Cited by 363Cannabis and Cannabinoid ResearchStress Responses and CortisolMemory and Neural Mechanisms

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Downregulation of Endocannabinoid Signaling in the Hippocampus Following Chronic Unpredictable Stress

Hill, Matthew N, Patel, Sachin, Carrier, Erica J, Rademacher, David J, Ormerod, Brandi K, Hillard, Cecilia J, Gorzalka, Boris B·2005·Neuropsychopharmacology

DOI 10.1038/sj.npp.1300601

Open this paper in CoChat — free account

Abstract

Deficits in cognitive functioning and flexibility are seen following both chronic stress and modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether alterations in eCB signaling might contribute to the cognitive impairments induced by chronic stress. Chronic stress impaired reversal learning and induced perseveratory behavior in the Morris water maze without significant effect on task acquisition. These cognitive impairments were reversed by exogenous cannabinoid administration, suggesting deficient eCB signaling underlies these phenomena. In line with this hypothesis, chronic stress downregulated CB1 receptor expression and significantly reduced the content of the endocannabinoid 2-arachidonylglycerol within the hippocampus. CB1 receptor density and 2-arachidonylglycerol content were unaffected in the limbic forebrain. These data suggest that stress-induced downregulation of hippocampal eCB signaling contributes to problems in behavioral flexibility and could play a role in the development of perseveratory and ruminatory behaviors in stress-related neuropsychiatric disorders.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300601

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
The prefontral cortex and cognitive control
Miller, E. K. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036228 · Cited by 2,016
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662
Leptin-regulated endocannabinoids are involved in maintaining food intake
Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559
A second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274

Flagged first, then by citations

Show all 56 references

Research works printed but not linked: 2

Grippo AJ, Francis J, Beltz TG, Felder RB, Johnson A (2003). Elevated cytokines in the chronic mild stress animal model of depression. Soc Neurosci Abstr 927: 10.
Wolf S, Matzinger P (2003). Relax—endogenous cannabinoids in enriched mice. 13th Annual Symposium on the Cannabinoids, p 89.

Sorted by citations

Items 201–300 of 363

Changes in the cannabinoids receptors in rats following treatment with antidepressants
Smaga, I., Zaniewska, M., Gawliński, D., Faron‐Górecka, A., Szafrański, P. W., Cegla, M. T., & Filip, M. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.08.012 · Cited by 30
Long-term cognitive deficits induced by a single, extremely low dose of tetrahydrocannabinol (THC): Behavioral, pharmacological and biochemical studies in mice
Senn, R., Keren, O., Hefetz, A., & Sarne, Y. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.08.005 · Cited by 30
Pharmacotherapy of schizophrenia: Mechanisms of antipsychotic accumulation, therapeutic action and failure
Chestnykh, D., Amato, D., Kornhuber, J., & Müller, C. P. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113144 · Cited by 33
Circulating endocannabinoids and prospective risk for depression in trauma-injury survivors
Fitzgerald, J. M., Chesney, S. A., Lee, T. S., Brasel, K. J., Larson, C. L., Hillard, C. J., & deRoon‐Cassini, T. A. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100304 · Cited by 32
Self-citation
Brain CB1 receptor expression following lipopolysaccharide-induced inflammation
Hu, H., Ho, W., Mackie, K., Pittman, Q. J., & Sharkey, K. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.067 · Cited by 29
Stress-induced impairments in prefrontal-mediated behaviors and the role of the N-methyl-d-aspartate receptor
Graybeal, C., Kiselycznyk, C., & Holmes, A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.02.042 · Cited by 30
Exploração farmacológica do sistema endocanabinoide: novas perspectivas para o tratamento de transtornos de ansiedade e depressão?
Saito, V. M., Wotjak, C. T., & Moreira, F. A. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010000500004 · Cited by 34
Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine
Fattore, L., Piva, A., Zanda, M. T., Fumagalli, G. F., & Chiamulera, C. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4793-4 · Cited by 26
MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.
Cunningham, J. I., Raudensky, J., Tonkiss, J., & Yamamoto, B. K. (2009) · Behavioral Neuroscience · doi:10.1037/a0016716 · Cited by 27
Exposure to Forced Swim Stress Alters Local Circuit Activity and Plasticity in the Dentate Gyrus of the Hippocampus
Yarom, O., Maroun, M., & Richter‐Levin, G. (2008) · Neural Plasticity · doi:10.1155/2008/194097 · Cited by 27
Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase
Fišar, Z. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.010 · Cited by 28
Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective
Oddi, S., Fiorenza, M. T., & Maccarrone, M. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101239 · Cited by 27
Endocannabinoid dysregulation in cognitive and stress-related brain regions in the Nrg1 mouse model of schizophrenia
Clarke, D. J., Stuart, J. M., McGregor, I. S., & Arnold, J. C. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.08.006 · Cited by 26
The Endocannabinoid System: An Osteopathic Perspective
McPartland, J. M. (2008) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2008.108.10.586 · Cited by 26
Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system
Zheng, Y., Wang, X.-L., Mo, F.-F., & Li, M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.047 · Cited by 22
Endocannabinoid signaling in stress, nausea, and vomiting
DeVuono, M. V., Venkatesan, T., & Hillard, C. J. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14911 · Cited by 24
Self-citation
Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice
Tomàs-Roig, J., Piscitelli, F., Gil, V., del Rı́o, J. A., Moore, T. P., Agbemenyah, H. Y., Salinas, G., Pommerenke, C., Lorenzen, S., Beißbarth, T., et al. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.01.036 · Cited by 24
Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link?
Fogaça, M. V., Galve‐Roperh, I., Guimarães, F. S., & Campos, A. C. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311030003 · Cited by 24
Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome
Forteza, F., Giorgini, G., & Raymond, F. (2021) · Cells · doi:10.3390/cells10040938 · Cited by 23
Loneliness, Circulating Endocannabinoid Concentrations, and Grief Trajectories in Bereaved Older Adults: A Longitudinal Study
Kang, M., Bohorquez‐Montoya, L., McAuliffe, T. L., Claesges, S. A., Blair, N.-O. P., Sauber, G., Reynolds, C. F., Hillard, C. J., & Goveas, J. S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.783187 · Cited by 22
Self-citation
The genetics of episodic memory
Koppel, J. L., & Goldberg, T. E. (2009) · Cognitive Neuropsychiatry · doi:10.1080/13546800902990438 · Cited by 24
Neuroanatomical substrates involved in cannabinoid modulation of defensive responses
Moreira, F. A., Aguiar, D., Resstel, L. B. M., Lisboa, S. F. D. S., Campos, A. C., Gomes, F. V., & Guimarães, F. S. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111400651 · Cited by 24
Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors
Thippaiah, S. M., Iyengar, S. S., & Vinod, K. Y. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.636228 · Cited by 21
Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine
Manna, S. S., & Umathe, S. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000104 · Cited by 21
Further evidence of anxiety- and depression-like behavior for total genetic ablation of cannabinoid receptor type 1
Soriano, D., Brusco, A., & Caltana, L. R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113007 · Cited by 18
Endocannabinoids and the cardiovascular response to stress
O’Sullivan, S. E., Kendall, P. J., & Kendall, D. A. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408457 · Cited by 20
Chronic unpredictable stress enhances cocaine-conditioned place preference in type 1 cannabinoid receptor knockout mice
Miller, L. L., Ward, S. J., & Dykstra, L. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830ded11 · Cited by 21
Psychopharmacology of chronic pain
Ciaramella, A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64012-3.00019-8 · Cited by 20
The antidepressant and anxiolytic effects of cannabinoids in chronic unpredictable stress: a preclinical systematic review and meta-analysis
Reuveni, N., Carlson, C. A., Schwartz, S., Meter, D. J., Barrett, T. S., & Freeman, S. M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01967-1 · Cited by 20
Integrating Endocannabinoid Signalling In Depression
Rana, T., Behl, T., Sehgal, A., Mehta, V., Singh, S., Kumar, R., & BUNGAU, S. G. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01774-7 · Cited by 20
Microglial morphological/inflammatory phenotypes and endocannabinoid signaling in a preclinical model of periodontitis and depression
Robledo‐Montaña, J., Díaz-García, C., Martínez, M., Ambrosio, N., Montero, E., Marín, M. J., Virto, L., Muñoz‐López, M., Herrera, D., Sanz, M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03213-5 · Cited by 19
Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological—cardiac comorbidity?
Carnevali, L., Rivara, S., Nalivaiko, E., Thayer, J. F., Vacondio, F., Mor, M., & Sgoifo, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.013 · Cited by 18
Chronic nicotine exposure attenuates the effects of Δ9‐tetrahydrocannabinol on anxiety‐related behavior and social interaction in adult male and female rats
Manwell, L. A., Miladinovic, T., Raaphorst, E., Rana, S. A., Malecki, S. L., & Mallet, P. E. (2019) · Brain and Behavior · doi:10.1002/brb3.1375 · Cited by 16
Estrogen pendulum in schizophrenia and Alzheimer’s disease: Review of therapeutic benefits and outstanding questions
Androvičová, R., Pfaus, J. G., & Ovsepian, S. V. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136038 · Cited by 19
Maternal High-Fat Diet Modulates Cnr1 Gene Expression in Male Rat Offspring
Gawliński, D., Gawlińska, K., & Smaga, I. (2021) · Nutrients · doi:10.3390/nu13082885 · Cited by 19
Exercise training and high-fat diet elicit endocannabinoid system modifications in the rat hypothalamus and hippocampus
Gamelin, F.-X., Aucouturier, J., Iannotti, F. A., Piscitelli, F., Mazzarella, E., Aveta, T., Leriche, M., Dupont, E., Cieniewski‐Bernard, C., Leclair, E., et al. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0557-1 · Cited by 18
A life-course, epigenetic perspective on resilience in brain and body
McEwen, B. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00001-x · Cited by 18
Cannabis use and posttraumatic stress disorder comorbidity: Epidemiology, biology and the potential for novel treatment approaches
Kondev, V., Winters, N. D., & Patel, S. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.007 · Cited by 21
Self-citation
An overview on stress neurobiology: Fundamental concepts and its consequences
Doewes, R. I., Gangadhar, L., & Subburaj, S. (2021) · Neuroscience Informatics · doi:10.1016/j.neuri.2021.100011 · Cited by 21
Chronic exposure to cannabinoids before an emotional trauma may have negative effects on emotional function
Sbarski, B., & Akirav, I. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.05.008 · Cited by 17
Circulating endocannabinoid concentrations in grieving adults
Harfmann, E. J., McAuliffe, T. L., Larson, E. R., Claesges, S. A., Sauber, G., Hillard, C. J., & Goveas, J. S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104801 · Cited by 17
Self-citation
Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume
Mazurka, R., Harkness, K. L., Hassel, S., Stensson, N., Nogovitsyn, N., Poppenk, J., Foster, J. A., Squires, S. D., Rowe, J., Milev, R. V., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03151-z · Cited by 17
Chronic corticosterone-induced impaired cognitive flexibility is not due to suppressed adult hippocampal neurogenesis
Lui, E., Salim, M., Chahal, M., Puri, N., Marandi, E., Quadrilatero, J., & Satvat, E. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.060 · Cited by 15
Delta(9)-tetrahydrocannabinol Enhances an Increase of Plasma Corticosterone Levels Induced by Forced Swim-Stress
Sano, K., Koushi, E., Irie, K., Higuchi, S., Tsuchihashi, R., Kinjo, J., Egashira, N., Oishi, R., Uchida, N., Nagai, H., et al. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.2065 · Cited by 15
Endocannabinoid system in the neurodevelopment of GABAergic interneurons: implications for neurological and psychiatric disorders
Song, C., Kang, X., Yang, F., Du, W., Zhang, J., Liu, L., Kang, J., Jia, N., Yue, H., Fan, L., et al. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0134 · Cited by 15
Suicide: Allostatic regulation and resilience
Stacy, M. A., & Schulkin, J. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105691 · Cited by 16
Novel therapeutic and drug development strategies for tobacco use disorder: endocannabinoid modulation
Butler, K., & Foll, B. L. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1767581 · Cited by 14
Endocannabinoids and Precision Medicine for Mood Disorders and Suicide
Pinna, G. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.658433 · Cited by 13
Is PTSD-Phenotype Associated with HPA-Axis Sensitivity?: The Endocannabinoid System in Modulating Stress Response in Rats
Danan, D., Todder, D., Zohar, J., & Cohen, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126416 · Cited by 13
Molecular Targets of Cannabinoids Associated with Depression
Paudel, P., Ross, S. A., & Li, X. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210623144658 · Cited by 14
Circulating endocannabinoids during hematopoietic stem cell transplantation: A pilot study
Knight, J. M., Szabó, A., Zhao, S., Lyness, J. M., Sahler, O. J. Z., Liesveld, J. L., Sander, T. L., Rizzo, J. D., Hillard, C. J., & Moynihan, J. A. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.05.001 · Cited by 13
Self-citation
Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
Bockstaele, E. J. V. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7940-6 · Cited by 14
Introduction to the special issue on stress, emotional behavior, and the endocannabinoid system: a decade of research
Hill, M. N. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.038 · Cited by 14
Self-citation
Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers
Isaac, A. R., de Velasco, P. C., Fraga, K. Y. D., Tavares‐do‐Carmo, M. D. G., Campos, R. M. P., Iannotti, F. A., Verde, R., Martins, D. B. G., Santos, T. W. D. A., Ferreira, B. K., et al. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108782 · Cited by 12
Family Income Mediates the Effect of Parental Education on Adolescents’ Hippocampus Activation During an N-Back Memory Task
Assari, S., Boyce, S., Bazargan, M., & Caldwell, C. H. (2020) · Brain Sciences · doi:10.3390/brainsci10080520 · Cited by 13
The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice
Topuz, R. D., Çetinkaya, M. Z., Erümit, D., Aydemir, K. D., Gündüz, Ö., Karadağ, Ç. H., & Ulugöl, A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174315 · Cited by 12
- Role of the Endocannabinoid System in the Neurobiology of Suicide
Dwivedi, Y. (2012) · CRC Press eBooks · doi:10.1201/b12215-11 · Cited by 12
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Alexander, C., & Vasefi, M. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2021.08.001 · Cited by 12
Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States
Spigelman, I. (2009) · Frontiers in neuroscience · doi:10.1201/9781439812105-c5 · Cited by 12
The Therapeutic Potential of Drugs that Target Cannabinoid Receptors or Modulate the Tissue Levels or Actions of Endocannabinoids
Pertwee, R. G. (2008) · Springer eBooks · doi:10.1007/978-0-387-76678-2_38 · Cited by 11
Discovery of a novel class of reversible monoacylglycerol lipase inhibitors for potential treatment of depression
Hao, Q., Shi, J., Zhang, Z., Yang, G., Zhi, Y., Wang, K., Ma, D., Fu, S., Dong, H., Zhi, Z., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116285 · Cited by 10
Brain region specific regulation of anandamide (down) and sphingosine-1-phosphate (up) in association with anxiety (AEA) and resilience (S1P) in a mouse model of chronic unpredictable mild stress
Fischer, C., Thomas, D., Gurke, R., & Tegeder, I. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03012-0 · Cited by 9
Repetitive and Inflexible Active Coping and Addiction-like Neuroplasticity in Stressed Mice of a Helplessness–Resistant Inbred Strain
Cabib, S., Campus, P., Latagliata, E. C., Orsini, C., & Tarmati, V. (2021) · Behavioral Sciences · doi:10.3390/bs11120174 · Cited by 12
Role of mesolimbic cannabinoid receptor 1 in stress-driven increases in cocaine self-administration in male rats
McReynolds, J. R., Wolf, C. P., Starck, D. M., Mathy, J. C., Schaps, R., Krause, L. A., Hillard, C. J., & Mantsch, J. R. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01589-1 · Cited by 10
Self-citation
Reversal effect of simvastatin on the decrease in cannabinoid receptor 1 density in 6-hydroxydopamine lesioned rat brains
Mackovski, N., Liao, J., Weng, R., Wei, X., Wang, R., Chen, Z., Liu, X., Yu, Y., Meyer, B. J., Xia, Y., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.05.005 · Cited by 9
The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress
Qin, X., Liu, Y., Zhu, M., & Yang, Z. R. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.054 · Cited by 9
The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats.
Sadeghi, M., Reisi, P., & Radahmadi, M. (2017) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2017.9619 · Cited by 9
Stress and Western diets increase vulnerability to neuropsychiatric disorders: A common mechanism
Dagnino‐Subiabre, A. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1661651 · Cited by 9
Bidirectional influence of amygdala β 1 -adrenoceptors blockade on cannabinoid signaling in contextual and auditory fear memory
Nasehi, M., Shahbazzadeh, S., Ebrahimi-Ghiri, M., & Zarrindast, M. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118760654 · Cited by 9
Endocannabinoids Link Rapid, Membrane-Mediated Corticosteroid Actions to Behavior
Denver, R. J. (2007) · Endocrinology · doi:10.1210/en.2006-1522 · Cited by 9
Cannabidiol Modulates Neuroinflammatory and Estrogen-Related Pathways in a Sex-Specific Manner in a Chronic Stress Model of Depression
Bright, U., & Akirav, I. (2025) · Cells · doi:10.3390/cells14020099 · Cited by 8
CB1 cannabinoid receptor ligands augment the antidepressant-like activity of biometals (magnesium and zinc) in the behavioural tests
Wośko, S., Serefko, A., Szopa, A., Właź, P., Wróbel, A., Właź, A., Górska, J., & Poleszak, E. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12880 · Cited by 8
Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain
Piggott, V. M., Lloyd, S. C., Matchynski, J. I., Perrine, S. A., & Conti, A. C. (2021) · Molecules · doi:10.3390/molecules26072086 · Cited by 8
Endocannabinoids Released in the Ventral Tegmental Area During Copulation to Satiety Modulate Changes in Glutamate Receptors Associated With Synaptic Plasticity Processes
Rodrı́guez–Manzo, G., González-Morales, E., & Garduño‐Gutierrez, R. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.701290 · Cited by 7
CB1 Activity Drives the Selection of Navigational Strategies: A Behavioral and c-Fos Immunoreactivity Study
Laricchiuta, D., Balsamo, F., Fabrizio, C., Panuccio, A., Termine, A., & Petrosini, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031072 · Cited by 6
Central and cardiac stress resilience consistently linked to integrated immuno‐neuroendocrine responses across stress models in male mice
Helman, T. J., Headrick, J. P., Peart, J. N., & Stapelberg, N. J. C. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15747 · Cited by 7
Adaptations of Striatal Endocannabinoid System During Stress
Rossi, S., Chiara, V. D., Musella, A., Mataluni, G., Sacchetti, L., Bernardi, G., Usiello, A., & Centonze, D. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8061-4 · Cited by 7
Emotional comorbidities in epilepsy result from seizure-induced corticosterone activity
Gom, R. C., George, A. G., Harris, S. A., Wickramarachchi, P., Bhatt, D., Acharjee, S., Pittman, Q. J., Hill, M. N., Colangeli, R., & Teskey, G. C. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100678 · Cited by 7
Self-citation
Chronic corticosterone improves perseverative behavior in mice during sequential reversal learning
Odland, A. U., Sandahl, R., & Andreasen, J. T. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114479 · Cited by 9
Lifestyle Interventions Improving Cannabinoid Tone During COVID-19 Lockdowns May Enhance Compliance With Preventive Regulations and Decrease Psychophysical Health Complications
Brugnatelli, V., Facco, E., & Zanette, G. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.565633 · Cited by 6
Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers
Fišar, Z. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7940-6_6 · Cited by 7
Endocannabinoid Signaling and Synaptic Plasticity During Stress
Gray, J. M., Vecchiarelli, H. A., & Hill, M. N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1056-4_6 · Cited by 5
Self-citation
Serum metabonomics as a diagnostic approach for cancer‑related fatigue
Wang, H., Zhao, T., Lv, C., Zhang, Z., Fang, F., & Li, B. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11181 · Cited by 5
Anxiogenic doses of rapamycin prevent URB597-induced anti-stress effects in socially defeated mice
Fusse, E. J., Scarante, F. F., Vicente, M. A., Marrubia, M. M., Turcato, F. C., Scomparin, D. S., Ribeiro, M. A., Figueiredo, M. J., Brigante, T. A. V., Guimarães, F. S., et al. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137519 · Cited by 5
St. John’s Wort Extract Ze 117 and Escitalopram Alter Plasma and Hippocampal Lipidome in a Rat Model of Chronic-Stress-Induced Depression
Bussmann, H., Bremer, S., Hernier, A. M., Drewe, J., Häberlein, H., Franken, S., Freytag, V., Boonen, G., & Butterweck, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312667 · Cited by 6
Cb1 receptor-mediated signaling emerges as a novel lead to evidence-based treatment development for stress-related psychopathology
Bailey, C. R., & Neumeister, A. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.07.011 · Cited by 4
Nociceptive sensitivity under stress influence
Alekseeva, I. V., Abramova, A. Y., & Pertsov, S. S. (2022) · Russian Journal of Pain · doi:10.17116/pain20222003142 · Cited by 7
Role of the Endocannabinoid System in the Neurobiology of Suicide
Vinod, K. (2012) · Frontiers in neuroscience · doi:10.1201/b12215-6 · Cited by 4
Anti-aversive effect of 2-arachidonoylglycerol in the dorsolateral periaqueductal gray of male rats in contextual fear conditioning and Vogel tests
Brianis, R. C., Lima, R. C., Moreira, F. A., & Aguiar, D. C. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000639 · Cited by 3
Cannabinoids, the Endocannabinoid System, and Cognitive Functions: Enemies or Friends?
Kitchigina, V. F. (2021) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-021-01148-5 · Cited by 7
How depression and antidepressant drugs affect endocannabinoid system?—review of clinical and preclinical studies
Dragon, J., & Obuchowicz, E. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02938-z · Cited by 4
Relationship between circulating plasma endocannabinoids in adolescents and maternal depressive symptoms
Jaster, A. M., Ely, S. L., Zundel, C. G., Gowatch, L. C., Shampine, M. M., Carpenter, C., O’Mara, E., Bhogal, A., Tamimi, R., Lewis, C., et al. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06831-w · Cited by 3
Chronic stress facilitates behavioral engagement and alters lateral habenula activity during flexible decision making in a sex-dependent manner
Wright, H. R., Fisher, Z. D. G., Schmid, R. M., Westbrook, S. R., Abeshima, R. A., Giannotti, G., & McLaughlin, R. J. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.01.031 · Cited by 3
Microbiota-driven gut-brain signaling underlies antidepressant effects of a GLP-1 analog
Bian, L., Cai, Y., Zhang, Y., Shen, L., Wang, H., Gao, F., Cai, N., Chen, W., You, C., Yang, Y., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.05.003 · Cited by 3
Relationships among peri-traumatic circulating endocannabinoids and long-term, negative outcomes following traumatic injury
Albertina, E. A., Tomas, C. W., Geier, T. J., Timmer‐Murillo, S. C., Piña, I., Jazinski-Chambers, K., Sauber, G., Fitzgerald, J. M., Larson, C. L., deRoon‐Cassini, T. A., et al. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06837-4 · Cited by 3
Self-citation
Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CB1 Receptors following Chronic Unpredictable Stress
Dandi, Ε., Kesidou, E., Simeonidou, C., Spandou, E., Grigoriadis, N., & Tata, D. Α. (2024) · Brain Sciences · doi:10.3390/brainsci14040357 · Cited by 3
Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats
Peñaloza‐Sancho, V., Pérez-Valenzuela, C., Gonzalez, C., Jujihara, G., Bustos, P., & Dagnino‐Subiabre, A. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1659561 · Cited by 3
Cannabinoids, endocannabinoids and stress
Hillard, C. J., Liu, Q., Liu, X., Pan, B., Roberts, C. J., & Shi, L. (2014) · Wiley eBooks · doi:10.1002/9781118451281.ch5 · Cited by 2
Self-citation
Cognitive and Neuropsychiatric Consequences of Endocannabinoid Signaling Dysfunction
Solowij, N., & Monterrubio, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300895 · Cited by 3
Letter to the Editor
Monterrubio, S., & Solowij, N. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.553 · Cited by 3

Authors: Hill, M. N., Patel, S., Carrier, E. J., Rademacher, D. J., Ormerod, B. K., Hillard, C. J., & Gorzalka, B. B.
Affiliations: University of British Columbia (CA)
Medical College of Wisconsin (US)
Corresponding author: Hillard, Cecilia J
Gorzalka, Boris B
ORCID: Hill, Matthew N
Patel, Sachin
Carrier, Erica J
Ormerod, Brandi K
Hillard, Cecilia J
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2004-11-03
Volume: 30
Issue: 3
Pages: 508-515
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300601
OpenAlex: W2124037107
Cited by: 363
References: 56
Citations by year: 2026: 8 · 2025: 12 · 2024: 16 · 2023: 7 · 2022: 12 · 2021: 29 · 2020: 15 · 2019: 15 · 2018: 11 · 2017: 14 · 2016: 20 · 2015: 21 · 2014: 21 · 2013: 18 · 2012: 20
FWCI: 8.15
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Michael Smith Health Research BC
National Institutes of Health
Natural Sciences and Engineering Research Council of Canada
National Institute on Drug Abuse (F32 DA-16510, F30 DA15575, R01DA016967, F30DA015575, F32DA016510)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: endocannabinoid signaling, chronic unpredictable mild stress, hippocampus, CB1 receptor, 2-arachidonoylglycerol, reversal learning, behavioral flexibility, perseveration, cognitive impairment, stress-related neuropsychiatric disorders
MeSH terms: Animals, Cannabinoids, Copulation, Female, Hippocampus, Male, Reference Values, Stress, Psychological, Signal Transduction, Maze Learning, Rats, Long-Evans, Receptor, Cannabinoid, CB1, Rats, Cannabinoid Receptor Modulators, Endocannabinoids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Downregulation of Endocannabinoid Signaling in the Hippocampus Following Chronic Unpredictable Stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks