The Scribble family in cancer: twentieth anniversary

The Phyre2 web portal for protein modeling, prediction and analysis

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Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

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The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

Cordenonsi, M., Zanconato, F., Azzolin, L., Forcato, M., Rosato, A., Frasson, C., Inui, M., Montagner, M., Parenti, A. R., Poletti, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.048 · Cited by 1,381 · see citing works

The leucine-rich repeat: a versatile binding motif

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Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

Bilder, D., & Perrimon, N. (2000) · Nature · doi:10.1038/35001108 · Cited by 716 · see citing works

The Varied Roles of Notch in Cancer

Aster, J. C., Pear, W. S., & Blacklow, S. C. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100127 · Cited by 707 · see citing works

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

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The basic biology of HER2

Rubin, I., & Yarden, Y. (2001) · Annals of Oncology · doi:10.1093/annonc/12.suppl_1.s3 · Cited by 502 · see citing works

PDZ Domain Proteins: Plug and Play!

Nourry, C., Grant, S. G. N., & Borg, J. (2003) · Science Signaling · doi:10.1126/stke.2003.179.re7 · Cited by 490 · see citing works

Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase

Nakagawa, S., & Huibregtse, J. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8244-8253.2000 · Cited by 466 · see citing works

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436 · see citing works

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

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Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Montcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J. D., Forge, A., Rachel, R. A., Copeland, N. G., Jenkins, N. A., Bogani, D., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4680-05.2006 · Cited by 322 · see citing works

ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

Borg, J., Marchetto, S., Bivic, A. L., Ollendorff, V., Jaulin‐Bastard, F., Saito, H., Fournier, E., Adélaı̈de, J., Margolis, B. L., & Birnbaum, D. (2000) · Nature Cell Biology · doi:10.1038/35017038 · Cited by 311 · see citing works

A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

Ludford‐Menting, M., Oliaro, J., Sacirbegovic, F., Cheah, E. T.-Y., Pedersen, N., Thomas, S. J., Pasam, A., Iazzolino, R. M., Dow, L. E., Waterhouse, N. J., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.009 · Cited by 266 · see citing works

Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration

Osmani, N., Vitale, N., Borg, J.-P., & Etienne-Manneville, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.026 · Cited by 239 · see citing works

Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

Navarro, C., Nola, S., Audebert, S., Santoni, M.-J., Arsanto, J.-P., Ginestier, C., Marchetto, S., Jacquemier, J., Isnardon, D., Le Bivic, A., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208632 · Cited by 237 · see citing works

Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor

Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lécine, P., Bellaiche, Y., Dupont, J.-L., Premont, R. T., Sempéré, C., Strub, J.-M., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.051 · Cited by 218 · see citing works

LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans

Legouis, R., Gansmuller, A., Sookhareea, S., Bosher, J. M., Baillie, D. L., & Labouesse, M. (2000) · Nature Cell Biology · doi:10.1038/35017046 · Cited by 189 · see citing works

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

Dow, L. E., Kauffman, J. S., Caddy, J., Peterson, A. S., Jane, S. M., Russell, S. M., & Humbert, P. O. (2007) · Oncogene · doi:10.1038/sj.onc.1210016 · Cited by 187 · see citing works

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58509 · Cited by 185 · see citing works

A Role for Erbin in the Regulation of Nod2-dependent NF-κB Signaling

McDonald, C., Chen, F. F., Ollendorff, V., Ogura, Y., Marchetto, S., Lécine, P., Borg, J., & Núñez, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508538200 · Cited by 178 · see citing works

Characterization of Densin-180, a New Brain-Specific Synaptic Protein of theO-Sialoglycoprotein Family

Apperson, M., Moon, I. S., & Kennedy, M. B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06839.1996 · Cited by 163 · see citing works

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

Skouloudaki, K., Puetz, M., Simons, M., Courbard, J.-R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M. J., Englert, C., Bollig, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811691106 · Cited by 163 · see citing works

Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains

Kallay, L. M., McNickle, A., Brennwald, P. J., Hubbard, A. L., & Braiterman, L. T. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20992 · Cited by 156 · see citing works

Basolateral targeting by leucine‐rich repeat domains in epithelial cells

Legouis, R., Jaulin‐Bastard, F., Schott, S., Navarro, C., Borg, J., & Labouesse, M. (2003) · The EMBO Reports · doi:10.1038/sj.embor.7400006 · Cited by 153 · see citing works

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

Robertson, J. M., Jacquemet, G., Byron, A., Jones, M., Warwood, S., Selley, J. N., Knight, D., Humphries, J. D., & Humphries, M. J. (2015) · Nature Communications · doi:10.1038/ncomms7265 · Cited by 144 · see citing works

Double agents: genes with both oncogenic and tumor-suppressor functions

Shen, L., Shi, Q., & Wang, W. (2018) · Oncogenesis · doi:10.1038/s41389-018-0034-x · Cited by 142 · see citing works

The Erbin PDZ Domain Binds with High Affinity and Specificity to the Carboxyl Termini of δ-Catenin and ARVCF

Laura, R. P., Witt, A. S., Held, H. A., Gerstner, R. B., Deshayes, K., Koehler, M. F. T., Kosik, K. S., Sidhu, S. S., & Lasky, L. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200818200 · Cited by 141 · see citing works

The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer

Nolan, M. E., Aranda, V., Lee, S., Lakshmi, B. V., Basu, S., Allred, D. C., & Muthuswamy, S. K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6567 · Cited by 139 · see citing works

Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer

Feigin, M. E., Akshinthala, S. D., Araki, K., Rosenberg, A. Z., Muthuswamy, L. B., Martin, B., Lehmann, B. D., Berman, H. K., Pietenpol, J. A., Cardiff, R. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3415 · Cited by 135 · see citing works

Domains controlling cell polarity and proliferation in the <i>Drosophila</i> tumor suppressor Scribble

Zeitler, J., Hsu, C. P., Dionne, H., & Bilder, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200407158 · Cited by 135 · see citing works

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

Ivarsson, Y., Arnold, R., McLaughlin, M., Nim, S., Joshi, R., Ray, D., Liu, B., Teyra, J., Pawson, T., Moffat, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312296111 · Cited by 135 · see citing works

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

Harmon, R. M., Simpson, C. L., Johnson, J. L., Koetsier, J. L., Dubash, A. D., Najor, N. A., Sarig, O., Sprecher, E., & Green, K. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65220 · Cited by 134 · see citing works

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Stephens, R., Lim, K., Portela, M., Kvansakul, M., Humbert, P. O., & Richardson, H. E. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.01.011 · Cited by 132 · see citing works

The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins

Thomas, M., Massimi, P., Navarro, C., Borg, J., & Banks, L. (2005) · Oncogene · doi:10.1038/sj.onc.1208757 · Cited by 128 · see citing works

Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

Bonello, T. T., & Peifer, M. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201810103 · Cited by 127 · see citing works

A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression

Anastas, J. N., Biechele, T. L., Robitaille, M., Muster, J., Allison, K. H., Angers, S., & Moon, R. T. (2011) · Oncogene · doi:10.1038/onc.2011.528 · Cited by 126 · see citing works

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

Dow, L. E., Brumby, A. M., Muratore, R., Coombe, M. L., Sedelies, K. A., Trapani, J. A., Russell, S. M., Richardson, H. E., & Humbert, P. O. (2003) · Oncogene · doi:10.1038/sj.onc.1207154 · Cited by 120 · see citing works

Erbin Suppresses the MAP Kinase Pathway

Huang, Y. Z., Zang, M., Xiong, W., Luo, Z., & Mei, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205413200 · Cited by 120 · see citing works

ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity

Chen, B., Zheng, B., DeRan, M., Jarugumilli, G. K., Fu, J., Brooks, Y. S., & Wu, X. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2119 · Cited by 119 · see citing works

An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth

Young, L. C., Hartig, N., Muñoz-Alegre, M., Osés-Prieto, J. A., Durdu, S., Bender, S., Vijayakumar, V., Rudan, M. V., Gewinner, C. A., Henderson, S. R., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.004 · Cited by 118 · see citing works

Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix

Nakagawa, S., Yano, T., Nakagawa, K., Takizawa, S., Suzuki, Y., Yasugi, T., Huibregtse, J. M., & Taketani, Y. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601465 · Cited by 112 · see citing works

Novel Mode of Ligand Recognition by the Erbin PDZ Domain

Birrane, G., Chung, J., & Ladias, J. A. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200571200 · Cited by 111 · see citing works

Scrib regulates PAK activity during the cell migration process

Nola, S., Sebbagh, M., Marchetto, S., Osmani, N., Nourry, C., Audebert, S., Navarro, C., Rachel, R. A., Montcouquiol, M., Sans, N., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn248 · Cited by 108 · see citing works

The ESEV PDZ-Binding Motif of the Avian Influenza A Virus NS1 Protein Protects Infected Cells from Apoptosis by Directly Targeting Scribble

Liu, H., Golebiewski, L., Dow, E. C., Krug, R. M., Javier, R. T., & Rice, A. P. (2010) · Journal of Virology · doi:10.1128/jvi.01278-10 · Cited by 102 · see citing works

Circletail, a New Mouse Mutant with Severe Neural Tube Defects: Chromosomal Localization and Interaction with the Loop-Tail Mutation

Murdoch, J. N., Rachel, R. A., Shah, S., Beermann, F., Stanier, P., Mason, C. A., & Copp, A. J. (2001) · Genomics · doi:10.1006/geno.2001.6638 · Cited by 101 · see citing works

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans

Lyons, J. J., Liu, Y., Ma, C. A., Yu, X., O’Connell, M. P., Lawrence, M. G., Zhang, Y., Karpe, K. A., Zhao, M., Siegel, A., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161435 · Cited by 99 · see citing works

Erbin Inhibits RAF Activation by Disrupting the Sur-8-Ras-Raf Complex

Dai, P., Xiong, W., & Mei, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507360200 · Cited by 95 · see citing works

Erbin Is a Protein Concentrated at Postsynaptic Membranes That Interacts with PSD-95

Huang, Y. Z., Wang, Q., Xiong, W., & Mei, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100494200 · Cited by 94 · see citing works

An Improved Method for the Synthesis of Cellulose Membrane-Bound Peptides with Free C Termini Is Useful for PDZ Domain Binding Studies

Boisguérin, P., Leben, R., Aÿ, B., Radziwill, G., Moelling, K., Dong, L., & Volkmer, R. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.03.010 · Cited by 91 · see citing works

The ERBB2/HER2 Receptor Differentially Interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 Domain Proteins

Jaulin‐Bastard, F., Saito, H., Bivic, A. L., Ollendorff, V., Marchetto, S., Birnbaum, D., & Borg, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010032200 · Cited by 91 · see citing works

Interaction between Erbin and a Catenin-related Protein in Epithelial Cells

Jaulin‐Bastard, F., Arsanto, J., Bivic, A. L., Navarro, C., Vely, F., Saito, H., Marchetto, S., Hatzfeld, M., Santoni, M.-J., Birnbaum, D., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109652200 · Cited by 90 · see citing works

The LAP family: a phylogenetic point of view

Santoni, M.-J., Pontarotti, P., Birnbaum, D., & Borg, J.-P. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02738-5 · Cited by 88 · see citing works

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

Elsum, I. A., Martin, C., & Humbert, P. O. (2013) · Journal of Cell Science · doi:10.1242/jcs.129387 · Cited by 87 · see citing works

Comparative Structural Analysis of the Erbin PDZ Domain and the First PDZ Domain of ZO-1

Appleton, B. A., Zhang, Y., Wu, P., Yin, J. P., Hunziker, W., Skelton, N. J., Sidhu, S. S., & Wiesmann, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602901200 · Cited by 83 · see citing works

Emerging Themes in PDZ Domain Signaling

Liu, X., & Fuentes, E. J. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.013 · Cited by 82 · see citing works

Collective nomenclature for LAP proteins

Bilder, D., Birnbaum, D., Borg, J.-P., Bryant, P., Huigbretse, J., Jansen, E., Kennedy, M. B., Labouesse, M., Legouis, R., Mechler, B., et al. (2000) · Nature Cell Biology · doi:10.1038/35017119 · Cited by 81 · see citing works

APT2 Inhibition Restores Scribble Localization and S -Palmitoylation in Snail-Transformed Cells

Hernandez, J. L., Davda, D., Kit, M. C. S., Majmudar, J. D., Won, S. J., Gang, M., Pasupuleti, S. C., Choi, A. I., Bartkowiak, C. M., & Martin, B. R. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2016.12.007 · Cited by 80 · see citing works

Scribble‐mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

Li, X., Yang, H., Liu, J., Schmidt, M. D., & Gao, T. (2011) · EMBO Reports · doi:10.1038/embor.2011.106 · Cited by 79 · see citing works

Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

Wan, S., Meyer, A., Weiler, S. M. E., Rupp, C., Tóth, M., Sticht, C., Singer, S., Thomann, S., Roessler, S., Schorpp‐Kistner, M., et al. (2018) · Hepatology · doi:10.1002/hep.29669 · Cited by 79 · see citing works

The Hemidesmosomal Protein Bullous Pemphigoid Antigen 1 and the Integrin β4 Subunit Bind to ERBIN

Favre, B., Fontao, L., Köster, J., Shafaatian, R., Jaunin, F., Saurat, J. ‐., Sonnenberg, A., & Borradori, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011005200 · Cited by 78 · see citing works

Human scribble, a novel tumor suppressor identified as a target of high‐risk HPV E6 for ubiquitin‐mediated degradation, interacts with adenomatous polyposis coli

Takizawa, S., Nagasaka, K., Nakagawa, S., Yano, T., Nakagawa, K., Yasugi, T., Takeuchi, T., Kanda, T., Huibregtse, J. M., Akiyama, T., et al. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00954.x · Cited by 78 · see citing works

Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment

Daulat, A. M., & Borg, J. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.01.001 · Cited by 78 · see citing works

Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation

Chastney, M. R., Lawless, C., Humphries, J. D., Warwood, S., Jones, M., Knight, D., Jørgensen, C., & Humphries, M. J. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202003038 · Cited by 78 · see citing works

Erbin regulates NRG1 signaling and myelination

Tao, Y., Dai, P., Liu, Y., Marchetto, S., Xiong, W., Borg, J., & Mei, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901844106 · Cited by 77 · see citing works

hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells

Métais, J.-Y., Navarro, C., Santoni, M.-J., Audebert, S., & Borg, J.-P. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.062 · Cited by 77 · see citing works

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

Nagasaka, K., Pim, D., Massimi, P., Thomas, M., Tomaić, V, Subbaiah, V. K., Kranjec, C., Nakagawa, S., Yano, T., Taketani, Y., et al. (2010) · Oncogene · doi:10.1038/onc.2010.265 · Cited by 75 · see citing works

Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium

Ivanov, A. I., Young, C., Beste, K. D., Capaldo, C. T., Humbert, P. O., Brennwald, P., Parkos, C. A., & Nusrat, A. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090220 · Cited by 73 · see citing works

Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic Potential

Thomas, M., Myers, M. P., Massimi, P., Guarnaccia, C., & Banks, L. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005766 · Cited by 73 · see citing works

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Sundell, G. N., Arnold, R. R., Ali, M., Naksukpaiboon, P., Orts, J., Güntert, P., Celestine, N., & Ivarsson, Y. (2018) · Molecular Systems Biology · doi:10.15252/msb.20178129 · Cited by 72 · see citing works

Primary decidual zone formation requires Scribble for pregnancy success in mice

Yuan, J., Aikawa, S., Deng, W., Bartos, A., Walz, G., Grahammer, F., Huber, T. B., Sun, X., & Dey, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-13489-4 · Cited by 70 · see citing works

The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function

Moreau, M. M., Piguel, N., Papouin, T., Koehl, M., Durand, C. M., Rubio, M. E., Loll, F., Richard, E. M., Mazzocco, C., Racca, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6007-09.2010 · Cited by 69 · see citing works

Erbin Regulates Mitogen-activated Protein (MAP) Kinase Activation and MAP Kinase-dependent Interactions between Merlin and Adherens Junction Protein Complexes in Schwann Cells

Rangwala, R. A., Banine, F., Borg, J., & Sherman, L. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414154200 · Cited by 69 · see citing works

Vimentin Regulates Scribble Activity by Protecting It from Proteasomal Degradation

Phua, D. C. Y., Humbert, P. O., & Hunziker, W. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0199 · Cited by 68 · see citing works

ERBIN associates with p0071, an armadillo protein, at cell‐cell junctions of epithelial cells

Izawa, I., Nishizawa, M., Tomono, Y., Ohtakara, K., Takahashi, T., & Inagaki, M. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00533.x · Cited by 67 · see citing works

Identification of three novel Smad binding proteins involved in cell polarity

Warner, D. R., Pisano, M., Roberts, E. A., & Greene, R. M. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00155-8 · Cited by 65 · see citing works

Lano, a Novel LAP Protein Directly Connected to MAGUK Proteins in Epithelial Cells

Saito, H., Santoni, M.-J., Arsanto, J., Jaulin‐Bastard, F., Bivic, A. L., Marchetto, S., Audebert, S., Isnardon, D., Adélaı̈de, J., Birnbaum, D., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100330200 · Cited by 64 · see citing works

Erbin Inhibits Transforming Growth Factor β Signaling through a Novel Smad-Interacting Domain

Dai, F., Chang, C., Lin, X., Dai, P., Mei, L., & Feng, X. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00132-07 · Cited by 61 · see citing works

Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland

Godde, N. J., Sheridan, J. M., Smith, L. K., Pearson, H. B., Britt, K. L., Galea, R. C., Yates, L. L., Visvader, J. E., & Humbert, P. O. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004323 · Cited by 60 · see citing works

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

Elsum, I. A., Yates, L. L., Pearson, H. B., Phesse, T. J., Long, F., O'Donoghue, R., Ernst, M., Cullinane, C., & Humbert, P. O. (2014) · Oncogene · doi:10.1038/onc.2013.498 · Cited by 60 · see citing works

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

Zheng, W., Umitsu, M., Jagan, I., Tran, C. W., Ishiyama, N., BeGora, M., Araki, K., Ohashi, P. S., Ikura, M., & Muthuswamy, S. K. (2016) · Nature Cell Biology · doi:10.1038/ncb3413 · Cited by 60 · see citing works

Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib

Ono, Y., Urata, Y., Goto, S., Nakagawa, S., Humbert, P. O., Li, T., & Zammit, P. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.045 · Cited by 59 · see citing works

Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex

Choi, J., Troyanovsky, R. B., Indra, I., Mitchell, B. J., & Troyanovsky, S. M. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201804201 · Cited by 53 · see citing works

Role of Erbin in ErbB2-dependent breast tumor growth

Tao, Y., Shen, C., Luo, S., Traoré, W., Marchetto, S., Santoni, M.-J., Xu, L., Wu, B., Shi, C., Mei, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407139111 · Cited by 49 · see citing works

Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

Wilkes, M. C., Repellin, C. E., Hong, M. Y., Bracamonte, M. P., Penheiter, S. G., Borg, J., & Leof, E. B. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.009 · Cited by 45 · see citing works

Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis in hepatocellular carcinoma

Wu, H., Yao, S., Zhang, S., Wang, J.-R., Guo, P.-D., Li, X., Gan, W. J., Mei, L., Gao, T.-M., & Li, J.-M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.01.030 · Cited by 43 · see citing works

Erbin interacts with c‐Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c‐Cbl‐mediated ubiquitination and down‐regulation of EGFR

Yao, S., Zheng, P., Wu, H., Song, L., Ying, X., Xing, C., Li, Y., Xiao, Z., Zhou, X., Shen, T., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4502 · Cited by 42 · see citing works

Identification of hub genes in hepatocellular carcinoma using integrated bioinformatic analysis

Hua, S., Ji, Z., Quan, Y., Zhan, M., Wang, H., Li, W., Li, Y., He, X., & Lu, L. (2020) · Aging · doi:10.18632/aging.102969 · Cited by 40 · see citing works

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Pearson, H. B., McGlinn, E., Phesse, T. J., Schlüter, H., Srikumar, A., Gödde, N. J., Woelwer, C. B., Ryan, A., Phillips, W. A., Ernst, M., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0440-z · Cited by 39 · see citing works

The polarity protein Scribble regulates myelination and remyelination in the central nervous system

Jarjour, A. A., Boyd, A., Dow, L. E., Holloway, R. K., Goebbels, S., Humbert, P. O., Williams, A., & ffrench-Constant, C. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002107 · Cited by 39 · see citing works

LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling

Liu, H., Wang, S., Hang, W., Gao, J., Zhang, W., Cheng, Z., Yang, C., He, J., Zhou, J., Chen, J., et al. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201705136 · Cited by 38 · see citing works

Distinct activities of Scrib module proteins organize epithelial polarity

Khoury, M. J., & Bilder, D. H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918462117 · Cited by 38 · see citing works

Basolateral targeting by leucine-rich repeat domains in epithelial cells

Legouis, R., Jaulin‐Bastard, F., Schott, S., et al. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor7400006 · Cited by 37 · see citing works

Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner

Hu, Y., Chen, H., Duan, C., Liu, D., Lü, Q., Yang, Z., Guo, L., Song, L., Yu, M., Hu, M., et al. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.18 · Cited by 36 · see citing works

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate

Althoff, M. J., Nayak, R. C., Hegde, S., Wellendorf, A. M., Bohan, B., Filippi, M., Xin, M., Lu, Q. R., Geiger, H., Zheng, Y., et al. (2020) · Blood · doi:10.1182/blood.2019004113 · Cited by 36 · see citing works

Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction

Okajima, M., Takahashi, M., Higuchi, M., Ohsawa, T., Yoshida, S., Yoshida, Y., Oie, M., Tanaka, Y., Gejyo, F., & Fujii, M. (2008) · Virus Genes · doi:10.1007/s11262-008-0259-4 · Cited by 34 · see citing works

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX

Lim, K. Y. B., Gödde, N. J., Humbert, P. O., & Kvansakul, M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.799452 · Cited by 34 · see citing works

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells

Arnaud, C., Sebbagh, M., Nola, S., Audebert, S., Bidaut, G., Hermant, A., Gayet, O., Dusetti, N., Ollendorff, V., Santoni, M.-J., et al. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.06.034 · Cited by 33 · see citing works

Erbin is a negative modulator of cardiac hypertrophy

Rachmin, I., Tshori, S., Smith, Y., Oppenheim, A., Marchetto, S., Kay, G., Foo, R., Dagan, N., Golomb, E., Gilon, D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320350111 · Cited by 33 · see citing works

SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

Awadia, S. S., Huq, F., Arnold, T. R., Goicoechea, S. M., Sun, Y. J., Hou, T., Kreider-Letterman, G., Massimi, P., Banks, L., Fuentes, E. J., et al. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201811114 · Cited by 33 · see citing works

Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin–catenin complexes

Yoshihara, K., Ikenouchi, J., Izumi, Y., Akashi, M., Tsukita, S., & Furuse, M. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.12.004 · Cited by 32 · see citing works

Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer

Stevens, P. D., Wen, Y., Xiong, X., Zaytseva, Y. Y., Li, A. T., Wang, C., Stevens, A. T., Farmer, T. N., Gan, T., Weiss, H. L., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3629 · Cited by 31 · see citing works

The high-risk HPV E6 target scribble (hScrib) is required for HPV E6 expression in cervical tumour-derived cell lines

Kranjec, C., Tomaić, V., Massimi, P., Nicolaides, L., Doorbar, J., & Banks, L. (2016) · Papillomavirus Research · doi:10.1016/j.pvr.2016.04.001 · Cited by 28 · see citing works

Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner

Valenzuela-Iglesias, A., Burks, H. E., Arnette, C. R., Yalamanchili, A., Nekrasova, O. E., Godsel, L. M., & Green, K. J. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0048 · Cited by 28 · see citing works

Identification of Erbin Interlinking MuSK and ErbB2 and Its Impact on Acetylcholine Receptor Aggregation at the Neuromuscular Junction

Simeone, L., Straubinger, M., Khan, M. A., Nalleweg, N., Cheusova, T., & Hashemolhosseini, S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5778-09.2010 · Cited by 27 · see citing works

Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma

Li, Y., Zhou, B., Dai, J., Liu, R., & Han, Z. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2549-8 · Cited by 27 · see citing works

ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

Sflomos, G., Kostaras, E., Panopoulou, E., Pappas, N., Kyrkou, A., Politou, A. S., Fotsis, T., & Murphy, C. (2011) · Journal of Cell Science · doi:10.1242/jcs.062307 · Cited by 27 · see citing works

The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling

Almeida, L. L., Sebbagh, M., Bertucci, F., Finetti, P., Wicinski, J., Marchetto, S., Castellano, R., Josselin, E., Charafe‐Jauffret, E., Ginestier, C., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.09.008 · Cited by 27 · see citing works

miR-183-5p Inhibits Occurrence and Progression of Acute Myeloid Leukemia via Targeting Erbin

Zheng, Z., Zheng, X. W., Zhu, Y., Gu, X., Gu, W., Xie, X., Hu, W., & Jiang, J. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.016 · Cited by 27 · see citing works

Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine

Li, H., Zhou, W., Li, L., Wu, J., Liu, X., Zhao, L., Jia, L., & Sun, Y. (2017) · Neoplasia · doi:10.1016/j.neo.2017.04.003 · Cited by 26 · see citing works

Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation

Chong, C. H., Li, Q., Mak, P. H. S., Ng, C. C. P., Leung, E. H. W., Tan, V. H., Chan, A. K. W., McAlonan, G. M., & Chan, S. Y. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0580-9 · Cited by 26 · see citing works

Comparative analysis of the expression of ERBIN and Erb-B2 in normal human skin and cutaneous carcinomas.

Lebeau, S., Masouyé, I., Berti, M., Augsburger, E., Saurat, J. ‐., Borradori, L., & Fontao, L. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06687.x · Cited by 25 · see citing works

Tax1 enhances cancer cell proliferation via Ras–Raf–MEK–ERK signaling pathway

Song, C., Wang, W., Li, M., Liu, Y., & Zheng, D. (2009) · IUBMB Life · doi:10.1002/iub.221 · Cited by 25 · see citing works

Palmitoylation of ERBIN is required for its plasma membrane localization

Izawa, I., Nishizawa, M., Hayashi, Y., & Inagaki, M. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01198.x · Cited by 24 · see citing works

PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice

Pérès, É., Blin, J., Ricci, E. P., Artesi, M., Hahaut, V., den Broeke, A. V., Corbin, A., Gazzolo, L., Ratner, L., Jalinot, P., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006933 · Cited by 24 · see citing works

The relocalization of v-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikba and nfkb1 and stabilization of I kappa B-alpha

Hrdličková, R., Nehyba, J., Roy, A., Humphries, E. H., & Bose, H. R. (1995) · Journal of Virology · doi:10.1128/jvi.69.1.403-413.1995 · Cited by 23 · see citing works

Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance

Liu, D., Shi, M., Duan, C., Chen, H., Hu, Y., Yang, Z., Duan, H., & Guo, N. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.04.007 · Cited by 22 · see citing works

Interaction Partners of the PDZ Domain of Erbin

Reß, A., & Moelling, K. (2006) · Protein and Peptide Letters · doi:10.2174/092986606778256126 · Cited by 20 · see citing works

Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling

Huang, H., Song, Y., Wu, Y., Guo, N., Yuan-fang Ma, A., & Lü, Q. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.071 · Cited by 19 · see citing works

Scribble acts as an oncogene in Eμ-myc-driven lymphoma

Hawkins, E. D., Oliaro, J., Ramsbottom, K. M., Newbold, A., Humbert, P. O., Johnstone, R. W., & Russell, S. M. (2015) · Oncogene · doi:10.1038/onc.2015.167 · Cited by 19 · see citing works

Crystal structure of the human Scribble <scp>PDZ</scp> 1 domain bound to the <scp>PDZ</scp> ‐binding motif of <scp>APC</scp>

How, J. Y., Caria, S., Humbert, P. O., & Kvansakul, M. (2019) · FEBS Letters · doi:10.1002/1873-3468.13329 · Cited by 19 · see citing works

Erbin-regulated Sensitivity of MCF-7 Breast Cancer Cells to TRAIL via ErbB2/AKT/NF- B Pathway

Liu, N., Zhang, J., Zhang, J., Liu, S., Liu, Y., & Zheng, D. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvn032 · Cited by 18 · see citing works

Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability

Straßburger, K., Kang, E., & Teleman, A. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0198149 · Cited by 18 · see citing works

The polarity protein Scrib limits atherosclerosis development in mice

Schürmann, C., Dienst, F. L., Pálfi, K., Vasconez, A. E., Oo, J. A., Wang, S., Buchmann, G., Offermanns, S., van de Sluis, B., Leisegang, M. S., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz093 · Cited by 15 · see citing works

The Tumor Suppressor SCRIB is a Negative Modulator of the Wnt/β‐Catenin Signaling Pathway

Daulat, A. M., Wagner, M. S., Walton, A., Baudelet, É., Audebert, S., Camoin, L., & Borg, J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800487 · Cited by 15 · see citing works

The PDZ Protein Erbin Modulates β-Catenin-Dependent Transcription

Ress, A., & Moelling, K. (2008) · European Surgical Research · doi:10.1159/000148241 · Cited by 13 · see citing works

Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland

Baker, L., BeGora, M. D., Yeung, F. A., Feigin, M. E., Rosenberg, A. Z., Lowe, S. W., Kislinger, T., & Muthuswamy, S. K. (2016) · Journal of Cell Science · doi:10.1242/jcs.185413 · Cited by 10 · see citing works

Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland

Baker, L., BeGora, M. D., Yeung, F. A., Feigin, M. E., Rosenberg, A. Z., Lowe, S. W., Kislinger, T., & Muthuswamy, S. K. (2016) · Development · doi:10.1242/dev.141093 · Cited by 3 · see citing works

Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viabilityPreprint

Straßburger, K., Kang, E., & Teleman, A. A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/365247 · Cited by 2 · see citing works

Definition of the fibroblast adhesome using multiplexed proximity biotinylationPreprint

Chastney, M. R., Lawless, C., Humphries, J. D., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.24.918458 · Cited by 2 · see citing works

KRAS G12C-mutant driven non-small cell lung cancer (NSCLC)

Rosell, R., Codony‐Servat, J., González, J., Santarpía, M., Jain, A. S., Shivamallu, C., Wang, Y., Giménez-Capitán, A. A., Molina‐Vila, M. Á., Nilsson, J. A., et al. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104228 · Cited by 39 · see citing works

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

Nardella, C., Visconti, L., Malagrinò, F., Pagano, L., Bufano, M., Nalli, M., Coluccia, A., Regina, G. L., Silvestri, R., Gianni, S., et al. (2021) · Biology Direct · doi:10.1186/s13062-021-00303-9 · Cited by 29 · see citing works

Emerging Therapeutic Agents for Colorectal Cancer

Nalli, M., Puxeddu, M., Regina, G. L., Gianni, S., & Silvestri, R. (2021) · Molecules · doi:10.3390/molecules26247463 · Cited by 28 · see citing works

A Scribble/Cdep/Rac pathway controls follower-cell crawling and cluster cohesion during collective border-cell migration

Campanale, J. P., Mondo, J. A., & Montell, D. J. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.10.004 · Cited by 25 · see citing works

A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer

Kotelevets, L., & Chastre, E. (2021) · Cancers · doi:10.3390/cancers13174264 · Cited by 21 · see citing works

Emerging Roles of YES1 in Cancer: The Putative Target in Drug Resistance

Kook, E., Chun, K., & Kim, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031450 · Cited by 18 · see citing works

Structural basis of the human Scribble–Vangl2 association in health and disease

How, J. Y., Stephens, R. K., Lim, K. Y. B., Humbert, P. O., & Kvansakul, M. (2021) · Biochemical Journal · doi:10.1042/bcj20200816 · Cited by 20 · see citing works

Altered expression of ACOX2 in non-small cell lung cancer

Sui, J. S. Y., Martin, P., Keogh, A., Murchan, P., Ryan, L., Nicholson, S. A., Cuffe, S. D., Broin, P. Ó., Finn, S. P., Fitzmaurice, G. J., et al. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02115-7 · Cited by 17 · see citing works

Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells

Riga, A., Cravo, J., Schmidt, R., Pires, H. R., Castiglioni, V. G., van den Heuvel, S., & Boxem, M. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009856 · Cited by 12 · see citing works

The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane

Martín, M., Salleron, L., Peyret, V., Geysels, R. C., Darrouzet, É., Lindenthal, S., Barquero, C. E. B., Masini-Repiso, A. M., Pourcher, T., & Nicola, J. P. (2021) · The FASEB Journal · doi:10.1096/fj.202100303r · Cited by 15 · see citing works

Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury

Liu, Y., Fang, Q., Ming, T., Zuo, J., Jing, G., & Song, X. (2023) · Clinical and Experimental Nephrology · doi:10.1007/s10157-023-02364-8 · Cited by 13 · see citing works

Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors

Willim, J., Woike, D., Greene, D. J., Das, S., Pfeifer, K., Yuan, W., Lindsey, A., Itani, O. A., Böhme, A. L., Tibbe, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52095-x · Cited by 15 · see citing works

Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity

Abedrabbo, M., Sloomy, S., Abu-Leil, R., Kfir-Cohen, E., & Ravid, S. (2023) · Cell Adhesion & Migration · doi:10.1080/19336918.2023.2260645 · Cited by 10 · see citing works

SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients

Hussein, U. K., Ahmed, A. G., Choi, W. K., Kim, K. M., Park, S., Park, H. S., Noh, S. J., Lee, H., Chung, M. J., Moon, W. S., et al. (2021) · Biomolecules · doi:10.3390/biom11030405 · Cited by 11 · see citing works

Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity

Troyanovsky, R. B., Indra, I., Kato, R., Mitchell, B. J., & Troyanovsky, S. M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101289 · Cited by 11 · see citing works

Claudin-4 localization in epithelial ovarian cancer

Neville, M. C., Webb, P. G., Baumgartner, H. K., & Bitler, B. G. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10862 · Cited by 10 · see citing works

Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble

Javorsky, A., Humbert, P. O., & Kvansakul, M. (2022) · Viruses · doi:10.3390/v14030583 · Cited by 9 · see citing works

Discovery of a small protein-encoding cis-regulatory overlapping gene of the tumor suppressor gene Scribble in humans

Nomura, Y., & Dohmae, N. (2021) · Communications Biology · doi:10.1038/s42003-021-02619-8 · Cited by 9 · see citing works

Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Thüring, E.-M., Hartmann, C., Maddumage, J. C., Javorsky, A., Michels, B. E., Gerke, V., Banks, L., Humbert, P. O., Kvansakul, M., & Ebnet, K. (2023) · Communications Biology · doi:10.1038/s42003-023-05088-3 · Cited by 7 · see citing works

PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Sharma, M., & Dey, C. S. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00987-0 · Cited by 7 · see citing works

Inhibitors of Tax1‐PDZ Interactions Block HTLV‐1 Viral Transmission by Changing EV Composition

Puttemans, J., Brammerloo, Y., Blibek, K., Blavier, J., Ntombela, T., Molle, I. V., Joseph, J., Olivet, J., Saha, D., Degey, M., et al. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70137 · Cited by 6 · see citing works

NoxO1 regulates EGFR signaling by its interaction with Erbin

Hebchen, M., Schader, T., Spaeth, M., Müller, N., Graumann, J., & Schröder, K. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103396 · Cited by 6 · see citing works

Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis

Lulić, L., Jakovčević, A., Manojlović, L., Dediol, E., Banks, L., & Tomaić, V. (2021) · Cancers · doi:10.3390/cancers13174461 · Cited by 6 · see citing works

Structural analysis of human papillomavirus E6 interactions with Scribble PDZ domains

Stewart, B. Z., Caria, S., Humbert, P. O., & Kvansakul, M. (2023) · FEBS Journal · doi:10.1111/febs.16718 · Cited by 6 · see citing works

Neuron-Specific Deletion of Scrib in Mice Leads to Neuroanatomical and Locomotor Deficits

Ezan, J., Moreau, M. M., Mamo, T. M., Shimbo, M., Decroo, M., Sans, N., & Montcouquiol, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.872700 · Cited by 6 · see citing works

Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Bermejo‐Rodríguez, C., Henríquez, J. A., Caligiuri, G., Teles, S. P., Park, Y., Evans, A., Barrera, L. N., Neeße, A., Grützmann, R., Aust, D. E., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-3419 · Cited by 5 · see citing works

KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation

Guo, S. S., Liu, Z., Wang, G., Sun, Z., Yu, K., Fawcett, J. P., Büttner, R., Gao, B., & Faessler, R. (2024) · Nature Communications · doi:10.1038/s41467-024-54645-9 · Cited by 5 · see citing works

Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

Javorsky, A., Humbert, P. O., & Kvansakul, M. (2022) · Biochemical Journal · doi:10.1042/bcj20220037 · Cited by 5 · see citing works

Viral subversion of the cell polarity regulator Scribble

Javorsky, A., Humbert, P. O., & Kvansakul, M. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221067 · Cited by 5 · see citing works

The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3

Wang, Y., Li, X., Guan, X., Song, Z., Liu, H., Guan, Z., Wang, J., Zhu, L., Zhang, D., Zhao, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052735 · Cited by 5 · see citing works

Erbin: an important therapeutic target for blocking tumor metastasis

Qiu, T., Tan, L., Yan, J., & Luo, Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1474798 · Cited by 4 · see citing works

Invertebrate models in translational research

Shukla, A. K., Wodrich, A. P. K., Sharma, A., & Giniger, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90042-3.00009-8 · Cited by 3 · see citing works

Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients

Jeong, T. Y., Lee, H. I., Park, M. S., Seo, M. Y., & Jang, K. Y. (2022) · Diagnostics · doi:10.3390/diagnostics12071579 · Cited by 4 · see citing works

Polarity in respiratory development, homeostasis and disease

Tilston-Lünel, A., & Varelas, X. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.02.004 · Cited by 3 · see citing works

Anti-metastatic cancer potential of 4H-chromene derivatives targeting JNK in Scribble knockdown induced epithelial cancer model: In vivo and in silico studies

Raghuvanshi, V., Singh, J., Sharma, S., Butcher, R. J., Srikrishna, S., & Katiyar, D. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108741 · Cited by 3 · see citing works

A Scribble/Cdep/Rac pathway regulates follower cell crawling and cluster cohesion during collective border cell migrationPreprint

Campanale, J. P., Mondo, J. A., & Montell, D. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.04.474957 · Cited by 3 · see citing works

Integrated profiling reveals polarity protein dysregulation during oral cancer progression

Ghose, S., Chaudry, U. R., Chakravarty, S., Sarangi, S., Biswas, N. K., Baral, R., & Ray, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-27447-2 · Cited by 2 · see citing works

LRRC1 Promotes Angiogenesis Through Regulating AKT/GSK3β/β-Catenin/VEGFA Signaling Pathway in Hepatocellular Carcinoma

Liu, H., Liu, Z., Xie, P., Liu, Z., Zhang, Y., Cao, L., Shang, N., Chen, M., Feng, H., Guan, X., et al. (2025) · Cells · doi:10.3390/cells14231919 · Cited by 2 · see citing works

Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis

Stewart, B. Z., Mamonova, T., Sneddon, W. B., Javorsky, A., Yang, Y., Wang, B., Nolin, T. D., Humbert, P. O., Friedman, P. A., & Kvansakul, M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220851120 · Cited by 2 · see citing works

The alphavirus TF protein plays a critical role in promoting viral propagation by altering cell-cell boundariesPreprint

Tatiya, P., Kumar, R., Dey, D., Ratra, Y., Mian, S. Y., Borkotoky, S., Jha, S., Bhawna, Arora, S., Suhag, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.550336 · Cited by 2 · see citing works

Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status

Lulić, L., Šimić, I., Božinović, K., Pešut, E., Manojlović, L., Grce, M., Dediol, E., Sabol, I., & Tomaić, V. (2024) · Cells · doi:10.3390/cells13121002 · Cited by 1 · see citing works

Tumour‐Derived Extracellular Vesicles Reprogramme Tumour‐Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma

Pan, X.-W., Li, M., Yang, T., Liu, Y. P., Zhou, J., Tang, Y., Zheng, H.-F., Liu, J., Liu, Z. H., Ma, W., et al. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70317 · Cited by 1 · see citing works

Platelets as regulators of anti-tumor immunity: mechanisms and clinical implications

Schlesinger, M. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10362-x · Cited by 1 · see citing works

Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects

Hatzold, J., Nett, V., Brantsch, S., Zhang, J.-L., Armistead, J., Wessendorf, H., Stephens, R. K., Humbert, P. O., Iden, S., & Hammerschmidt, M. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010873 · Cited by 1 · see citing works

Exploring tumor-normal cross-talk with TranNet: Role of the environment in tumor progression

Amgalan, B., Day, C., & Przytycka, T. M. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011472 · Cited by 1 · see citing works

The cell adhesion receptor TMIGD1 recruits Scribble to the basolateral membrane via direct interactionPreprint

Ebnet, K., Thüring, E.-M., Hartmann, C., Maddumage, J. C., Javorsky, A., Michels, B. E., Gerke, V., Banks, L., Humbert, P. O., & Kvansakul, M. (2023) · Research Square · doi:10.21203/rs.3.rs-2639220/v1

The research of implementing the computer-supported collaborative learning environment with Google Slides

Dinh, B. T., & Pham, T. N. V. (2023) · Proceedings of the AsiaCALL International Conference · doi:10.54855/paic.23110

NoxO1 as novel regulator of EGFR signaling and endosomal dynamics

Hebchen, M. (2025) · doi:10.21248/gups.88428

Integrated transcriptomic analysis identifies LRRC1 as a prognostic and immune-related biomarker in pancreatic cancer

Xu, Z., Tan, J., Li, J., & Liu, G. (2025) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2025.08.036

The Double Life of Shading of Cell 2 (SHOC2): Guardian of Skin Homeostasis and Accomplice of RAS- ERK Signaling

Rojas, J. M. (2025) · Journal of Regenerative Medicine and Biology Research · doi:10.46889/jrmbr.2025/6305

Additional file 6 of PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Sharma, M., & Dey, C. S. (2022) · Figshare · doi:10.6084/m9.figshare.21557546

Additional file 3 of PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Sharma, M., & Dey, C. S. (2022) · Figshare · doi:10.6084/m9.figshare.21557537

Additional file 5 of PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Sharma, M., & Dey, C. S. (2022) · Figshare · doi:10.6084/m9.figshare.21557543

Additional file 4 of PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Sharma, M., & Dey, C. S. (2022) · Figshare · doi:10.6084/m9.figshare.21557540

Additional file 1 of Altered expression of ACOX2 in non-small cell lung cancer

Sui, J. S. Y., Martin, P., Keogh, A., Murchan, P., Ryan, L., Nicholson, S. A., Cuffe, S. D., Broin, P. Ó., Finn, S. P., Fitzmaurice, G. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20579709

Additional file 2 of PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Sharma, M., & Dey, C. S. (2022) · Figshare · doi:10.6084/m9.figshare.21557534

Additional file 7 of PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Sharma, M., & Dey, C. S. (2022) · Figshare · doi:10.6084/m9.figshare.21557549

Study of septin 9 in the cell polarity and development of cholangiocarcinoma

Cai, T. (2022) · doi:10.70675/c3888784z575bz4056z8b60z98cb8e7e8719

Polyploidy reprograms epithelial cells for motility and phagocytosis via stress signaling

Zhou, Y., Wang, X., Tan, X., 奈良, 真., Huang, Y., Tamori, Y., & Deng, W. (2026) · The Journal of Cell Biology · doi:10.1083/jcb.202507096

ADSL drives fumarate mediated scrib-rictor complex formation to promote metastasis dissemination in triple-negative breast cancer

Fan, Y., He, X., Deng, W., Sun, J., 秦金坤, Zou, Y., Zhu, X., Xie, X., Tang, H., Yu, P., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02742-2

SCRIB inhibits PP1 phosphatase activity without blocking or structurally altering its active site

Alharbi, S., Kumawat, A., Huntington, B., Momin, A. A., Alfaiyz, S., Florio, V. D., Rigoli, M., Cardona‐Londoño, K. J., Rocchia, W., Sandholu, A., et al. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113599

Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell‐cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells

Nagasaka, K., Nakagawa, S., Yano, T., Takizawa, S., Matsumoto, Y., Tsuruga, T., Nakagawa, K., Minaguchi, T., Oda, K., Hiraike‐Wada, O., et al. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00315.x · Cited by 67 · see citing works

Delineating the tumor suppressive role of Scribble in prostate cancer progression and metastasis

Borsetti, Y. C. (2013) · Minerva Access (University of Melbourne)

Identification de nouveaux partenaires pour les protéïnes LAP humaines Erbin et hScrib

Métais, J. (2005)

An Atypical ligand for the fourth PDZ domain of Scribble

Tesse, L., Gallo, F., Frascà, & Panni, S. (2014)

Identification of new binding partners for the human lap proteins Erbin and hScrib

METAIS, J.-Y., Borg, J., & Baty, D. (2005) · OpenGrey (Institut de l'Information Scientifique et Technique)