The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

Chromatin modifications and their function

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microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells

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Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

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Regulation of B lymphocyte and macrophage development by graded expression of PU.1

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Multilineage gene expression precedes commitment in the hemopoietic system.Preprint

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Erythroleukemic Differentiation

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Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates

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Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

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High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma

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Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

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Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

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Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

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PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

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Spi-1 is a putative oncogene in virally induced murine erythroleukaemias

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Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

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GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts.

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Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor

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PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

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CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

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PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

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Reprogramming of Committed T Cell Progenitors to Macrophages and Dendritic Cells by C/EBPα and PU.1 Transcription Factors

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Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOGPreprint

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GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription

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PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells

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Acute leukemia with promyelocytic features in PML/RARα transgenic mice

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Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors

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A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex

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Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages

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Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies

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The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.

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Developmental stage–selective effect of somatically mutated leukemogenic transcription factor GATA1

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PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

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PU.1 regulates both cytokine‐dependent proliferation and differentiation of granulocyte/macrophage progenitors

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Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates

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Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

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Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation

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Assembling a Gene Regulatory Network for Specification of the B Cell Fate

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Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

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High expression of B‐cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma

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Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1

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Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins

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Essential and Instructive Roles of GATA Factors in Eosinophil Development

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Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1

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ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

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Untitled work

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PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

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Spi-1/PU.1 Transgenic Mice Develop Multistep Erythroleukemias

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A Recurrent Network Involving the Transcription Factors PU.1 and Gfi1 Orchestrates Innate and Adaptive Immune Cell Fates

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c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

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PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.

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PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory elementPreprint

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Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element

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The core-binding factor β subunit is required for bone formation and hematopoietic maturation

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Induction of transformed cells to terminal differentiation and the modulation of gene expression.

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PU.1 inhibits the erythroid program by binding to GATA‐1 on DNA and creating a repressive chromatin structure

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Functional Cross-Antagonism between Transcription Factors FLI-1 and EKLF

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Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins

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Transcription factor‐mediated lineage switching reveals plasticity in primary committed progenitor cells

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The lineage commitment of haemopoietic progenitor cells

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Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.Preprint

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Pax5 Determines the Identity of B Cells from the Beginning to the End of B-lymphopoiesis

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Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

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Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε Isoforms Regulate Transcription of the Gene Encoding Eosinophil Granule Major Basic Protein

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Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus.

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C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

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A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia

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Regulation of the PU.1 gene by distal elements

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The role of transcription factors PU.1 and GATA-1 during leukemia differentiation

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Corresponding authors:

Gupta, P., Gangenahalli, G. U., Saluja, D., Verma, Y. K., Zack, J., Singh, V. K., Satija, N. K., Rajendra, P., Gangenahalli, G. U., & Saluja, D. (2015)