The DOI matches its Crossref record; 398 of the 399 references it cites were found in a registry or an index.
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Abstract
This review critically summarizes the neuropathology and genetics of schizophrenia, the relationship between them, and speculates on their functional convergence. The morphological correlates of schizophrenia are subtle, and range from a slight reduction in brain size to localized alterations in the morphology and molecular composition of specific neuronal, synaptic, and glial populations in the hippocampus, dorsolateral prefrontal cortex, and dorsal thalamus. These findings have fostered the view of schizophrenia as a disorder of connectivity and of the synapse. Although attractive, such concepts are vague, and differentiating primary events from epiphenomena has been difficult. A way forward is provided by the recent identification of several putative susceptibility genes (including neuregulin, dysbindin, COMT, DISC1, RGS4, GRM3, and G72). We discuss the evidence for these and other genes, along with what is known of their expression profiles and biological roles in brain and how these may be altered in schizophrenia. The evidence for several of the genes is now strong. However, for none, with the likely exception of COMT, has a causative allele or the mechanism by which it predisposes to schizophrenia been identified. Nevertheless, we speculate that the genes may all converge functionally upon schizophrenia risk via an influence upon synaptic plasticity and the development and stabilization of cortical microcircuitry. NMDA receptor-mediated glutamate transmission may be especially implicated, though there are also direct and indirect links to dopamine and GABA signalling. Hence, there is a correspondence between the putative roles of the genes at the molecular and synaptic levels and the existing understanding of the disorder at the neural systems level. Characterization of a core molecular pathway and a 'genetic cytoarchitecture' would be a profound advance in understanding schizophrenia, and may have equally significant therapeutic implications.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“One of the possible mechanisms that may be involved is dysfunction of the glutamatergic system (figure 1), which might affect synaptic plasticity and cortical microcircuitry, in particular (N-methyl-D-aspartate) NMDA-receptor signaling.10”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [10]
Citations
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Self-citationRecent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Self-citationSchizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788
Flagged first, then by citations
1 of the 399 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Grossman MH, Littrel JB, Weinstein R, Szumlanski C, Weinshilboum R . Identification of the possible basis for inherited differences in human catechol-O-methyltransferase. Trans Neurosci Soc 1992; 18: 70.
- Straub RE, Egan MF, Hashimoto R, Matsumoto M, Weickert CS, Goldberg T et al. The schizophrenia susceptibility gene dysbindin (DTNBP1, 6p22.3): analysis of haplotypes, intermediate phenotypes, and alternative transcripts. Biol Psychiatry 2003; 53: 167S.
- Callicott JH, Pezeawas L, Egan MF, Hariri AR, Mattay VS, Goldberg TE et al. Genetic variationVariation in DISC-1 affects hippocampal structure and function associated with increased risk for schizophrenia and with normal hippocampal structure and function. (in review).
- Toro CT, Kasher PR, Deakin JFW . Altered D-serine metabolism in schizophrenia? A post-mortem study using Stanley Consortium brains [Abstract]. Schizophr Res 2004; 67(Suppl): 125.
Cited by
Sorted by citations
Items 801–900 of 1,003
Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia
O’Donnell, P. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08130.x · Cited by 47
Mohler, E. G., Baker, P. M., Gannon, K. S., Jones, S. S., Shacham, S., Sweeney, J. A., & Ragozzino, M. E. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2518-7 · Cited by 48
Association of NPAS3 exonic variation with schizophrenia
MacIntyre, G., Alford, T., Xiong, L., Rouleau, G. A., Tibbo, P. G., & Cox, D. W. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.04.002 · Cited by 48
Rünker, A. E., O’Tuathaigh, C. M. P., Dunleavy, M., Morris, D. W., Little, G. E., Corvin, A. P., Gill, M., Henshall, D. C., Waddington, J. L., & Mitchell, K. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026488 · Cited by 52
Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models
Moran, P. M., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J. L., & O’Tuathaigh, C. M. P. (2016) · Neural Plasticity · doi:10.1155/2016/2173748 · Cited by 55
Early life exposures, neurodevelopmental disorders, and transposable elements
Lapp, H. E., & Hunter, R. G. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100174 · Cited by 45
Schwab, S. G., Knapp, M., Sklar, P. B., Eckstein, G., Sewekow, C., Borrmann-Hassenbach, M., Albus, M., Becker, T., Hallmayer, J. F., Lerer, B., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001864 · Cited by 46
Retinoic Acid Signaling in the Functioning Brain
Dräger, U. C. (2006) · Science s STKE · doi:10.1126/stke.3242006pe10 · Cited by 46
Malaspina, A., & Michael-Titus, A. T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05071.x · Cited by 45
Wong, P., Sze, Y., Chang, C. C. R., Lee, J., & Zhang, X. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.21 · Cited by 45
What are genes “for” or where are traits “from”? What is the question?
Buchanan, A. V., Sholtis, S. J., Richtsmeier, J. T., & Weiss, K. M. (2009) · BioEssays · doi:10.1002/bies.200800133 · Cited by 46
Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease
Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci85594 · Cited by 45
MacDonald, A. W., Becker, T. M., & Carter, C. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.041 · Cited by 45
Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics
Diaz-Asper, C. M., Weinberger, D. R., & Goldberg, T. E. (2006) · NeuroRx · doi:10.1016/j.nurx.2005.12.010 · Cited by 45
Self-citationWędzony, K., Fijał, K., Maćkowiak, M., Chocyk, A., & Zajaczkowski, W. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.016 · Cited by 45
Burnet, P. W. J., Hutchinson, L. J., VONHESLING, M., Gilbert, E. M., Brandon, N. J., Rutter, A. R., Hutson, P. H., & Harrison, P. J. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.02.009 · Cited by 45
Self-citationWorking memory genetics in schizophrenia and related disorders: An RDoC perspective
Schwarz, E., Tost, H., & Meyer‐Lindenberg, A. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32353 · Cited by 46
The Uses of Biomarkers in Drug Development
Hurko, O. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04946.x · Cited by 44
fMRI evidence for functional epistasis between COMT and RGS4
Buckholtz, J. W., Sust, S., Tan, H. Y., Mattay, V. S., Straub, R. E., Meyer‐Lindenberg, A., Weinberger, D. R., & Callicott, J. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002008 · Cited by 44
Self-citationRegulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1
Wei, J., Graziane, N., Wang, H., Zhong, P., Wang, Q., Liu, W., Hayashi‐Takagi, A., Korth, C., Sawa, A., Brandon, N. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.009 · Cited by 48
Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice
Babovic, D., O’Tuathaigh, C. M. P., O'Sullivan, G. J., Clifford, J. J., Tighe, O., Croke, D. T., Karayiorgou, M., Gogos, J. A., Cotter, D., & Waddington, J. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.006 · Cited by 44
Millan, M. J., & Brocco, M. (2008) · Therapies · doi:10.2515/therapie:2008041 · Cited by 44
Functional Genomics and Schizophrenia: Endophenotypes and Mutant Models
Waddington, J. L., Corvin, A. P., Donohoe, G. J., O’Tuathaigh, C. M. P., Mitchell, K. J., & Gill, M. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2007.04.011 · Cited by 45
Personalized medicine in psychiatry: ethical challenges and opportunities
Evers, K. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/kevers · Cited by 43
Jacklin, D. L., Goel, A., Clementino, K. J., Hall, A. W. M., Talpos, J. C., & Winters, B. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.84 · Cited by 43
Markov, V., Krug, A., Krach, S., Jansen, A., Eggermann, T., Zerres, K., Stöcker, T., Shah, N. J., Nöthen, M. M., Treutlein, J., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20862 · Cited by 43
Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders
Sato, C., Hane, M., & Kitajima, K. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.04.015 · Cited by 44
Biomarkers for Psychiatric Disorders
Turck, C. W. (2009) · Springer eBooks · doi:10.1007/978-0-387-79251-4 · Cited by 42
Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms
Greenwood, T. A., Shutes‐David, A., & Tsuang, D. W. (2019) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20190005 · Cited by 46
Lane, H., Liu, Y., Huang, C.-L., Chang, Y., Wu, P.-L., Huang, C.-H., & Tsai, G. E. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181603f5a · Cited by 42
Ding, L., & Hegde, A. N. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.026 · Cited by 45
Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice
Eastwood, S. L., Lyon, L., George, L., Andrieux, A., Job, D., & Harrison, P. J. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106068825 · Cited by 49
Self-citationModulation of D-serine levels in brains of mice lacking PICK1.
Hikida, T., Mustafa, A., Maeda, K., Fujii, K., Barrow, R., Saleh, M., Huganir, R., Snyder, S., Hashimoto, K., & Sawa, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.025 · Cited by 42
Is there an association between the COMT gene and P300 endophenotypes?
Bramon, E., Dempster, E. L., Frangou, S., McDonald, C., Schoenberg, P. L. A., MacCabe, J. H., Walshe, M., Sham, P. C., Collier, D. A., & Murray, R. M. (2006) · European Psychiatry · doi:10.1016/j.eurpsy.2005.11.001 · Cited by 43
Neuregulin-1 and the P300 waveform—A preliminary association study using a psychosis endophenotype
Bramon, E., Dempster, E. L., Frangou, S., Shaikh, M., Walshe, M., Filbey, F. M., McDonald, C., Sham, P. C., Collier, D. A., & Murray, R. M. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.03.025 · Cited by 45
Insights from spatially mapped gene expression in the mouse brain
Sunkin, S. M., & Hohmann, J. G. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm183 · Cited by 41
Raznahan, A., Lee, Y., Long, R. T., Greenstein, D., Clasen, L., Addington, A., Rapoport, J., & Giedd, J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.72 · Cited by 49
Cortical–basal ganglia imbalance in schizophrenia patients and unaffected first-degree relatives
Oertel‐Knöchel, V., Knöchel, C., Matura, S., Rotarska-Jagiela, A., Magerkurth, J., Prvulovic, D., Haenschel, C., Hampel, H. J., & Linden, D. E. J. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.029 · Cited by 42
Schizophrenia polygenic risk score predicts mnemonic hippocampal activity
Chen, Q., Ursini, G., Romer, A. L., Knodt, A. R., Mezeivtch, K., Xiao, E., Pergola, G., Blasi, G., Straub, R. E., Callicott, J. H., et al. (2018) · Brain · doi:10.1093/brain/awy004 · Cited by 40
Self-citationEffects of Dietary Food Components on Cognitive Functions in Older Adults
Ozawa, H., Miyazawa, T., & Miyazawa, T. (2021) · Nutrients · doi:10.3390/nu13082804 · Cited by 44
Anterior Hippocampus in Schizophrenia Pathogenesis: Molecular Evidence from a Proteome Study
Nesvaderani, M., Matsumoto, I., & Sivagnanasundaram, S. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670902721103 · Cited by 41
Price, G. W., Cercignani, M., Bagary, M. S., Barnes, T. R. E., Barker, G. J., Joyce, E. M., & Ron, M. A. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.06.019 · Cited by 42
Reiner, O., Sapoznik, S., & Sapir, T. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:4:547 · Cited by 43
Association study of polymorphisms between DISC1 and schizophrenia in a Korean population
Kim, H., Park, H. J., Jung, K. H., Ban, J. Y., Ra, J., Kim, J.-W., Park, J. K., Choe, B., Yim, S. V., Kwon, Y. K., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.10.010 · Cited by 42
Introduction to the Special Section: Myelin and oligodendrocyte abnormalities in schizophrenia
Haroutunian, V. H., & Davis, K. L. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007449 · Cited by 42
Phosphodiesterase 10A in Schizophrenia: A PET Study Using [11C]IMA107
Marques, T. R., Natesan, S., Niccolini, F., Politis, M., Gunn, R. N., Searle, G. E., Howes, O. D., Rabiner, E. A., & Kapur, S. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15040518 · Cited by 42
Lodge, D. J., & Perez, S. M. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s42708 · Cited by 42
Markov, V., Krug, A., Krach, S., Whitney, C., Eggermann, T., Zerres, K., Stöcker, T., Shah, N. J., Nöthen, M. M., Treutlein, J., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.067 · Cited by 41
Hida, H., Mouri, A., & Noda, Y. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12r15cp · Cited by 42
Bois, C., Ronan, L., Levita, L., Whalley, H. C., Giles, S., McIntosh, A. M., Fletcher, P. C., Owens, D. G. C., Johnstone, E. C., & Lawrie, S. M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.030 · Cited by 40
First- and second-generation antipsychotic medication and cognitive processing in schizophrenia
Weickert, T. W., & Goldberg, T. E. (2005) · Current Psychiatry Reports · doi:10.1007/s11920-005-0085-5 · Cited by 41
The impact of pharmacogenetics on the development and use of antipsychotic drugs
Reynolds, G. P. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.07.018 · Cited by 41
Model-based dynamical analysis of functional disconnection in schizophrenia
Bányai, M., Diwadkar, V. A., & Érdi, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.046 · Cited by 40
Kaalund, S. S., Riise, J., Broberg, B. V., Fabricius, K., Karlsen, A. S., Secher, T., Plath, N., & Pakkenberg, B. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12061 · Cited by 39
Urbanek, C., Neuhaus, A. H., Opgen‐Rhein, C., Strathmann, S., Wieseke, N., Schaub, R., Hahn, E. W., & Dettling, M. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.04.006 · Cited by 40
Association of RGS2 and RGS5 variants with schizophrenia symptom severity
Campbell, D. B., Lange, L. A., Skelly, T. J., Lieberman, J. A., Levitt, P. R., & Sullivan, P. F. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.006 · Cited by 40
Wadehra, S., Pruitt, P. J., Murphy, E. R., & Diwadkar, V. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.05.010 · Cited by 42
Associative learning and the genetics of schizophrenia
Hall, J., Romaniuk, L., McIntosh, A. M., Steele, J. D., Johnstone, E. C., & Lawrie, S. M. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.011 · Cited by 39
Wang, Q., Deng, W., Huang, C.-W., Li, M., Ma, X., Wang, Y., Jiang, L., Lui, S., Huang, X., Chua, S. E., et al. (2010) · Psychological Medicine · doi:10.1017/s0033291710002412 · Cited by 40
Kotlar, A., Mercer, K. B., Zwick, M. E., & Mullé, J. G. (2015) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2015.10.008 · Cited by 42
Role of the mesolimbic dopamine system in relief learning
Mayer, D., Kahl, E., Uzuneser, T. C., & Fendt, M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0020-1 · Cited by 39
Pergola, G., Carlo, P. D., Jaffe, A. E., Papalino, M., Chen, Q., Hyde, T. M., Kleinman, J. E., Shin, J. H., Rampino, A., Blasi, G., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.981 · Cited by 36
Self-citationAssociation between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia
Cordeiro, Q., Siqueira-Roberto, J., Zung, S., & Vallada, H. (2009) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2009000200004 · Cited by 40
Rockstroh, B. S., Wienbruch, C., Ray, W. J., & Elbert, T. R. (2007) · BMC Psychiatry · doi:10.1186/1471-244x-7-44 · Cited by 40
Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age
Eastwood, S. L., Weickert, C. S., Webster, M. J., Herman, M. M., Kleinman, J. E., & Harrison, P. J. (2006) · Hippocampus · doi:10.1002/hipo.20194 · Cited by 41
Self-citationStructural and Functional Magnetic Resonance Imaging in Psychiatric Disorders
Pearlson, G. D., & Calhoun, V. D. (2007) · The Canadian Journal of Psychiatry · doi:10.1177/070674370705200304 · Cited by 39
Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
Zhang, Y., Yang, L., Gai, C., Cheng, C., Guo, Z., Sun, H., & Hu, D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.976428 · Cited by 39
Tan, H. Y., Chen, A. G., Chen, Q., Browne, L. B., Verchinski, B. A., Kolachana, B. S., Zhang, F., Apud, J. A., Callicott, J. H., Mattay, V. S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.91 · Cited by 39
Self-citationGroup II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase
Trepanier, C. H., Lei, G., Xie, Y., & MacDonald, J. F. (2013) · Scientific Reports · doi:10.1038/srep00926 · Cited by 39
DTNBP1, NRG1, DAOA, DAO and GRM3 Polymorphisms and Schizophrenia: An Association Study
Jönsson, E. G., Saetre, P., Vares, M., Andreou, D., Larsson, K., Timm, S., Rasmussen, H. B., Djurovic, S., Melle, I. S., Andreassen, O. A., et al. (2009) · Neuropsychobiology · doi:10.1159/000218076 · Cited by 39
Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia
Inoue, S., Imamura, A., Okazaki, Y., Yokota, H., Arai, M., Hayashi, N., Furukawa, A., Itokawa, M., & Oishi, M. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30465 · Cited by 40
Substantial Genetic Overlap Between Schizotypy and Neuroticism: A Twin Study
Macare, C., Bates, T. C., Heath, A. C., Martin, N. G., & Ettinger, U. (2012) · Behavior Genetics · doi:10.1007/s10519-012-9558-6 · Cited by 39
Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
Shaikh, M., Hall, M., Schulze, K., Dutt, A., Walshe, M., Williams, I. L., Constante, M., Picchioni, M., Toulopoulou, T., Collier, D. A., et al. (2010) · Psychological Medicine · doi:10.1017/s003329170999239x · Cited by 40
Intermediate or brainless phenotypes for psychiatric research?
Meyer‐Lindenberg, A. (2009) · Psychological Medicine · doi:10.1017/s0033291709991929 · Cited by 39
Brain Biomarkers of Vulnerability and Progression to Psychosis
Cannon, T. D. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv173 · Cited by 41
Progress in iPSC-Based Modeling of Psychiatric Disorders
Hoffmann, A., Ziller, M. J., & Spengler, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194896 · Cited by 39
Evidence that the frontal pole has a significant role in the pathophysiology of schizophrenia
Snelleksz, M., Rossell, S. L., Gibbons, A., Nithianantharajah, J., & Dean, B. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114850 · Cited by 41
Meta-analysis of association between ApoE ε4 allele and schizophrenia
Xu, M., Clair, D. S., & He, L. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.02.015 · Cited by 39
Habl, G., Zink, M., Petroianu, G. A., Bauer, M., Schneider-Axmann, T., von Wilmsdorff, M., Falkai, P., Henn, F. A., & Schmitt, A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0312-z · Cited by 39
From antipsychotic to anti-schizophrenia drugs: role of animal models
Geyer, M. A., Olivier, B., Joëls, M., & Kahn, R. S. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.06.006 · Cited by 40
Quednow, B. B., Geyer, M. A., & Halberstadt, A. L. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70102-8 · Cited by 40
Sivagnanasundaram, S., Fletcher, D., Hubank, M. J. F., Illingworth, E. A., Skuse, D., & Scambler, P. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.014 · Cited by 39
Dopamine genes and schizophrenia: case closed or evidence pending?
Talkowski, M. E., Bamne, M., Mansour, H. A., & Nimgaonkar, V. (2007) · Schizophrenia bulletin · doi:10.1093/schbul/sbm076 · Cited by 39
Potential primary roles of glial cells in the mechanisms of psychiatric disorders
Yamamuro, K., Kimoto, S., Rosen, K. M., Kishimoto, T., & Makinodan, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00154 · Cited by 40
Nixon, D. C., Prust, M. J., Sambataro, F., Tan, H. Y., Mattay, V. S., Weinberger, D. R., & Callicott, J. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.031 · Cited by 38
Self-citationAntipsychotic treatment and neuregulin 1–ErbB4 signalling in schizophrenia
Pan, B., Huang, X., & Deng, C. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.04.002 · Cited by 39
Costafreda, S. G., Fu, C. H. Y., Picchioni, M., Kane, F., McDonald, C., Prata, D. P., Kalidindi, S., Walshe, M., Curtis, V. A., Bramon, E., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20749 · Cited by 38
Shilling, P. D., Marie, R. L. S., Shoemaker, J. M., & Swerdlow, N. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.015 · Cited by 38
Mitochondria in the striatum of subjects with schizophrenia
Somerville, S. M., Conley, R. R., & Roberts, R. C. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.505662 · Cited by 38
Progress in defining the biological causes of schizophrenia
Pickard, B. S. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001955 · Cited by 40
Zheng, F., Wang, L.-F., Jia, M.-X., Yue, W., Ruan, Y., Lu, T.-L., Liu, J., Li, J., & Zhang, D. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-14 · Cited by 45
MacDonald, M. L., Ciccimaro, E., Prakash, A., Banerjee, A., Seeholzer, S. H., Blair, I. A., & Hahn, C.-G. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021766 · Cited by 35
Schizophrenia-Associated MicroRNA–Gene Interactions in the Dorsolateral Prefrontal Cortex
Santarelli, D. M., Carroll, A. P., Cairns, H. M., Tooney, P. A., & Cairns, M. J. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2019.10.003 · Cited by 38
Functional impairment of cortical AMPA receptors in schizophrenia
Zeppillo, T., Schulmann, A., Macciardi, F. M., Hjelm, B. E., Föcking, M., Sequeira, P. A., Guella, I., Cotter, D., Bunney, W. E., Limón, A., et al. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.03.037 · Cited by 38
Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?
Delorme, T. C., Srivastava, L. K., & Cermakian, N. (2020) · Journal of Biological Rhythms · doi:10.1177/0748730420929448 · Cited by 44
Cytosolic protein interactions of the schizophrenia susceptibility gene dysbindin
Mead, C.-L., Kuzyk, M. A., Moradian, A., Wilson, G. M., Holt, R. A., & Morin, G. B. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06690.x · Cited by 37
Parlapani, E., Schmitt, A., Erdmann, A., Bernstein, H., Breunig, B., Gruber, O., Petroianu, G. A., von Wilmsdorff, M., Schneider-Axmann, T., Honer, W. G., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.007 · Cited by 38
Olsen, L., Hansen, T. F., Jakobsen, K. D., Djurovic, S., Melle, I. S., Agartz, I., Hall, H., Ullum, H., Timm, S., Wang, A. G., et al. (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-39 · Cited by 38
Tunbridge, E. M., Weinberger, D. R., & Harrison, P. J. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001767 · Cited by 38
Self-citationPositive Selection within the Schizophrenia-Associated GABAA Receptor β2 Gene
Lo, W.-S., Xu, Z., Yu, Z., Pun, F. W., Ng, S.-K., Chen, J., Tong, K.-L., Zhao, C., Xu, X., Tsang, S., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000462 · Cited by 38
Metadata
- Authors
- Harrison, P. J., & Weinberger, D. R.
- Affiliations
- Warneford Hospital (GB)
- National Institutes of Health (US)
- Venue
- Molecular Psychiatry
- Published
- 2004-07-20
- Volume
- 10
- Issue
- 1
- Pages
- 40-68
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2071090720
- Cited by
- 2,020
- References
- 399
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 22 · 2023: 38 · 2022: 38 · 2021: 34 · 2020: 34 · 2019: 42 · 2018: 52 · 2017: 58 · 2016: 66 · 2015: 88 · 2014: 102 · 2013: 92 · 2012: 129
- FWCI
- 22.22
- Type
- journal article
- Language
- en
- Update notices
- erratum (2005-03-29)
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, schizophrenia genetics, susceptibility genes, gene expression, synaptic plasticity, cortical microcircuitry, NMDA receptor, glutamatergic neurotransmission, dopamine signalling, GABA signalling, neuregulin, dysbindin, catechol-O-methyltransferase, DISC1, RGS4, GRM3, G72, hippocampus, dorsolateral prefrontal cortex, dorsal thalamus, brain connectivity
- MeSH terms
- Dysbindin, Brain, Carrier Proteins, Catechol O-Methyltransferase, Gene Expression Regulation, Humans, Schizophrenia, Genetic Predisposition to Disease, Neuregulin-1, Dystrophin-Associated Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
