The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Assessment of the Dexamethasone/CRH Test as a State-Dependent Marker for Hypothalamic-Pituitary-Adrenal (HPA) Axis Abnormalities in Major Depressive Episode: A Multicenter Study
Open accessAbstract
There is compelling evidence for the involvement of hypothalamic-pituitary-adrenal (HPA) axis abnormalities in depression. Growing evidence has suggested that the combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test is highly sensitive to detect HPA axis abnormalities. We organized a multicenter study to assess the DEX/CRH test as a state-dependent marker for major depressive episode in the Japanese population. We conducted the DEX/CRH test in 61 inpatients with major depressive episode (Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV)) and 57 healthy subjects. In all, 35 patients were repeatedly assessed with the DEX/CRH test on admission and before discharge. The possible relationships between clinical variables and the DEX/CRH test were also examined. Significantly enhanced pituitary-adrenocortical responses to the DEX/CRH test were observed in patients on admission compared with controls. Such abnormalities in patients were significantly reduced after treatment, particularly in those who underwent electroconvulsive therapy (ECT) in addition to pharmacotherapy. Age and female gender were associated with enhanced hormonal responses to the DEX/CRH test. Severity of depression correlated with DEX/CRH test results, although this was explained, at least in part, by a positive correlation between age and severity in our patients. Medication per se was unrelated to DEX/CRH test results. These results suggest that the DEX/CRH test is a sensitive state-dependent marker to monitor HPA axis abnormalities in major depressive episode during treatment. Restoration from HPA axis abnormalities occurred with clinical responses to treatment, particularly in depressed patients who underwent ECT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243
Psychopharmacology: The Fourth Generation of Progress
Green, A. I. (1996) · Psychiatric Services · doi:10.1176/ps.47.3.312 · Cited by 1,147
The Dexamethasone Suppression Test for Melancholia
Carroll, B. J. (1982) · The British Journal of Psychiatry · doi:10.1192/bjp.140.3.292 · Cited by 770
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION
Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672
The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders
Heuser, I., Yassouridis, A., & Holsboer, F. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90017-5 · Cited by 662
Holsboer, F., Lauer, C. J., Schreiber, W., & Krieg, J.-C. (2008) · Neuroendocrinology · doi:10.1159/000127023 · Cited by 369
Zobel, A. W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F., & Ising, M. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00013-9 · Cited by 354
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–198 of 198
Abnormal stress responsiveness and suicidal behavior: a risk phenotype
Steinberg, L. J., & Mann, J. J. (2020) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2020.100011 · Cited by 29
Tsuchimine, S., Matsuno, H., O’Hashi, K., Chiba, S., Yoshimura, A., Kunugi, H., & Sohya, K. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.073 · Cited by 33
Self-citationKishimoto, T., Takamiya, A., Liang, K., Funaki, K., Fujita, T., Kitazawa, M., Yoshimura, M., Tazawa, Y., Horigome, T., Eguchi, Y., et al. (2020) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2020.100649 · Cited by 30
“Several other biological, objective methods have been investigated with the aim of ensuring a more objective measurement of depression severity, such as monoamine levels in cerebrospinal fluids [32], cytokines [33], positron emission tomography (PET) [34], neuroendocrine tests [35], and magnetic resonance imaging (MRI…”
BackgroundPaslakis, G., Krumm, B., Gilles, M., Schweiger, U., Heuser, I., Richter, I., & Deuschle, M. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.10.002 · Cited by 32
Hori, H., Yoshida, F., Ishida, I., Matsuo, J., Ogawa, S., Hattori, K., Kim, Y., & Kunugi, H. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.080 · Cited by 30
Self-citationXing, H., Zhang, K., Zhang, R., Zhang, Y., Gu, L., Shi, H., Bi, K., & Chen, X. (2015) · Journal of Chromatography B · doi:10.1016/j.jchromb.2015.02.037 · Cited by 26
Cizza, G., Mistry, S., Nguyen, V. T., Eskandari, F., Martinez, P. E., Torvik, S., Reynolds, J. C., Gold, P. W., Sinai, N. B., Csákó, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040894 · Cited by 25
Chen, Y., Cheung, Y.-T., Kong, L., Ng, T. B., Qiao, C., Mo, S., Xu, H., & Kung, H. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.03.014 · Cited by 25
Bschor, T., Ritter, D., Winkelmann, P., Erbe, S., Uhr, M., Ising, M., & Lewitzka, U. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027613 · Cited by 23
Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder
Itagaki, K., Takebayashi, M., Abe, H., Shibasaki, C., Kajitani, N., Okada‐Tsuchioka, M., Hattori, K., Yoshida, S., Kunugi, H., & Yamawaki, S. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz005 · Cited by 24
Self-citationBidirectional relationship between heroin addiction and depression: Behavioural and neural studies
Moustafa, A. A., Tindle, R., Cashel, S., Parkes, D., Mohamed, E., & Hamza, E. A. (2020) · Current Psychology · doi:10.1007/s12144-020-01032-4 · Cited by 28
“Depressive symptoms and disorders have been linked to a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis (Gold 2015; Juruena et al. 2018; Kunugi et al. 2006).”
BackgroundSasayama, D., Hori, H., Iijima, Y., Teraishi, T., Hattori, K., Ota, M., Fujii, T., Higuchi, T., Amano, N., & Kunugi, H. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-23 · Cited by 24
“We have also reported heightened HPA axis in major depression and its normalization after treatment as assessed with the combined dexamethasone (DEX)/ corticotropin releasing hormone (CRH) test [17,18].”
MethodResultSelf-citationHori, H., Teraishi, T., Sasayama, D., Hattori, K., Hashikura, M., Higuchi, T., & Kunugi, H. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.022 · Cited by 23
Self-citationNikkheslat, N., Pariante, C. M., & Zunszain, P. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00003-9 · Cited by 23
Narita, K., Fujihara, K., Takei, Y., Suda, M., Aoyama, Y., Uehara, T., Majima, T., Kosaka, H., Amanuma, M., Fukuda, M., et al. (2011) · Human Brain Mapping · doi:10.1002/hbm.21354 · Cited by 22
“…test, researchers used 1–1.5 mg of DEX to determine HPA axis hyperactivity in patients with several psychiatric disorders, such as major depression [Kunugi et al., 2006], whereas the DEX test at a low dose of DEX (0.5 mg) has been frequently performed to estimate HPA axis hypoactivity in patients…”
BackgroundMethodInfluentialSelf-citationRampp, C., Eichelkraut, A., Best, J., Czamara, D., Rex‐Haffner, M., Uhr, M., Binder, E. B., & Menke, A. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.12.020 · Cited by 22
Izáková, Ľ., Hlaváčová, N., Segeda, V., Kapsdorfer, D., Morovicsová, E., & Ježová, D. (2020) · Neuroendocrinology · doi:10.1159/000505921 · Cited by 21
Amygdalar corticotropin-releasing factor mediates stress-induced anxiety.
Ventura-Silva, A. P., Borges, S., Sousa, N. J., Rodrigues, A., & Pêgo, J. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146622 · Cited by 21
Mori, M., Shizunaga, H., Harada, H., Tajiri, Y., Murata, Y., Terada, K., Ohe, K., & Enjoji, M. (2022) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12271 · Cited by 20
The molecular basis for sex differences in depression susceptibility
Issler, O., & Nestler, E. J. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.12.019 · Cited by 19
Paslakis, G., Heuser, I., Schweiger, U., & Deuschle, M. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.010 · Cited by 18
“An alteration of the HPA system during an acute episode of major depression and its normalisation after successful treatment is one of the most consistently observed laboratory findings in depression (Kunugi et al., 2006).”
BackgroundDepressive Symptoms Mediate the Relationship between Emotional Cutoff and Type 2 Diabetes Mellitus
Cohen, A., Peleg, O., Sarhana, A., Lam, S., & Haimov, I. (2019) · International Journal of Behavioral Medicine · doi:10.1007/s12529-019-09816-0 · Cited by 18
The influence of psychiatric comorbidity on the dexamethasone/CRH test in major depression
Veen, G., DeRijk, R. H., Giltay, E. J., van Vliet, I. M., PELT, J. V., & Zitman, F. G. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.007 · Cited by 20
Kim, S., Yang, S., Kim, J., Chung, K. W., Jung, Y., Chung, H. Y., & Lee, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03785-y · Cited by 16
“Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis in patients with MDD is a well-established finding in biological psychiatry [3], and when activated in response to physiological or psychological stressors, the HPA triggers the secretion of corticotropin-releasing hormone (CRH) from…”
Glucocorticoid affects dendritic transport of BDNF-containing vesicles
Adachi, N., Numakawa, T., Nakajima, S., Fukuoka, M., Odaka, H., Katanuma, Y., Ooshima, Y., Hohjoh, H., & Kunugi, H. (2015) · Scientific Reports · doi:10.1038/srep12684 · Cited by 17
Self-citationAlemu, J. L., Elberling, F., Azam, B., Pakkenberg, B., & Olesen, M. V. (2019) · Brain and Behavior · doi:10.1002/brb3.1195 · Cited by 16
Environmental risk factors for schizophrenia: implications for prevention
Stilo, S. A., Forti, M. D., & Murray, R. M. (2011) · Neuropsychiatry · doi:10.2217/npy.11.42 · Cited by 15
Stress and glucocorticoid modulation of feeding and metabolism
Balsevich, G., Abizaid, A. B., Chen, A., Karatsoreos, I. N., & Schmidt, M. V. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100171 · Cited by 17
Sakaida, M., Sukeno, M., Imoto, Y., Tsuchiya, S., Sugimoto, Y., Okuno, Y., & Segi‐Nishida, E. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113497612 · Cited by 15
“Conversely, the restoration of HPA axis abnormalities has been shown with clinical responses to treatment in patients with depression, who underwent ECT (Kunugi et al., 2006).”
BackgroundHori, H., Teraishi, T., Ozeki, Y., Hattori, K., Sasayama, D., Matsuo, J., Kawamoto, Y., Kinoshita, Y., Higuchi, T., & Kunugi, H. (2011) · Neuropsychobiology · doi:10.1159/000322146 · Cited by 14
Self-citationVassiliadi, D. A., Tzanela, M., Tsatlidis, V., Margelou, E., Tampourlou, M., Mazarakis, N., Piaditis, G. P., & Tsagarakis, S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1653 · Cited by 14
Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression
Kinoshita, S., Kanazawa, T., Kikuyama, H., & Yoneda, H. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0108-x · Cited by 13
“Moreover, most previous studies utilizing DEX/CRH test have been based on data obtained from inpatients [18, 20], which implies a clinical subgroup with severe symptoms, whereas our current sample consisted of a depression severity at the outpatient level.”
BackgroundResultPeleg, O. (2021) · Nutrients · doi:10.3390/nu14010039 · Cited by 14
Numakawa, T., Odaka, H., Adachi, N., Chiba, S., Ooshima, Y., Matsuno, H., Nakajima, S., Yoshimura, A., Fumimoto, K., Hirai, Y., et al. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.06.009 · Cited by 12
“Basic FGF (bFGF), also known as FGF2, is one of the most characterized FGF ligands and plays important roles in the proliferation, differentiation, growth, and survival of many cell types (Turner et al., 2012). bFGF has also been studied with respect to MDD, and its antidepressant-like effects have also been reported.”
InfluentialSelf-citationKnorr, U. B., Vinberg, M., Hansen, A. R. E., Klose, M., Feldt‐Rasmussen, U., Hilsted, L. M., Hasselstrøm, J. B., Gether, U., Winkel, P., Gluud, C. N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021224 · Cited by 12
“The response to the DEX-CRH test may be sensitive to age [32] and sex [33], and in our trial, stratification by these factors resulted in equal distributions in the two intervention groups.”
MethodAnthenelli, R. M., Heffner, J. L., Blom, T. J., Daniel, B. E., McKenna, B. S., & Wand, G. S. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.007 · Cited by 11
“Our finding that women respond more robustly to the Dex/CRF test than men replicates other groups’ results (Heuser et al., 1994b; Kunugi et al., 2006) and may indicate that in the setting of markedly reduced endogenous cortisol concentrations following dexamethasone suppres-”
ResultEx vivo glucocorticoid receptor-mediated IL-10 response predicts the course of depression severity
von Zimmermann, C., Böhm, L., Richter‐Schmidinger, T., Kornhuber, J., Lenz, B., & Mühle, C. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-020-02288-7 · Cited by 11
Tsuru, J., Ishitobi, Y., Ninomiya, T., Kanehisa, M., Imanaga, J., Inoue, A., Okamoto, S., Maruyama, Y., Higuma, H., Tanaka, Y., et al. (2013) · PubMed · Cited by 11
Self-citationHori, H. (2012) · The Open Neuropsychopharmacology Journal · doi:10.2174/1876523801205010018 · Cited by 9
Gyger, L., Regen, F., Ramponi, C., Marquis, R., Mall, J., Swierkosz-Lenart, K., von Gunten, A., Toni, N., Kherif, F., Heuser, I., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01310-0 · Cited by 10
Sex and gender differences in genetic and lifestyle risk and protective factors for dementia
Sindi, S., Toopchiani, S. T., Barbera, M., Håkansson, K., Lehtisalo, J., Rosenberg, A., Stephen, R., Udeh‐Momoh, C. T., & Kivipelto, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819344-0.00013-2 · Cited by 11
Major depressive disorder and bistability in an HPA-CNS toggle switch
Mizrachi, B. R., Tendler, A., Karin, O., Milo, T., Haran, D., Mayo, A., & Alon, U. S. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011645 · Cited by 11
“A similar analysis explains the elevated ACTH in DEX-CRH test in depressed patients [20,21].”
BackgroundKyritsi, E. M., Koltsida, G., Farakla, I., Papanikolaou, A., Critselis, E., Mantzou, A., Zoumakis, E., Kolaitis, G. A., Chrousos, G. P., & Charmandari, E. (2017) · HORMONES · doi:10.14310/horm.2002.1718 · Cited by 10
Owashi, T., Otsubo, T., Oshima, A., Nakagome, K., Higuchi, T., & Kamijima, K. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.01.006 · Cited by 9
“Finally, medications received by subjects might have affected the results of hormonal tests, although we excluded subjects receiving carbamazepine, and no significant relationships were found between test results and types of antidepressants in this study, as in previous reports (Heuser et al., 1996; Correa et al., 20…”
BackgroundResultSelf-citationTerada, Y., Ohashi, H., Otani, Y., Tokunaga, K., & Takenaka, A. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520001889 · Cited by 9
“Increased corticosterone levels resulting from this mechanism have been observed in depressed patients and could cause emotional disorders(33).”
BackgroundGuerrieri, G. M., Dor, R. R. B., Li, X., Wei, S.-M., Martinez, P. E., Neiman, L. K., Rubinow, D. R., & Schmidt, P. J. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab407 · Cited by 9
Affective Symptoms in Early-Onset Dementia
Podell, K., & Torres, K. (2010) · Neurologic Clinics · doi:10.1016/j.ncl.2010.10.009 · Cited by 9
Matsushima, Y., Terada, K., Takata, J., Karube, Y., Kamei, C., & Sugimoto, Y. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1553607 · Cited by 9
Depressive symptoms mediate the relationship between sleep disturbances and type 2 diabetes mellitus
Peleg, O., Cohen, A., & Haimov, I. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12996 · Cited by 10
Lymphocyte glucocorticoid receptor resistance and depressive symptoms severity: A preliminary report
Tanke, M. A. C., Bosker, F. J., Gladkevich, A. V., Medema, H. M., den Boer, J. A., & Korf, J. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.04.006 · Cited by 7
“Arguably, restoration of HPA-axis functioning is necessary for full remission (Holsboer and Barden, 1996; Kunugi et al., 2006).”
BackgroundCarpenter, L. L., Tyrka, A. R., Lee, J. K., Tracy, A. P., Wilkinson, C. W., & Price, L. H. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2336-y · Cited by 7
“…a collection of clinical and demographic variables exerting significant effects on the cortisol response to the Dex/ CRH test, including age (Kunugi et al. 2006), sex (Haefner et al. 2008), temperament (Tyrka et al. 2008b), coping style (Hori et al. 2010), early life adversity (Carpenter et…”
InfluentialFivecoat, H. C., Mattson, R. E., Cameron, N. M., & Johnson, M. D. (2024) · Journal of Social and Personal Relationships · doi:10.1177/02654075241229755 · Cited by 8
“Indeed, HPA axis dysfunction is associated with depression (Kunugi et al., 2006), obesity (Steptoe et al., 2004), and cardiovascular disease (Girod & Brotman, 2004).”
BackgroundDouglas, K. M., & Porter, R. (2012) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2012.02364.x · Cited by 6
“Furthermore, studies using the dex/CRH test have found an elevated cortisol response to dexamethasone before CRH injection in depressed samples.(23) Importantly, there was no evidence to suggest that differences in dexamethasone metabolism were biasing the results.”
ResultHypothalamic-Pituitary-Adrenal Axis Hyperactivity and Brain Differences in Healthy Women
Ota, M., Hori, H., Sato, N., Sasayama, D., Hattori, K., Teraishi, T., Obu, S., Nakata, Y., & Kunugi, H. (2013) · Neuropsychobiology · doi:10.1159/000355298 · Cited by 6
Self-citationHarada, Y., Yamaguchi, T., Hu, A., Otani, S., Han, C., Kurihara, Y., Kobayashi, H., & Arai, H. (2018) · Traditional & Kampo Medicine · doi:10.1002/tkm2.1095 · Cited by 6
“For example, it has been known since the 1960s that urine and blood cortisol and its metabolites are high in patients with depression [4,5].”
BackgroundMolecular biomarkers in depression: Toward personalized psychiatric treatment
Gururajan, A., Cryan, J. F., & Dinan, T. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813176-3.00026-2 · Cited by 5
Barroca, N. C. B., Baes, C. V. W., Martins, C. M. S., Bosaipo, N. B., Umeoka, M. S. D. S., Tejada, J., Antunes‐Rodrigues, J., de Castro, M., Juruena, M. F., Garcia‐Cairasco, N., et al. (2020) · eNeuro · doi:10.1523/eneuro.0222-20.2020 · Cited by 5
“medication or not, independently of the type and number of antidepressant treatments during the index episode (Künzel et al., 2003; Kunugi et al., 2006).”
BackgroundAntiglucocorticoids in psychiatry
McIsaac, S. A., Westrin, Å., & Young, A. H. (2009) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.105.001834 · Cited by 5
Tolerability of the dexamethasone–corticotropin releasing hormone test in major depressive disorder
Dunlop, B. W., Betancourt, Y., Binder, E. B., Heim, C. C., Holsboer, F., Ising, M., McKenzie, M., Mletzko, T., Pfister, H., Nemeroff, C. B., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.020 · Cited by 4
“HPA axis dysregulation during a major depressive episode, and its normalization after recovery, has been confirmed in several studies using the Dex-CRH test (Hatzinger et al., 2002; Heuser et al., 1994; Kunugi et al., 2006).”
Liu, H., Yamaguchi, T., Ryotokuji, K., Otani, S., Kobayashi, H., Iseki, M., & Inada, E. (2015) · Health · doi:10.4236/health.2015.710144 · Cited by 4
Epigenetische Mechanismen der Depression
Paslakis, G., Bleich, S., Frieling, H., & Deuschle, M. (2011) · Der Nervenarzt · doi:10.1007/s00115-010-3200-8 · Cited by 5
Tsuru, J., Akiyoshi, J., Tanaka, Y., Matsushita, H., Hanada, H., Kodama, K., Hikichi, T., Ohgami, H., Tsutsumi, T., Isogawa, K., et al. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.02.001 · Cited by 4
Self-citationReelin, the HPA Axis, and Chronic Stress: Implications for the Neurobiology of Depression
Thom, S. A., Halvorson, C. S., Reive, B. S., Sánchez-Lafuente, C. L., Kalynchuk, L. E., & Caruncho, H. J. (2026) · Chronic Stress · doi:10.1177/24705470261427267 · Cited by 3
The Hypothalamic–Pituitary–Adrenal Axis in Bipolar Disorder
Bond, D. J., & Young, A. H. (2007) · Medical psychiatry · doi:10.3109/9781420021158.008 · Cited by 3
Biomarkers for the Development of Antidepressant and Anxiolytic Drugs
Ising, M., & Holsboer, F. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_17 · Cited by 3
Melatonin, a Neuroprotective Agent: Relevance for Stress-Induced Neuropsychiatric Disorders
Govitrapong, P., Ekthuwapranee, K., Ruksee, N., & Boontem, P. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_8 · Cited by 3
Cizza, G., Mistry, S., Nguyen, V. T., Eskandari, F., Martinez, P., Torvik, S., Reynolds, J. C., Gold, P. W., Sinaii, N., Csákó, G., et al. (2012) · PLoS ONE · doi:10.1371/annotation/193f2b29-b8b0-41e8-808a-290df5577a53 · Cited by 3
Xia, L., Wu, N., Wang, D., Zhou, H., & Zhang, X. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03784-8 · Cited by 5
“Cys C may also increase SI in depressed patients by inducing neuronal apoptosis [139, 142, 143].”
Alcohol, Inflammation, and Depression: The Gut-Brain Axis
Cannon, A. R., Hammer, A. M., & Choudhry, M. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00029-5 · Cited by 2
Kunugi, H., & Tikhonova, M. A. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.01.023 · Cited by 2
Self-citationGene-Environment Interactions, Stress, and Depression
Cohen‐Woods, S., & Harkess, K. N. (2016) · Springer eBooks · doi:10.1007/978-981-4560-53-5_41-2 · Cited by 2
Shimizu, M., Tateishi, H., Kojima, R., Kunitake, H., Imamura, Y., Kunitake, Y., Murakawa‐Hirachi, T., Shiraishi, T., Monji, A., & Mizoguchi, Y. (2026) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2026.101089 · Cited by 1
Biomarker in der Depressionsbehandlung: mehr als nur Worte?
Bosch, O. G., & Breitenstein, B. (2015) · Zeitschrift für Psychiatrie Psychologie und Psychotherapie · doi:10.1024/1661-4747/a000244 · Cited by 1
Trujillo, V., Durando, P. E., & Suárez, M. M. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1550398 · Cited by 1
Rotvig, D. H., Jorgensen, A., Jensen, J. H., Hansen, A. R., Eller, N. H., Jonsson, S. H., Knorr, U. B., Klose, M., Feldt‐Rasmussen, U., Menke, A., et al. (2024) · Stress · doi:10.1080/10253890.2024.2353781 · Cited by 1
“…2007). contrary to this, our results resemble those found in participants with MDD, which have shown hPa-axis hyperactivity (heuser et al., 1994; Kunugi et al., 2006; Kunugi et al., 2004; Mokhtari et al., 2013). an exception from this is atypical MDD which in some studies has shown hypoactivity…”
Eloge, J. C., Cooper, J. J., & Ross, D. A. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.10.014 · Cited by 1
Yoshida, S., Aizawa, E., Ishihara, N., Hattori, K., Segawa, K., & Kunugi, H. (2025) · Nutrients · doi:10.3390/nu17040613 · Cited by 1
“…be that stress triggers both depression and DM. Psychological pressures affect the autonomic nervous system and alter the hypothalamic–pituitary– adrenal axis, which leads to depressive disorder [44–47] and metabolic abnormalities including visceral fat accumulation and insulin resistance [48].”
Self-citationGene-Environment Interactions, Stress, and Depression
Cohen‐Woods, S., & Harkess, K. N. (2015) · Springer eBooks · doi:10.1007/978-981-4560-53-5_41-1 · Cited by 1
Depressive Disorders: Major Depressive Disorder and Persistent Depressive Disorder
MacKinnon, D. F. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch50 · Cited by 2
Studies on cellular changes and amnesia in a rat model of electroconvulsive therapy
Jansson, L. (2011) · Lund University Publications (Lund University) · Cited by 1
Detera‐Wadleigh, S. D., & Yoshikawa, T. (2008) · Nucleic acids and molecular biology · doi:10.1007/978-3-540-85383-1_1
An Update on Psychotic Depression
Matthews, J. (2012) · InTech eBooks · doi:10.5772/31564
Bipolar Disorder: not only in the Brain - immunological aspects
Knijff, E. M. (2006) · RePub (Erasmus University Rotterdam)
Voelkel, A. G. (2008) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.8578
Psychobiological Processes and Therapies in Depression
Cristancho, P., & Thase, M. E. (2015) · Wiley eBooks · doi:10.1002/9781119114482.ch4
Recent Findings in the Pathophysiology of Depression
Suzuki, M. (2012) · Journal of Nihon University Medical Association · doi:10.4264/numa.71.375
Complementation of Pharmacogenetics with Biomarkers and Neuroimaging in Major Depression
Menke, A., Dusi, N., & Brambilla, P. (2016) · Springer eBooks · doi:10.1007/978-3-319-27040-1_5
The Hypothalamic–Pituitary–Adrenal Axis in Bipolar Disorder
Bond, D. J., & Young, A. H. (2007) · CRC Press eBooks · doi:10.3109/9781420021158-11
Baes, C. V. W. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-27072016-152342
Zhang, L., Chen, Y., Sun, G., Zhang, L., Hu, D., & Zhe, W. (2018) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v16i11.25
“Heuser et al and Kudielka et al [15,16] reported significant hormonal changes with age, but those studies were performed with healthy individuals.”
ResultViolence against women: impacts on psychological health and stress hormones
Chivers-Wilson, K. (2009) · doi:10.7939/r3xw2z
Camacho, M. B. (2018) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Gene-Environment Interactions, Stress, and Depression
Cohen‐Woods, S., & Harkess, K. N. (2016) · Springer eBooks · doi:10.1007/978-981-287-206-7_41
Sztechman, D., Żera, T., Czarzasta, K., Szczepanska‐Sadowska, E. K., & Cudnoch‐Jędrzejewska, A. (2025) · Physiological Reports · doi:10.14814/phy2.70549
“These results allow us to assume that chronic stress-induced HPA axis dysfunction can be connected rather to decreased sensitivity of GRs than decreased GRs expression (Hartmann et al., 2021; Hori et al., 2024; Kunugi et al., 2006; Lewis-Tuffin & Cidlowski, 2006).”
Impact of stress exposure and pharmacological intervention on a mouse model of Alzheimer’s disease
Sierksma, S. R. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20121220ss
Metadata
- Authors
- Kunugi, H., Ida, I., Owashi, T., Kimura, M., Inoue, Y., Nakagawa, S., Yabana, T., Urushibara, T., Kanai, R., Aihara, M., Yuuki, N., Otsubo, T., Oshima, A., Kudo, K., Inoue, T., Kitaichi, Y., Shirakawa, O., Isogawa, K., Nagayama, H., Kamijima, K., Nanko, S., Kanba, S., Higuchi, T., & Mikuni, M.
- Affiliations
- Teikyo University (JP)
- Gunma University (JP)
- SHOWA Medical University (JP)
- Nippon Medical School (JP)
- University of Yamanashi (JP)
- Hokkaido University (JP)
- National Center of Neurology and Psychiatry (JP)
- Kobe University (JP)
- Oita University (JP)
- Kyushu University (JP)
- Corresponding author
- Kunugi, Hiroshi
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2005-08-17
- Volume
- 31
- Issue
- 1
- Pages
- 212-220
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2165668731
- Cited by
- 200
- References
- 52
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 11 · 2019: 11 · 2018: 14 · 2017: 8 · 2016: 12 · 2015: 15 · 2014: 8 · 2013: 7 · 2012: 18
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- dexamethasone/corticotropin-releasing hormone test, hypothalamic-pituitary-adrenal axis, major depressive episode, depression, electroconvulsive therapy, depression severity, age and sex differences, treatment response monitoring, Japanese patients
- MeSH terms
- Adult, Age Factors, Corticotropin-Releasing Hormone, Major Depressive Disorder, Depressive Disorder, Major, Dexamethasone, Female, Humans, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Psychiatric Status Rating Scales, Sex Characteristics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
