The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis
Abstract
Progressive advances using zebrafish as a model organism have provided hematologists with an additional genetic system to study blood cell formation and hematological malignancies. Despite extensive evolutionary divergence between bony fish (teleosts) and mammals, the molecular pathways governing hematopoiesis have been highly conserved. As a result, most (if not all) of the critical hematopoietic transcription factor genes identified in mammals have orthologues in zebrafish. As in other vertebrates, all of the teleost blood lineages are believed to originate from a pool of pluripotent, self-renewing hematopoietic stem cells. Here, we provide a detailed review of the timing, anatomical location, and transcriptional regulation of zebrafish 'primitive' and 'definitive' hematopoiesis as well as discuss a model of T-cell leukemia and recent advances in blood cell transplantation. Given that many of the regulatory genes that control embryonic hematopoiesis have been implicated in oncogenic pathways in adults, an understanding of blood cell ontogeny is likely to provide insights into the pathophysiology of human leukemias.
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“Hematopoiesis in zebrafish embryos occurs in three distinct waves: primitive, transient, and definitive (Davidson & Zon, 2004).”
From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Davidson & Zon, 2004
In the citing paper
“The primitive wave initiates the generation of blood cells to supply oxygen and establish the immune system (Davidson & Zon, 2004; Kulkeaw & Sugiyama, 2012).”
From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Davidson & Zon, 2004
Citations
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The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish
Hall, C. J., Flores, M. V., Storm, T., Crosier, K., & Crosier, P. S. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-42 · Cited by 589
Murayama, E., Kissa, K., Zapata, A. G., Mordelet, E., Briolat, V., Lin, H.-F., Handin, R. I., & Herbomel, P. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.015 · Cited by 545
Molecular Genetics of Axis Formation in Zebrafish
Schier, A. F., & Talbot, W. S. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143752 · Cited by 499
Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases
Novoa, B., & Figueras, A. J. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_15 · Cited by 297
Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface
Hunter, M. V., Moncada, R. M., Weiss, J. M., Yanai, I., & White, R. M. (2021) · Nature Communications · doi:10.1038/s41467-021-26614-z · Cited by 295
Metadata
- Authors
- Davidson, A. J., & Zon, L. I.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Zon, Leonard I
- Venue
- Oncogene
- Published
- 2004-09-20
- Volume
- 23
- Issue
- 43
- Pages
- 7233-7246
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2032417286
- Cited by
- 419
- References
- 108
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 19 · 2023: 12 · 2022: 21 · 2021: 18 · 2020: 18 · 2019: 20 · 2018: 25 · 2017: 24 · 2016: 26 · 2015: 16 · 2014: 25 · 2013: 17 · 2012: 21
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- definitive hematopoiesis, primitive hematopoiesis, hematopoietic stem cells, hematopoietic transcription factors, orthologs, T-cell leukemia, hematologic malignancies, leukemogenesis
- MeSH terms
- Animals, Blood Cells, Embryo, Nonmammalian, Forecasting, Gastrula, Genetic Complementation Test, Growth Substances, Hematopoiesis, Hematopoietic Stem Cells, Leukemia, Mesoderm, Radiation Chimera, Transcription Factors, Transcription, Genetic, Zebrafish, Mutagenesis, Hematopoietic Stem Cell Transplantation, Gene Expression Regulation, Developmental, Cell Lineage, Models, Animal, Zebrafish Proteins, Animals, Genetically Modified, Pluripotent Stem Cells
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