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Cited by 117

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins

Thomas, Miranda, Massimi, Paola, Navarro, Christel, Borg, Jean-Paul, Banks, Lawrence·2005·Oncogene
DOI 10.1038/sj.onc.1208757
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Abstract

The E6 proteins of the high-risk Human papillomaviruses (HPV) types have a well-documented ability to target certain cellular proteins for ubiquitin-mediated degradation via the proteasome. Previous studies have shown that E6 proteins interact differently with different target proteins, and that the viral proteins, depending upon the target, may recruit diverse cellular ubiquitin-protein ligases. In this study, we have examined the abilities of E6 proteins from HPV-16 and HPV-18 to interact with and induce the degradation of two PDZ domain-containing targets, Dlg and hScrib. We have also mapped the binding site of E6 on hScrib and shown that the interaction of E6 with hScrib is distinct from its interactions with other PDZ domain-containing targets. This is reflected in the efficiency with which the two viral E6 proteins can inhibit hScrib's suppression of cell transformation.Dlg and hScrib have complementary activities in the control of epithelial cell polarity and the fact that both are targeted by high-risk HPV E6 proteins underlines their importance. Our finding that they are each targeted differently by HPV-16 and HPV-18 E 6 s suggests that the two viruses are subjected to somewhat different constraints and provides a possible explanation for the apparent redundancy in targeting both parts of this important control mechanism.

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Crossref · 10.1038/sj.onc.1208757

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Research works printed but not linked: 35

  1. Bilder D . (2004). Genes Dev., 18, 1909–1925. · DOI
  2. Bilder D, Li M and Perrimon N . (2000). Science, 289, 113–116. · DOI
  3. Bilder D, Schober M and Perrimon N . (2003). Nat. Cell Biol., 5, 53–58. · DOI · Paper page
  4. Bryant PJ and Huwe A . (2000). Nat. Cell Biol., 2, E141–3. · DOI
  5. Cavatorta AL, Fumero G, Chouhy D, Aguirre R, Nocito AL, Giri AA, Banks L and Gardiol D . (2004). Int. J. Cancer, 111, 373–380. · DOI
  6. Dobrosotskaya IY and James GL . (2000). Biochem. Biophys. Res. Commun., 270, 903–909. · DOI
  7. Dobrosotskaya IY . (2001). Biochem. Biophys. Res. Commun., 283, 969–975. · DOI
  8. Dow LE, Brumby AM, Muratore R, Coombe ML, Sedelies KA, Trapani JA, Russell SM, Richardson HE and Humbert PO . (2003). Oncogene, 22, 9225–9230. · DOI
  9. Gardiol D, Galizzi S and Banks L . (2002). J. Gen. Virol., 83, 283–289. · DOI
  10. Gardiol D, Kuhne C, Glaunsinger B, Lee SS, Javier R and Banks L . (1999). Oncogene, 18, 5487–5496. · DOI · Paper page
  11. Glaunsinger BA, Lee SS, Thomas M, Banks L and Javier R . (2000). Oncogene, 19, 5270–5280. · DOI · Paper page
  12. Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A and Cavicchi S Strand D . (2004). Oncogene, 23, 8688–8694. · DOI
  13. Humbert P, Russell S and Richardson H . (2003). Bioessays, 6, 542–553. · DOI
  14. Kiyono T, Hiraiwa A, Fujita M, Hayashi Y, Akiyama T and Ishibashi M . (1997). Proc. Natl. Acad. Sci. USA, 94, 11612–11616. · DOI · Paper page
  15. Lee SS, Weiss RS and Javier RT . (1997). Proc. Natl. Acad. Sci. USA, 94, 6670–6675. · DOI · Paper page
  16. Massimi P, Gammoh N, Thomas M and Banks L . (2004). Oncogene, 23, 8033–8039. · DOI
  17. Massimi P, Gardiol D, Roberts S and Banks L . (2003). Exp. Cell Res., 290, 265–274. · DOI
  18. Mathew D, Gramates LS, Packard M, Thomas U, Bilder D, Perrimon N and Gorczyca M Budnik V . (2002). Curr. Biol., 12, 531–539. · DOI · Paper page
  19. Nakagawa S and Huibregtse JM . (2000). Mol. Cell Biol., 20, 8244–8253. · DOI · Paper page
  20. Nakagawa S, Yano T, Nakagawa K, Takizawa S, Suzuki Y, Yasugi T, Huibregtse JM and Taketani Y . (2004). Br. J. Cancer, 90, 194–199. · DOI
  21. Pim D, Thomas M and Banks L . (2002). Oncogene, 21, 8140–8148. · DOI
  22. Pim D, Thomas M, Javier R, Gardiol D and Banks L . (2000). Oncogene, 19, 719–725. · DOI
  23. Saras J and Heldin CH . (1996). Trends Biochem. Sci., 12, 455–458. · DOI
  24. Tanentzapf G and Tepass U . (2003). Nat. Cell Biol., 5, 46–52. · DOI · Paper page
  25. Thomas M, Glaunsinger B, Pim D, Javier R and Banks L . (2001). Oncogene, 20, 5431–5439. · DOI
  26. Thomas M, Kalita A, Labreque S, Pim D, Banks L and Matlashewski G . (1999). Mol. Cell. Biol., 19, 1092–1100. · DOI
  27. Thomas M, Laura R, Hepner K, Guccione E, Sawyers C, Lasky L and Banks L . (2002). Oncogene, 21, 5088–5096. · DOI
  28. Thomas U, Phannavong B, Muller B, Garner CC and Gundelfinger ED . (1997). Mech. Dev., 62, 161–174. · DOI
  29. Watson RA, Rollason TP, Reynolds GM, Murray PG, Banks L and Roberts S . (2002). Carcinogenesis, 11, 1791–1796. · DOI
  30. Watson RA, Thomas M, Banks L and Roberts S . (2003). J. Cell Sci., 116, 4925–4934. · DOI
  31. Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S and Axel R . (1979). Cell, 16, 777–785. · DOI
  32. Woods DF and Bryant PJ . (1991). Cell, 66, 451–464. · DOI
  33. Woods DF, Hough C, Peel D, Callaini G and Bryant PJ . (1996). J. Cell Biol., 134, 1469–1482. · DOI · Paper page
  34. Woods DF, Wu JW and Bryant PJ . (1997). Dev. Genet., 20, 111–118. · DOI
  35. zur Hausen H . (1991). Virology, 184, 9–13. · DOI

Cited by

Metadata

Authors
Thomas, M., Massimi, P., Navarro, C., Borg, J.-P., & Banks, L.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2005-08-15
Volume
24
Issue
41
Pages
6222-6230
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/sj.onc.1208757
Cited by
117
References
4
Language
en
Licence

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