Cited by 2,020Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorMental Health and Psychiatry

The DOI matches its Crossref record; 398 of the 399 references it cites were found in a registry or an index.

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

Harrison, P J, Weinberger, D R·2005·Molecular Psychiatry

DOI 10.1038/sj.mp.4001558

Open this paper in CoChat — free account

Abstract

This review critically summarizes the neuropathology and genetics of schizophrenia, the relationship between them, and speculates on their functional convergence. The morphological correlates of schizophrenia are subtle, and range from a slight reduction in brain size to localized alterations in the morphology and molecular composition of specific neuronal, synaptic, and glial populations in the hippocampus, dorsolateral prefrontal cortex, and dorsal thalamus. These findings have fostered the view of schizophrenia as a disorder of connectivity and of the synapse. Although attractive, such concepts are vague, and differentiating primary events from epiphenomena has been difficult. A way forward is provided by the recent identification of several putative susceptibility genes (including neuregulin, dysbindin, COMT, DISC1, RGS4, GRM3, and G72). We discuss the evidence for these and other genes, along with what is known of their expression profiles and biological roles in brain and how these may be altered in schizophrenia. The evidence for several of the genes is now strong. However, for none, with the likely exception of COMT, has a causative allele or the mechanism by which it predisposes to schizophrenia been identified. Nevertheless, we speculate that the genes may all converge functionally upon schizophrenia risk via an influence upon synaptic plasticity and the development and stabilization of cortical microcircuitry. NMDA receptor-mediated glutamate transmission may be especially implicated, though there are also direct and indirect links to dopamine and GABA signalling. Hence, there is a correspondence between the putative roles of the genes at the molecular and synaptic levels and the existing understanding of the disorder at the neural systems level. Characterization of a core molecular pathway and a 'genetic cytoarchitecture' would be a profound advance in understanding schizophrenia, and may have equally significant therapeutic implications.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4001558

Cites

398 of 398 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Self-citation
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Self-citation
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788

Show all 399 references

Research works printed but not linked: 4

Grossman MH, Littrel JB, Weinstein R, Szumlanski C, Weinshilboum R . Identification of the possible basis for inherited differences in human catechol-O-methyltransferase. Trans Neurosci Soc 1992; 18: 70.
Straub RE, Egan MF, Hashimoto R, Matsumoto M, Weickert CS, Goldberg T et al. The schizophrenia susceptibility gene dysbindin (DTNBP1, 6p22.3): analysis of haplotypes, intermediate phenotypes, and alternative transcripts. Biol Psychiatry 2003; 53: 167S.
Callicott JH, Pezeawas L, Egan MF, Hariri AR, Mattay VS, Goldberg TE et al. Genetic variationVariation in DISC-1 affects hippocampal structure and function associated with increased risk for schizophrenia and with normal hippocampal structure and function. (in review).
Toro CT, Kasher PR, Deakin JFW . Altered D-serine metabolism in schizophrenia? A post-mortem study using Stanley Consortium brains [Abstract]. Schizophr Res 2004; 67(Suppl): 125.

Sorted by citations

Items 701–800 of 1,003

Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia
Zinkstok, J., Schmitz, N., van Amelsvoort, T., Moeton, M., Baas, F., & Linszen, D. H. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00326.x · Cited by 56
Sensorimotor Gating of Schizophrenia Patients Depends on Catechol O-Methyltransferase Val158Met Polymorphism
Quednow, B. B., Wagner, M., Mößner, R., Maier, W., & Kühn, K. ‐. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn088 · Cited by 55
Lack of Change in Markers of Presynaptic Terminal Abundance Alongside Subtle Reductions in Markers of Presynaptic Terminal Plasticity in Prefrontal Cortex of Schizophrenia Patients
Fung, S. J., Sivagnanasundaram, S., & Weickert, C. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.036 · Cited by 54
Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex
Yamamura, S., Ohoyama, K., Hamaguchi, T., Nakagawa, M., Suzuki, D., Matsumoto, T., Motomura, E., Tanii, H., Shiroyama, T., & Okada, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00175.x · Cited by 54
Augmentation strategies in partial responder and/or treatment-resistant schizophrenia patients treated with clozapine
Muscatello, M. R. A., Bruno, A., Fazio, P. D., Segura‐Garcìa, C., Pandolfo, G., & Zoccali, R. A. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.956082 · Cited by 58
N-Methyl-D-Aspartate Receptor and Calbindin-Containing Neurons in the Anterior Cingulate Cortex in Schizophrenia and Bipolar Disorder
Woo, T.-U. W., Shrestha, K., Lamb, D., Minns, M., & Benes, F. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.034 · Cited by 54
Novel Linkage to Chromosome 20p Using Latent Classes of Psychotic Illness in 270 Irish High-Density Families
Fanous, A. H., Neale, M. C., Webb, B. T., Straub, R. E., O’Neill, F. A., Walsh, D., Riley, B. P., & Kendler, K. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.023 · Cited by 54
The DISC1 promoter: characterization and regulation by FOXP2
Walker, R. M., Hill, A. E., Newman, A. C., Hamilton, G., Torrance, H. S., Anderson, S. M., Ogawa, F., Deriziotis, P., Nicod, J., Vernes, S. C., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds111 · Cited by 55
Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
Colantuoni, C., Hyde, T. M., Mitkus, S. N., Joseph, A., Sartorius, L. J., Aguirre, C., Creswell, J., Johnson, E., Deep‐Soboslay, A., Herman, M. M., et al. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0181-5 · Cited by 55
Self-citation
Beyond static measures: A review of functional magnetic resonance spectroscopy and its potential to investigate dynamic glutamatergic abnormalities in schizophrenia
Jelen, L. A., King, S., Mullins, P. G., & Stone, J. M. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117747579 · Cited by 54
Association between schizophrenia and genetic variation in DCC: a case–control study
Grant, A., Fathalli, F., Rouleau, G., Joober, R., & Flores, C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.023 · Cited by 53
Schizophrenia; from structure to function with special focus on the mediodorsal thalamic prefrontal loop
Pakkenberg, B., Scheel‐Krüger, J., & Kristiansen, L. V. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01447.x · Cited by 53
Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1−/− mice
Asp, L., Holtze, M., Powell, S. B., Karlsson, H., & Erhardt, S. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990253 · Cited by 54
Cognitive impairments in the STOP null mouse model of schizophrenia.
Powell, K. J., Hori, S. E., Leslie, R. A., Andrieux, A., Schellinck, H. M., Thorne, M., & Robertson, G. S. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.826 · Cited by 62
Use-Dependent Inhibition of Synaptic Transmission by the Secretion of Intravesicularly Accumulated Antipsychotic Drugs
Tischbirek, C. H., Wenzel, E. M., Zheng, F., Huth, T., Amato, D., Trapp, S., Denker, A., Welzel, O., Lueke, K., Svetlitchny, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.019 · Cited by 52
Strain Dependent Effects of Prenatal Stress on Gene Expression in the Rat Hippocampus
Neeley, E. W., Berger, R., Koenig, J., & Leonard, S. (2011) · Physiology and Behavior · doi:10.1016/j.physbeh.2011.02.032 · Cited by 52
High-frequency neural oscillations and visual processing deficits in schizophrenia
Tan, H. M., Lana, L., & Uhlhaas, P. J. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00621 · Cited by 53
Glial biomarkers in human central nervous system disease
Garden, G. A., & Campbell, B. M. (2016) · Glia · doi:10.1002/glia.22998 · Cited by 59
Investigating Gene‐to‐Behavior Pathways in Psychiatric Disorders
Takao, K., & Miyakawa, T. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.008 · Cited by 53
p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling
Sheffler, D. J., Kroeze, W. K., Garcia, B. G., Deutch, A. Y., Hufeisen, S. J., Leahy, P. S., Brüning, J. C., & Roth, B. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600585103 · Cited by 56
A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3
Ogawa, F., Kasai, M., & Akiyama, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.013 · Cited by 53
Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia
Brigman, J. L. (2010) · Frontiers in Neuroscience · doi:10.3389/neuro.01.013.2010 · Cited by 52
Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia
Hagihara, H., Ohira, K., Takao, K., & Miyakawa, T. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-41 · Cited by 52
Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes
Willi, R., Weinmann, O., Winter, C., Klein, J., Sohr, R., Schnell, L., Yee, B. K., Feldon, J., & Schwab, M. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4393-09.2010 · Cited by 52
Bayesian inference, predictive coding and delusions
Adams, R. A., Brown, H. R., & Friston, K. J. (2014) · Avant · doi:10.26913/50302014.0112.0004 · Cited by 55
Study of OH● Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia
Korotkova, E. I., Misini, B., Дорожко, Е. В., Bukkel, M. V., Plotnikov, E. V., & Linert, W. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12010401 · Cited by 52
Variants of the RELA Gene are Associated with Schizophrenia and their Startle Responses
Hashimoto, R., Ohi, K., Yasuda, Y., Fukumoto, M., Yamamori, H., Takahashi, H., Iwase, M., Okochi, T., Kazui, H., Saitoh, O., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.78 · Cited by 52
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda, S. A., Jagannathan, K., Gelernter, J. E., Calhoun, V. D., Liu, J., Stevens, M. C. G., & Pearlson, G. D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.052 · Cited by 52
Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis
Daumann, J., Heekeren, K., Neukirch, A., Thiel, C. M., Möller‐Hartmann, W., & Gouzoulis‐Mayfrank, E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1237-1 · Cited by 53
The interplay between mitochondrial complex I, dopamine and Sp1 in schizophrenia
Ben‐Shachar, D. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0319-5 · Cited by 53
Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
Vrajová, M., Šťastný, F., Horáček, J., Lochman, J., Šerý, O., Peková, Š., Klaschka, J., & Höschl, C. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0145-z · Cited by 54
DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth
Hattori, T., Shimizu, S., Koyama, Y., Yamada, K., Kuwahara, R., Kumamoto, N., Matsuzaki, S., Ito, A., Katayama, T., & Tohyama, M. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.60 · Cited by 52
Schizophrenia and depression, two poles of endocannabinoid system deregulation
Rodríguez-Muñoz, M., Sánchez‐Blázquez, P., Callado, L. F., Meana, J. J., & Garzón-Niño, J. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0029-y · Cited by 52
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders
Thalman, C., Horta, G., Qiao, L., Endle, H., Tegeder, I., Cheng, H., Laube, G., Sigurdsson, T., Hauser, M. J., Tenzer, S., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0053-1 · Cited by 52
RETRACTED ARTICLE: mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
Wang, H.-Y., MacDonald, M. L., Borgmann‐Winter, K. E., Banerjee, A., Abou‐Sleiman, P. M., Tom, A., Khan, A., Lee, K.-C., Roussos, P., Siegel, S. J., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0234-y · Cited by 53
Retracted
Emerging Opportunities for Antipsychotic Drug Discovery in the Postgenomic Era
Marino, M. J., Knutsen, L. J. S., & Williams, M. R. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701094q · Cited by 52
Neuroimaging-Genetic Paradigms: A New Approach to Investigate the Pathophysiology and Treatment of Cognitive Deficits in Schizophrenia
Roffman, J. L., Weiss, A. P., GOFF, D. C., Rauch, S. L., & Weinberger, D. R. (2006) · Harvard Review of Psychiatry · doi:10.1080/10673220600642945 · Cited by 53
Self-citation
Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: A preliminary study
Tabarés‐Seisdedos, R., Escámez, T., Giménez, J. A. M., Balanzá‐Martínez, V., Salazar, J., Selva, G., Rubio, C., Vieta, E., Geijo‐Barrientos, E., Martínez‐Arán, A., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.054 · Cited by 51
Schizophrenia: A unique translational opportunity in behavioral neuroendocrinology
Koenig, J. I. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.027 · Cited by 51
Anti-NMDA-Rezeptor-Enzephalitis
Prüß, H., Dalmau, J. O., Arolt, V., & Wandinger, K.-P. (2010) · Der Nervenarzt · doi:10.1007/s00115-009-2908-9 · Cited by 48
Polymorphisms associated with normal memory variation also affect memory impairment in schizophrenia
Jablensky, A. V., Morar, B., Wiltshire, S., Carter, K. W., Dragović, M., Badcock, J. C., Chandler, D., Peters, K. E., & Kalaydjieva, L. V. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00679.x · Cited by 52
Proton Magnetic Resonance Spectroscopy in 22q11 Deletion Syndrome
Alves, F. D. S., Boot, E., Schmitz, N., Nederveen, A. J., Vorstman, J. A. S., Lavini, C., Pouwels, P. J. W., de Haan, L., LINSZEN, D. H., & van Amelsvoort, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021685 · Cited by 50
RGS3 and RGS4 Differentially Associate with G Protein-coupled Receptor-Kir3 Channel Signaling Complexes Revealing Two Modes of RGS Modulation
Jaén, C., & Doupnik, C. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603177200 · Cited by 53
Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample
Réthelyi, J., Bakker, S. C., Polgár, P., Czobor, P., Strengman, E., Pásztor, P., Kahn, R. S., & Bitter, I. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31049 · Cited by 51
N400 deficits from semantic matching of pictures in probands and first-degree relatives from multiplex schizophrenia families
Guerra, S., Ibáñez, A. M., Martín, M., Bobes, M. A., Reyes, A., Quiñones, R. M., Bravo, T. M., Domínguez, M., & Sosa, M. V. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.02.004 · Cited by 51
Neural correlates of cognitive impairment in schizophrenia
Ortiz‐Gil, J., Pomarol‐Clotet, E., Salvador, R. M., Canales-Rodríguez, E. J., Sarró, S., Gomar, J. J., Guerrero, A., Sans-Sansa, B., Capdevila, A., Junqué, C., et al. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.083600 · Cited by 51
Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
Parlapani, E., Schmitt, A., Wirths, O., Bauer, M., Sommer, C., Rueb, U., Skowronek, M. H., Treutlein, J., Petroianu, G. A., Rietschel, M., et al. (2008) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802022376 · Cited by 53
The role of MACF1 in nervous system development and maintenance
Moffat, J. J., Ka, M., Jung, E., Smith, A. L., & Kim, W.-Y. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.020 · Cited by 49
Two Genes Link Two Distinct Psychoses
Sawa, A., & Snyder, S. H. (2005) · Science · doi:10.1126/science.1121114 · Cited by 51
Recent advances in postmortem pathology and neurochemistry in schizophrenia
Dean, B., Boer, S., Gibbons, A. S., Money, T., & Scarr, E. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328323d52e · Cited by 50
Psychiatric genetics – the new era: genetic research and some clinical implications
Prathikanti, S., & Weinberger, D. R. (2005) · British Medical Bulletin · doi:10.1093/bmb/ldh055 · Cited by 50
Self-citation
Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
Schmitt, A., Koschel, J., Zink, M., Bauer, M., Sommer, C., Frank, J., Treutlein, J., Schulze, T. G., Schneider-Axmann, T., Parlapani, E., et al. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0017-1 · Cited by 53
The emperors of the schizophrenia polygene have no clothes
Crow, T. J. (2008) · Psychological Medicine · doi:10.1017/s0033291708003395 · Cited by 51
Cognitive Remediation in Schizophrenia
Kaneko, Y., & Keshavan, M. (2012) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2012.10.3.125 · Cited by 51
Association study of a new schizophrenia susceptibility locus of 10q24.32–33 in a Han Chinese population
Guan, F., Wei, S., Feng, J., Zhang, C. Y., Xing, B., Zhang, H., Gao, C., Yang, H., & Li, S. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.03.030 · Cited by 50
The Molecular and Cellular Neurobiology of Nicotine Abuse in Schizophrenia
Mobascher, A., & Winterer, G. (2008) · Pharmacopsychiatry · doi:10.1055/s-2008-1081463 · Cited by 50
Association analyses of the DAOA/G30 and d-amino-acid oxidase genes in schizophrenia: Further evidence for a role in schizophrenia
Shinkai, T., Luca, V. D., Hwang, R., Müller, D. J., Lanktree, M. B., Zai, G. C., Shaikh, S. A., Wong, G. W. H., Sicard, T., Potapova, N., et al. (2007) · NeuroMolecular Medicine · doi:10.1007/bf02685890 · Cited by 50
Disturbed synaptic connectivity in schizophrenia: Convergence of genetic risk factors during neurodevelopment
Hayashi‐Takagi, A., & Sawa, A. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.007 · Cited by 50
Decreased gray matter volume in the left middle temporal gyrus as a candidate biomarker for schizophrenia: A study of drug naive, first-episode schizophrenia patients and unaffected siblings
Guo, W., Hu, M., Fan, X., Liu, F., Wu, R., Chen, J., Guo, X., Xiao, C., Quan, M., Chen, H., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.051 · Cited by 50
Genetic Consideration of Schizotypal Traits: A Review
Walter, E. E., Fernandez, F., Snelling, M., & Barkus, E. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01769 · Cited by 55
Schizophrenia and neurogenesis: A stem cell approach
Iannitelli, A., Quartini, A., Tirassa, P., & Bersani, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.010 · Cited by 52
Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia.
Hall, J., Whalley, H., Moorhead, T. W., Baig, B., McIntosh, A., Job, D., Owens, D. G., Lawrie, S., & Johnstone, E. C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.009 · Cited by 53
Two isoforms of GABAA receptor β2 subunit with different electrophysiological properties: differential expression and genotypical correlations in schizophrenia
Zhao, C., Xu, Z., Chen, J., Yu, Z., Tong, K.-L., Lo, W.-S., Pun, F. W., Ng, S.-K., Tsang, S. Y., & Xue, H. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001899 · Cited by 50
Preclinical evaluation of non-imidazole histamine H3 receptor antagonists in comparison to atypical antipsychotics for the treatment of cognitive deficits associated with schizophrenia
Brown, J. W., Whitehead, C. A., Basso, A. M., Rueter, L. E., & Zhang, M. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000739 · Cited by 50
The schizophrenic faces of PICK1
Dev, K. K., & Henley, J. M. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.09.007 · Cited by 51
Polymorphism in the 5′-promoter region of serine racemase gene in schizophrenia
Goltsov, A. Y., Loseva, J. G., Андреева, Т. В., Grigorenko, A. P., Abramova, L. I., Каледа, В. Г., Александровна, О. В., Moliaka, Y. K., & Rogaev, E. I. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001801 · Cited by 50
PhenoChipping of psychotic disorders: A novel approach for deconstructing and quantitating psychiatric phenotypes
Niculescu, A. B., Lulow, L. L., Ogden, C. A., Le-Niculescu, H., Salomon, D. R., Schork, N. J., Caligiuri, M. P., & Lohr, J. B. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30404 · Cited by 48
Genetic mechanisms of psychosis: In vivo and postmortem genomics
Weinberger, D. R. (2005) · Clinical Therapeutics · doi:10.1016/j.clinthera.2005.07.016 · Cited by 50
Self-citation
Disrupted in schizophrenia 1: building brains and memories
Porteous, D. J., & Millar, J. K. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.04.009 · Cited by 51
NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia
Ramsey, A. J. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17906-2 · Cited by 50
Traditional Knowledge and Formulations of Medicinal Plants Used by the Traditional Medical Practitioners of Bangladesh to Treat Schizophrenia Like Psychosis
Ahmed, M. N., & Azam, M. N. K. (2014) · Schizophrenia Research and Treatment · doi:10.1155/2014/679810 · Cited by 52
The Glutamate Hypothesis of Schizophrenia: Neuroimaging and Drug Development
Egerton, A., & Stone, J. M. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112800784961 · Cited by 51
Genetic insight of schizophrenia: past and future perspectives
Singh, S., Kumar, A., Agarwal, S., Phadke, S. R., & Jaiswal, Y. (2013) · Gene · doi:10.1016/j.gene.2013.09.110 · Cited by 52
Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP
Vogt, J., Yang, J., Mobascher, A., Cheng, J., Li, Y., Liu, X., Baumgart, J., Thalman, C., Kirischuk, S., Unichenko, P., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505677 · Cited by 50
Discovery of Innovative Therapeutics: Today’s Realities and Tomorrow’s Vision. 2. Pharma’s Challenges and Their Commitment to Innovation
Abou-Gharbia, M. A., & Childers, W. E. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401564r · Cited by 52
Oscillations in cortico-basal ganglia circuits: implications for Parkinson’s disease and other neurologic and psychiatric conditions
Halje, P., Brys, I., Mariman, J. J., Cunha, C. D., Fuentes, R., & Petersson, P. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00590.2018 · Cited by 49
Schizophrenia drug says goodbye to dopamine
Weinberger, D. R. (2007) · Nature Medicine · doi:10.1038/nm0907-1018 · Cited by 49
Self-citation
Neurodevelopmental Origins of Schizophrenia
Weinberger, D. R., & Levitt, P. R. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch19 · Cited by 49
Self-citation
Pharmacogenomics of antipsychotics efficacy for schizophrenia
Cacabelos, R., Hashimoto, R., & Takeda, M. (2011) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02168.x · Cited by 46
Endophenotypes in the personality disorders
Siever, L. J. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.2/lsiever · Cited by 47
Sustained brain‐derived neurotrophic factor up‐regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment
Takahashi, M., Kakita, A., Futamura, T., Watanabe, Y., Mizuno, M., Sakimura, K., Ċastrén, E., Nabeshima, T., Someya, T., & Nawa, H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04106.x · Cited by 48
Exploring intermediate phenotypes with EEG: Working memory dysfunction in schizophrenia
Haenschel, C., & Linden, D. E. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.045 · Cited by 54
An entropy-based approach for testing genetic epistasis underlying complex diseases
Kang, G., Yue, W., Zhang, J., Cui, Y., Zuo, Y., & Zhang, D. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.10.001 · Cited by 48
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.
Takahashi, T., Suzuki, M., Tsunoda, M., Maeno, N., Kawasaki, Y., Zhou, S.-Y., Hagino, H., Niu, L., Tsuneki, H., Kobayashi, S., et al. (2009) · Psychiatry Research · doi:10.1016/j.pscychresns.2009.01.005 · Cited by 56
NMDA Receptor Phosphorylation at a Site Affected in Schizophrenia Controls Synaptic and Behavioral Plasticity
Li, B., Devidze, N., Barengolts, D., Prostak, N., Sphicas, E., Apicella, A. J., Malinow, R., & Emamian, E. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2109-09.2009 · Cited by 48
Influence of NOS1 on Verbal Intelligence and Working Memory in Both Patients With Schizophrenia and Healthy Control Subjects
Donohoe, G. J., Walters, J., Morris, D. W., Quinn, E. M., Judge, R., Norton, N., Giegling, I., Hartmann, A. M., Möller, H. J., Muglia, P., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.139 · Cited by 48
Role of glutamate in schizophrenia: integrating excitatory avenues of research
Sodhi, M., Wood, K. H., & Meador‐Woodruff, J. H. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.9.1389 · Cited by 49
Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review
Grayson, B., Barnes, S. A., Markou, A., Piercy, C., Podda, G., & Neill, J. C. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_403 · Cited by 51
Stargazin involvement with bipolar disorder and response to lithium treatment
Silberberg, G., Levit, A., Collier, D. A., Clair, D. S., Munro, J., Kerwin, R. W., Tondo, L., Floris, G., Breen, G. D., & Navon, R. (2008) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3282f974ca · Cited by 48
The Role of Caspase-3 Activation in Phencyclidine-Induced Neuronal Death in Postnatal Rats
Wang, C. Z., & Johnson, K. M. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301202 · Cited by 48
Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes
Takahashi, N., Sakurai, T., Bozdagi-Gunal, O., Dorr, N. P., Moy, J., Krug, L., Gama-Sosa, M. A., Elder, G. A., Koch, R. J., Walker, R. H., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.8 · Cited by 49
Impaired associative learning in schizophrenia: behavioral and computational studies
Diwadkar, V. A., Flaugher, B., Jones, T., Zalányi, L., Ujfalussy, B. B., Keshavan, M. S., & Érdi, P. (2008) · Cognitive Neurodynamics · doi:10.1007/s11571-008-9054-0 · Cited by 50
Neuropathology of schizophrenia
Harrison, P. J. (2005) · Psychiatry · doi:10.1383/psyt.2005.4.10.18 · Cited by 47
Self-citation
Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia
Berman, J. A., Talmage, D. A., & Role, L. W. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78007-2 · Cited by 47
An overview of the genetics of substance use disorders
Lachman, H. M. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0013-3 · Cited by 47
Error processing-associated event-related potentials in schizophrenia and unaffected siblings
Simmonite, M., Bates, A. T., Groom, M. J., Jackson, G. M., Hollis, C. P., & Liddle, P. F. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.01.012 · Cited by 47
Neurodevelopment in Schizophrenia: The Role of the Wnt Pathways
Panaccione, I., Napoletano, F., Forte, A. M., Kotzalidis, G. D., CASALE, A. D., Rapinesi, C., Brugnoli, C., Serata, D., Caccia, F., Cuomo, I., et al. (2013) · Current Neuropharmacology · doi:10.2174/1570159x113119990037 · Cited by 49
The influence of the glutamatergic system on cognition in schizophrenia: A systematic review
Thomas, E. H. X., Bozaoglu, K., Rossell, S. L., & Gurvich, C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.005 · Cited by 47
Homer splice variants modulation within cortico-subcortical regions by dopamine D2 antagonists, a partial agonist, and an indirect agonist: implication for glutamatergic postsynaptic density in antipsychotics action.
Tomasetti, C., Dell’Aversano, C., Iasevoli, F., & de Bartolomeis, A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.022 · Cited by 51
GABRB2 Association with Schizophrenia: Commonalities and Differences Between Ethnic Groups and Clinical Subtypes
Lo, W.-S., Harano, M., Gawlik, M., Yu, Z., Chen, J., Pun, F. W., Tong, K.-L., Zhao, C., Ng, S.-K., Tsang, S., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.003 · Cited by 46

Authors: Harrison, P. J., & Weinberger, D. R.
Affiliations: Warneford Hospital (GB)
National Institutes of Health (US)
ORCID: Harrison, P J
Weinberger, D R
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2004-07-20
Volume: 10
Issue: 1
Pages: 40-68
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001558
OpenAlex: W2071090720
Cited by: 2,020
References: 399
Citations by year: 2026: 10 · 2025: 20 · 2024: 22 · 2023: 38 · 2022: 38 · 2021: 34 · 2020: 34 · 2019: 42 · 2018: 52 · 2017: 58 · 2016: 66 · 2015: 88 · 2014: 102 · 2013: 92 · 2012: 129
FWCI: 22.22
Type: journal article
Language: en
Update notices: erratum (2005-03-29)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, schizophrenia genetics, susceptibility genes, gene expression, synaptic plasticity, cortical microcircuitry, NMDA receptor, glutamatergic neurotransmission, dopamine signalling, GABA signalling, neuregulin, dysbindin, catechol-O-methyltransferase, DISC1, RGS4, GRM3, G72, hippocampus, dorsolateral prefrontal cortex, dorsal thalamus, brain connectivity
MeSH terms: Dysbindin, Brain, Carrier Proteins, Catechol O-Methyltransferase, Gene Expression Regulation, Humans, Schizophrenia, Genetic Predisposition to Disease, Neuregulin-1, Dystrophin-Associated Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks