neural information processing: directions for research and targets for therapy
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Abstract
The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which they feed, is hampered by the large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging, and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself.
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“Belmonte and colleagues have articulated a cogent unifying model based on imaging, electrophysiological and anatomical data, which implicates abnormal neural connectivity disrupting timing and information processing [51, 52].”
From Genetics of autism spectrum disorders (2011) · cites this paper as [52]
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“Models of ASD as a brain dysconnection syndrome (8-13) have emerged from analyses of abnormalities in cortico-cortical connections.”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [9]
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Metadata
- Authors
- Belmonte, M. K., Cook, E. H., Anderson, G. M., Rubenstein, J. L. R., Greenough, W. T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L. M., Powell, S. B., Levitt, P. R., Perry, E. K., Jiang, Y. H., DeLorey, T. M., & Tierney, E.
- Affiliations
- University of Cambridge (GB)
- University of Chicago (US)
- Yale University (US)
- University of California, San Francisco (US)
- University of Illinois Urbana-Champaign (US)
- University of California San Diego (US)
- Harvard University (US)
- Vanderbilt University (US)
- Newcastle University (GB)
- Baylor College of Medicine (US)
- Molecular Research Institute (US)
- Kennedy Krieger Institute (US)
- Corresponding author
- Belmonte, M K
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2004-03-23
- Volume
- 9
- Issue
- 7
- Pages
- 646-663
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2139092938
- Cited by
- 442
- References
- 283
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 13 · 2017: 22 · 2016: 14 · 2015: 30 · 2014: 21 · 2013: 31 · 2012: 24
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
- PsyArXiv (OSF Preprints) (submittedVersion)
- PsyArXiv (OSF Preprints) (submittedVersion, cc-by)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, neural information processing, brain development, developmental trajectories, genetic syndromes, endophenotypes, animal models, activity-dependent development, neuroimaging, genetic susceptibility, autism treatment
- MeSH terms
- Animals, Autistic Disorder, Cognition Disorders, Humans
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