Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 3,419

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

Hockenbery, David M., Oltvai, Zoltan N., Yin, Xiao-Ming, Milliman, Curt L., Korsmeyer, Stanley J.·1993·Cell
DOI 10.1016/0092-8674(93)80066-n
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/0092-8674(93)80066-n

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Research works printed but not linked: 50

  1. Abrams, 1993, Programmed cell death during Drosophila embryogenesis, Development, 117, 29, 10.1242/dev.117.1.29 · DOI · Paper page
  2. Amstad, 1991, The balance between Cu, Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress, Biochemistry, 30, 9305, 10.1021/bi00102a024 · DOI · Paper page
  3. Applegate, 1991, Induction of heme oxygenase: a general response to oxidative stress in cultured mammalian cells, Cancer Res., 51, 974
  4. Bass, 1983, Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation, J. Immunol., 130, 1910, 10.4049/jimmunol.130.4.1910 · DOI · Paper page
  5. Boissy, 1989, Separation of pigmented and albino melanocytes and the concomitant evaluation of endogenous peroxide content using flow cytometry, Cytometry, 10, 779, 10.1002/cyto.990100616 · doi:10.1002/cyto.990100616
  6. Boveris, 1973, The mitochondrial generation of hydrogen peroxide, Biochem. J., 134, 707, 10.1042/bj1340707 · DOI · Paper page
  7. Cathcart, 1983, Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay, Anal. Biochem., 134, 111, 10.1016/0003-2697(83)90270-1 · DOI · Paper page
  8. Chen-Levy, 1990, Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vivo, J. Biol. Chem., 265, 4929, 10.1016/S0021-9258(19)34063-3 · DOI
  9. Chen-Levy, 1989, The Bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18), Mol. Cell. Biol., 9, 701, 10.1128/MCB.9.2.701 · DOI · Paper page
  10. Crawford, 1988, Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells, Oncogene, 3, 27
  11. Cross, 1991, Enzymic mechanisms of superoxide production, Biochim. Biophys. Acta, 1057, 281, 10.1016/S0005-2728(05)80140-9 · DOI · Paper page
  12. Dewey, 1960, Effect of oxygen and nitric oxide on the radiosensitivity of human cells in tissue culture, Nature, 186, 780, 10.1038/186780a0 · DOI
  13. Ernster, 1986, Oxygen as an environmental poison, Chemica Scripta, 26, 525
  14. Gutteridge, 1986, Aspects to consider when detecting and measuring lipid peroxidation, Free Radical Res. Commun., 1, 173, 10.3109/10715768609083149 · DOI
  15. Halliwell, 1984, Oxygen toxicity, oxygen radicals, transition metals and disease, Biochem. J., 219, 1, 10.1042/bj2190001 · DOI · Paper page
  16. Halliwell, 1986, Oxygen free radicals and iron in relation to biology and medicine; some problems and concepts, Arch. Biochem. Biophys., 246, 501, 10.1016/0003-9861(86)90305-X · DOI · Paper page
  17. Hedley, 1992, Flow cytometric measurement of lipid peroxidation in vital cells using parinaric acid, Cytometry, 13, 686, 10.1002/cyto.990130704 · DOI
  18. Hengartner, 1992, Caenorhabditis elegans gene ced-9 protects cells from programmed cell death, Nature, 356, 494, 10.1038/356494a0 · DOI · Paper page
  19. Hirose, 1993, Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation, FASEB J., 7, 361, 10.1096/fasebj.7.2.8440412 · DOI · Paper page
  20. Hockenbery, 1990, Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death, Nature, 348, 334, 10.1038/348334a0 · DOI · Paper page
  21. Holbrook, 1991, Response to adversity: molecular control of gene activation following genotoxic stress, New Biologist, 3, 825
  22. Jacobson, 1993, Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA, Nature, 361, 365, 10.1038/361365a0 · DOI · Paper page
  23. Kerr, 1972, Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer, 26, 239, 10.1038/bjc.1972.33 · DOI · Paper page
  24. Korsmeyer, 1992, Bcl-2 initiates a new category of oncogenes: regulators of cell death, Blood, 80, 879, 10.1182/blood.V80.4.879.879 · DOI · Paper page
  25. Kuypers, 1987, Parinaric acid as a sensitive fluorescent probe for the determination of lipid peroxidation, Biochem. Biophys. Acta, 921, 266, 10.1016/0005-2760(87)90027-0 · DOI
  26. LeBrun, 1993, Expression of bcl-2 in fetal tissues suggests a role in morphogenesis, Am. J. Pathol., 142, 743
  27. McConkey, 1988, Stimulation of endogenous endonuclease in cells exposed to oxidative stress, Toxicol. Lett., 42, 123, 10.1016/0378-4274(88)90069-0 · DOI
  28. McConkey, 1989, Calcium-activated DNA fragmentation kills immature thymocytes, FASEB J., 3, 1843, 10.1096/fasebj.3.7.2497041 · DOI · Paper page
  29. McCord, 1978, Superoxide-dependent production of hydroxyl radical catalysed by an iron-EDTA complex, FEBS Lett., 86, 139, 10.1016/0014-5793(78)80116-1 · DOI · Paper page
  30. Meister, 1983, Glutathione, Annu. Rev. Biochem., 52, 711, 10.1146/annurev.bi.52.070183.003431 · DOI · Paper page
  31. Miyashita, 1993, Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line, Blood, 81, 151, 10.1182/blood.V81.1.151.151 · DOI · Paper page
  32. Monaghan, 1992, Ultrastructural localization of Bcl-2 protein, J. Histochem. Cytochem., 40, 1819, 10.1177/40.12.1453000 · DOI · Paper page
  33. Nguyen, 1993, Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal—anchor sequence, J. Biol. Chem., 10.1016/S0021-9258(19)74386-5 · DOI · Paper page
  34. Pagnonec, 1992, The helix-loop-helix leucine repeat transcription factor can be functionally regulated in a redox-dependent manner, J. Biol. Chem., 267, 24563, 10.1016/S0021-9258(18)35801-0 · DOI
  35. Schreck, 1991, Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1, EMBO J., 10, 2247, 10.1002/j.1460-2075.1991.tb07761.x · DOI · Paper page
  36. Sentman, 1991, bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes, Cell, 67, 879, 10.1016/0092-8674(91)90361-2 · DOI · Paper page
  37. Seto, 1988, Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-lg fusion gene in lymphoma, EMBO J., 7, 123, 10.1002/j.1460-2075.1988.tb02791.x · DOI · Paper page
  38. Shibanuma, 1988, Induction of DNA replication and expression of proto-oncogenes c-myc and c-fos in quiescent Balb/3T3 cells by xanthine/xanthine oxidase, Oncogene, 3, 17
  39. Smeyne, 1993, Continuous c-fos expression precedes programmed cell death in vivo, Nature, 363, 166, 10.1038/363166a0 · DOI · Paper page
  40. Strasser, 1991, bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship, Cell, 67, 889, 10.1016/0092-8674(91)90362-3 · DOI · Paper page
  41. Sulston, 1977, Post-embryonic cell lineages of the nematode, Caenorhabditis elegans, Dev. Biol., 56, 110, 10.1016/0012-1606(77)90158-0 · DOI · Paper page
  42. Thor, 1982, The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes, J. Biol. Chem., 257, 12419, 10.1016/S0021-9258(18)33730-X · DOI · Paper page
  43. Tsujimoto, 1989, Stress-resistance conferred by high level of Bcl-2 protein in human B lymphoblastoid cell line, Oncogene, 4, 1331
  44. Vaux, 1988, Bcl-2 promotes the survival of haemopoietic cells and cooperates with c-myc to immortalize pre-B cells, Nature, 335, 440, 10.1038/335440a0 · DOI · Paper page
  45. Veis, 1993, Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair, Cell, 10.1016/0092-8674(93)80065-M · DOI · Paper page
  46. Walton, 1993, Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis, Cancer Res., 53, 1853
  47. Weisiger, 1973, Mitochondrial superoxide dismutase, site of synthesis and intramitochondrial localization, J. Biol. Chem., 248, 4793, 10.1016/S0021-9258(19)43735-6 · DOI · Paper page
  48. Wong, 1989, Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor, Cell, 58, 923, 10.1016/0092-8674(89)90944-6 · DOI · Paper page
  49. Wyllie, 1980, Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation, Nature, 284, 555, 10.1038/284555a0 · DOI · Paper page
  50. Wyllie, 1980, Cell death: the significance of apoptosis, Int. Rev. Cytol., 68, 251, 10.1016/S0074-7696(08)62312-8 · DOI · Paper page

Cited by

See all 3,419

Metadata

Authors
Hockenbery, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L., & Korsmeyer, S. J.
Venue
Cell
Publisher
Elsevier BV
Published
1993-10
Volume
75
Issue
2
Pages
241-251
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(93)80066-n
OpenAlex
W1997208169
Cited by
3,419
References
7
FWCI
79.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. https://app.cochat.ai/papers/10.1016/0092-8674(93)80066-n
The paper
Hockenbery, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L., & Korsmeyer, S. J. (1993). Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. https://doi.org/10.1016/0092-8674(93)80066-n

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.