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p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
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Citations
Cites
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“Using the tetracycline (tet)-regulated vector system (Gossen and Bujard, 1992), we generated p21Waf1/Cip1/Sdi1 inducible cell lines.”
MethodMice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
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Radiation-induced cell cycle arrest compromised by p21 deficiency
Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., & Hannon, G. J. (1995) · Nature · doi:10.1038/377552a0 · Cited by 1,242 · cited 1×
“The inability of p53 to induce G1 arrest after DNA damage in p21-null mice strongly supports this concept (Brugarolas et al., 1995; Deng et al., 1995). p53-independent induction of p21Waf1/Cip1/Sdi1 also occurs under a variety of conditions such as following serum or TGF-b stimulation (Michieli et…”
BackgroundAgarwal, M. L., Agarwal, A., Taylor, W. R., & Stark, G. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8493 · Cited by 858
Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science · doi:10.1126/science.277.5327.831 · Cited by 804
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature · doi:10.1038/374386a0 · Cited by 548 · cited 1×
“…1994; Harper et al., 1995; Medema et al., 1995). p21Waf1/Cip1/Sdi1 can also bind to proliferating cell nuclear antigen (PCNA), a subunit of DNA polymerase d which is involved in DNA replication and repair (Flores-Rozas et al., 1994; Waga et al., 1994; Chen et al., 1995; Nakanishi et al., 1995).”
Background
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Ewald, J. A., Desotelle, J. A., Wilding, G., & Jarrard, D. F. (2010) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djq364 · Cited by 824
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Hallmarks of senescence in carcinogenesis and cancer therapy
Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502
Roninson, I. B. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00847-3 · Cited by 443
Metadata
- Authors
- Fang, L., Igarashi, M., Leung, J., Sugrue, M. M., Lee, S. W., & Aaronson, S. A.
- Venue
- Oncogene
- Published
- 1999-05-06
- Volume
- 18
- Issue
- 18
- Pages
- 2789-2797
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2067473930
- Cited by
- 207
- References
- 12
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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- Fang, L., Igarashi, M., Leung, J., Sugrue, M. M., Lee, S. W., & Aaronson, S. A. (1999). p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene. https://doi.org/10.1038/sj.onc.1202615
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