The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis

Oikawa, Tsuneyuki; Yamada, Toshiyuki; Kihara-Negishi, Fumiko; Yamamoto, Hitomi; Kondoh, Nobuo; Hitomi, Yoshiaki; Hashimoto, Yoshiyuki

doi:10.1038/sj.cdd.4400534

Cited by 117Genomics and Chromatin DynamicsHematopoietic Stem Cell TransplantationRetinoids in leukemia and cellular processes

The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis

Oikawa, Tsuneyuki, Yamada, Toshiyuki, Kihara-Negishi, Fumiko, Yamamoto, Hitomi, Kondoh, Nobuo, Hitomi, Yoshiaki, Hashimoto, Yoshiyuki·1999·Cell Death & Differentiation

DOI 10.1038/sj.cdd.4400534

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Abstract

The PU.1 gene encodes an Ets family transcription factor which controls expression of many B cell- and macrophage-specific genes. Expression of the gene is critical for development of lymphoid and myeloid cell lineages, since PU.1-deficient mice exhibit defects in the development of these cell lineages. The PU.1 gene is identical to the Spi-1 gene isolated from common proviral integration sites in Friend virus-induced murine erythroleukemia (MEL), and deregulated expression of the gene is believed to be an essential step of the disease. We recently demonstrated that overexpression of PU.1 inhibits erythroid differentiation of MEL cells induced with the differentiating agent DMSO. We also noticed unexpectedly that overexpression of PU.1 together with DMSO induces marked growth arrest and apoptosis in MEL cells, supporting the notion that some oncogenes induce growth inhibition and apoptosis rather than cell proliferation and transformation under specific circumstances as shown with the c-myc gene. In this review, the role of PU.1 in hematopoietic cell differentiation, proliferation and apoptosis is described and the possible molecular mechanisms of PU.1-induced effects in MEL cells are discussed.

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Borzoi correctly predicts upregulation of SHTN1 expression owing to the creation of a CEBP binding motif.
“Borzoi correctly predicts the upregulation of SHTN1 expression owing to the creation of a CEBP binding motif69–72 (see Supplementary Fig. 9a and Extended Data Fig. 6a,b for additional examples).”
From Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation (2025) · cites this paper as [70]
PU.1 is commonly characterized as a lineage differentiation factor, and its role as a regulator of cell proliferation has also been extensively studied.
“while PU.1 is commonly characterized as a lineage differentiation factor, its role as a regulator of cell proliferation has also been extensively studied (Delestré et al., 2017; Fukuchi et al., 2008; Oikawa et al., 1999; Solomon et al., 2017; Ziliotto et al., 2014).”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Oikawa et al., 1999

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The Role of Ets Transcription Factors in the Development and Function of the Mammalian Immune System
Bassuk, A. G., & Leiden, J. M. (1997) · Advances in immunology · doi:10.1016/s0065-2776(08)60887-1 · Cited by 110 · see citing works
Spi-1/PU.1: an oncogene of the Ets family
Moreau-Gachelin, F. (1994) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)90011-6 · Cited by 110 · see citing works
Phosphorylation of the erythroid transcription factor GATA-1
Crossley, M., & Orkin, S. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89430-9 · Cited by 107 · see citing works
DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter.
Ray-Gallet, D., Mao, C. D., Tavitian, A., & Moreau-Gachelin, F. (1995) · PubMed · Cited by 105 · see citing works
The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb
Hallier, M., Tavitian, A., & Moreau-Gachelin, F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11177 · Cited by 104 · see citing works
PU.1 as an essential activator for the expression of gp91 phox gene in human peripheral neutrophils, monocytes, and B lymphocytes
Suzuki, S., Kumatori, A., Haagen, I.-A., Fujii, Y., Sadat, M., Jun, H. L., Tsuji, Y., Roos, D., & Nakamura, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6085 · Cited by 101 · see citing works
AP1 Regulation of Proliferation and Initiation of Apoptosis in Erythropoietin-Dependent Erythroid Cells
Jacobs-Helber, S. M., Wickrema, A., Birrer, M. J., & Sawyer, S. T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3699 · Cited by 101 · see citing works
Ets Proteins: New Factors That Regulate Immunoglobulin Heavy-Chain Gene Expression
Rivera, R. R., Stuiver, M. H., Steenbergen, R. D. M., & Murre, C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.11.7163 · Cited by 99 · see citing works
CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.
Rosmarin, A. G., Caprio, D. G., Levy, R., & Simkevich, C. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.801 · Cited by 94 · see citing works
Mechanism of c-myc Regulation by c-Myb in Different Cell Lineages
Cogswell, J. P., Cogswell, P. C., Kuehl, W. M., Cuddihy, A. M., Bender, T. M., Engelke, U., Marcu, K. B., & Ting, J. P. ‐. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2858 · Cited by 91 · see citing works
Overexpression of PU.1 Induces Growth and Differentiation Inhibition and Apoptotic Cell Death in Murine Erythroleukemia Cells
Yamada, T., Kondoh, N., Matsumoto, M., Yoshida, M., Maekawa, A., & Oikawa, T. (1997) · Blood · doi:10.1182/blood.v89.4.1383 · Cited by 91 · see citing works
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Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation
Rao, G., Rekhtman, N., Cheng, G., Krasikov, T., & Skoultchi, A. I. (1997) · Oncogene · doi:10.1038/sj.onc.1200807 · Cited by 89 · see citing works
PU.1 and an HLH family member contribute to the myeloid‐specific transcription of the Fc gamma RIIIA promoter.
Feinman, R., Qiu, W. Q., Pearse, R. N., Nikolajczyk, B. S., Sen, R., Sheffery, M., & Ravetch, J. V. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06696.x · Cited by 88 · see citing works
The Ets-Related Transcription Factor PU.1 Immortalizes Erythroblasts
Schuetze, S. M., Stenberg, P. E., & Kabat, D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5670 · Cited by 87 · see citing works
Increased expression of the ETS-related transcription factor FLI-1/ERGB correlates with and can induce the megakaryocytic phenotype.
Athanasiou, M., Clausen, P. A., Mavrothalassitis, G. J., Zhang, X. K., Watson, D. K., & Blair, D. G. (1996) · PubMed · Cited by 86 · see citing works
PU.1 can participate in an active enhancer complex without its transcriptional activation domain
Pongubala, J. M. R., & Atchison, M. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.127 · Cited by 86 · see citing works
Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif.
Moulton, K. S., Semple, K., Wu, H., & Glass, C. K. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4408 · Cited by 86 · see citing works
Role of the PU.1 Transcription Factor in Controlling Differentiation of Friend Erythroleukemia Cells
Schuetze, S. M., Paul, R. W., Gliniak, B., & Kabat, D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.7.2967 · Cited by 85 · see citing works
PU.1/Pip and Basic Helix Loop Helix Zipper Transcription Factors Interact With Binding Sites in the CD20 Promoter to Help Confer Lineage- and Stage-Specific Expression of CD20 in B Lymphocytes
Himmelmann, A. W., Riva, A., Wilson, G. L., Lucas, B. P., Thévenin, C., & Kehrl, J. H. (1997) · Blood · doi:10.1182/blood.v90.10.3984 · Cited by 84 · see citing works
Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.
Perez, C., Coeffier, E., Moreau-Gachelin, F., Wietzerbin, J., & Benech, P. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5023 · Cited by 84 · see citing works
p53 in Tumor Progression: Life, Death, and Everything
Mowat, M. R. A. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60764-2 · Cited by 78 · see citing works
PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells
Henkel, G., McKercher, Sr., Yamamoto, H., Anderson, K., Oshima, R., & Maki, R. (1996) · Blood · doi:10.1182/blood.v88.8.2917.bloodjournal8882917 · Cited by 76 · see citing works
Self-citation
Essential fatty acids and breast cancer: A case-control study in Uruguay
Stéfani, E. D., Deneo‐Pellegrini, H., Mendilaharsu, M., & Ronco, Á. L. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980518)76:4 · Cited by 75 · see citing works
MyD genes in negative growth control
Liebermann, D. A., & Hoffman, B. (1998) · Oncogene · doi:10.1038/sj.onc.1202574 · Cited by 75 · see citing works
c-Myc in the Controlm of Cell Proliferation and Embryonic Development
Lemaı̂tre, J.-M., Buckle, R. S., & Méchali, M. (1996) · Advances in cancer research · doi:10.1016/s0065-230x(08)60873-8 · Cited by 75 · see citing works
Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors: a possible target for v-erbA oncogene action.
Schroeder, C., Gibson, L., Zenke, M., & Beug, H. (1992) · PubMed · Cited by 75 · see citing works
Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell Lines
Starck, J., Doubeikovski, A., Sarrazin, S., Gonnet, C., Rao, G., Skoultchi, A. I., Godet, J., Dusanter‐Fourt, I., & Morlé, F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.121 · Cited by 74 · see citing works
GABP Cooperates With c-Myb and C/EBP to Activate the Neutrophil Elastase Promoter
Nuchprayoon, I., Simkevich, C. P., Luo, M., Friedman, A. D., & Rosmarin, A. G. (1997) · Blood · doi:10.1182/blood.v89.12.4546 · Cited by 73 · see citing works
PU.1 Is Essential for p47 Promoter Activity in Myeloid Cells
Li, S.-L., Valente, A. J., Zhao, S.-J., & Clark, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17802 · Cited by 71 · see citing works
Transactivation of GATA-1 promoter with ETS1, ETS2 and ERGB/Hu-FLI-1 proteins: stabilization of the ETS1 protein binding on GATA-1 promoter sequences by monoclonal antibody.
Seth, A. K., Robinson, L., Thompson, D. M., Watson, D. K., & Papas, T. S. (1993) · PubMed · Cited by 69 · see citing works
Analysis of the Bruton's tyrosine kinase gene promoter reveals critical PU.1 and SP1 sites
Himmelmann, A. W., Thévenin, C., Harrison, K., & Kehrl, J. H. (1996) · Blood · doi:10.1182/blood.v87.3.1036.bloodjournal8731036 · Cited by 65 · see citing works
Characterization of the p150,95 leukocyte integrin alpha subunit (CD11c) gene promoter. Identification of cis-acting elements.
López‐Cabrera, M., Nueda, A., Vara, A., García‐Aguilar, J., Tugores, A., & Corbí, A. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54058-8 · Cited by 64 · see citing works
Murine Macrophage Mannose Receptor Promoter Is Regulated by the Transcription Factors PU.1 and SP1
Eichbaum, Q. G., Heney, D., Raveh, D., Chung, M., Davidson, M. B., Epstein, J. E., & Ezekowitz, R. A. B. (1997) · Blood · doi:10.1182/blood.v90.10.4135 · Cited by 62 · see citing works
Granulocytic Differentiation of Normal Hematopoietic Precursor Cells Induced by Transcription Factor PU.1 Correlates With Negative Regulation of the c-myb Promoter
Bellón, T., Perrotti, D., & Calabretta, B. (1997) · Blood · doi:10.1182/blood.v90.5.1828 · Cited by 62 · see citing works
ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers
Erman, B., Cortes, M., Nikolajczyk, B. S., Speck, N. A., & Sen, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1322 · Cited by 60 · see citing works
Multiple motifs regulate the B-cell-specific promoter of the B29 gene.
Omori, S. A., & Wall, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11723 · Cited by 59 · see citing works
π1 Binding Sites Are Negative Regulators of bcl -2 Expression in Pre-B Cells
Chen, H.-M., & Boxer, L. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3840 · Cited by 59 · see citing works
Octamer Binding Factors and Their Coactivator Can Activate the Murine PU.1 (spi-1) Promoter
Chen, H.-M., Zhang, P., Radomska, H. S., Hetherington, C. J., Zhang, D.-E., & Tenen, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15743 · Cited by 59 · see citing works
Erythropoietin increases c-myc mRNA by a protein kinase C-dependent pathway.
Spangler, R., Bailey, S. C., & Sytkowski, A. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35223-7 · Cited by 59 · see citing works
Functional interference between the Spi‐1/PU.1 oncoprotein and steroid hormone or vitamin receptors.
Gauthier, J. M., Bourachot, B., Doucas, V., Yaniv, M., & Moreau-Gachelin, F. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06203.x · Cited by 58 · see citing works
Anti-IgM-mediated Regulation of c-myc and Its Possible Relationship to Apoptosis
Kaptein, J. S., Lin, C.-K. E., Wang, C. L., Nguyen, T. T., Kalunta, C. I., Park, E., Chen, F.-S., & Lad, P. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18875 · Cited by 56 · see citing works
Transcriptional Regulation of the Stem Cell Leukemia Gene by PU.1 and Elf-1
Bockamp, E., Fordham, J., Göttgens, B., Murrell, A., Sánchez, M. J., & Green, A. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29032 · Cited by 56 · see citing works
Human Proteinase-3 Expression Is Regulated by PU.1 in Conjunction with a Cytidine-rich Element
Sturrock, A., Franklin, K. F., & Hoidal, J. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.32392 · Cited by 55 · see citing works
A common site for immortalizing proviral integrations in Friend erythroleukemia: molecular cloning and characterization
Paul, R. W., Schuetze, S. M., Kozak, S. L., & Kabat, D. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4958-4961.1989 · Cited by 55 · see citing works
Regulation and function of transcription factor GATA-1 during red blood cell differentiation
Briegel, K. J., Bartůněk, P., Stengl, G., Lim, K.-C., Beug, H., Engel, J. D., & Zenke, M. (1996) · Development · doi:10.1242/dev.122.12.3839 · Cited by 50 · see citing works
Normal Myeloid Development Requires Both the Glutamine-Rich Transactivation Domain and the PEST Region of Transcription Factor PU.1 but Not the Potent Acidic Transactivation Domain
Fisher, R. C., Olson, M. C., Pongubala, J. M. R., Perkel, J. M., Atchison, M. L., Scott, E. W., & Simon, M. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4347 · Cited by 49 · see citing works
Transcriptional Up-Regulation of the Mouse Cytosolic Glutathione Peroxidase Gene in Erythroid Cells is Due to a Tissue-Specific 3' Enhancer Containing Functionally Important CACC/GT Motifs and Binding Sites for GATA and Ets Transcription Factors
O’Prey, J., Ramsay, S., Chambers, I., & Harrison, P. R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6290 · Cited by 47 · see citing works
Activation of the Megakaryocyte-specific Gene Platelet Basic Protein (PBP) by the Ets Family Factor PU.1
Zhang, C., Gadue, P. J., Scott, E. W., Atchison, M. L., & Poncz, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26236 · Cited by 46 · see citing works
Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c- myc genes and apoptosis
Shimamoto, T., Nakamura, S., Bollekens, J. A., Ruddle, F. H., & Takeshita, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3245 · Cited by 44 · see citing works
Inhibition of Friend cells proliferation by spi-1 antisense oligodeoxynucleotides.
Delgado, M. D., Hallier, M., Meneceur, P., Tavitian, A., & Moreau-Gachelin, F. (1994) · PubMed · Cited by 44 · see citing works
The Role of Transcription Factor PU.I in the Activity of the Intronic Enhancer of the Eosinophil-Derived Neurotoxin (RNS2) Gene
van Dijk, T. B., Caldenhoven, E., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L., & de Groot, R. P. (1998) · Blood · doi:10.1182/blood.v91.6.2126 · Cited by 43 · see citing works
Thrombopoietin-induced Expression of the Glycoprotein IIb Gene Involves the Transcription Factor PU.1/Spi-1 in UT7-Mpl Cells
Doubeikovski, A., Uzan, G., Doubeikovski, Z., Prandini, M., Porteu, F., Gisselbrecht, S., & Dusanter‐Fourt, I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24300 · Cited by 41 · see citing works
Repression of I-Aβ Gene Expression by the Transcription Factor PU.1
Borràs, F. E., Lloberas, J., Maki, R. A., & Celada, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.24385 · Cited by 40 · see citing works
The PU.1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter
Carvalho, M. D. G., & Derse, D. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3885-3890.1993 · Cited by 39 · see citing works
Early G1 growth arrest of hybridoma B cells by DMSO involves cyclin D2 inhibition and p21[CIP1] induction
Ponzio, G., Loubat, A., Rochet, N., Turchi, L., Rezzonico, R., Far, D. F., Dulić, V., & Rossi, B. (1998) · Oncogene · doi:10.1038/sj.onc.1202040 · Cited by 37 · see citing works
A variant form of ETS1 induces apoptosis in human colon cancer cells
Huang, C., Papas, T. S., & BHAT, N. K. (1997) · Oncogene · doi:10.1038/sj.onc.1201408 · Cited by 35 · see citing works
Reduction of DNA Binding Activity of the GATA-1 Transcription Factor in the Apoptotic Process Induced by Overexpression of PU.1 in Murine Erythroleukemia Cells
Yamada, T., Kihara-Negishi, F., Yamamoto, H., Yamamoto, M., Hashimoto, Y., & Oikawa, T. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4251 · Cited by 35 · see citing works
Self-citation
Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1
Simon, M. C., Olson, M. C., Scott, E., Hack, A. A., Su, G. H., & Singh, H. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-85232-9_11 · Cited by 34 · see citing works
Oncogenic Role of “Master” Transcription Factors in Human Leukemias And Sarcomas: A Developmental Model
Look, A. T. (1995) · Advances in cancer research · doi:10.1016/s0065-230x(08)60709-5 · Cited by 33 · see citing works
Transcriptional Control of Hematopoiesis
Robb, L. G., Elefanty, A. G., & Begley, C. G. (1999) · Elsevier eBooks · doi:10.1016/b978-012624960-6/50003-0 · Cited by 27 · see citing works
PU.1/Spi-1 Is Essential for the B Cell-Specific Activity of the Mouse CD72 Promoter
Ying, H., Chang, J.-F., & Parnes, J. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.5.2287 · Cited by 27 · see citing works
The Murine Interleukin-5 Receptor α-Subunit Gene: Characterization of the Gene Structure and Chromosome Mapping
Imamura, F., Τακακι, S., Akagi, K., Ando, M., Yamamura, K., Takatsu, K., & Tominaga, A. (1994) · DNA and Cell Biology · doi:10.1089/dna.1994.13.283 · Cited by 26 · see citing works
Spi-1/PU.1 Proto-oncogene Induces Opposite Effects on Monocytic and Erythroid Differentiation of K562 Cells
Delgado, M. D., Gutiérrez, P., Richard, C., Cuadrado, M. A., Moreau-Gachelin, F., & León, J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9587 · Cited by 19 · see citing works
A new pattern for helix–turn–helix recognition revealed by the PU.1 ETS-domain–DNA complex
Kodandapani, R., Pio, F., Ni, C., Piccialli, G., Klemsz, M. J., McKercher, S. R., Maki, R. A., & Ely, K. R. (1998) · Nature · doi:10.1038/33467 · Cited by 18 · see citing works
PU.1 Regulates the CXCR1 Promoter
Wilkinson, N., & Navarro, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.438 · Cited by 17 · see citing works
Leukemia: the sophisticated subversion of hematopoiesis by nuclear receptor oncoproteins
Stunnenberg, H. G., García‐Jiménez, C., & Betz, J. L. (1999) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(98)00036-5 · Cited by 16 · see citing works
Molecular cloning and functional analysis of the CD33 promoter
Bodger, M. P., & Hart, D. N. J. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00863.x · Cited by 15 · see citing works
Involvement of the Transcription Factor PU.1/Spi-1 in Myeloid Cell-Restricted Expression of an Interferon-Inducible Gene Encoding the Human High-Affinity Fcγ Receptor
Perez, C., Coëffier, E., Moreau-Gachelin, F., Wietzerbin, J., & Benech, P. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5023-5031.1994 · Cited by 15 · see citing works
The PU.1 binding site is a cis-element that regulates pro-B/pre-B specificity of Vkappa-Jkappa joining
Hayashi, R., Takemori, T., Kodama, M., Suzuki, M., Tsuboi, A., Nagawa, F., & Sakano, H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.9.4145 · Cited by 15 · see citing works
c-myb down regulation is associated with apoptosis in human neuroblastoma cells.
Piacentini, M., Raschellà, G., Calabretta, B., & Melino, G. (1994) · PubMed · Cited by 13 · see citing works
Extinction of expression of the PU.1/Sfpi-1 putative oncogene encoding a B-cell- and macrophage-specific transcription factor in somatic cell hybrids.
Hitomi, Y., Yamada, T., & Oikawa, T. (1993) · PubMed · Cited by 11 · see citing works
Self-citation
Transcriptional Up-Regulation of the Mouse Cytosolic Glutathione Peroxidase Gene in Erythroid Cells is Due to a Tissue-Specific 3' Enhancer Containing Functionally Important CACC/GT Motifs and Binding Sites for GATA and Ets Transcription Factors
O’Prey, J., Ramsay, S. L., Chambers, I., & Harrison, P. R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6290-6303.1993 · Cited by 11 · see citing works
Enhanced expression of the urokinase-type plasminogen activator gene and reduced colony formation in soft agar by ectopic expression of PU.1 in HT1080 human fibrosarcoma cells
Kondoh, N., Yamada, T., Kihara‐Negishi, F., Yamamoto, M., & Oikawa, T. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.567 · Cited by 6 · see citing works
Self-citation
By-pass of TPA-induced differentiation and cell cycle arrest by the c-Myb DNA-binding domain.
Engelke, U., Šmarda, J., & Lipsick, J. S. (1995) · PubMed · Cited by 4 · see citing works

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Molecular biology of the Ets family of transcription factors
Oikawa, T., & Yamada, T. (2003) · Gene · doi:10.1016/s0378-1119(02)01156-3 · Cited by 684 · see citing works
Self-citation
Cooperative Interaction of Hypoxia-inducible Factor-2α (HIF-2α) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)
Elvert, G., Kappel, A., Heidenreich, R., Englmeier, U., Lanz, S., Acker, T., Rauter, M., Plate, K. H., Sieweke, M. H., Breier, G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211298200 · Cited by 272 · see citing works
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation
Linder, J., Srivastava, D., Yuan, H., Agarwal, V., & Kelley, D. R. (2025) · Nature Genetics · doi:10.1038/s41588-024-02053-6 · Cited by 265 · see citing works
Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway
Gatto, G., Rossi, A., Rossi, D. P., Kroening, S., Bonatti, S., & Mallardo, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn666 · Cited by 254 · see citing works
Erythropoiesis: Model systems, molecular regulators, and developmental programs
Tsiftsoglou, A. S., Vizirianakis, I. S., & Strouboulis, J. (2009) · IUBMB Life · doi:10.1002/iub.226 · Cited by 199 · see citing works
ETS transcription factors: Possible targets for cancer therapy
Oikawa, T. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03320.x · Cited by 191 · see citing works
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Mechanisms involved in the induced differentiation of leukemia cells
Tsiftsoglou, A. S., Pappas, I. S., & Vizirianakis, I. S. (2003) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.09.002 · Cited by 156 · see citing works
Functional Cross-Antagonism between Transcription Factors FLI-1 and EKLF
Starck, J., Cohet, N., Gonnet, C., Sarrazin, S., Doubeikovskaia, Z., Doubeikovski, A., Verger, A., Duterque‐Coquillaud, M., & Morlé, F. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1390-1402.2003 · Cited by 144 · see citing works
Towards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1
Roeder, I., & Glauche, I. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.01.021 · Cited by 143 · see citing works
Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b
Suzuki, M., Yamada, T., Kihara-Negishi, F., Sakurai, T., Hara, E., Tenen, D. G., Hozumi, N., & Oikawa, T. (2006) · Oncogene · doi:10.1038/sj.onc.1209272 · Cited by 132 · see citing works
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The Transcription Factor PU.1, Necessary for B-Cell Development Is Expressed in Lymphocyte Predominance, But Not Classical Hodgkin’s Disease
Torlakovic, E., Tierens, A. M., Dang, H. D., & Delabie, J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63027-1 · Cited by 128 · see citing works
The B-Cell Transcription Factors BSAP, Oct-2, and BOB.1 and the Pan-B-Cell Markers CD20, CD22, and CD79a Are Useful in the Differential Diagnosis of Classic Hodgkin Lymphoma
Browne, P. J., Petrosyan, K., Antonio Hernandez, M., & Chan, J. A. (2003) · American Journal of Clinical Pathology · doi:10.1309/ych8-dwuf-fqbk-gpvb · Cited by 120 · see citing works
Notch/Delta signaling constrains reengineering of pro-T cells by PU.1
Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., & Rothenberg, E. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601188103 · Cited by 109 · see citing works
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression
Scolan, E. L., Pchejetski, D., Banno, Y., Denis, N., Mayeux, P., Vainchenker, W., Levade, T., & Moreau-Gachelin, F. (2005) · Blood · doi:10.1182/blood-2004-12-4832 · Cited by 107 · see citing works
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201169 · Cited by 91 · see citing works
“1 is commonly characterized as a lineage differentiation factor, its role as a regulator of cell proliferation has also been extensively studied (Delestré et al., 2017; Fukuchi et al., 2008; Oikawa et al., 1999; Solomon et al., 2017; Ziliotto et al., 2014).”
Background
Epstein-Barr Virus LMP2A Interferes with Global Transcription Factor Regulation When Expressed during B-Lymphocyte Development
Portis, T., & Longnecker, R. (2002) · Journal of Virology · doi:10.1128/jvi.77.1.105-114.2003 · Cited by 81 · see citing works
Identification and Functional Analysis of the Rat Caspase-3 Gene Promoter
Liu, W., Wang, G., & Yakovlev, A. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110768200 · Cited by 77 · see citing works
PU.1 and NFATc1 mediate osteoclastic induction of the mouse β<sub>3</sub> integrin promoter
Crotti, T. N., Sharma, S. M., Fleming, J. D., Flannery, M. R., Ostrowski, M. C., Goldring, S. R., & McHugh, K. P. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21344 · Cited by 76 · see citing works
In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repression
Kihara-Negishi, F., Yamamoto, H., Suzuki, M., Yamada, T., Sakurai, T., Tamura, T., & Oikawa, T. (2001) · Oncogene · doi:10.1038/sj.onc.1204756 · Cited by 65 · see citing works
Self-citation
Stem Cell Fate Specification: Role of Master Regulatory Switch Transcription Factor PU.1 in Differential Hematopoiesis
Gangenahalli, G. U., Gupta, P., Saluja, D., Verma, Y. K., Kishore, V., Chandra, R., Sharma, R. K., & Ravindranath, T. (2005) · Stem Cells and Development · doi:10.1089/scd.2005.14.140 · Cited by 53 · see citing works
Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis
Serezani, C. H., Kane, S., Collins, L., Morato-Marques, M., Osterholzer, J. J., & Peters-Golden, M. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200257 · Cited by 49 · see citing works
Caspase-1 Is a Direct Target Gene of ETS1 and Plays a Role in ETS1-Induced Apoptosis
Pei, H., Li, C., Adereth, Y., Hsu, T., Watson, D. K., & Li, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3566 · Cited by 46 · see citing works
The Ets-transcription factor family in embryonic development: lessons from the amphibian and bird
Remy, P., & Baltzinger, M. (2000) · Oncogene · doi:10.1038/sj.onc.1204044 · Cited by 52 · see citing works
1α,25-Dihydroxyvitamin D3Transrepresses Retinoic Acid Transcriptional Activity via Vitamin D Receptor in Myeloid Cells
Bastie, J.-N., Balitrand, N., Guidez, F., Guillemot, I., Larghero, J., Calabresse, C., Chomienne, C., & Delva, L. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0412 · Cited by 43 · see citing works
Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway
Wu, X., Liu, P., Zhang, H., Li, Y., Salmani, J. M. M., Wang, F., Yang, K., Rong, F., Chen, Z., & Chen, B. (2017) · BMC Cancer · doi:10.1186/s12885-017-3145-4 · Cited by 40 · see citing works
Comprehensive Analysis of Immune Implications and Prognostic Value of SPI1 in Gastric Cancer
Huang, J., Chen, W., Jie, Z., & Jiang, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.820568 · Cited by 38 · see citing works
LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination
Wu, Z. K., Bai, X., Lu, Z., Liu, S., & Jiang, H. (2022) · Journal of Immunology Research · doi:10.1155/2022/6450721 · Cited by 36 · see citing works
CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter
Mikheev, A. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.19.3762 · Cited by 36 · see citing works
Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells
Yamada, T., Abe, M., Higashi, T., Yamamoto, H., Kihara‐Negishi, F., Sakurai, T., Shirai, T., & Oikawa, T. (2001) · Blood · doi:10.1182/blood.v97.8.2300 · Cited by 38 · see citing works
Self-citation
An E2F Binding-Deficient Rb1 Protein Partially Rescues Developmental Defects Associated with Rb1 Nullizygosity
Sun, H., Chang, Y., Schweers, B. A., Dyer, M. A., Zhang, X., Hayward, S. W., & Goodrich, D. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1527-1537.2006 · Cited by 34 · see citing works
The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies
Becker, N. M., Moore, S. A., & Jones, K. A. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01320-z · Cited by 32 · see citing works
Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity
Xia, J., Liu, M., Zhu, C., Liu, S., Ai, L., Ma, D., Zhu, P., Wang, L., & Liu, F. (2023) · Cell Research · doi:10.1038/s41422-023-00797-0 · Cited by 32 · see citing works
The role of stat1b in zebrafish hematopoiesis
Song, H., Yan, Y., Titus, T. A., He, X., & Postlethwait, J. H. (2011) · Mechanisms of Development · doi:10.1016/j.mod.2011.08.004 · Cited by 32 · see citing works
The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells
Kubosaki, A., Lindgren, G., Tagami, M., Simon, C., Tomaru, Y., Miura, H., Suzuki, T., Arner, E., Forrest, A. R. R., Irvine, K. M., et al. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.05.289 · Cited by 29 · see citing works
Essential role of spi-1–like (spi-1l) in zebrafish myeloid cell differentiation
Bukrinsky, A., Griffin, K. J. P., Zhao, Y., Lin, S., & Banerjee, U. K. (2009) · Blood · doi:10.1182/blood-2008-06-162495 · Cited by 29 · see citing works
The possible functions of duplicated ets (GGAA) motifs located near transcription start sites of various human genes
Uchiumi, F., Miyazaki, S., & Tanuma, S.-I. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0674-x · Cited by 27 · see citing works
Early Life Events and Maturation of the Dentate Gyrus: Implications for Neurons and Glial Cells
Aniol, V. A., Манолова, А. О., & Gulyaeva, N. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084261 · Cited by 27 · see citing works
PD-L1 enhances migration and invasion of trophoblasts by upregulating ARHGDIB via transcription factor PU.1
Zhang, R., Jia, L., Meng, L., Peng, H., Zhang, D., He, Q., Duan, T., & Wang, K. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01171-6 · Cited by 26 · see citing works
Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBPα
Lian, T., Guan, R., Zhou, B., & Bai, Y. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01189-z · Cited by 26 · see citing works
Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene
Barnache, S., Scolan, E. L., Kosmider, O., Denis, N., & Moreau-Gachelin, F. (2005) · Oncogene · doi:10.1038/sj.onc.1209187 · Cited by 26 · see citing works
Down-regulation of hematopoiesis master regulator PU.1 via aberrant methylation in chronic myeloid leukemia
Yang, H., Liang, H., Yan, J.-S., Tao, R., Hao, S., & Ma, L. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1106-x · Cited by 26 · see citing works
Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1–Cα1 germline transcription in epithelial cancer cells
Duan, Z., Zheng, H., Xu, S., Jiang, Y., Liu, H., Li, M., Hu, D., Li, W., Bode, A. M., Dong, Z., et al. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.52 · Cited by 24 · see citing works
Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly
Jian, W., Yan, B., Huang, S., & Qiu, Y. (2017) · The FASEB Journal · doi:10.1096/fj.201700022r · Cited by 23 · see citing works
PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression
Haimovici, A., Humbert, M., Federzoni, E. A., Shan, D., Brunner, T., Frese, S., Kaufmann, T., Torbett, B. E., & Tschan, M. P. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.40 · Cited by 23 · see citing works
Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias
Inomata, M., Takahashi, S., Harigae, H., Kameoka, J., Kaku, M., & Sasaki, T. (2005) · Leukemia Research · doi:10.1016/j.leukres.2005.07.015 · Cited by 22 · see citing works
Downregulation of PU.1 Leads to Decreased Expression of Dectin-1 in Alveolar Macrophages during Pneumocystis Pneumonia
Zhang, C., WANG, S., Liao, C.-P., Shao, S., Lasbury, M. E., Durant, P. J., & Lee, C. (2010) · Infection and Immunity · doi:10.1128/iai.01141-09 · Cited by 23 · see citing works
Conserved ETS Domain Arginines Mediate DNA Binding, Nuclear Localization, and a Novel Mode of bZIP Interaction
Listman, J. A., Wara-aswapati, N., Race, J. E., Blystone, L. W., Walker‐Kopp, N., Yang, Z., & Auron, P. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509143200 · Cited by 21 · see citing works
Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation
Haimovici, A., Brigger, D., Torbett, B. E., Fey, M. F., & Tschan, M. P. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.06.010 · Cited by 20 · see citing works
Computational Prediction of Biomarkers, Pathways, and New Target Drugs in the Pathogenesis of Immune-Based Diseases Regarding Kidney Transplantation Rejection
Alfaro, R., Martínez‐Banaclocha, H., Llorente, S., Jiménez-Coll, V., Galián, J. A., Botella, C., Moya‐Quiles, M. R., Parrado, A., Muro-Pérez, M., Minguela, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.800968 · Cited by 20 · see citing works
Platelet-derived growth factor up-regulates the expression of transcription factors NF-E2, GATA-1 and c-Fos in megakaryocytic cell lines.
Chui, C. M. Y., Li, K., Yang, M., Chuen, C. K. Y., Fok, T., Li, C.-K., & Yuen, P. (2003) · Cytokine · doi:10.1016/s1043-4666(02)00499-4 · Cited by 22 · see citing works
A novel GATA-like zinc finger transcription factor involving in hematopoiesis of Eriocheir sinensis
Li, Y., Jia, Z., Yi, Q., Song, X., Liu, Y., Jia, Y., Wang, L., & Song, L. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.01.007 · Cited by 19 · see citing works
Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics
Schator, D., Gómez-Valero, L., Buchrieser, C., & Rolando, M. (2021) · microLife · doi:10.1093/femsml/uqab013 · Cited by 18 · see citing works
The Utility of PU.1 as an Immunohistochemical Marker for Histiocytic and Dendritic Lesions of the Skin
Muirhead, D., Stone, M. S., & Syrbu, S. (2009) · American Journal of Dermatopathology · doi:10.1097/dad.0b013e31818866a7 · Cited by 17 · see citing works
Single-cell omics identifies inflammatory signaling as a trans-differentiation trigger in mouse embryos
Zhang, Y., Kang, Z., Liu, M., Wang, L., & Liu, F. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.02.010 · Cited by 16 · see citing works
DNA binding protein CgIkaros-like regulates the proliferation of agranulocytes and granulocytes in oyster (Crassostrea gigas)
Sun, W., Song, X., Dong, M., Liu, Z., Song, Y., Wang, L., & Song, L. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104201 · Cited by 15 · see citing works
C/EBPα and PU.1 are involved in distinct differentiation responses of acute promyelocytic leukemia HL-60 and NB4 cells via chromatin remodeling
Savickienė, J., Treigytė, G., Valiulienė, G., Tunaitis, V., Magnusson, K., & Navakauskienė, R. (2010) · Differentiation · doi:10.1016/j.diff.2010.08.003 · Cited by 15 · see citing works
Transcriptional regulation of the proto‐oncogene Zfp521 by SPI1 (PU.1) and HOXC13
Yu, M., Aldallal, S., Al‐Haj, L., Panjwani, S., McCartney, A. S., Edwards, S. M., Manjunath, P., Walker, C., Awgulewitsch, A., & Hentges, K. E. (2016) · genesis · doi:10.1002/dvg.22963 · Cited by 14 · see citing works
Exploring the pathogenesis of chronic atrophic gastritis with atherosclerosis via microarray data analysis
Men, X., Shi, X., Xu, Q., Liu, M., Yang, H., Wang, L., Men, X., & Xu, H. (2024) · Medicine · doi:10.1097/md.0000000000037798 · Cited by 13 · see citing works
Spi-1/PU.1 but not Fli-1 inhibits erythroid-specific alternative splicing of 4.1R pre-mRNA in murine erythroleukemia cells
Théoleyre, O., Deguillien, M., Morinière, M., Starck, J., Moreau-Gachelin, F., Morlé, F., & Baklouti, F. (2003) · Oncogene · doi:10.1038/sj.onc.1207206 · Cited by 13 · see citing works
Hematopoietic Stem Cell Transcription Factors in Cardiovascular Pathology
Duddu, S., Chakrabarti, R., Ghosh, A., & Shukla, P. C. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.588602 · Cited by 12 · see citing works
SPaRTAN, a computational framework for linking cell-surface receptors to transcriptional regulators
Ma, X., Somasundaram, A., Qi, Z., Hartman, D. J., Singh, H., & Osmanbeyoglu, H. U. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab745 · Cited by 12 · see citing works
PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL‐6, CD10, CD20 and CD22 : identification of PU.1 putative binding sites in the BCL‐6 promotor
Torlakovic, E., Małecka, A., Myklebust, J. H., Tierens, A. M., Aasheim, H., Nesland, J. M., Smeland, E. B., Kvaløy, S., & Delabie, J. (2005) · The Journal of Pathology · doi:10.1002/path.1777 · Cited by 11 · see citing works
Promoter Analysis of TFPT (FB1), a Molecular Partner of TCF3 (E2A) in Childhood Acute Lymphoblastic Leukemia
Brambillasca, F., Mosna, G., Ballabio, E., Biondi, A., Boulukos, K. E., & Privitera, E. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5906 · Cited by 11 · see citing works
The synergistic role of Pu.1 and Fms in zebrafish osteoclast-reducing osteopetrosis and possible therapeutic strategies
Liu, W., Di, Q., Li, K., Li, J., Ma, N., Huang, Z., Chen, J., Zhang, S., Zhang, W., & Zhang, Y. (2020) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2020.09.002 · Cited by 10 · see citing works
Transcription Factors Mediating Interleukin‐3 Survival Signals
Yen, J. J., & Yang‐Yen, H. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74006-7 · Cited by 10 · see citing works
The Early Immune Response of Lymphoid and Myeloid Head-Kidney Cells of Rainbow Trout (Oncorhynchus mykiss) Stimulated with Aeromonas salmonicida
Sarais, F., Montero, R., Ostermann, S., Rebl, A., Köllner, B., & Goldammer, T. (2022) · Fishes · doi:10.3390/fishes7010012 · Cited by 9 · see citing works
Characterization of the Promoter of Human Leukocyte-specific Transcript 1
Yu, X., & Weissman, S. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004700200 · Cited by 9 · see citing works
Identification of a monopartite sequence in PU.1 essential for nuclear import, DNA‐binding and transcription of myeloid‐specific genes
Kwok, J. C., Perdomo, J., & Chong, B. H. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21264 · Cited by 9 · see citing works
PU.1 induces tumor-associated macrophages promoting glioma progression through BTK-mediated Akt/mTOR pathway activation
Gu, S. (2024) · American Journal of Cancer Research · doi:10.62347/usaj2794 · Cited by 8 · see citing works
Identification of hub genes, miRNAs and regulatory factors relevant for Duchenne muscular dystrophy by bioinformatics analysis
Xiu, M., Zeng, B., & Kuang, B. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1810030 · Cited by 8 · see citing works
The clinically relevant CHK1 inhibitor MK-8776 induces the degradation of the oncogenic protein PML-RARα and overcomes ATRA resistance in acute promyelocytic leukemia cells
Franza, M., Albanesi, J., Mancini, B., Pennisi, R., Leone, S., Acconcia, F., Bianchi, F., & di Masi, A. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115675 · Cited by 7 · see citing works
The mechanism underlying B-cell developmental dysfunction in Kawasaki disease based on single-cell transcriptomic sequencing
Lin, Q., Wang, Z., Ding, G., Li, G., Chen, L., Qiu, Q., Song, S., Liu, W. X., Jiang, X., Huang, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1438640 · Cited by 7 · see citing works
Disruption of the PU.1 gene in chicken B lymphoma DT40 cells and its effect on reported target gene expression
Matsudo, H., Otsuka, A., Ozawa, Y., & Ono, M. (2003) · Gene · doi:10.1016/j.gene.2003.08.021 · Cited by 7 · see citing works
Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma
Cavazzini, F., Wolf‐Peeters, C. D., & Włodarska, I. (2005) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2004.09.005 · Cited by 7 · see citing works
SPI1 exacerbates iron accumulation and promotes osteoclast formation through inhibiting the expression of Hepcidin
Liu, L., Liu, Z.-R., Xiao, Y., Xiao, J.-H., Huang, W., Liu, W.-Y., Zhao, K., & Ye, Y.-J. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112103 · Cited by 6 · see citing works
Differentiation-dependent repression of c-myc, B22, COXII and COXIV genes in murine erythroleukemia (MEL) cells
Vizirianakis, I. S., Pappas, I. S., & Tsiftsoglou, A. S. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00937-6 · Cited by 6 · see citing works
In-depth functional analysis of BRD9 in fetal hematopoiesis reveals context-dependent roles
Zhang, Y., Nomura, M., Nishimura, K., Zang, W., Koike, Y., Xiao, M., Ito, H., Fukumoto, M., Tanaka, A., Aoyama, Y., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112010 · Cited by 5 · see citing works
Epigenomic landscape exhibits interferon signaling suppression in the patient of myocarditis after BNT162b2 vaccination
Kim, H., Ahn, H., Hwang, N., Huh, Y., Bu, S., Seo, K. J., Kwon, S. H., Lee, H.-K., Kim, J. W., Yoon, B. K., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-36070-y · Cited by 6 · see citing works
Integrative genomic analyses reveal putative cell type-specific targets of the Drosophila ets transcription factor Pointed
Raja, K. K. B., Yeung, K., Shim, Y.-K., & Mardon, G. (2024) · BMC Genomics · doi:10.1186/s12864-024-10017-7 · Cited by 5 · see citing works
Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts
Scolan, E. L., Wendling, F., Barnache, S., Denis, N., Tulliez, M., Vainchenker, W., & Moreau-Gachelin, F. (2001) · Oncogene · doi:10.1038/sj.onc.1204708 · Cited by 5 · see citing works
Temporal dynamics of a CSF1R signaling gene regulatory network involved in epilepsy
Gérard, C., Mot, L. D., Cordi, S., van Eyll, J. M., & Lemaigre, F. P. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008854 · Cited by 4 · see citing works
STAN, a computational framework for inferring spatially informed transcription factor activity
Zhang, L., Sagan, A., Qin, B., Wang, H., Kim, E. S., Hu, B., & Osmanbeyoglu, H. U. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1473 · Cited by 4 · see citing works
A comprehensive study of immune function and immunophenotyping of white blood cells from β‐thalassaemia/ HbE patients on hydroxyurea supports the safety of the drug
Siriworadetkun, S., Thiengtavor, C., Thubthed, R., Paiboonsukwong, K., Fucharoen, S., Pattanapanyasat, K., Vadolas, J., Svasti, S., & Chaichompoo, P. (2022) · British Journal of Haematology · doi:10.1111/bjh.18508 · Cited by 5 · see citing works
The PU.1 transcription factor induces cyclin D2 expression in U937 cells
Vicari, L., Eramo, A., Manzella, L., Malaguarnera, L., Iannolo, G., Gulisano, M., Maria, R. D., Messina, A., & Vigneri, P. G. (2006) · Leukemia · doi:10.1038/sj.leu.2404447 · Cited by 4 · see citing works
DNase I hypersensitive sites and histone acetylation status in the chicken Ig-β locus
Murakami, R., Osano, K., & Ono, M. (2004) · Gene · doi:10.1016/j.gene.2004.04.019 · Cited by 4 · see citing works
LncRNA018392 promotes the proliferation of Liaoning cashmere goat skin fibroblasts by upregulating CSF1R through binding to SPI1
Jin, M., Fan, W., Lv, S., Xue, T., Cong, L., Liu, X., & Cui, L. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09851-5 · Cited by 3 · see citing works
Nervous system-related gene regulatory networks and functional evolution of ETS proteins across species
Babal, Y. K., Sönmez, E., & Kurnaz, I. A. (2023) · Biosystems · doi:10.1016/j.biosystems.2023.104891 · Cited by 4 · see citing works
Upregulation of nuclear protein Hemgn by transcriptional repressor Gfi1 through repressing PU.1 contributes to the anti-apoptotic activity of Gfi1
Binod, G. C., Hoyt, L. J., Dovat, S., & Dong, F. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107860 · Cited by 3 · see citing works
Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis
Zhang, H., Zeng, J., Zhang, F., Liu, J., & Liang, L. (2025) · Biology · doi:10.3390/biology14010026 · Cited by 3 · see citing works
Biological Functions of the Duplicated GGAA-motifs in Various Human Promoter Regions
Uchiumi, F., Miyazaki, S., & Tanuma, S.-I. (2011) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.131.1787 · Cited by 4 · see citing works
DeepG4 : A deep learning approach to predict active G-quadruplexes from DNAPreprint
Rocher, V., Genais, M., Nassereddine, E., & Mourad, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.22.215699 · Cited by 3 · see citing works
PU.1 alleviates the inhibitory effects of cigarette smoke on endothelial progenitor cell function and lung-homing through Wnt/β-catenin and CXCL12/CXCR4 pathways
He, X., sup, Y. C. S., Li, T., Luo, L., Zeng, Z., Ma, Y., & Chen, Y. (2024) · Tobacco Induced Diseases · doi:10.18332/tid/174661 · Cited by 2 · see citing works
PU.1, a Versatile Transcription Factor and a Suppressor of Myeloid Leukemia
Takahashi, S. (2011) · InTech eBooks · doi:10.5772/25853 · Cited by 2 · see citing works
Hijacking the transcriptional activation potential of the BAF complex via Induced ProximityPreprint
Chia, L., Mayhew, D. L., Sherbanee, B., Lahr, D. L., & Taherbhoy, A. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.18.572217 · Cited by 2 · see citing works
SPI1 triggers the formation of neutrophil extracellular traps in multiple sclerosis through CXCL4
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Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells
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Prevention of PU.1-induced growth inhibition and apoptosis but not differentiation block in murine erythroleukemia cells by overexpression of CBP
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Function of Transcription Factor PU.1 in Haematopoietic Differentiation
Wang, H. (2004) · Foreign Medical Sciences

Authors: Oikawa, T., Yamada, T., Kihara-Negishi, F., Yamamoto, H., Kondoh, N., Hitomi, Y., & Hashimoto, Y.
Affiliations: Sasaki Institute (JP)
Corresponding author: Oikawa, Tsuneyuki
ORCID: Yamada, Toshiyuki
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 1999-07
Volume: 6
Issue: 7
Pages: 599-608
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/sj.cdd.4400534
OpenAlex: W2319992695
Cited by: 109
References: 159
Citations by year: 2026: 4 · 2025: 6 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 4 · 2018: 1 · 2017: 3 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 3
FWCI: 0.29
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
Funders: Taiho Pharmaceutical
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Keywords: PU.1, ETS transcription factors, SPI-1, hematopoietic differentiation, hematopoietic cell proliferation, apoptosis, erythroid differentiation, Friend virus, MEL cells, dimethyl sulfoxide
MeSH terms: Proto-Oncogene Protein Spi-1, Animals, Cell Differentiation, Cell Division, DNA-Binding Proteins, Leukemia, Erythroblastic, Acute, Hematopoiesis, Proto-Oncogene Proteins, Transcription Factors, Trans-Activators, Genes, myc, Apoptosis, Erythroid-Specific DNA-Binding Factors, Mice

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The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis

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