Zon, Leonard I.

The zebrafish reference genome sequence and its relationship to the human genome.

Howe, K., Clark, M. D., Torroja, C. F., Torrance, J., Berthelot, C., Muffato, M., Collins, J. E., Humphray, S., McLaren, K., Matthews, L., et al. (2013) · Nature

Zebrafish Biomedical Research ApplicationsGenomics and Phylogenetic Studies

Cited by 5,100

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

Orkin, S. H., & Zon, L. I. (2008) · Cell

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 2,570

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature

Iron Metabolism and DisordersTrace Elements in Health

Cited by 1,667

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

White, R. M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C., Bourque, C., Dovey, M., Goessling, W., Burns, C. E., et al. (2008) · Cell Stem Cell

Zebrafish Biomedical Research ApplicationsHematopoietic Stem Cell Transplantation

Cited by 1,408

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 1,275

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants

Traver, D., Paw, B. H., Poss, K. D., Penberthy, W. T., Lin, S., & Zon, L. I. (2003) · Nature Immunology

Zebrafish Biomedical Research ApplicationsHematopoietic Stem Cell Transplantation

Cited by 800

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

Lian, C. G., Xu, Y., Ceol, C., Wu, F., Larson, A., Dresser, K., Xu, W., Tan, L., Hu, Y., Zhan, Q., et al. (2012) · Cell

Epigenetics and DNA MethylationChromatin Remodeling and Cancer

Cited by 789

Mitoferrin is essential for erythroid iron assimilation

Shaw, G. C., Cope, J. J., Li, L., Corson, K., Hersey, C., Ackermann, G. E., Gwynn, B., Lambert, A. J., Wingert, R. A., Traver, D., et al. (2006) · Nature

Iron Metabolism and DisordersMitochondrial Function and Pathology

Cited by 624

Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism

Protas, M. E., Hersey, C., Kochanek, D., Zhou, Y., Wilkens, H., Jeffery, W. R., Zon, L. I., Borowsky, R., & Tabin, C. J. (2006) · Nature Genetics

Subterranean biodiversity and taxonomymelanin and skin pigmentation

Cited by 543

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

Ceol, C. J., Houvras, Y., Jane-Valbuena, J., Bilodeau, S., Orlando, D. A., Battisti, V., Fritsch, L., Lin, W. M., Hollmann, T. J., Ferré, F., et al. (2011) · Nature

Melanoma and MAPK PathwaysZebrafish Biomedical Research Applications

Cited by 542

The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis

Davidson, A. J., & Zon, L. I. (2004) · Oncogene

Zebrafish Biomedical Research ApplicationsHematopoietic Stem Cell Transplantation

Cited by 419

Hematopoietic stem cell fate is established by the Notch-Runx pathway

Burns, C. E., Traver, D., Mayhall, E., Shepard, J. L., & Zon, L. I. (2005) · Genes & Development

Hematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

Cited by 401

An orthologue of the kit -related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio

Parichy, D. M., Ransom, D. G., Paw, B., Zon, L. I., & Johnson, S. L. (2000) · Development

melanin and skin pigmentationDevelopmental Biology and Gene Regulation

Cited by 384

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

The Tübingen 2000 Screen Consortium, Wingert, R. A., Galloway, J. L., Barut, B., Foott, H., Fraenkel, P., Axe, J. L., Weber, G. J., Dooley, K., Davidson, A. J., et al. (2005) · Nature

Iron Metabolism and DisordersHemoglobin structure and function

Cited by 370

Effects of RAS on the genesis of embryonal rhabdomyosarcoma

Langenau, D. M., Keefe, M. D., Storer, N. Y., Guyon, J. R., Kutok, J. L., Le, X., Goessling, W., Neuberg, D. S., Kunkel, L. M., & Zon, L. I. (2007) · Genes & Development

Sarcoma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 320

Transcription factors interact with RNA to regulate genes

Oksuz, O., Henninger, J. E., Warneford-Thomson, R., Zheng, M. M., Erb, H., Vancura, A., Overholt, K. J., Hawken, S. W., Banani, S. F., Lauman, R., et al. (2023) · Molecular Cell

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 275

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease

Burberry, A., Suzuki, N., Wang, J.-Y., Moccia, R., Mordes, D. A., Stewart, M. H., Suzuki-Uematsu, S., Ghosh, S., Singh, A., Merkle, F. T., et al. (2016) · Science Translational Medicine

Amyotrophic Lateral Sclerosis ResearchT-cell and B-cell Immunology

Cited by 269

Loss of Gata1 but Not Gata2 Converts Erythropoiesis to Myelopoiesis in Zebrafish Embryos

Galloway, J. L., Wingert, R. A., Thisse, C., Thisse, B., & Zon, L. I. (2005) · Developmental Cell

Hematopoietic Stem Cell TransplantationZebrafish Biomedical Research Applications

Cited by 242

Activation of the erythropoietin receptor promoter by transcription factor GATA-1.

Zon, L. I., Youssoufian, H., Mather, C., Lodish, H. F., & Orkin, S. H. (1991) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentHemoglobinopathies and Related Disorders

Cited by 221

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

Avagyan, S., Henninger, J. E., Mannherz, W. P., Mistry, M., Yoon, J., Yang, S., Weber, M. C., Moore, J. L., & Zon, L. I. (2021) · Science

Acute Myeloid Leukemia ResearchZebrafish Biomedical Research Applications

Cited by 192

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., et al. (2018) · Cancer Cell

Melanoma and MAPK PathwaysEpigenetics and DNA Methylation

Cited by 156

Cross-species analysis of enhancer logic using deep learning

Minnoye, L., Taskiran, I. I., Mauduit, D., Fazio, M., Van Aerschot, L., Hulselmans, G., Christiaens, V., Makhzami, S., Seltenhammer, M., Karras, P., et al. (2020) · Genome Research

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 116

Clonal hematopoiesis and inflammation – the perpetual cycle

Avagyan, S., & Zon, L. I. (2023) · Trends in Cell Biology

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 79

Structural basis for inactivation of PRC2 by G-quadruplex RNA

Song, J., Gooding, A. R., Hemphill, W. O., Love, B. D., Robertson, A., Yao, L., Zon, L. I., North, T. E., Kasinath, V., & Cech, T. R. (2023) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 73