The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury
Abstract
The complex biochemical interactions following acute spinal cord injury have undergone considerable investigation recently. Progress has been made in discovering both primary and secondary injury cascades that combine to produce the ultimate neurologic insult. Traditionally, neuronal and supporting cell death following spinal cord injury have focused on necrotic death pathways resulting passively from the actual mechanical tissue damage and inflammatory processes which follow. However, the occurrence of programmed apoptotic cell death which is an actively mediated cellular process may occur following acute spinal cord injury and, if present, may play a role in the ultimate neurologic insult. In this study, we document a chronologically-specific course of apoptotic cell death by the TUNEL assay technique following an acute experimental spinal cord injury in the rat model. In this manner, apoptotic cell death following acute spinal cord injury may play a pivotal role in the secondary injury cascade which produces the ultimate neurologic insult and may allow potential for mediating neuronal survival via anti-apoptotic factors such as the protooncogene Bcl-2.
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“Many of these noxious stimuli activate apoptosis among spinal cells during the weeks that follow the injury [2,3,4,5].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [5]
Citations
Cites
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Death from natural and unnatural causes
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Cited by
Temporal–Spatial Pattern of Acute Neuronal and Glial Loss after Spinal Cord Contusion
Grossman, S. D., Rosenberg, L. J., & Wrathall, J. R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7628 · Cited by 310
Maza, R. M., Barreda-Manso, M. A., Reigada, D., Silván, Á., Muñoz-Galdeano, T., Soto, A., del Águila, Á., & Nieto-Díaz, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071559 · Cited by 12
Metadata
- Authors
- Lou, J., Lenke, L. G., Ludwig, F. J., & O'Brien, M. F.
- Venue
- Spinal Cord
- Published
- 1998-06-30
- Volume
- 36
- Issue
- 10
- Pages
- 683-690
- ISSN
- 1362-4393
- 1476-5624
- Cited by
- 108
- References
- 21
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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