CoChat
Sign Up
Cited by 107

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Interaction of the HPV E7 proteins with the pCAF acetyltransferase

Avvakumov, Nikita, Torchia, Joe, Mymryk, Joe S·2003·Oncogene
DOI 10.1038/sj.onc.1206562
Open this paper in CoChat — free account

Abstract

Most cervical carcinomas express the E6 and E7 proteins of a high-risk human papillomavirus (HPV). These proteins affect growth control by interfering with the functions of cell regulatory proteins, promoting oncogenic transformation. A key target of E7 is the tumor suppressor protein pRb, which directly interacts with E7. However, binding to additional cellular regulatory proteins is clearly required for oncogenesis, as mutants of E7 have been identified that bind to pRb, yet fail to transform efficiently. Here we demonstrate the interaction of the HPV 6, 16 and 18 E7 proteins with the pCAF acetyltransferase, which has been reported to function as a coactivator for a variety of transcription factors including p53. Mutation of a highly conserved leucine residue within the zinc finger region of HPV 16 E7 disrupts binding to pCAF and also impairs transformation and transcriptional activation. HPV 16 E7 interacts with the acetyltransferase domain of pCAF, and reduces its acetyltransferase activity in vitro. Our analysis of the interaction between the pCAF acetyltransferase and E7 provides new insight into the mechanisms by which the E7 oncoproteins can alter cellular gene expression and growth.

Overview

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1206562

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 4 references

Research works printed but not linked: 47

  1. Adams A, Gottschling DE, Kaiser CA and Stearns T (ed) (1998). Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press: Plainview, NY.
  2. Berezutskaya E and Bagchi S . (1997). J. Biol. Chem., 272, 30135–30140. · DOI
  3. Berger SL, Pina B, Silverman N, Marcus GA, Agapite J, Regier JL, Triezenberg SJ and Guarente L . (1992). Cell, 70, 251–265. · DOI · Paper page
  4. Blanco JC, Minucci S, Lu J, Yang XJ, Walker KK, Chen H, Evans RM, Nakatani Y and Ozato K . (1998). Genes Dev., 12, 1638–1651. · DOI
  5. Brehm A, Nielsen SJ, Miska EA, McCance DJ, Reid JL, Bannister AJ and Kouzarides T . (1999a). EMBO J., 18, 2449–2458. · DOI · Paper page
  6. Brehm A, Ohbo K, Zwerschke W, Botquin V, Jansen-Durr P and Scholer HR . (1999b). Mol. Cell. Biol., 19, 2635–2643. · DOI
  7. Bryant LA, Mixon P, Davidson M, Bannister AJ, Kouzarides T and Sinclair JH . (2000). J. Virol., 74, 7230–7237. · DOI
  8. Carter JJ, Yaegashi N, Jenison SA and Galloway DA . (1991). Virology, 182, 513–521. · DOI
  9. Chan HM, Krstic-Demonacos M, Smith L, Demonacos C and La Thangue NB . (2001). Nat. Cell Biol., 3, 667–674. · DOI
  10. Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC and Nevins JR . (1992). Proc. Natl. Acad. Sci. USA, 89, 4549–4553. · DOI
  11. Demers GW, Espling E, Harry JB, Etscheid BG and Galloway DA . (1996). J. Virol., 70, 6862–6869. · DOI
  12. Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR and Goff SP . (1994). Cell, 79, 119–130. · DOI
  13. Dyson N, Guida P, Munger K and Harlow E . (1992). J. Virol., 66, 6893–6902. · DOI · Paper page
  14. Edmonds C and Vousden KH . (1989). J. Virol., 63, 2650–2656. · DOI
  15. Gulliver GA, Herber RL, Liem A and Lambert PF . (1997). J. Virol., 71, 5905–5914. · DOI · Paper page
  16. Halbert CL, Demers GW and Galloway DA . (1991). J. Virol., 65, 473–478. · DOI · Paper page
  17. Hamamori Y, Sartorelli V, Ogryzko V, Puri PL, Wu HY, Wang JY, Nakatani Y and Kedes L . (1999). Cell, 96, 405–413. · DOI · Paper page
  18. Herber R, Liem A, Pitot H and Lambert PF . (1996). J. Virol., 70, 1873–1881. · DOI
  19. Huang SM and McCance DJ . (2002). J. Virol., 76, 8710–8721. · DOI · Paper page
  20. Itoh S, Ericsson J, Nishikawa J, Heldin CH and Dijke P . (2000). Nucleic Acids Res., 28, 4291–4298. · DOI
  21. Jewers RJ, Hildebrandt P, Ludlow JW, Kell B and McCance DJ . (1992). J. Virol., 66, 1329–1335. · DOI
  22. Jiang H, Lu H, Schiltz RL, Pise-Masison CA, Ogryzko VV, Nakatani Y and Brady JN . (1999). Mol. Cell. Biol., 19, 8136–8145. · DOI
  23. Jones DL, Alani RM and Munger K . (1997). Genes Dev., 11, 2101–2111. · DOI · Paper page
  24. Kuo MH and Allis CD . (1998). Bioessays, 20, 615–626. · DOI
  25. Kurooka H and Honjo T . (2000). J. Biol. Chem., 275, 17211–17220. · DOI
  26. Liu Y, Colosimo AL, Yang XJ and Liao D . (2000). Mol. Cell. Biol., 20, 5540–5553. · DOI
  27. Luscher-Firzlaff JM, Westendorf JM, Zwicker J, Burkhardt H, Henriksson M, Muller R, Pirollet F and Luscher B . (1999). Oncogene, 18, 5620–5630. · DOI
  28. Massimi P and Banks L . (1997). Virology, 227, 255–259. · DOI
  29. Massimi P, Pim D and Banks L . (1997). J. Gen. Virol., 78(Part 10), 2607–2613. · DOI
  30. Munger K, Werness BA, Dyson N, Phelps WC, Harlow E and Howley PM . (1989). EMBO J., 8, 4099–4105. · DOI · Paper page
  31. Ogryzko VV, Kotani T, Zhang X, Schlitz RL, Howard T, Yang XJ, Howard BH, Qin J and Nakatani Y . (1998). Cell, 94, 35–44. · DOI
  32. Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE and Um SJ . (2000). J. Biol. Chem., 275, 6764–6769. · DOI · Paper page
  33. Phelps WC, Munger K, Yee CL, Barnes JA and Howley PM . (1992). J. Virol., 66, 2418–2427. · DOI · Paper page
  34. Phelps WC, Yee CL, Munger K and Howley PM . (1988). Cell, 53, 539–547. · DOI · Paper page
  35. Polesskaya A, Duquet A, Naguibneva I, Weise C, Vervisch A, Bengal E, Hucho F, Robin P and Harel-Bellan A . (2000). J. Biol. Chem., 275, 34359–34364. · DOI
  36. Roberts SM and Winston F . (1997). Genetics, 147, 451–465. · DOI
  37. Schiltz RL and Nakatani Y . (2000). Biochim. Biophys. Acta, 1470, M37–M53. · DOI
  38. Sheppard KA, Rose DW, Haque ZK, Kurokawa R, McInerney E, Westin S, Thanos D, Rosenfeld MG, Glass CK and Collins T . (1999). Mol. Cell. Biol., 19, 6367–6378. · DOI
  39. Song S, Gulliver GA and Lambert PF . (1998). Proc. Natl. Acad. Sci. USA, 95, 2290–2295. · DOI
  40. Spilianakis C, Papamatheakis J and Kretsovali A . (2000). Mol. Cell. Biol., 20, 8489–8498. · DOI
  41. Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG and Benchimol S . (1997). EMBO J., 16, 6018–6033. · DOI
  42. Vousden K . (1993). FASEB J., 7, 872–879. · DOI
  43. Wang L, Grossman SR and Kieff E . (2000). Proc. Natl. Acad. Sci. USA, 97, 430–435. · DOI
  44. Xue Y, Wong J, Moreno GT, Young MK, Cote J and Wang W . (1998). Mol. Cell, 2, 851–861. · DOI
  45. Yang XJ, Ogryzko VV, Nishikawa J, Howard BH and Nakatani Y . (1996). Nature, 382, 319–324. · DOI
  46. zur Hausen H . (1996). Biochim. Biophys. Acta, 1288, F55–F78. · DOI
  47. zur Hausen H and de Villiers EM . (1994). Annu. Rev. Microbiol., 48, 427–447. · DOI

Cited by

See all 107

Metadata

Authors
Avvakumov, N., Torchia, J., & Mymryk, J. S.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2003-06-17
Volume
22
Issue
25
Pages
3833-3841
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/sj.onc.1206562
Cited by
107
References
4
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Interaction of the HPV E7 proteins with the pCAF acetyltransferase. https://app.cochat.ai/papers/10.1038/sj.onc.1206562
The paper
Avvakumov, N., Torchia, J., & Mymryk, J. S. (2003). Interaction of the HPV E7 proteins with the pCAF acetyltransferase. Oncogene. https://doi.org/10.1038/sj.onc.1206562