Cited by 942Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid ChemistryDNA Repair Mechanisms

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Protection of mammalian telomeres

de Lange, Titia·2002·Oncogene

DOI 10.1038/sj.onc.1205080

Open this paper in CoChat — free account

Abstract

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. It is not clear exactly how the structure of telomere ends differs from sites of DNA damage and how telomeres protect chromosome ends from DNA repair activities. What are the defining structural features of telomeres and through which mechanisms do they ensure chromosome end protection? What is the molecular basis of the telomeric cap and how does it act to sequester the chromosome end? Here I discuss data gathered in the last few years, suggesting that the protection of human chromosome ends primarily depends on the telomeric protein TRF2 and that telomere capping involves the formation of a higher order structure, the telomeric loop or t-loop.

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1205080

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108
TRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709
THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS
McClintock, B. (1941) · Genetics · doi:10.1093/genetics/26.2.234 · Cited by 1,605
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes & Development · doi:10.1101/gad.8.21.2540 · Cited by 1,215
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086
Inhibition of telomerase limits the growth of human cancer cells
Hahn, W. C., Stewart, S. A., Brooks, M. W., York, S. G., Eaton, E. N., Kurachi, A. L., Beijersbergen, R. L., Knoll, J. H. M., Meyerson, M. M., & Weinberg, R. A. (1999) · Nature Medicine · doi:10.1038/13495 · Cited by 1,038
Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
Baumann, P., & Cech, T. R. (2001) · Science · doi:10.1126/science.1060036 · Cited by 1,028
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979

Show all 77 references

Research works printed but not linked: 1

de Lange T . 1995 Telomeres Blackburn EH, Greider CW (ed) CSH press: CSH pp 265–293

Sorted by citations

Items 701–800 of 942

Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways
Silva, B. A., Stambaugh, J. R., & Berns, M. W. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.9.095003 · Cited by 6
Erosion of telomeric 3′-overhangs in white blood cells of aged subjects with high frequency of very short telomeres
Mattarocci, S., D’Ambrosio, E., Tafaro, L., Somma, V., Zannino, G., Marigliano, V., Ascenzioni, F., & Cimino-Reale, G. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.11.002 · Cited by 6
Telomere and G-Quadruplex Colocalization Analysis by Immunofluorescence Fluorescence In Situ Hybridization (IF-FISH).
Zhang, M., Liu, R., & Wang, F. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9500-4_23 · Cited by 5
Telomere length variation does not correspond with the growth disturbances in the rainbow trout (Oncorhynchus mykiss)
Panasiak, L., Szubert, K., Polonis, M., & Ocalewicz, K. (2021) · Journal of Applied Genetics · doi:10.1007/s13353-021-00669-6 · Cited by 6
Novel Efficient Cell-Penetrating, Peptide-Mediated Strategy for Enhancing Telomerase Inhibitor Oligonucleotides
Muñoz‐Alarcón, A., Eriksson, J., & Langel, Ü. (2015) · Nucleic Acid Therapeutics · doi:10.1089/nat.2015.0558 · Cited by 6
Duplicated chromosomal fragments stabilize shortened telomeres in normal human IMR‐90 cells before transition to senescence
Zahnreich, S., Krunic, D., Mel’nikova, L. M., Szejka, A., Drossel, B., Sabatier, L., Durante, M., Ritter, S., & Fournier, C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22921 · Cited by 6
Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition
Yasaei, H., Chianea, Y. G., & Slijepčević, P. (2013) · Genome Integrity · doi:10.1186/2041-9414-4-2 · Cited by 6
The differential impact of oxytocin receptor gene in violence‐exposed boys and girls
Merrill, L. C., Jones, C. W., Drury, S. S., & Theall, K. P. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.03.009 · Cited by 6
G4 DNA present at human telomeric DNA contributes toward reduced sensitivity to γ-radiation induced oxidative damage, but not bulky adduct formation
Ray, U., Sharma, S., Kapoor, I., Kumari, S., Gopalakrishnan, V., Vartak, S. V., Kumari, N., Varshney, U., & Raghavan, S. C. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1955997 · Cited by 6
Complexes of telomeric oligonucleotide d(TTAGGG)4 with the new recombinant protein vector PGEk carrying nucleic acids into proliferating cells
Ia, B., Pozmogova, G. E., Chuvilin, A. N., Shchyolkina, A. K., & Borisova, O. F. (2006) · Molecular Biology · doi:10.1134/s0026893306030101 · Cited by 6
Structural Aspects of Ku and the DNA-Dependent Protein Kinase Complex
Hendrickson, E. A., Huffman, J. L., & Tainer, J. A. (2005) · doi:10.1201/9780849352683-38 · Cited by 6
Oxidative DNA Damage and Telomere Shortening
Richter, T., & von Zglinicki, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-72974-9_8 · Cited by 6
Malleability of Short Telomeres by Telomerase Activators: A Mini-review
Paolisso, V. B. G. (2013) · Journal of Aging Science · doi:10.4172/2329-8847.1000108 · Cited by 5
Development and optimization of a cascade of screening assays for inhibitors of TRF2
Guo, T., Dong, Y., Chen, Y., Liu, L., & Sun, H. (2020) · Analytical Biochemistry · doi:10.1016/j.ab.2020.113796 · Cited by 5
Hypothesis: Paralog Formation from Progenitor Proteins and Paralog Mutagenesis Spur the Rapid Evolution of Telomere Binding Proteins
Lustig, A. J. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00010 · Cited by 5
Syndromes Associated with Telomere Shortening
Nag, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88792 · Cited by 4
Genomic Distribution of Telomeric DNA Sequences – What Do We Learn from Fish About Telomere Evolution?
Ocalewicz, K. (2012) · InTech eBooks · doi:10.5772/38397 · Cited by 5
Clinical utility of telomere length measurements in cancer
Pepper, C. J., Norris, K., & Fegan, C. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.02.012 · Cited by 5
Telomerase and non-Telomerase Mechanisms of Telomere Maintenance
Morrish, T. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.73734 · Cited by 6
Telomeres and Telomerase Regulation
Lansdorp, P. M. (2004) · Elsevier eBooks · doi:10.1016/b978-012436643-5/50101-2 · Cited by 6
Studying the biological and technical sources of variation in telomere length of individual chromosomes
de Pauw, E. S. D., Roelofs, H., Zwinderman, A. H., van Houwelingen, H. C., Fibbe, W. E., de Knijff, P., Pearson, P. L., & Tanke, H. J. (2005) · Cytometry Part A · doi:10.1002/cyto.a.20131 · Cited by 5
Telomere homolog oligonucleotides and the skin: current status and future perspectives
Shariftabrizi, A., & Eller, M. S. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00580.x · Cited by 5
Telomerase dysfunction and dyskeratosis congenita
Walne, A. J., & Dokal, I. S. (2004) · Cytotechnology · doi:10.1007/s10616-004-5121-5 · Cited by 5
Identification of alternative transcripts of the TRF1/Pin2 gene
Lages, C. S., Etienne, O., Comte, J., Gauthier, L., Granotier-Beckers, C., Pennarun, G., & Boussin, F. D. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20235 · Cited by 5
Analysis of Average Telomere Length in Cultured Human Cells
Liu, D. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-092-8_2 · Cited by 5
The Mechanism of V(D)J Recombination
Sekiguchi, J., Alt, F. W., & Oettinger, M. A. (2004) · Elsevier eBooks · doi:10.1016/b978-012053641-2/50006-x · Cited by 5
Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicity
Joo, S. Y., Sung, K., & Lee, H. (2024) · BioEssays · doi:10.1002/bies.202300229 · Cited by 3
The Association of Multiple Sensory Impairment and Telomere Length: The Health ABC Study
Vohra, V., Cheng, M. Z., Xue, Q., Simonsick, E. M., Lane, A. P., Agrawal, Y., & Rowan, N. R. (2023) · The Laryngoscope · doi:10.1002/lary.30842 · Cited by 4
Molecular inhibition of telomerase recruitment using designer peptides: anin silicoapproach
Jaiswal, A., & Lakshmi, P. T. V. (2014) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2014.953207 · Cited by 4
Telomere dynamics and genome stability in the human pancreatic tumor cell line MIAPaCa-2
Vidaček, N. Š., Ćukušić, A., Kiš, M. F., Ivanković, M., Jevtov, I., Mrsić, S. D., & Rubelj, I. (2007) · Cytogenetic and Genome Research · doi:10.1159/000109620 · Cited by 4
Molecular mechanisms of cellular senescence
Nehme, J., Varela-Eirín, M., & Demaria, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823318-4.00034-2 · Cited by 4
Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells
Lynes, M. D., Carlone, D. L., Townsend, K. L., Breault, D. T., & Tseng, Y. (2022) · Stem Cells · doi:10.1093/stmcls/sxab005 · Cited by 5
Introduction to Telomeres and Telomerase
Songyang, Z. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6892-3_1 · Cited by 4
Blood Telomerase activity and DNA Dielectric Properties in Human Hepatocellular Carcinoma and Chronic Liver Disease
Ghannam, M. M., Ibrahim, F. F., Sayed, M., & El-garem, H. A. (2008) · Biotechnology(Faisalabad) · doi:10.3923/biotech.2008.66.72 · Cited by 4
Detection of Circular Telomeric DNA without 2D Gel Electrophoresis
Dlaska, M., Anderl, C., Eisterer, W., & Bechter, O. E. (2008) · DNA and Cell Biology · doi:10.1089/dna.2008.0741 · Cited by 4
A switch‐like dynamic mechanism for the initiation of replicative senescence
Zhang, Q.-H., Tian, X., Liu, F., & Wang, W. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.09.043 · Cited by 4
Assessing the variability of telomere length measures by means of Telomeric Restriction Fragments (TRF) in different tissues of cod Gadus morhua
de Abechuco, E. L., Hartmann, N., Soto, M., & Díez, G. (2016) · Gene Reports · doi:10.1016/j.genrep.2016.09.009 · Cited by 5
Telomere Biology in Senescence and Aging
Zhu, H., & van der Harst, P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00007-1 · Cited by 5
Functional Landscape of hnRNPA3 in Disease Pathogenesis
Chen, F., Li, G., Fu, S., & Zhang, J. (2025) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70010 · Cited by 3
The Role of Telomeres in Senescence, Aging and Disease: Fiction and Reality
Saretzki, G. C. (2025) · OBM Geriatrics · doi:10.21926/obm.geriatr.2503324 · Cited by 3
Biological Aging and Venous Thromboembolism: A Review of Telomeres and Beyond
Vostatek, R., & Ay, C. (2024) · Biomedicines · doi:10.3390/biomedicines13010015 · Cited by 5
Inhibiting Telomerase Activity and Inducing Apoptosis in Cancer Cells by Several Natural Food Compounds
Turgut, D., & Soyocak, A. (2012) · InTech eBooks · doi:10.5772/53226 · Cited by 3
Stem Cell Aging
Rožman, P. J., Jazbec, K., & Jež, M. (2018) · InTech eBooks · doi:10.5772/intechopen.71764 · Cited by 4
The link between attachment orientations and cellular aging among former prisoners of war
Ein‐Dor, T., Hirschberger, G., Tsur, N., Mikulincer, M., Bazak, S. B., & Solomon, Z. (2019) · Attachment & Human Development · doi:10.1080/14616734.2019.1589545 · Cited by 3
Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions
Kitakaze, M., Chijimatsu, R., Vecchione, A. M., Kitagawa, T., Doki, Y., Eguchi, H., & Ishii, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147544 · Cited by 3
Telomerase detection using a DNA-PAINT strategy
Zong, S., Ye, X., Zong, J., Li, J., Wang, Z., & Cui, Y. (2021) · Nanotechnology · doi:10.1088/1361-6528/ac23f6 · Cited by 3
Somatic Cloning and Epigenetic Reprogramming in Mammals
Niemann, H., Kues, W. A., Lucas‐Hahn, A., & Carnwath, J. W. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00012-3 · Cited by 3
The Origin of Cancer
Yu, E. Y., & Hahn, W. C. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-8107-3_1 · Cited by 3
Role of Telomerase in Cancer Therapeutics
Choi, K. H., & Ouellette, M. M. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0131-6_6 · Cited by 3
Li-Fraumeni Syndrome and the Role of the Pediatric Nurse Practitioner
Beauchemin, M. (2011) · Clinical journal of oncology nursing · doi:10.1188/11.cjon.79-87 · Cited by 3
253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients
Orun, O., Özden, S., Tiber, P. M., Serakıncı, N., Özgen, Z., & Özyurt, H. (2014) · European Journal of Cancer · doi:10.1016/s0959-8049(14)50223-7 · Cited by 3
Fluorescence In Situ Hybridization for the Detection of Chromosome Aberrations and Aneuploidy Induced by Environmental Toxicants
Pacchierotti, F., & Sgura, A. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-548-0_13 · Cited by 3
Yeast RecQ Helicases: Clues to DNA Repair, Genome Stability and Aging
Anderson, R. M., & Sinclair, D. A. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9032-7_6 · Cited by 3
Epidemiology and Molecular Mechanisms of Hepatocarcinogenesis
El‐Serag, H. B., Lechel, A., & Rudolph, K. L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0881-3.00010-3 · Cited by 3
Subtelomeres: Evolution in the Human Genome
Rudd, M. K. (2007) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0020840 · Cited by 3
Telomeres Thrown for a Loop
Haber, J. E. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.006 · Cited by 3
The epigenetic impacts of pubertal acceleration following early caregiver disruptions
Jopling, E., Drury, S. S., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2504216122 · Cited by 2
Telomere-based treatment strategy of cardiovascular diseases: imagination comes to reality
Abdel‐Gabbar, M., & Kordy, M. G. M. (2024) · Genome Instability & Disease · doi:10.1007/s42764-024-00123-x · Cited by 2
The epigenetic impacts of pubertal acceleration following early caregiver disruptions
Jopling, E. N., Drury, S. S., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106616 · Cited by 2
The Establishment of Asian Black Bear (Ursus thibetanus) Fibroblast Cell Line
Hu, Y., Song, W., Zhang, L., Yuan, L., & Jin, Y. (2026) · Animals · doi:10.3390/ani16030436 · Cited by 2
Mutual interactions between telomere heterogeneity and cell culture growth dynamics shape stochasticity of cell aging
Nanić, L., Vidaček, N. Š., Ravlić, S., Šatović-Vukšić, E., Huzak, M., & Rubelj, I. (2017) · Biogerontology · doi:10.1007/s10522-017-9736-2 · Cited by 2
Proteomic Profiles and Protein Network Analysis of Primary Human Leukocytes Revealed Possible Clearance Biomarkers for Staphylococcus aureus Infection
Sirichoat, A., Kaewseekhao, B., Nithichanon, A., Roytrakul, S., & Faksri, K. (2023) · Current Microbiology · doi:10.1007/s00284-023-03450-6 · Cited by 2
Leukocyte Telomere Length: A Potential Biomarker for the Prognosis of Coronary Artery Disease
Sun, Y., Wang, W., Jiao, Y.-R., Ren, J. H., Gao, L., Li, Y., Hu, P., Ren, T.-Y., Han, Q.-F., Chen, C., et al. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2020-0171 · Cited by 2
Novel Hypothesis on Telomere Length: Heterogenic Targets as Genomic/Somatic Diverse Value in Breast Cancer and Brain Tumor
Mehdipour, P. (2012) · Springer eBooks · doi:10.1007/978-94-007-4632-9_5 · Cited by 2
Telomere Metabolism and DNA Damage Response
Pandita, T. K. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_7 · Cited by 2
Telomerase Mutations and Premature Ageing in Humans
Du, H., Bessler, M., & Mason, P. J. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_5 · Cited by 2
Epigenetics of Cloned Livestock Embryos and Offspring
Niemann, H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-386541-0.00036-9 · Cited by 2
NMR studies of telomeric nucleoprotein complexes involving the Myb-like domain of the human telomeric protein TRF2
Bilbille, Y., Paquet, F., Meudal, H., Giraud-Panis, M.-J. E., & Lancelot, G. (2005) · Comptes Rendus Chimie · doi:10.1016/j.crci.2005.06.016 · Cited by 2
Sequence‐Specific Binding of the Schizosaccharomyces pombe His1 Protein to Fission Yeast Telomeric DNA
Tomita, K., Uritani, M., Ushimaru, T., Yoshinaga, K., & Ueno, M. (2004) · Chemistry & Biodiversity · doi:10.1002/cbdv.200490097 · Cited by 2
Structural and energetic properties of canonical and oxidized telomeric complexes studied by molecular dynamics simulations
Czeleń, P., & Cysewski, P. (2013) · Journal of Molecular Modeling · doi:10.1007/s00894-013-1859-z · Cited by 2
Telomeres and viruses: common themes of genome
Wang, Z., & Lieberman, P. M. (2012) · Cited by 2
Protocol III: Detection of Alternative Lengthening of Telomeres
Jiang, W.-Q., Henson, J. D., Neumann, A. A., & Reddel, R. R. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_16 · Cited by 2
Cloning and sequencing of Tert gene in gilthead seabream, Sparus aurata, and European seabass, Dicentrarchus labrax: Expression patterns in germ and somatic cells
Úbeda-Manzanaro, M., Ortiz-Delgado, J. B., & Sarasquete, C. (2016) · Agri Gene · doi:10.1016/j.aggene.2016.05.003 · Cited by 2
Functional variants in CYP1B1, KRAS and MTHFR genes are associated with shorter telomere length in postmenopausal women
Cerne, J. Z., Perme, M. P., Cerkovnik, P., Geršak, K., & Novaković, S. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.05.003 · Cited by 2
Telomerase Activity in Androgenetic Rainbow Trout with Growth Deficiency and in Normally Developed Individuals
Panasiak, L., Kuciński, M., Błaszczyk, A., & Ocalewicz, K. (2022) · Zebrafish · doi:10.1089/zeb.2022.0012 · Cited by 2
EFFECT OF RADIATION ON AGING PROCESSES AND TELOMERE LENGTH
Dondoladze, K., Nikolaishvili, M., Museliani, T., & Jikia, G. (2022) · Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology · doi:10.33145/2304-8336-2022-27-107-119 · Cited by 3
Molekulare Grundlagen der Apoptose
Daniel, P. T. (2008) · Springer eBooks · doi:10.1007/978-3-540-69414-4_8 · Cited by 2
Analysis of Telomere-Homologous DNA with Different Conformations Using 2D Agarose Electrophoresis and In-Gel Hybridization
Zhang, Z., Hu, Q., & Zhao, Y. B. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6892-3_18 · Cited by 2
Telomere Binding Proteins and Disease
Blasco, M. A. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_12 · Cited by 2
Masked complex chromosome rearrangement in a child thought to have del(8qter) as the sole cytogenetic abnormality
Surace, C., Digilio, M. C., Lombardo, A., Sirleto, P., Tomaiuolo, A. C., Roberti, M. C., Capolino, R., & Angioni, A. (2008) · Cytogenetic and Genome Research · doi:10.1159/000138888 · Cited by 2
Telomere configuration influences the choice of telomere maintenance pathways
Wen, W.-Y., Tsai, H.-J., Lin, C., Tseng, S., Wong, C., & Teng, S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.011 · Cited by 2
Assignment of telomeric repeat binding factor genes TERF1 and TERF2 to Indian muntjac chromosome bands 1p32 and 2q33 by in situ hybridization
Hartmann, N., & Scherthan, H. (2005) · Cytogenetic and Genome Research · doi:10.1159/000086393 · Cited by 2
Assignment1 of the telomere-repeat binding factor genes TERF1 and TERF2 to Chinese muntjac (2n = 46) chromosome bands 12q3 and 2q33 by in situ hybridization
Hartmann, N., & Scherthan, H. (2005) · Cytogenetic and Genome Research · doi:10.1159/000085680 · Cited by 2
Engineering the End: DNA Processing at Human Telomeres
Price, C. M., & Jacob, N. K. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.024 · Cited by 2
Sulfasalazine and Chromotrope 2B reduce oxidative stress in murine bone marrow-derived mesenchymal stem cells
Iqbal, H., Naeem, N., Haneef, K., & Salim, A. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08321-8 · Cited by 1
Protective role of Cockayne Syndrome B (CSB) protein in maintaining genome integrity in human cells under oxidative stress
Low, G. K. M., Ng, G. Y.-Q., Zeegers, D., Ting, A. P. L., Gopalakrishnan, K., Khaw, A. K., Jayapal, M., & Hande, M. P. (2025) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2025.503887 · Cited by 1
Biomarkers of Cardiovascular Aging
Neki, N. S., Tappia, P. S., & Dhalla, N. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0268-2_20 · Cited by 1
Cellular Senescence and Its Relation with Telomere
Arenas-Aranda, D. J., Hernández-Caballero, M. E., & Salamanca‐G�mez, F. (2012) · InTech eBooks · doi:10.5772/32949 · Cited by 1
Telomeres and human disease
Slijepčević, P. (2007) · Acta Medica Academica · Cited by 1
Telomeres and Brain Tumors
La, D., Raffa, G., Tomasello, C., Aguennouz, M., & Germanò, A. (2013) · InTech eBooks · doi:10.5772/52426
Cellular versus Organismal Aging
Dillin, A. G., & Karlseder, J. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_1 · Cited by 1
Separating the effects of telomere size from the mechanism of telomere elongation
Lustig, A. J. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.66 · Cited by 1
Telomere Biology in T Cells: An Important Brake on the Road of Their Life Span?
Röth, A., & Baerlocher, G. M. (2009) · Clinical Leukemia · doi:10.3816/clk.2009.n.005 · Cited by 1
Progeroid syndromes: models for stem cell aging?
Bellantuono, I., Sanguinetti, G., & Keith, W. N. (2011) · Biogerontology · doi:10.1007/s10522-011-9347-2 · Cited by 1
The conservation and divergence of telomeric structures, effects, and functions
Bass, H. W. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3322-2 · Cited by 1
Telomeres, Senescence and Longevity: The Role of Oxidative Stress and Antioxidants
Saretzki, G. C. (2005) · Current Pharmacogenomics · doi:10.2174/1570160054022926 · Cited by 1
Dna Glycosylases Remove Oxidized Base Damages From G-Quadruplex Dna Structures
Zhou, J. (2015) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 1
Establishing the microcrustacean Daphnia as a model system for research on aging
Schumpert, C. A. (2015) · Scholar Commons (University of South Carolina) · Cited by 1
Replicative Senescence, Telomeres and Werner’s Syndrome
Faragher, R. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9032-7_9 · Cited by 1
Telomere Formation Systems in Budding and Fission Yeasts
Audry, J., & Runge, K. W. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86176 · Cited by 1

Authors: de Lange, T.
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2002-01-21
Volume: 21
Issue: 4
Pages: 532-540
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1205080
OpenAlex: W1541877559
Cited by: 942
References: 77
Citations by year: 2026: 3 · 2025: 7 · 2024: 13 · 2023: 12 · 2022: 14 · 2021: 15 · 2020: 19 · 2019: 27 · 2018: 18 · 2017: 28 · 2016: 29 · 2015: 26 · 2014: 41 · 2013: 36 · 2012: 36
FWCI: 12.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: telomeres, telomere capping, chromosome end protection, TRF2, T-loop, DNA damage response, DNA repair, genomic instability, telomere structure, telomere length
MeSH terms: Ku Autoantigen, Animals, Chromosome Aberrations, DNA Helicases, DNA-Binding Proteins, Humans, Models, Genetic, Nuclear Proteins, Nucleic Acid Conformation, Recombination, Genetic, Yeasts, Telomere, Cellular Senescence, Apoptosis, Protein Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Antigens, Nuclear, Telomeric Repeat Binding Protein 2, DNA-Activated Protein Kinase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Protection of mammalian telomeres

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks