Cited by 451Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

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Autism as a disorder of neural information processing: directions for research and targets for therapy

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Belmonte, M K, Cook, E H, Anderson, G M, Rubenstein, J L R, Greenough, W T, Beckel-Mitchener, A, Courchesne, E, Boulanger, L M, Powell, S B, Levitt, P R, Perry, E K, Jiang, Y H, DeLorey, T M, Tierney, E·2004·Molecular Psychiatry

DOI 10.1038/sj.mp.4001499

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Abstract

The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which they feed, is hampered by the large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging, and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself.

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Authors: Belmonte, M. K., Cook, E. H., Anderson, G. M., Rubenstein, J. L. R., Greenough, W. T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L. M., Powell, S. B., Levitt, P. R., Perry, E. K., Jiang, Y. H., DeLorey, T. M., & Tierney, E.
Affiliations: University of Cambridge (GB)
University of Chicago (US)
Yale University (US)
University of California, San Francisco (US)
University of Illinois Urbana-Champaign (US)
University of California San Diego (US)
Harvard University (US)
Vanderbilt University (US)
Newcastle University (GB)
Baylor College of Medicine (US)
Molecular Research Institute (US)
Kennedy Krieger Institute (US)
Corresponding author: Belmonte, M K
ORCID: Belmonte, M K
Cook, E H
Anderson, G M
Rubenstein, J L R
Beckel-Mitchener, A
Boulanger, L M
Powell, S B
Levitt, P R
Tierney, E
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2004-03-23
Volume: 9
Issue: 7
Pages: 646-663
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001499
OpenAlex: W2139092938
Cited by: 442
References: 283
Citations by year: 2026: 7 · 2025: 8 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 13 · 2017: 22 · 2016: 14 · 2015: 30 · 2014: 21 · 2013: 31 · 2012: 24
FWCI: 2.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
PsyArXiv (OSF Preprints) (submittedVersion)
PsyArXiv (OSF Preprints) (submittedVersion, cc-by)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: autism spectrum disorder, neural information processing, brain development, developmental trajectories, genetic syndromes, endophenotypes, animal models, activity-dependent development, neuroimaging, genetic susceptibility, autism treatment
MeSH terms: Animals, Autistic Disorder, Cognition Disorders, Humans

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