Cited by 942Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid ChemistryDNA Repair Mechanisms

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Protection of mammalian telomeres

de Lange, Titia·2002·Oncogene

DOI 10.1038/sj.onc.1205080

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Abstract

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. It is not clear exactly how the structure of telomere ends differs from sites of DNA damage and how telomeres protect chromosome ends from DNA repair activities. What are the defining structural features of telomeres and through which mechanisms do they ensure chromosome end protection? What is the molecular basis of the telomeric cap and how does it act to sequester the chromosome end? Here I discuss data gathered in the last few years, suggesting that the protection of human chromosome ends primarily depends on the telomeric protein TRF2 and that telomere capping involves the formation of a higher order structure, the telomeric loop or t-loop.

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de Lange T . 1995 Telomeres Blackburn EH, Greider CW (ed) CSH press: CSH pp 265–293

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Authors: de Lange, T.
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2002-01-21
Volume: 21
Issue: 4
Pages: 532-540
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1205080
OpenAlex: W1541877559
Cited by: 942
References: 77
Citations by year: 2026: 3 · 2025: 7 · 2024: 13 · 2023: 12 · 2022: 14 · 2021: 15 · 2020: 19 · 2019: 27 · 2018: 18 · 2017: 28 · 2016: 29 · 2015: 26 · 2014: 41 · 2013: 36 · 2012: 36
FWCI: 12.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: telomeres, telomere capping, chromosome end protection, TRF2, T-loop, DNA damage response, DNA repair, genomic instability, telomere structure, telomere length
MeSH terms: Ku Autoantigen, Animals, Chromosome Aberrations, DNA Helicases, DNA-Binding Proteins, Humans, Models, Genetic, Nuclear Proteins, Nucleic Acid Conformation, Recombination, Genetic, Yeasts, Telomere, Cellular Senescence, Apoptosis, Protein Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Antigens, Nuclear, Telomeric Repeat Binding Protein 2, DNA-Activated Protein Kinase

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