Apoptosis protection and survival signal by the CD53 tetraspanin antigen
Abstract
The CD53 antigen is a tetraspanin protein of the lymphoid-myeloid lineage, but its implication in biological effects is hardly known. Radioresistant tumor cells express very high levels of this antigen. We have studied the effect of CD53 antigen ligation on the survival response of tumor cells to serum deprivation, a well-known stimulator of cell death that may mimic the tumor environment; for this aim IR938F and Jurkat cells, a B- and T-cell lymphoma, were used. Ligation of CD53 triggers a survival response and reduces the number of cells that enter apoptosis. In CD53- stimulated cells there is a significant reduction in caspase activation, measured by caspase processing of poly ADP-ribose polymerase, as well as a reduction in the fragmentation of DNA. CD53- stimulated cells also have an increase in the level of bcl-X(L) and a reduction of bax protein, two components of the mitochondrial apoptotic pathway, changing their ratio by 24-fold in the direction of survival. This survival signal appears to be mediated by activation of the AKT, as detected by its phosphorylation in Ser473 upon CD53 ligation. The CD53 antigen interactions might contribute to cell survival in poorly vascularized regions of the tumor mass.
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Several molecules demonstrated strong co-expression with IL1R1, including CD53, CD9, and ANXA1.
“Several molecules demonstrated strong co-expression with IL1R1, among which are the CD53 (CD53) and CD9 (CD9) markers, known to complex with integrins, and annexin I (ANXA1), credited with a potential anti-inflammatory activity, all of them performing important homeostatic roles by modulating innate immunity [34-36].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [35]
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- Authors
- Yunta, M., & Lazo, P. A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Lazo, Pedro A
- Venue
- Oncogene
- Published
- 2003-02-27
- Volume
- 22
- Issue
- 8
- Pages
- 1219-1224
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W1972426382
- Cited by
- 69
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 8 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- CD53, tetraspanins, apoptosis, cell survival signaling, serum deprivation, caspase activation, Bcl-xL, Bax, mitochondrial apoptosis, Akt phosphorylation, lymphoma cells, tumor hypoxia
- MeSH terms
- Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Cell Survival, Cysteine Endopeptidases, Enzyme Activation, Humans, Neoplasm Proteins, Phosphorylation, Poly(ADP-ribose) Polymerases, Protein Processing, Post-Translational, Proto-Oncogene Proteins, Tumor Cells, Cultured, Antigens, CD, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Leukemic, Lymphoma, B-Cell, Culture Media, Serum-Free, Apoptosis, Protein Serine-Threonine Kinases, Jurkat Cells, Proto-Oncogene Proteins c-bcl-2, bcl-X Protein, bcl-2-Associated X Protein, Proto-Oncogene Proteins c-akt, Rats, DNA Fragmentation, Tetraspanin 25
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