The DOI matches its Crossref record.
Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation
Abstract
Murine erythroleukemia (MEL) cells are transformed erythroid precursors that are blocked from completing the late stages of erythroid differentiation. A frequent event in the generation of these malignant cells is deregulation of the hematopoietic-specific transcription factor PU.1 (Spi-1) by retroviral insertion of the spleen-focus-forming virus component of Friend virus. During chemically induced reinitiation of MEL cell terminal differentiation, expression of PU.1 is rapidly down-regulated, suggesting that PU.1 might interfere with processes required for terminal differentiation of erythroid precursors. To investigate the role of PU.1 in erythroid differentiation we transfected MEL cells with a PU.1 cDNA controlled by the eucaryotic translation elongation factor EF1 alpha promoter. Deregulated expression of PU.1 blocked chemically induced differentiation and terminal cell division. Deregulated expression of two other protooncogenes, c-myc and c-myb, also has been shown to block MEL differentiation. We present evidence that PU.1 inhibits terminal differentiation at an earlier step than c-Myc and c-Myb. Thus reinitiation of MEL cell terminal differentiation appears to be controlled by an ordered program of turning off several protooncogenes. Down-regulation of PU.1 may be a very early step in this program.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and the block can be relieved by co-expression of GATA-1.”
From Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1 (2006) · cites this paper as [9]
Citations
Cited by
Sorted by citations
Transcription factors in myeloid development: balancing differentiation with transformation
Rosenbauer, F., & Tenen, D. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2024 · Cited by 606
Rekhtman, N., Radparvar, F., Evans, T., & Skoultchi, A. I. (1999) · Genes & Development · doi:10.1101/gad.13.11.1398 · Cited by 454
“1-transfectant (PU.1 clone 605; Rao et al. 1997) a second time with a construct expressing a conditionally active form of GATA-1, achieved by fusing GATA-1 coding sequences to the ligand-binding domain of the human estrogen receptor (ER).”
BackgroundMethodResultInfluentialSelf-citationPU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K. A., Mueller, B. U., Narravula, S., Torbett, B. E., Orkin, S. H., & Tenen, D. G. (2000) · Blood · doi:10.1182/blood.v96.8.2641 · Cited by 368
Nerlov, C., Querfurth, E., Kulessa, H., & Graf, T. (2000) · Blood · doi:10.1182/blood.v95.8.2543 · Cited by 366
The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
Burda, P., Laslo, P., & Stopka, T. (2010) · Leukemia · doi:10.1038/leu.2010.104 · Cited by 184
Fisher, R. C., & Scott, E. W. (1998) · STEM CELLS · doi:10.1002/stem.160025 · Cited by 158
Stopka, T., Amanatullah, D. F., Papetti, M., & Skoultchi, A. I. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600834 · Cited by 154
Self-citationSite-specific DNA methylation by a complex of PU.1 and Dnmt3a/b
Suzuki, M., Yamada, T., Kihara-Negishi, F., Sakurai, T., Hara, E., Tenen, D. G., Hozumi, N., & Oikawa, T. (2006) · Oncogene · doi:10.1038/sj.onc.1209272 · Cited by 132
PU.1 determines the self-renewal capacity of erythroid progenitor cells
Back, J., Dierich, A., Bronn, C., Kastner, P., & Chan, S. (2004) · Blood · doi:10.1182/blood-2003-11-4089 · Cited by 123
Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP
Yamamoto, H., Kihara-Negishi, F., Yamada, T., Hashimoto, Y., & Oikawa, T. (1999) · Oncogene · doi:10.1038/sj.onc.1202427 · Cited by 113
Oikawa, T., Yamada, T., Kihara-Negishi, F., Yamamoto, H., Kondoh, N., Hitomi, Y., & Hashimoto, Y. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400534 · Cited by 109
Suh, H. C., Gooya, J., Renn, K., Friedman, A. D., Johnson, P. F., & Keller, J. R. (2006) · Blood · doi:10.1182/blood-2005-06-2216 · Cited by 95
Matushansky, I., Radparvar, F., & Skoultchi, A. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250488697 · Cited by 84
Self-citationWontakal, S. N., Guo, X., Smith, C., MacCarthy, T., Bresnick, E. H., Bergman, A., Snyder, M. P., Weissman, S. M., Zheng, D., & Skoultchi, A. I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121019109 · Cited by 79
Self-citationPU.1 and Haematopoietic Cell Fate: Dosage Matters
Mak, K. S., Funnell, A. P. W., Pearson, R. C. M., & Crossley, M. (2011) · International Journal of Cell Biology · doi:10.1155/2011/808524 · Cited by 77
Inhibition of CBP-Mediated Protein Acetylation by the Ets Family Oncoprotein PU.1
Hong, W., Kim, A. Y., Ky, S., Rakowski, C., Seo, S.-B., Chakravarti, D., Atchison, M., & Blobel, G. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3729-3743.2002 · Cited by 74
Liew, C. W., Rand, K. D., Simpson, R. J. Y., Yung, W. W., Mansfield, R. E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F. M., & Mackay, J. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602830200 · Cited by 63
Wontakal, S. N., Guo, X., Will, B., Shi, M., Raha, D., Mahajan, M. C., Weissman, S., Snyder, M., Steidl, U., Zheng, D., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001392 · Cited by 53
Self-citationGangenahalli, G. U., Gupta, P., Saluja, D., Verma, Y. K., Kishore, V., Chandra, R., Sharma, R. K., & Ravindranath, T. (2005) · Stem Cells and Development · doi:10.1089/scd.2005.14.140 · Cited by 53
Matsumura, I., Kawasaki, A., Tanaka, H., Sonoyama, J., Ezoe, S., Minegishi, N., Nakajima, K., Yamamoto, M., & Kanakura, Y. (2000) · Blood · doi:10.1182/blood.v96.7.2440 · Cited by 53
Rimmelé, P., Kosmider, O., Mayeux, P., Moreau-Gachelin, F., & Guillouf, C. (2007) · Blood · doi:10.1182/blood-2006-03-006718 · Cited by 35
Jian, W., Yan, B., Huang, S., & Qiu, Y. (2017) · The FASEB Journal · doi:10.1096/fj.201700022r · Cited by 23
PU.1 Is Degraded in Differentiation of Erythrocytes Through a Proteasome-Dependent Pathway
Konishi, Y., & Tominaga, A. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.340 · Cited by 6
Metadata
- Authors
- Rao, G., Rekhtman, N., Cheng, G., Krasikov, T., & Skoultchi, A. I.
- Venue
- Oncogene
- Published
- 1997-01-09
- Volume
- 14
- Issue
- 1
- Pages
- 123-131
- ISSN
- 0950-9232
- 1476-5594
- Cited by
- 89
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
