Kunugi, Hiroshi

Improving polygenic prediction in ancestrally diverse populations

Ruan, Y., Lin, Y.-F., Feng, Y.-C. A., Chen, C.-Y., Lam, M., Guo, Z., Initiatives, S. G. A., Ahn, Y. M., Akiyama, K., Arai, M., et al. (2022) · Nature Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 707

Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex

Chiba, S., Numakawa, T., Ninomiya, M., Richards, M. C., Wakabayashi, C., & Kunugi, H. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 673

Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder

Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., Ota, M., Koga, N., Hattori, K., & Kunugi, H. (2016) · Journal of Affective Disorders

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 576

Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease

Ota, M., Matsuo, J., Ishida, I., Takano, H., Yokoi, Y., Hori, H., Yoshida, S., Ashida, K., Nakamura, K., Takahashi, T., et al. (2019) · Neuroscience Letters

Diet and metabolism studiesDementia and Cognitive Impairment Research

Cited by 276

Assessment of the Dexamethasone/CRH Test as a State-Dependent Marker for Hypothalamic-Pituitary-Adrenal (HPA) Axis Abnormalities in Major Depressive Episode: A Multicenter Study

Kunugi, H., Ida, I., Owashi, T., Kimura, M., Inoue, Y., Nakagawa, S., Yabana, T., Urushibara, T., Kanai, R., Aihara, M., et al. (2006) · Neuropsychopharmacology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 200

Interface between hypothalamic‐pituitary‐adrenal axis and brain‐derived neurotrophic factor in depression

Kunugi, H., Hori, H., Adachi, N., & Numakawa, T. (2010) · Psychiatry and Clinical Neurosciences

Stress Responses and CortisolTreatment of Major Depression

Cited by 200

Plasma L -Tryptophan Concentration in Major Depressive Disorder: New Data and Meta-Analysis

Ogawa, S., Fujii, T., Koga, N., Hori, H., Teraishi, T., Hattori, K., Noda, T., Higuchi, T., Motohashi, N., & Kunugi, H. (2014) · The Journal of Clinical Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 183

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial

Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019) · Nutrients

Tryptophan and brain disordersMedicinal Plant Extracts Effects

Cited by 170

Association between vascular endothelial growth factor-mediated blood-brain barrier dysfunction and stress-induced depression

Matsuno, H., Tsuchimine, S., O’Hashi, K., Sakai, K., Hattori, K., Hidese, S., Nakajima, S., Chiba, S., Yoshimura, A., Fukuzato, N., et al. (2022) · Molecular Psychiatry

Barrier Structure and Function StudiesTreatment of Major Depression

Cited by 164

Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging

Mori, T., Ohnishi, T., Hashimoto, R., Nemoto, K., Moriguchi, Y., Noguchi, H., Nakabayashi, T., Hori, H., Harada, S., Saitoh, O., et al. (2007) · Psychiatry Research: Neuroimaging

Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and Applications

Cited by 132

Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release

Yagasaki, Y., Numakawa, T., Kumamaru, E., Hayashi, T., Su, T.-P., & Kunugi, H. (2006) · Journal of Biological Chemistry

Pharmacological Receptor Mechanisms and EffectsTreatment of Major Depression

Cited by 122

The depression anxiety stress scale 8-items expresses robust psychometric properties as an ideal shorter version of the depression anxiety stress scale 21 among healthy respondents from three continents

Ali, A. M., Hori, H., Kim, Y., & Kunugi, H. (2022) · Frontiers in Psychology

Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychometric Methodologies and Testing

Cited by 122

Epigenetic aberration of the human REELIN gene in psychiatric disorders

Tamura, Y., Kunugi, H., Ohashi, J., & Hohjoh, H. (2007) · Molecular Psychiatry

Epigenetics and DNA MethylationSchizophrenia research and treatment

Cited by 121

Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia

Koga, M., Ishiguro, H., Yazaki, S., Horiuchi, Y., Arai, M., Niizato, K., Iritani, S., Itokawa, M., Inada, T., Iwata, N., et al. (2009) · Human Molecular Genetics

Schizophrenia research and treatmentChromatin Remodeling and Cancer

Cited by 112

The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition

Numakawa, T., Richards, M., Nakajima, S., Adachi, N., Furuta, M., Odaka, H., & Kunugi, H. (2014) · Frontiers in Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 86

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study

Hidese, S., Ota, M., Wakabayashi, C., Noda, T., Ozawa, H., Okubo, T., & Kunugi, H. (2017) · Acta Neuropsychiatrica

Treatment of Major DepressionMedicinal Plant Extracts Effects

Cited by 81

24-h activity rhythm and sleep in depressed outpatients

Hori, H., Koga, N., Hidese, S., Nagashima, A., Kim, Y., Higuchi, T., & Kunugi, H. (2016) · Journal of Psychiatric Research

Sleep and related disordersCircadian rhythm and melatonin

Cited by 78

Behavioral and molecular evidence for psychotropic effects in l-theanine

Wakabayashi, C., Numakawa, T., Ninomiya, M., Chiba, S., & Kunugi, H. (2012) · Psychopharmacology

Neuroscience and Neuropharmacology ResearchTryptophan and brain disorders

Cited by 65

The Efficacy of Pramipexole, a Dopamine Receptor Agonist, as an Adjunctive Treatment in Treatment-Resistant Depression: An Open-Label Trial

Hori, H., & Kunugi, H. (2012) · The Scientific World Journal

Treatment of Major DepressionBipolar Disorder and Treatment

Cited by 62

Association of obesity with cognitive function and brain structure in patients with major depressive disorder

Hidese, S., Ota, M., Matsuo, J., Ishida, I., Hiraishi, M., Yoshida, S., Noda, T., Sato, N., Teraishi, T., Hattori, K., et al. (2018) · Journal of Affective Disorders

Treatment of Major DepressionNeural and Behavioral Psychology Studies

Cited by 62

Effect of l-theanine on glutamatergic function in patients with schizophrenia

Ota, M., Wakabayashi, C., Sato, N., Hori, H., Hattori, K., Teraishi, T., Ozawa, H., Okubo, T., & Kunugi, H. (2015) · Acta Neuropsychiatrica

Schizophrenia research and treatmentAmino Acid Enzymes and Metabolism

Cited by 52

Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome

Sasayama, D., Hattori, K., Ogawa, S., Yokota, Y., Matsumura, R., Teraishi, T., Hori, H., Ota, M., Yoshida, S., & Kunugi, H. (2016) · Human Molecular Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 43

Effects of l-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wistar Kyoto rats

Ogawa, S., Ota, M., Ogura, J., Kato, K., & Kunugi, H. (2018) · Psychopharmacology

Neuroscience and Neuropharmacology ResearchMedicinal Plant Extracts Effects

Cited by 37

A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: Altered l-serine level associated with disruption of PSAT1 gene expression

Ozeki, Y., Pickard, B. S., Kano, S.-I., Malloy, M. P., Zeledon, M., Sun, D. Q., Fujii, K., Wakui, K., Shirayama, Y., Fukushima, Y., et al. (2011) · Neuroscience Research

Schizophrenia research and treatmentAmino Acid Enzymes and Metabolism

Cited by 34