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MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors

Peter, M, Rosty, C, Couturier, J, Radvanyi, F, Teshima, H, Sastre-Garau, X·2006·Oncogene
DOI 10.1038/sj.onc.1209625
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Abstract

To determine whether integration of human papillomavirus (HPV) DNA sequences could lead to the deregulation of genes implied in oncogenesis, we analysed the HPV integration sites in a series of nine cell lines derived from invasive genital carcinomas. Using in situ hybridization, HPV16 or 18 sequences were found at chromosome band 8q24, the localization of MYC, in IC1, IC2, IC3, IC6 and CAC-1 cells and at other sites in IC4, IC5, IC7 and IC8 cells. We then localized viral sequences at the molecular level and searched for alterations of MYC structure and expression in these cells. MYC genomic status and viral integration sites were also analysed in primary tumors from which IC1, IC2, IC3 and IC6 cells were derived. In IC1, IC2 and CAC-1 cells, HPV DNA was located within 58 kb of MYC, downstream, upstream, or within MYC. In IC3 and IC6 cells, HPV DNA was located 400-500 kb upstream of MYC. Amplification studies showed that, in IC1, IC2 and IC3, viral and MYC sequences were co-amplified in an amplicon between less than 50 and 800 kb in size. MYC amplification was also observed in primary tumors, indicating that this genetic alteration, together with viral insertion at the MYC locus, had already taken place in vivo. MYC was not amplified in the other cell lines. MYC mRNA and protein overexpression was observed in the five cell lines in which the HPV DNA was inserted close to the MYC locus, but in none of the lines where the insertion had occurred at other sites. MYC activation, t…

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Research works printed but not linked: 51

  1. Alonso L, Fuchs E . (2003). Proc Natl Acad Sci USA 100 (Suppl 1): 11830–11835. · DOI
  2. Bosch FX, Manos M, Munoz N, Sherman M, Jansen AM, Peto J et al. (1995). J Natl Cancer Inst 87: 796–802. · DOI
  3. Bouallaga I, Massicard S, Yaniv M, Thierry F . (2000). EMBO Rep 1: 422–427. · DOI · Paper page
  4. Brink AA, Wiegant JC, Szuhai K, Tanke HJ, Kenter GG, Fleuren GJ et al. (2002). Cancer Genet Cytogenet 134: 145–150. · DOI
  5. Cappellen D, De Oliveira C, Ricol D, Gil Diez de Medina S, Bourdin J, Sastre-Garau X et al. (1999). Nat Genet 23: 18–20. · DOI
  6. Couturier J, Sastre-Garau X, Schneider-Maunoury S, Labib A, Orth G . (1991). J Virol 65: 4534–4538. · DOI
  7. Crook T, Storey A, Almond N, Osborn K, Crawford L . (1988). Proc Natl Acad Sci USA 85: 8820–8824. · DOI
  8. Cullen AP, Reid R, Campion M, Lörincz AT . (1991). J Virol 65: 606–612. · DOI · Paper page
  9. Dang CV . (1999). Mol Cell Biol 19: 1–11. · DOI
  10. Daniel R, Katz RA, Skalka AM . (1999). Science 284: 644–647. · DOI
  11. Dürst M, Croce CM, Gissmann L, Schwarz E, Huebner K . (1987). Proc Natl Acad Sci USA 84: 1070–1074. · DOI · Paper page
  12. Ferber MJ, Montoya DP, Yu C, Aderca I, McGee A, Thorland EC et al. (2003a). Oncogene 22: 3813–3820. · DOI
  13. Ferber MJ, Thorland EC, Brink AA, Rapp AK, Phillips LA, McGovern R et al. (2003b). Oncogene 22: 7233–7242. · DOI
  14. Fourel G, Couturier J, Wei Y, Apiou F, Tiollais P, Buendia M . (1994). EMBO J 13: 2526–2534. · DOI
  15. Frye M, Gardner C, Li ER, Arnold I, Watt FM . (2003). Development 130: 2793–2808. · DOI
  16. Gandarillas A, Watt FM . (1997). Genes Dev 11: 2869–2882. · DOI · Paper page
  17. Halbert CL, Demers GW, Galloway DA . (1991). J Virol 65: 473–478. · DOI · Paper page
  18. Henglein B, Synovzik H, Groitl P, Bornkamm G, Hartl P, Lipp M . (1989). Mol Cell Biol 9: 2105–2113. · DOI
  19. Herrick J, Conti C, Teissier S, Thierry F, Couturier J, Sastre-Garau X et al. (2005). Cancer Res 65: 1174–1179. · DOI
  20. Hori T, Ichimura H, Minamihisamatsu M, Takahashi E, Yamauchi M, Hama Y et al. (1991). Jap J Cancer Res 82: 371–375. · DOI
  21. Jeon S, Lambert P . (1995). Proc Natl Acad Sci USA 92: 1654–1658. · DOI
  22. Jiko K, Tsuda H, Sato S, Hirohashi S . (1994). Int J Cancer 59: 601–606. · DOI
  23. Kalantari M, Blennow E, Hagmar B, Johansson B . (2001). Diagn Mol Pathol 10: 46–54. · DOI
  24. Klimov E, Vinokourova S, Moisjak E, Rakhmanaliev E, Kobseva V, Laimins L et al. (2002). BMC Cancer 2: 24. · DOI
  25. Kraus I, Ziegert C, Koch T, Schneider A, Dürst M . (2005). 22nd International Papillomavirus Conference and Clinical Workshop, Vol. P-023. UCSF: Vancouver, pp 157.
  26. Livak KJ, Schmittgen TD . (2001). Methods 25: 402–408. · DOI · Paper page
  27. Lombard I, Vincent-Salomon A, Validire P, Zafrani B, de la Rochefordière A, Clough K et al (1998). J Clin Oncol 16: 2613–2619. · DOI
  28. Luft F, Klaes R, Nees M, Dürst M, Heilmann V, Melsheimer P et al. (2001). Int J Cancer 92: 9–17. · DOI
  29. Munger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M et al. (2004). J Virol 78: 11451–11460. · DOI · Paper page
  30. Münger K, Werness B, Dyson N, Phelps W, Harlow E, Howley M . (1989). EMBO J 8: 4099–4105. · DOI · Paper page
  31. Nesbit C, Tersak J, Prochownik E . (1999). Oncogene 18: 3004–3016. · DOI
  32. Pei XF, Meck JM, Greenhalgh D, Schlegel R . (1993). Virology 196: 855–860. · DOI · Paper page
  33. Pelengaris S, Khan M, Evan G . (2002). Nat Rev Cancer 2: 764–776. · DOI
  34. Pelengaris S, Littlewood T, Khan M, Elia G, Evan G . (1999). Mol Cell 3: 565–577. · DOI
  35. Popescu N, DiPaolo J, Amsbaugh S . (1987). Cytogenet Cell Genet 44: 58–62. · DOI
  36. Riou G, Lê M, Le Doussal V, Barrois M, George M, Hair C . (1987). The Lancet, 761–763. · DOI
  37. Roix JJ, McQueen PG, Munson PJ, Parada LA, Misteli T . (2003). Nat Genet 34: 287–291. · DOI
  38. Rosty C, Aubriot MH, Cappellen D, Bourdin J, Cartier I, Thiery JP et al. (2005a). Mol Cancer 4: 15. · DOI
  39. Sastre-Garau X, Favre M, Couturier J, Orth G . (2000). J Gen Virol 81: 1983–1993. · DOI
  40. Schroder AR, Shinn P, Chen H, Berry C, Ecker JR, Bushman F . (2002). Cell 110: 521–529. · DOI · Paper page
  41. Schwarz E, Freese U, Gissmann L, Mayer W, Roggenbuck B, Stremlau A et al. (1985). Nature 314: 114. · DOI
  42. Selten G, Cuypers H, Zijlstra M, Melief C, Berns A . (1984). EMBO J 3: 3215–3222. · DOI
  43. Thorland EC, Myers SL, Gostout BS, Smith DI . (2003). Oncogene 22: 1225–1237. · DOI
  44. Veldman T, Liu X, Yuan H, Schlegel R . (2003). Proc Natl Acad Sci USA 100: 8211–8216. · DOI · Paper page
  45. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV et al. (1999). J Pathol 189: 12–19. · DOI
  46. Wentzensen N, Ridder R, Klaes R, Vinokurova S, Schaefer U, Doeberitz MK . (2002). Oncogene 21: 419–426. · DOI
  47. Wentzensen N, Vinokurova S, von Knebel Doeberitz M . (2004). Cancer Res 64: 3878–3884. · DOI · Paper page
  48. Wilke C, Hall B, Hoge A, Paradee W, Smith D, Glover T . (1996). Hum Mol Genet 5: 187–195. · DOI
  49. Zeidler R, Joos S, Delecluse H, Klobeck G, Vuillaume M, Lenoir G et al. (1994). Genes Chromosomes Cancer 9: 282–287. · DOI
  50. Zhang A, Maner S, Betz R, Angstrom T, Stendahl U, Bergman F et al. (2002). Int J Cancer 101: 427–433. · DOI
  51. Ziegert C, Wentzensen N, Vinokurova S, Kisseljov F, Einenkel J, Hoeckel M et al. (2003). Oncogene 22: 3977–3984. · DOI

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Metadata

Authors
Peter, M., Rosty, C., Couturier, J., Radvanyi, F., Teshima, H., & Sastre-Garau, X.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2006-05-08
Volume
25
Issue
44
Pages
5985-5993
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/sj.onc.1209625
Cited by
114
References
3
Language
en
Licence

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