Successful Immunization with a Single Injection of Non-integrating Lentiviral Vector

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903 · see citing works

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., et al. (2003) · Science · doi:10.1126/science.1088547 · Cited by 3,587 · see citing works

The World Health report 2006 1 : Working together for health 2

Guilbert, J.-J. (2006) · Education for Health · doi:10.1080/13576280600937911 · Cited by 2,657 · see citing works

Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery

Zufferey, R., Dull, T., Mandel, R. J., Bukovsky, A., Quiroz, D., Naldini, L., & Trono, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9873-9880.1998 · Cited by 1,815 · see citing works

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

Shiver, J. W., Fu, T., Chen, L., Casimiro, D. R., Davies, M.-E., Evans, R. K., Zhang, Z., Simon, A. J., Trigona, W. L., Dubey, S. A., et al. (2002) · Nature · doi:10.1038/415331a · Cited by 1,173 · see citing works

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

Amara, R. R. (2001) · Science · doi:10.1126/science.1058915 · Cited by 1,110 · see citing works

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination

Barouch, D. H., Santra, S., Schmitz, J. E., Kuroda, M. J., Fu, T., Wagner, W., Bilska, M., Craiu, A., Zheng, X. X., Krivulka, G. R., et al. (2000) · Science · doi:10.1126/science.290.5491.486 · Cited by 881 · see citing works

Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

Kafri, T., Blömer, U., Peterson, D. A., Gage, F. H., & Verma, I. M. (1997) · Nature Genetics · doi:10.1038/ng1197-314 · Cited by 604 · see citing works

Effective gene therapy with nonintegrating lentiviral vectors

Yáñez-Muñoz, R. J., Balaggan, K. S., MacNeil, A., Howe, S. J., Schmidt, M., Smith, A. J., Buch, P., MacLaren, R. E., Anderson, P. N., Barker, S. E., et al. (2006) · Nature Medicine · doi:10.1038/nm1365 · Cited by 460 · see citing works

Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

Baba, T. W., Liška, V., Khimani, A. H., Ray, N. B., Dailey, P. J., Penninck, D. G., Bronson, R. T., Greene, M. F., McClure, H. M., Martin, L. N., et al. (1999) · Nature Medicine · doi:10.1038/5557 · Cited by 355 · see citing works

Increased Immune Response Elicited by DNA Vaccination with a Synthetic gp120 Sequence with Optimized Codon Usage

André, S., Seed, B., Eberle, J., Schraut, W., Bültmann, A., & Haas, J. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1497-1503.1998 · Cited by 305 · see citing works

The bone marrow: a nest for migratory memory T cells

Rosa, F. D., & Pabst, R. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.011 · Cited by 272 · see citing works

HIV vaccine design: insights from live attenuated SIV vaccines

Koff, W. C., Johnson, P. R., Watkins, D. I., Burton, D. R., Lifson, J. D., Hasenkrug, K. J., McDermott, A. B., Schultz, A. M., Zamb, T. J., Boyle, R., et al. (2005) · Nature Immunology · doi:10.1038/ni1296 · Cited by 256 · see citing works

Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression <i>in vitro</i> and <i>in vivo</i>

Philippe, S., Sarkis, C., Barkats, M., Mammeri, H., Ladroue, C., Petit, C., Mallet, J., & Serguera, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606197103 · Cited by 249 · see citing works

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection

Leavitt, A. D., Robles, G., Alesandro, N., & Varmus, H. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.721-728.1996 · Cited by 232 · see citing works

Transient Gene Expression by Nonintegrating Lentiviral Vectors

Nightingale, S. J., Hollis, R. P., Pepper, K. A., Petersen, D., Yu, X.-J., Yang, C., Bahner, I., & Kohn, D. B. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.008 · Cited by 192 · see citing works

Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: identification of an H2-Kd-restricted CTL epitope

Gambotto, A. A., Dworacki, G., Cicinnati, V. R., Kenniston, T. W., Steitz, J., Tüting, T., Robbins, P., & Deleo, A. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301335 · Cited by 183 · see citing works

As Gelsinger Case Ends, Gene Therapy Suffers Another Blow

Couzin, J., & Kaiser, J. (2005) · Science · doi:10.1126/science.307.5712.1028b · Cited by 140 · see citing works

CD8 Cell Division Maintaining Cytotoxic Memory Occurs Predominantly in the Bone Marrow

Parretta, E., Cassese, G., Barba, P., Santoni, A., Guardiola, J., & Rosa, F. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7654 · Cited by 136 · see citing works

Novel Integrase-Defective Lentiviral Episomal Vectors for Gene Transfer

Vargas, J., Gusella, G. L., Najfeld, V., Klotman, M., & Cara, A. (2004) · Human Gene Therapy · doi:10.1089/104303404322959515 · Cited by 132 · see citing works

Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys

Seaman, M. S., Xu, L., Beaudry, K. R., Martin, K. L., Beddall, M. H., Miura, A., Sambor, A., Chakrabarti, B. K., Huang, Y., Bailer, R. T., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.2956-2963.2005 · Cited by 132 · see citing works

Early Transcription from Nonintegrated DNA in Human Immunodeficiency Virus Infection

Wu, Y., & Marsh, J. W. (2003) · Journal of Virology · doi:10.1128/jvi.77.19.10376-10382.2003 · Cited by 125 · see citing works

Effects of Antigen and Genetic Adjuvants on Immune Responses to Human Immunodeficiency Virus DNA Vaccines in Mice

Moore, A., Kong, W., Chakrabarti, B. K., & Nabel, G. J. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.243-250.2002 · Cited by 120 · see citing works

Unintegrated Lentivirus DNA Persistence and Accessibility to Expression in Nondividing Cells: Analysis with Class I Integrase Mutants

Saenz, D. T., Loewen, N. A., Peretz, M., Whitwam, T., Barraza, R., Howell, K. G., Holmes, J. M., Good, M. S., & Poeschla, E. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.6.2906-2920.2004 · Cited by 119 · see citing works

Human Immunodeficiency Virus Type 1 Replication in the Absence of Integrase-Mediated DNA Recombination: Definition of Permissive and Nonpermissive T-Cell Lines

Nakajima, N., Lu, R., & Engelman, A. (2001) · Journal of Virology · doi:10.1128/jvi.75.17.7944-7955.2001 · Cited by 113 · see citing works

Live attenuated HIV vaccines: pitfalls and prospects

Whitney, J. B., & Ruprecht, R. M. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200402000-00004 · Cited by 108 · see citing works

Erratum: Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

Baba, T. W., Liška, V., Khimani, A. H., Ray, N. B., Dailey, P. J., Penninck, D., Bronson, R. T., Greene, M. F., McClure, H. M., Martin, L. N., et al. (1999) · Nature Medicine · doi:10.1038/8859 · Cited by 106 · see citing works

Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Enhances Expression from Unintegrated HIV-1 DNA

Poon, B., & Chen, I. S. Y. (2003) · Journal of Virology · doi:10.1128/jvi.77.7.3962-3972.2003 · Cited by 105 · see citing works

Human Immunodeficiency Virus Type 1 Incorporated with Fusion Proteins Consisting of Integrase and the Designed Polydactyl Zinc Finger Protein E2C Can Bias Integration of Viral DNA into a Predetermined Chromosomal Region in Human Cells

Tan, W., Dong, Z., Wilkinson, T. A., Barbas, C., & Chow, S. A. (2006) · Journal of Virology · doi:10.1128/jvi.80.4.1939-1948.2006 · Cited by 89 · see citing works

Integrase mutants of human immunodeficiency virus type 1 with a specific defect in integration

Taddeo, B., Haseltine, W. A., & Farnet, C. M. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8401-8405.1994 · Cited by 78 · see citing works

HIV-1 Extrachromosomal 2-LTR Circular DNA Is Long-Lived in Human Macrophages

Gillim-Ross, L., Cara, A., & Klotman, M. E. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.190 · Cited by 74 · see citing works

Protective efficacy of a multicomponent vector vaccine in cynomolgus monkeys after intrarectal simian immunodeficiency virus challenge

Negri, D. R. M., Baroncelli, S., Catone, S., Comini, A., Michelini, Z., Maggiorella, M. T., Sernicola, L., Crostarosa, F., Belli, R., Mancini, M. G., et al. (2004) · Journal of General Virology · doi:10.1099/vir.0.79794-0 · Cited by 68 · see citing works

Evidence for Recombination of Live, Attenuated Immunodeficiency Virus Vaccine with Challenge Virus to a More Virulent Strain

Gundlach, B. R., Lewis, M. G., Sopper, S., Schnell, T., Sodroski, J., Stahl‐Hennig, C., & Überla, K. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3537-3542.2000 · Cited by 66 · see citing works

Sequence Conservation and Antibody Cross‐Recognition of Clade B Human Immunodeficiency Virus (HIV) Type 1 Tat Protein in HIV‐1–Infected Italians, Ugandans, and South Africans

Buttò, S., Valeria Fiorelli, A., Tripiciano, A., Alvarez, M. J. R., Scoglio, A., Ensoli, F., Ciccozzi, M., Collacchi, B., Sabbatucci, M., Cafaro, A., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/378412 · Cited by 64 · see citing works

Treatment of the mouse model of mucopolysaccharidosis type IIIB with lentiviral-NAGLU vector

Natale, P. D., Domenico, C. D., Gargiulo, N., Castaldo, S., Reyero, E. G. Y., Mithbaokar, P., Felice, M. D., Follenzi, A., Naldini, L., & Villani, G. R. D. (2005) · Biochemical Journal · doi:10.1042/bj20041702 · Cited by 60 · see citing works

Self-Limiting, Cell Type-Dependent Replication of an Integrase-Defective Human Immunodeficiency Virus Type 1 in Human Primary Macrophages but Not T Lymphocytes

Cara, A., Guarnaccia, F., Reitz, M. S., Gallo, R. C., & Lori, F. (1995) · Virology · doi:10.1006/viro.1995.1148 · Cited by 56 · see citing works

Clustering, duplication and chromosomal distribution of mouse SINE retrotransposons

Jurka, J., Kohany, O., Pavlı́ček, A., Kapitonov, V. V., & Jurka, M. V. (2005) · Cytogenetic and Genome Research · doi:10.1159/000084943 · Cited by 41 · see citing works

Retroviral E-DNA: persistence and gene expression in nondividing immune cells

Cara, A., & Klotman, M. E. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306151 · Cited by 39 · see citing works

Simian Virus 40-Based Replication of Catalytically Inactive Human Immunodeficiency Virus Type 1 Integrase Mutants in Nonpermissive T Cells and Monocyte-Derived Macrophages

Lu, R. Q., Nakajima, N., Hofmann, W., Benkirane, M., Jeang, K., Sodroski, J., & Engelman, A. (2004) · Journal of Virology · doi:10.1128/jvi.78.2.658-668.2004 · Cited by 36 · see citing works

Evaluation of a Self-Inactivating Lentiviral Vector Expressing Simian Immunodeficiency Virus Gag for Induction of Specific Immune Responses in Vitro and in Vivo

Buffa, V., Negri, D. R. M., Leone, P., Borghi, M., Bona, R., Michelini, Z., Compagnoni, D., Sgadari, C., Ensoli, B., & Cara, A. (2006) · Viral Immunology · doi:10.1089/vim.2006.19.690 · Cited by 35 · see citing works

Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-1 envelope protein to human cytotoxic T lymphocytes

Alexander‐Miller, M. A., Parker, K. C., Tsukui, T., Pendleton, C. D., Coligan, J. E., & Berzofsky, J. A. (1996) · International Immunology · doi:10.1093/intimm/8.5.641 · Cited by 35 · see citing works

A Consecutive Priming-Boosting Vaccination of Mice with Simian Immunodeficiency Virus (SIV)gag/polDNA and Recombinant Vaccinia Virus Strain DIs Elicits Effective Anti-SIV Immunity

Someya, K., Xin, K.-Q., Matsuo, K., Okuda, K., Yamamoto, N., & Honda, M. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.9842-9853.2004 · Cited by 30 · see citing works

A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)HXB2 Rev/Env or codon-optimized HIV-1JR-FL gp120 generates durable immune responses in mice

Buffa, V., Negri, D. R. M., Leone, P., Bona, R., Borghi, M., Bacigalupo, I., Carlei, D., Sgadari, C., Ensoli, B., & Cara, A. (2006) · Journal of General Virology · doi:10.1099/vir.0.81706-0 · Cited by 29 · see citing works

Lentiviral transduction of murine oligodendrocytes in vivo

McIver, S. R., Lee, C.-S., Lee, J., Green, S. H., Sands, M. S., Snider, B. J., & Goldberg, M. P. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20626 · Cited by 28 · see citing works

Lentiviral Vectors

Loewen, N. A., & Poeschla, E. M. (2005) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_007 · Cited by 22 · see citing works

Separate Isolation of Genomic DNA and Total RNA from Single Samples Using the SV Total RNA

Otto, P., Bitner, R. M., Huber, S., & Volkerding, K. (1998) · Cited by 22 · see citing works

Efficient CD8+ T cell response to the HIV-env V3 loop epitope from multiple virus isolates by a DNA prime/vaccinia virus boost (rWR and rMVA strains) immunization regime and enhancement by the cytokine IFN-γ

Gómez, C. E., Abaitua, F., Rodrı́guez, D., & Estéban, M. (2004) · Virus Research · doi:10.1016/j.virusres.2004.04.008 · Cited by 22 · see citing works

Adenoviral Gene Delivery for HIV-1 Vaccination

Vanniasinkam, T., & Ertl, H. C. J. (2005) · Current Gene Therapy · doi:10.2174/1566523053544236 · Cited by 21 · see citing works

Development of a Human Immunodeficiency Virus Vector-Based, Single-Cycle Assay for Evaluation of Anti-Integrase Compounds

Bona, R., Andreotti, M., Buffa, V., Leone, P., Galluzzo, C. M., Amici, R., Palmisano, L., Mancini, M. G., Michelini, Z., Santo, R. D., et al. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00517-06 · Cited by 18 · see citing works

Nuclear architecture dictates HIV-1 integration site selection

Marini, B., Kertész‐Farkas, A., Ali, H., Lucic, B., Lisek, K., Manganaro, L., Pongor, S., Luzzati, R., Recchia, A., Mavilio, F., et al. (2015) · Nature · doi:10.1038/nature14226 · Cited by 336 · see citing works

Integration-deficient Lentiviral Vectors: A Slow Coming of Age

Wanisch, K., & Yáñez-Muñoz, R. J. (2009) · Molecular Therapy · doi:10.1038/mt.2009.122 · Cited by 222 · see citing works

Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing

Ortinski, P. I., O’Donovan, B., Dong, X., & Kantor, B. (2017) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2017.04.002 · Cited by 146 · see citing works

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

Mátrai, J., Cantore, A., Bartholomae, C. C., Annoni, A., Wang, W., Acosta-Sanchez, A., Samara-Kuko, E., De Waele, L., Ma, L., Genovese, P., et al. (2011) · Hepatology · doi:10.1002/hep.24230 · Cited by 139 · see citing works

Integrase-defective lentiviral vectors: Progress and applications

Banasik, M. B., & McCray, P. B. (2010) · Gene Therapy · doi:10.1038/gt.2009.135 · Cited by 129 · see citing works

Viral complementation allows HIV-1 replication without integration

Gelderblom, H. C., Vatakis, D. N., Burke, S. A., Lawrie, S. D., Bristol, G. C., & Levy, D. N. (2008) · Retrovirology · doi:10.1186/1742-4690-5-60 · Cited by 113 · see citing works

A Large U3 Deletion Causes Increased In Vivo Expression from a Nonintegrating Lentiviral Vector

Bayer, M., Kantor, B., Cockrell, A., Ma, H., Zeithaml, B., Li, X., McCown, T., & Kafri, T. (2008) · Molecular Therapy · doi:10.1038/mt.2008.199 · Cited by 94 · see citing works

Nonintegrating Lentivector Vaccines Stimulate Prolonged T-Cell and Antibody Responses and Are Effective in Tumor Therapy

Karwacz, K., Mukherjee, S., Apolonia, L., Blundell, M. P., Bouma, G., Escors, D., Collins, M. K., & Thrasher, A. J. (2009) · Journal of Virology · doi:10.1128/jvi.02519-08 · Cited by 87 · see citing works

Immunization delivered by lentiviral vectors for cancer and infectious diseases

Hu, B., Tai, A., & Wang, P. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00967.x · Cited by 85 · see citing works

Non-Integrating Lentiviral Vectors

Sarkis, C., Philippe, S., Mallet, J. J., & Serguera, C. (2008) · Current Gene Therapy · doi:10.2174/156652308786848012 · Cited by 74 · see citing works

Protective Antiviral Immunity Conferred by a Nonintegrative Lentiviral Vector-Based Vaccine

Coutant, F., Frenkiel, M.-P., Despres, P., & Charneau, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003973 · Cited by 70 · see citing works

Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through

Gurumoorthy, N., Nordin, F., Tye, G. J., Wan Kamarul Zaman, W. S., & Ng, M. H. (2022) · Biomedicines · doi:10.3390/biomedicines10010107 · Cited by 69 · see citing works

Design and potential of non-integrating lentiviral vectors

Shaw, A., & Cornetta, K. (2014) · Biomedicines · doi:10.3390/biomedicines2010014 · Cited by 60 · see citing works

The old and the new: Prospects for non-integrating lentiviral vector technology

Apolonia, L. (2020) · Viruses · doi:10.3390/v12101103 · Cited by 58 · see citing works

Successful therapeutic vaccination with integrase defective lentiviral vector expressing nononcogenic human papillomavirus E7 protein

Grasso, F., Negri, D. R. M., Mochi, S., Rossi, A., Cesolini, A., Giovannelli, A., Chiantore, M. V., Leone, P., Giorgi, C., & Cara, A. (2012) · International Journal of Cancer · doi:10.1002/ijc.27676 · Cited by 48 · see citing works

Development and use of SIV-based Integrase defective lentiviral vector for immunization

Michelini, Z., Negri, D. R. M., Baroncelli, S., Spada, M., Leone, P., Bona, R., Klotman, M. E., & Cara, A. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.05.070 · Cited by 47 · see citing works

Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity

Hu, B., Dai, B., & Wang, P. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.08.012 · Cited by 45 · see citing works

Integration-deficient Lentiviral Vectors Expressing Codon-optimized R338L Human FIX Restore Normal Hemostasis in Hemophilia B Mice

Suwanmanee, T., Hu, G., Gui, T., Bartholomae, C. C., Kutschera, I., Kalle, C. V., Schmidt, M., Monahan, P. E., & Kafri, T. (2013) · Molecular Therapy · doi:10.1038/mt.2013.188 · Cited by 44 · see citing works

Integrase Defective Lentiviral Vector as a Vaccine Platform for Delivering Influenza Antigens

Gallinaro, A., Borghi, M., Bona, R., Grasso, F., Calzoletti, L., Palladino, L., Cecchetti, S., Vescio, M. F., Macchia, D., Morante, V., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00171 · Cited by 44 · see citing works

Lentiviral Vectors for Cancer Immunotherapy and Clinical Applications

Liechtenstein, T., Pérez‐Janices, N., & Escors, D. (2013) · Cancers · doi:10.3390/cancers5030815 · Cited by 40 · see citing works

Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase

Moldt, B., Staunstrup, N. H., Jakobsen, M., Yáñez-Muñoz, R. J., & Mikkelsen, J. G. (2008) · BMC Biotechnology · doi:10.1186/1472-6750-8-60 · Cited by 44 · see citing works

Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses

Cousin, C., Oberkampf, M., Félix, T., Rosenbaum, P., Weil, R., Fabrega, S., Morante, V., Negri, D. R. M., Cara, A., Dadaglio, G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.025 · Cited by 37 · see citing works

Measurement of Human Immunodeficiency Virus Type 1 Preintegration Transcription by Using Rev-Dependent Rev-CEM Cells Reveals a Sizable Transcribing DNA Population Comparable to That from Proviral Templates

Iyer, S. R., Yu, D., Biancotto, A., Margolis, L. B., & Wu, Y. (2009) · Journal of Virology · doi:10.1128/jvi.00874-09 · Cited by 37 · see citing works

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation

Sabbatucci, M., Covino, D. A., Purificato, C., Mallano, A., Federico, M., Lu, J. N., Rinaldi, A. O., Pellegrini, M. A., Bona, R., Michelini, Z., et al. (2015) · Retrovirology · doi:10.1186/s12977-014-0132-6 · Cited by 37 · see citing works

Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques

Negri, D. R. M., Blasi, M., LaBranche, C. C., Parks, R., Balachandran, H., Lifton, M. A., Shen, X., Denny, T. N., Ferrari, G., Vescio, M. F., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.123 · Cited by 35 · see citing works

Lentiviral Vectors in Cancer Immunotherapy

Oldham, R. A. A., Berinstein, E. M., & Medin, J. A. (2015) · Immunotherapy · doi:10.2217/imt.14.108 · Cited by 35 · see citing works

Transduction of Human Antigen-Presenting Cells with Integrase-Defective Lentiviral Vector Enables Functional Expansion of Primed Antigen-Specific CD8 + T Cells

Negri, D. R. M., Bona, R., Michelini, Z., Leone, P., Macchia, I., Klotman, M. E., Salvatore, M., & Cara, A. (2010) · Human Gene Therapy · doi:10.1089/hum.2009.200 · Cited by 34 · see citing works

Use of lentiviral vectors in vaccination

Ku, M.-W., Charneau, P., & Majlessi, L. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1988854 · Cited by 35 · see citing works

A Nonintegrative Lentiviral Vector-Based Vaccine Provides Long-Term Sterile Protection against Malaria

Coutant, F., Sanchez David, R. Y., Félix, T., Boulay, A., Caleechurn, L., Souque, P., Thouvenot, C., Bourgouin, C., Beignon, A.-S., & Charneau, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048644 · Cited by 32 · see citing works

HIV-derived vectors for therapy and vaccination against HIV

Nunzio, F. D., Félix, T., Arhel, N. J., Nisole, S., Charneau, P., & Beignon, A. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.089 · Cited by 31 · see citing works

Lentiviral vectors for immune cells targeting

Froelich, S., Tai, A., & Wang, P. (2010) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923970903420582 · Cited by 31 · see citing works

Development of single-cycle replicable human immunodeficiency virus 1 mutants

Zabihollahi, R., Sadat, S. M., Vahabpour, R., Aghasadegh, M. R., Memarnejadian, A., Ghazanfari, T., Salehi, M., Rezaei, A., & Azadmanesh, K. (2011) · Acta Virologica · doi:10.4149/av_2011_01_15 · Cited by 31 · see citing works

Integrase-defective lentiviral-vector-based vaccine: a new vector for induction of T cell immunity

Negri, D. R. M., Michelini, Z., Bona, R., Blasi, M., Filati, P., Leone, P., Rossi, A., Franco, M., & Cara, A. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.571670 · Cited by 30 · see citing works

Lentiviral Vectors as a Vaccine Platform against Infectious Diseases

Nemirov, K., Bourgine, M., Anna, F., Yu, W., Charneau, P., & Majlessi, L. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030846 · Cited by 28 · see citing works

IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells

Blasi, M., Negri, D. R. M., LaBranche, C. C., Alam, S. M., Baker, E. J., Brunner, E. C., Gladden, M. A., Michelini, Z., Vandergrift, N., Wiehe, K. J., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0131-6 · Cited by 27 · see citing works

The second chance story of HIV-1 DNA: Unintegrated? Not a problem!

Wu, Y. (2008) · Retrovirology · doi:10.1186/1742-4690-5-61 · Cited by 26 · see citing works

Nonintegrating Lentiviral Vectors Can Effectively Deliver Ovalbumin Antigen for Induction of Antitumor Immunity

Hu, B., Yang, H., Dai, B., Tai, A., & Wang, P. (2009) · Human Gene Therapy · doi:10.1089/hum.2009.012 · Cited by 26 · see citing works

Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

Lin, Y.-Y., Belle, I., Blasi, M., Huang, M.-N., Buckley, A. F., Rountree, W., Klotman, M. E., Cara, A., & Negri, D. R. M. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.03.008 · Cited by 26 · see citing works

Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice

Negri, D. R. M., Michelini, Z., Baroncelli, S., Spada, M., Vendetti, S., Bona, R., Leone, P., Klotman, M. E., & Cara, A. (2010) · BioMed Research International · doi:10.1155/2010/534501 · Cited by 24 · see citing works

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

Morante, V., Borghi, M., Farina, I., Michelini, Z., Grasso, F., Gallinaro, A., Cecchetti, S., Virgilio, A. D., Canitano, A., Pirillo, M. F., et al. (2021) · Viruses · doi:10.3390/v13020355 · Cited by 24 · see citing works

Lentiviral vectors in cancer immunotherapy

Lin, S., Wang, B., & Wang, L. (2008) · 国际外科学杂志 · doi:10.3760/cma.j.issn.1673-4203.2008.03.011 · Cited by 23 · see citing works

Single-Chain Antibodies That Target Lentiviral Vectors to MHC Class II on Antigen-Presenting Cells

Gennari, F., Lopes, L. M., Verhoeyen, E., Marasco, W. A., & Collins, M. K. (2009) · Human Gene Therapy · doi:10.1089/hum.2008.189 · Cited by 23 · see citing works

Recombinant lentivector as a genetic immunization vehicle for antitumor immunity

He, Y., Munn, D. H., & Falo, L. D. (2007) · Expert Review of Vaccines · doi:10.1586/14760584.6.6.913 · Cited by 22 · see citing works

Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines

Negri, D. R. M., Rossi, A., Blasi, M., Michelini, Z., Leone, P., Chiantore, M. V., Baroncelli, S., Perretta, G., Cimarelli, A., Klotman, M. E., et al. (2012) · Retrovirology · doi:10.1186/1742-4690-9-69 · Cited by 22 · see citing works

Induction of Broadly Neutralising HCV Antibodies in Mice by Integration-Deficient Lentiviral Vector-Based Pseudotyped Particles

Deng, Y., Guan, J., Wen, B., Zhu, N., Chen, H., Song, J., Yang, Y., Wang, Y., & Tan, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062684 · Cited by 21 · see citing works

Integrase-defective lentiviral vectors encoding cytokines induce differentiation of human dendritic cells and stimulate multivalent immune responses in vitro and in vivo

Daenthanasanmak, A., Salguero, G., Borchers, S., Figueiredo, C., Jacobs, R., Sundarasetty, B. S., Schneider, A., Schambach, A., Eiz‐Vesper, B., Blasczyk, R., et al. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.05.063 · Cited by 21 · see citing works

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity

Meo, S. D., Dell’Oste, V., Molfetta, R., Tassinari, V., Lotti, L. V., Vespa, S., Pignoloni, B., Covino, D. A., Fantuzzi, L., Bona, R., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008855 · Cited by 19 · see citing works

Kunjin replicon-based simian immunodeficiency virus gag vaccines

Anraku, I., Mokhonov, V. V., Rattanasena, P., Mokhonova, E. I., Leung, J. Y., Pijlman, G. P., Cara, A., Schroder, W. A., Khromykh, A. A., & Suhrbier, A. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.04.001 · Cited by 19 · see citing works

Mucosal Immunization with Integrase-Defective Lentiviral Vectors Protects against Influenza Virus Challenge in Mice

Fontana, J. M., Christos, P. J., Michelini, Z., Negri, D. R. M., Cara, A., & Salvatore, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097270 · Cited by 18 · see citing works

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation

Sundarasetty, B. S., Kloeß, S., Oberschmidt, O., Naundorf, S., Kuehlcke, K., Daenthanasanmak, A., Gerasch, L., Figueiredo, C., Blasczyk, R., Ruggiero, E., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0599-5 · Cited by 17 · see citing works

Targeting Lentiviral Vectors for Cancer Immunotherapy

Vargas, F. A., Breckpot, K., Collins, M. K., & Escors, D. (2011) · Current Cancer Therapy Reviews · doi:10.2174/157339411797642605 · Cited by 17 · see citing works

Integrase deficient lentiviral vector: prospects for safe clinical applications

Yew, C.-H. T., Gurumoorthy, N., Nordin, F., Tye, G. J., Zaman, W. S. W. K., Tan, J. J., & Ng, M. H. (2022) · PeerJ · doi:10.7717/peerj.13704 · Cited by 18 · see citing works

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques

Blasi, M., Wescott, E. C., Baker, E. J., Mildenberg, B., LaBranche, C. C., Rountree, W., Haynes, B. F., Saunders, K. O., Moody, M. A., Negri, D. R. M., et al. (2020) · npj Vaccines · doi:10.1038/s41541-020-0186-5 · Cited by 16 · see citing works

Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Gallinaro, A., Borghi, M., Pirillo, M. F., Cecchetti, S., Bona, R., Canitano, A., Michelini, Z., Di Virgilio, A., Olvera, A., Brander, C., et al. (2020) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2020.01.013 · Cited by 15 · see citing works

Integrase Defective, Nonintegrating Lentiviral Vectors

Michelini, Z., Negri, D. R. M., & Cara, A. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-533-0_6 · Cited by 15 · see citing works

Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors

Hu, P., Li, Y., Sands, M. S., McCown, T. J., & Kafri, T. (2015) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2015.25 · Cited by 15 · see citing works

Optimization of Mucosal Responses after Intramuscular Immunization with Integrase Defective Lentiviral Vector

Rossi, A., Michelini, Z., Leone, P., Borghi, M., Blasi, M., Bona, R., Spada, M., Grasso, F., Gugliotta, A., Klotman, M. E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107377 · Cited by 14 · see citing works

Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization

Bona, R., Michelini, Z., Mazzei, C., Gallinaro, A., Canitano, A., Borghi, M., Vescio, M. F., Virgilio, A. D., Pirillo, M. F., Klotman, M. E., et al. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.09.011 · Cited by 11 · see citing works

Improving the Transduction of Bone Marrow–Derived Cells with an Integrase-Defective Lentiviral Vector

Pay, S. L., Qi, X., Willard, J. F., de Godoy, J. A. P., Sankhavaram, K., Horton, R., Mitter, S. K., Quigley, J., Chang, L., Grant, M. B., et al. (2017) · Human Gene Therapy Methods · doi:10.1089/hgtb.2017.082 · Cited by 10 · see citing works

Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized by distinct immunogenicity profiles

Borghi, M., Gallinaro, A., Pirillo, M. F., Canitano, A., Michelini, Z., Angelis, M. L. D., Cecchetti, S., Tinari, A., Falce, C., Mariotti, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147953 · Cited by 9 · see citing works

Emerging applications of lentiviral vectors in dendritic cell-based immunotherapy

Wang, H., Zhang, L. N., & Kung, S. K. P. (2010) · Immunotherapy · doi:10.2217/imt.10.44 · Cited by 9 · see citing works

Lentiviral vector-based therapy in head and neck cancer (Review)

Upreti, D., Pathak, A., & Kung, S. K. P. (2013) · Oncology Letters · doi:10.3892/ol.2013.1652 · Cited by 9 · see citing works

Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Gallinaro, A., Pirillo, M. F., Aldon, Y., Cecchetti, S., Michelini, Z., Tinari, A., Borghi, M., Canitano, A., McKay, P. F., Bona, R., et al. (2022) · npj Vaccines · doi:10.1038/s41541-022-00465-1 · Cited by 8 · see citing works

Differences in vector-genome processing and illegitimate integration of non-integrating lentiviral vectors

Shaw, A., Joseph, G. L., Jasti, A. C., Sastry, L., Witting, S. R., & Cornetta, K. G. (2016) · Gene Therapy · doi:10.1038/gt.2016.69 · Cited by 8 · see citing works

A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine

Moussa, M., Arrode-Bruses, G., Manoylov, I. K., Malogolovkin, A. S., Mompelat, D., Ishimwe, H., Smaoune, A., Ouzrout, B., Gagnon, J., & Chebloune, Y. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.021 · Cited by 6 · see citing works

Integrase-Defective Lentiviral Vectors for Delivery of Monoclonal Antibodies against Influenza

Michelini, Z., Minkoff, J. M., Yang, J., Negri, D., Cara, A., Hanson, B. J., & Salvatore, M. (2020) · Viruses · doi:10.3390/v12121460 · Cited by 6 · see citing works

Integrase Defective Lentiviral Vector Promoter Impacts Transgene Expression in Target Cells and Magnitude of Vector-Induced Immune Responses

Mahesh, S., Li, J., Travieso, T., Psaradelli, D., Negri, D. R. M., Klotman, M. E., Cara, A., & Blasi, M. (2023) · Viruses · doi:10.3390/v15112255 · Cited by 3 · see citing works

Lentivector Vaccines

Bryson, P. D., & Wang, P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394295-1.00024-x · Cited by 3 · see citing works

Dendritic Cells and Lentiviral Vectors: Mapping the Way to Successful Immuno Gene Therapy

Goyvaerts, C., Kochan, G. T., Escors, D., & Breckpot, K. (2011) · InTech eBooks · doi:10.5772/17367 · Cited by 2 · see citing works

Engineered Viruses as Vaccine Platforms

Folgori, A., & Capone, S. (2012) · Springer eBooks · doi:10.1007/978-94-007-4543-8_4 · Cited by 2 · see citing works

HIV Preintegration Transcription and Host Antagonism

Wu, Y. (2023) · Current HIV Research · doi:10.2174/1570162x21666230621122637 · Cited by 1 · see citing works

Murine Granulocyte–Macrophage Colony-Stimulating Factor Expressed from a Bicistronic Simian Immunodeficiency Virus-Based Integrase-Defective Lentiviral Vector Does Not Enhance T-Cell Responses in Mice

Michelini, Z., Negri, D. R. M., Biava, M., Baroncelli, S., Spada, M., Leone, P., Bona, R., Blasi, M., Négre, D., Klotman, M. E., et al. (2014) · Viral Immunology · doi:10.1089/vim.2014.0062 · Cited by 1 · see citing works

Dévelappement de vecteurs lentiviraux non-intergratifs en vue du transfert de gènes dans le système nerveux central.

Philippe, S. (2007) · HAL

Consequences of persistent antigen presentation following administration of HIV-1-derived lentiviral vectors

Vargas, F. A. (2010) · Doctoral thesis, UCL (University College London).

Robust Adaptive Control of Switched Systems

El, K., & Youcef‐Toumi, K. (2009) · InTech eBooks · doi:10.5772/7041

Characterization of the Mucosal and Systemic Immune Responses Following Virus Vector-Based Gene Delivery into the Colonic Mucosa

Safroneeva, E. (2009) · MacSphere (McMaster University) · doi:10.71548/10686

Lentivector based gene transfer for immunotherapy – application of integration deficient vectors and PDL1knockdown as tools to manipulate immune responses

Karwacz, K. (2012) · UCL Discovery (University College London)

Immunomodulation by Genetic Modification Using Lentiviral Vectors

Arce, F., Breckpot, K., Kochan, G., & Escors, D. (2012) · SpringerBriefs in biochemistry and molecular biology · doi:10.1007/978-3-0348-0402-8_4

Factors affecting the formation, stability, and expression of unintegrated lentiviral vector genomes

Bayer, M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/j9mp-1c47

Pharmacodynamic Evaluation: Gene Therapy

Grandchamp, N. (2020) · Springer eBooks · doi:10.1007/978-3-319-68864-0_51

Pharmacodynamic Evaluation: Gene Therapy

Grandchamp, N. (2019) · Springer eBooks · doi:10.1007/978-3-319-56637-5_51-1

Lentiviral vectors for treatment of haemophilia

Ward, N. J. (2010) · UCL Discovery (University College London)

Application of lentiviral vector in vaccinology

Ku, M. (2020) · theses.fr (ABES) · doi:10.70675/18309422z66eez4f9fz9b16zd621476d44cd

Development and application of non-integrating lentiviral vectors for gene therapy

Apolonia, L. (2009) · UCL Discovery (University College London)

Development and use of SIV-based Integrase defective lentiviral vector for immunization

Michelini, Z., Negri, D. R. M., Baroncelli, S., Spada, M., Leone, P., Bona, R., Klotman, M. E., & Cara, A. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.05.070 · Cited by 47 · see citing works

A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)HXB2 Rev/Env or codon-optimized HIV-1JR-FL gp120 generates durable immune responses in mice

Buffa, V., Negri, D. R. M., Leone, P., Bona, R., Borghi, M., Bacigalupo, I., Carlei, D., Sgadari, C., Ensoli, B., & Cara, A. (2006) · Journal of General Virology · doi:10.1099/vir.0.81706-0 · Cited by 29 · see citing works

Evaluation of a Self-Inactivating Lentiviral Vector Expressing Simian Immunodeficiency Virus Gag for Induction of Specific Immune Responses in Vitro and in Vivo

Buffa, V., Negri, D. R. M., Leone, P., Borghi, M., Bona, R., Michelini, Z., Compagnoni, D., Sgadari, C., Ensoli, B., & Cara, A. (2006) · Viral Immunology · doi:10.1089/vim.2006.19.690 · Cited by 35 · see citing works

Integrase defective lentiviral vector as a vaccine platform for delivering HIV-1 antigens

Gallinaro, A. (2019) · IRIS Research product catalog (Sapienza University of Rome)

H-101 Potential of integrase-defective lentiviral vectors for HIV vaccine delivery

Klotman, M. E. (2018) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000532622.33637.c4