The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
Abstract
The contribution of the E6 and E7 open reading frames of human papillomavirus type 6b (HPV6b) and HPV16 to immortalization of human keratinocytes was evaluated by using amphotropic recombinant retroviruses. The HPV16 E7 gene could immortalize primary human keratinocytes without the cooperation of the viral E6 gene; however, E6 was able to contribute significantly to the efficiency of the E7 immortalizing function. Infection of HFE cells with retroviruses carrying the 16E6, 6bE6, or 6bE6E7 open reading frame did not result in immortalization.
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“co-transformation assays in murine kidney cells and human mammary epithelial cells established that HPV-16 E6 has transforming properties, inducing anchorage-independent growth and tumour formation in nude mice [95,96]; however, low-risk E6 were unable to do so [97]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [97]
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Cites
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
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Cited by
Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206
Self-citationChen, L., Ashe, S., Brady, W. A., Hellström, I., Hellström, K. E., Ledbetter, J. A., McGowan, P., & Linsley, P. S. (1992) · Cell · doi:10.1016/s0092-8674(05)80059-5 · Cited by 1,050
Different telomere damage signaling pathways in human and mouse cells
Smogorzewska, A., & de Lange, T. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf433 · Cited by 482
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
Gray-Schopfer, V. C., Cheong, S. C., Chong, H., Chow, J., Moss, T., Abdel-Malek, Z. A., Marais, R., Wynford-Thomas, D., & Bennett, D. C. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603283 · Cited by 394
Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle
Verdun, R. E., Crabbe, L., Haggblom, C., & Karlseder, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.024 · Cited by 284
Metadata
- Authors
- Halbert, C. L., Demers, G. W., & Galloway, D. A.
- Affiliations
- Fred Hutchinson Cancer Research Center, Seattle, Washington 98104-2092.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1991-01
- Volume
- 65
- Issue
- 1
- Pages
- 473-478
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 462
- References
- 1
- Language
- en
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- CoChat. (2026). Citation check: The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. https://app.cochat.ai/papers/10.1128/jvi.65.1.473-478.1991
- The paper
- Halbert, C. L., Demers, G. W., & Galloway, D. A. (1991). The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. Journal of Virology. https://doi.org/10.1128/jvi.65.1.473-478.1991
