Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe

The American Journal of Physiology

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Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation

Zanardo, R. C. O., Brancaleone, V., Distrutti, E., Fiorucci, S., Cirino, G., & Wallace, J. L. (2006) · The FASEB Journal · doi:10.1096/fj.06-6270fje · Cited by 859 · see citing works

Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse

Li, L., Bhatia, M., Zhu, Y. Z., Zhu, Y. C., Ramnath, R. D., Wang, Z. J., Anuar, F., Whiteman, M., Salto‐Tellez, M., & Moore, P. K. (2005) · The FASEB Journal · doi:10.1096/fj.04-3583fje · Cited by 773 · see citing works

H 2 S: A Universal Defense Against Antibiotics in Bacteria

Shatalin, K. Y., Shatalina, E., Mironov, A. S., & Nudler, E. (2011) · Science · doi:10.1126/science.1209855 · Cited by 769 · see citing works

Reaction-Based Fluorescent Probes for Selective Imaging of Hydrogen Sulfide in Living Cells

Lippert, A. R., New, E. J., & Chang, C. J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203661j · Cited by 760 · see citing works

Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat

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Development of a Highly Selective Fluorescence Probe for Hydrogen Sulfide

Sasakura, K., Hanaoka, K., Shibuya, N., Mikami, Y., Kimura, Y., Komatsu, T., Ueno, T., Terai, T., Kimura, H., & Nagano, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207851s · Cited by 661 · see citing works

A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood

Peng, H., Cheng, Y., Dai, C., King, A. L., Predmore, B. L., Lefer, D. J., & Wang, B. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104236 · Cited by 637 · see citing works

Vascular Endothelium Expresses 3-Mercaptopyruvate Sulfurtransferase and Produces Hydrogen Sulfide

Shibuya, N., Mikami, Y., Kimura, Y., Nagahara, N., & Kimura, H. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp111 · Cited by 481 · see citing works

Hydrogen sulfide inhibits nitric oxide production and nuclear factor-κB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide

Oh, G., Pae, H., Lee, B.-S., Kim, B.-N., Kim, J., Kim, H., Jeon, S. B., Jeon, W. K., Chae, H., & Chung, H. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.021 · Cited by 421 · see citing works

The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation

CAI, W., WANG, M., MOORE, P., JIN, H., YAO, T., & Zhu, Y. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.026 · Cited by 421 · see citing works

The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms

Hapfelmeier, S., Stecher, B., Barthel, M., Kremer, M., Müller, A. J., Heikenwälder, M. F., Stallmach, T., Hensel, M., Pfeffer, K., Akira, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1675 · Cited by 394 · see citing works

The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages

Whiteman, M., Li, L., Rose, P. E., Tan, C., Parkinson, D. B., & Moore, P. K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2899 · Cited by 367 · see citing works

Measurement of plasma hydrogen sulfide in vivo and in vitro

Shen, X., Pattillo, C. B., Pardue, S., Bir, S. C., Wang, R., & Kevil, C. G. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.025 · Cited by 325 · see citing works

Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats

Wallace, J. L., Vong, L., McKnight, W., Dicay, M., & Martin, G. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.012 · Cited by 308 · see citing works

Hydrogen sulfide attenuates lipopolysaccharide‐induced inflammation by inhibition of p38 mitogen‐activated protein kinase in microglia

Hu, L., Wong, P. T. ‐., Moore, P. K., & Bian, J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04283.x · Cited by 306 · see citing works

Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising

Whiteman, M., & Winyard, P. G. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.134 · Cited by 304 · see citing works

Role of hydrogen sulfide in acute pancreatitis and associated lung injury

Bhatia, M., Wong, F. L., Fu, D., Lau, H. Y., Moochhala, S., & Moore, P. K. (2005) · The FASEB Journal · doi:10.1096/fj.04-3023fje · Cited by 302 · see citing works

Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide

Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Ogasawara, Y., & Kimura, H. (2011) · Biochemical Journal · doi:10.1042/bj20110841 · Cited by 295 · see citing works

Hydrogen sulfide enhances ulcer healing in rats

Wallace, J. L., Dicay, M., McKnight, W., & Martin, G. R. (2007) · The FASEB Journal · doi:10.1096/fj.07-8669com · Cited by 236 · see citing works

Hydrogen Sulfide: An Endogenous Mediator of Resolution of Inflammation and Injury

Wallace, J. L., Ferraz, J. G., & Muscará, M. N. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4351 · Cited by 234 · see citing works

Cystathionine γ-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury

Ishii, I., Akahoshi, N., Yamada, H., Nakano, S., Izumi, T., & Suematsu, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147439 · Cited by 233 · see citing works

The Hydrogen Sulfide Donor NaHS Promotes Angiogenesis in a Rat Model of Hind Limb Ischemia

Wang, M.-J., Cai, W., Li, N., Ding, Y.-J., Chen, Y., & Zhu, Y. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2945 · Cited by 184 · see citing works

Passive loss of hydrogen sulfide in biological experiments

DeLeon, E. R., Stoy, G. F., & Olson, K. R. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.10.016 · Cited by 176 · see citing works

Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-κB pathway

Liang, Z., Ang, A. D., Zhang, H., Moore, P. K., & Bhatia, M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1006599 · Cited by 175 · see citing works

Hydrogen sulfide: a new EDRF

Wang, R. (2009) · Kidney International · doi:10.1038/ki.2009.221 · Cited by 156 · see citing works

Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3

Rinaldi, L., Gobbi, G., Pambianco, M., Micheloni, C., Mirandola, P., & Vitale, M. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700391 · Cited by 152 · see citing works

Production of the gaseous signal molecule hydrogen sulfide in mouse tissues

Linden, D. R., Sha, L., Mazzone, A., Stoltz, G. J., Bernard, C. E., Furne, J. K., Levitt, M. D., Farrugia, G., & Szurszewski, J. H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05502.x · Cited by 141 · see citing works

Physiological and Pathophysiological Roles of Hydrogen Sulfide in the Gastrointestinal Tract

Wallace, J. L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2900 · Cited by 131 · see citing works

Endogenous Hydrogen Sulfide Regulates Inflammatory Response by Activating the ERK Pathway in Polymicrobial Sepsis

Zhang, H., Moochhala, S., & Bhatia, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4320 · Cited by 122 · see citing works

Spatial and Temporal Profiles for Anti-Inflammatory Gene Expression in Leukocytes during a Resolving Model of Peritonitis

Damazo, A. S., Yona, S., Flower, R. J., Perretti, M., & Oliani, S. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4410 · Cited by 114 · see citing works

Glucocorticoids suppress cystathionine gamma-lyase expression and H2S production in lipopolysaccharide-treated macrophages

Zhu, X., Liu, S.-J., Liu, Y., Wang, S., & Ni, X. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0250-9 · Cited by 111 · see citing works

Hydrogen sulfide‐releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation

Lee, M., Sparatore, A., Soldato, P. D., McGeer, E. G., & McGeer, P. L. (2009) · Glia · doi:10.1002/glia.20905 · Cited by 104 · see citing works

Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo

Chattopadhyay, M., Kodela, R., Nath, N., Barsegian, A., Boring, D. L., & Kashfi, K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.019 · Cited by 96 · see citing works

Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells

Pupo, E., Fiorio, A., Avanzato, D., Moccia, F. D., Avelino-Cruz, J. E., Tanzi, F., Merlino, A., Mancardi, D., & Munaron, L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.007 · Cited by 89 · see citing works

Hydrogen Sulfide Augments Neutrophil Migration through Enhancement of Adhesion Molecule Expression and Prevention of CXCR2 Internalization: Role of ATP-Sensitive Potassium Channels

Dal-Secco, D., Cunha, T. M., de Freitas, A., Alves-Filho, J. C., Souto, F. O., Fukada, S. Y., Grespan, R., de Alencar, N. M. N., Neto, A. F., Rossi, M. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4287 · Cited by 88 · see citing works

S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism

Pan, L., Liu, X., Gong, Q., & Zhu, Y. Z. (2011) · Amino Acids · doi:10.1007/s00726-011-0834-1 · Cited by 75 · see citing works

Detection of hydrogen sulfide in plasma and knee‐joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation

Whiteman, M., Haigh, R. C., Tarr, J. M., Gooding, K. M., Shore, A. C., & Winyard, P. G. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05556.x · Cited by 73 · see citing works

Endogenous hydrogen sulfide is an anti-inflammatory molecule in dextran sodium sulfate-induced colitis in mice

Hirata, I., Naito, Y., Takagi, T., Mizushima, K., Suzuki, T., Omatsu, T., Handa, O., Ichikawa, H., Ueda, H., & Yoshikawa, T. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1461-5 · Cited by 72 · see citing works

Eukaryotic and prokaryotic contributions to colonic hydrogen sulfide synthesis

Flannigan, K. L., McCoy, K. D., & Wallace, J. L. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00105.2011 · Cited by 68 · see citing works

Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment

Maclean, K. N., Sikora, J., Kožich, V., Jiang, H., Greiner, L. S., Kraus, E., Krijt, J., Crnic, L. S., Allen, R. H., Stabler, S. P., et al. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.06.007 · Cited by 66 · see citing works

H2S Protects Hippocampal Neurons from Anoxia–Reoxygenation Through cAMP-Mediated PI3K/Akt/p70S6K Cell-Survival Signaling Pathways

Shao, J., Wan, X., Chen, Y., Bi, C., Chen, H., Zhong, Y., Xin-hua, H., & Qian, J. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9464-4 · Cited by 51 · see citing works

Serum hydrogen sulfide as a novel marker predicting bacterial involvement in patients with community‐acquired lower respiratory tract infections

Ya‐Hong, C. H. E. N., Yao, W.-Z., Gao, J., Geng, B., Pei‐Pei, W. A. N. G., & Tang, C. (2009) · Respirology · doi:10.1111/j.1440-1843.2009.01550.x · Cited by 44 · see citing works

A role for endogenous histamine in interleukin‐8‐induced neutrophil infiltration into mouse air‐pouch: investigation of the modulatory action of systemic and local dexamethasone

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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works

Resolution of inflammation: a new therapeutic frontier

Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937 · see citing works

Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

Cirino, G., Szabó, C., & Papapetropoulos, A. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 568 · see citing works

Anti‐inflammatory hydrogel dressings and skin wound healing

Huang, C., Dong, L., Zhao, B., Lu, Y., Huang, S., Yuan, Z., Luo, G., Xu, Y. X., & Qian, W. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1094 · Cited by 452 · see citing works

Hydrogen sulfide: An endogenous regulator of the immune system

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Hydrogen sulfide in physiology and diseases of the digestive tract

Singh, S., & Lin, H. (2015) · Microorganisms · doi:10.3390/microorganisms3040866 · Cited by 260 · see citing works

A Bright Fluorescent Probe for H2S Enables Analyte-Responsive, 3D Imaging in Live Zebrafish Using Light Sheet Fluorescence Microscopy

Hammers, M. D., Taormina, M. J., Cerda, M. M., Montoya, L. A., Seidenkranz, D. T., Parthasarathy, R., & Pluth, M. D. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b04196 · Cited by 226 · see citing works

Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages

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Mediators of the Resolution of the Inflammatory Response

Sugimoto, M. A., Vago, J. P., Perretti, M., & Teixeira, M. M. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.01.007 · Cited by 201 · see citing works

Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production

Motta, J.-P., Flannigan, K. L., Agbor, T. A., Beatty, J. K., Blackler, R. W., Workentine, M. L., Da Silva, G. J., Wang, R., Buret, A. G., & Wallace, J. L. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000345 · Cited by 200 · see citing works

Inflammation Resolution: Implications for Atherosclerosis

Doran, A. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319822 · Cited by 177 · see citing works

Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy

Wallace, J. L. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i12.1861 · Cited by 171 · see citing works

Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes

Gonzalez‐Carter, D., Leo, B. F., Ruenraroengsak, P., Chen, S., Goode, A. E., Theodorou, I. G., Chung, K. F., Carzaniga, R., Shaffer, M. S. P., Dexter, D. T., et al. (2017) · Scientific Reports · doi:10.1038/srep42871 · Cited by 170 · see citing works

Chemiluminescent probes for imaging H 2 S in living animals

Cao, J., Lopez, R., Thacker, J. M., Moon, J. Y., Jiang, C., Morris, S. N. S., Bauer, J. H., Tao, P., Mason, R. P., & Lippert, A. R. (2015) · Chemical Science · doi:10.1039/c4sc03516j · Cited by 168 · see citing works

Reaction-Based Luminescent Probes for Reactive Sulfur, Oxygen, and Nitrogen Species: Analytical Techniques and Recent Progress

Bezner, B. J., Ryan, L. S., & Lippert, A. R. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04990 · Cited by 120 · see citing works

Gaseous mediators in resolution of inflammation

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Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases

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H2S-releasing drugs: Anti-inflammatory, cytoprotective and chemopreventative potential

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Proresolving and Tissue-Protective Actions of Annexin A1–Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor

Dalli, J., Consalvo, A. P., Ray, V., Filippo, C. D., D’Amico, M., Mehta, N., & Perretti, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203000 · Cited by 105 · see citing works

Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments

Chan, M. V., & Wallace, J. L. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00169.2013 · Cited by 98 · see citing works

Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease

Barnig, C., Bezema, T., Calder, P. C., Charloux, A., Frossard, N., Garssen, J., Haworth, O., Dilevskaya, K., Levi‐Schaffer, F., Lonsdorfer‐Wolf, E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01699 · Cited by 99 · see citing works

Resolution metabolomes activated by hypoxic environment

Norris, P. C., Libreros, S., & Serhan, C. N. (2019) · Science Advances · doi:10.1126/sciadv.aax4895 · Cited by 85 · see citing works

A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice

Zhang, L., Zheng, X. E., Zou, F., Shang, Y., Meng, W., Lai, E., Xu, Z., Liu, Y., & Zhao, J. (2016) · Scientific Reports · doi:10.1038/srep18868 · Cited by 84 · see citing works

An ICT-based fluorescent switch-on probe for hydrogen sulfide in living cells

Li, X., Zhang, S., Cao, J., Xie, N., Liu, T., Yang, B., He, Q., & Hu, Y. (2013) · Chemical Communications · doi:10.1039/c3cc44539a · Cited by 81 · see citing works

Anti-inflammatory and Cytoprotective Properties of Hydrogen Sulfide

Gemici, B., & Wallace, J. L. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.11.034 · Cited by 79 · see citing works

Enhanced Synthesis and Diminished Degradation of Hydrogen Sulfide in Experimental Colitis: A Site-Specific, Pro-Resolution Mechanism

Flannigan, K. L., Ferraz, J. G., Wang, R., & Wallace, J. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071962 · Cited by 73 · see citing works

A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo

Huang, C. W., Feng, W., Peh, M. T., Peh, K., Dymock, B. W., & Moore, P. K. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.09.032 · Cited by 67 · see citing works

Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling

Takano, Y., Echizen, H., & Hanaoka, K. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7070 · Cited by 59 · see citing works

Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

Sunzini, F., Stefano, S. D., Chimenti, M. S., & Melino, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041180 · Cited by 59 · see citing works

Resolution of inflammation pathways in preeclampsia—a narrative review

Perucci, L. O., Júnior, M. D. C., Dusse, L. M. S., Gomes, K. B., & Sousa, L. P. (2017) · Immunologic Research · doi:10.1007/s12026-017-8921-3 · Cited by 57 · see citing works

Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia‐inducible factor‐1α

Flannigan, K. L., Agbor, T. A., Motta, J., Ferraz, J. G., Wang, R., Buret, A. G., & Wallace, J. L. (2014) · The FASEB Journal · doi:10.1096/fj.14-266015 · Cited by 57 · see citing works

Dual-Responsive Benzo-Hemicyanine-Based Fluorescent Probe for Detection of Cyanide and Hydrogen Sulfide: Real-Time Application in Identification of Food Spoilage

Magesh, K., Vijay, N., Wu, S., & Velmathi, S. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05567 · Cited by 55 · see citing works

Therapeutic potential of sulfur-containing natural products in inflammatory diseases

Cao, X., Cao, L., Zhang, W., Lu, R., Bian, J., & Nie, X. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107687 · Cited by 54 · see citing works

Hydrogen sulfide as a potential biomarker of asthma

Chung, K. F. (2013) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2014.856267 · Cited by 53 · see citing works

Role of Hydrogen Sulfide in Early Blood-Brain Barrier Disruption following Transient Focal Cerebral Ischemia

Jiang, Z., Li, C., Manuel, M. L., Yuan, S. S., Kevil, C. G., McCarter, K. D., Lu, W., & Sun, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117982 · Cited by 50 · see citing works

Fluorescent probes for hydrogen sulfide (H2S) and sulfane sulfur and their applications to biological studies

Shimamoto, K., & Hanaoka, K. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.11.008 · Cited by 50 · see citing works

Depletion of H 2 S during obesity enhances store-operated Ca 2+ entry in adipose tissue macrophages to increase cytokine production

Velmurugan, G. V., Huang, H., Sun, H., Candela, J., Jaiswal, M. K., Beaman, K. D., Yamashita, M., Prakriya, M., & White, C. (2015) · Science Signaling · doi:10.1126/scisignal.aac7135 · Cited by 48 · see citing works

Colorimetric sensor for the detection of H2S and its application in molecular half-subtractor

Kaushik, R., Ghosh, A., Singh, A., & Jose, D. A. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.08.028 · Cited by 48 · see citing works

Insights into the Evolution of Host Association through the Isolation and Characterization of a Novel Human Periodontal Pathobiont, Desulfobulbus oralis

Cross, K. L., Chirania, P., Xiong, W., Beall, C. J., Elkins, J. G., Giannone, R. J., Griffen, A. L., Guss, A. M., Hettich, R. L., Joshi, S. S., et al. (2018) · mBio · doi:10.1128/mbio.02061-17 · Cited by 46 · see citing works

pH-responsive and on-demand hydrogen sulfide-releasing injectable hydrogel for wound healing promotion

Sun, L., Zhang, Z., Cao, Y., Lu, Z., Zhang, Y., He, X., Wang, Z., & Pei, R. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160904 · Cited by 44 · see citing works

The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

Herrera, B. S., Coimbra, L. S., da Silva, A. R., Teixeira, S. A., Costa, S. K. P., Wallace, J. L., Spolidório, L. C., & Muscará, M. N. (2015) · Medical Gas Research · doi:10.1186/s13618-015-0025-3 · Cited by 41 · see citing works

Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease

Gonzalez, A. L., Dungan, M. M., Smart, C. D., Madhur, M. S., & Doran, A. C. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0284 · Cited by 41 · see citing works

Sensitivity and Selectivity Analysis of Fluorescent Probes for Hydrogen Sulfide Detection

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Construction of a Band‐Aid Like Cardiac Patch for Myocardial Infarction with Controllable H2S Release

Li, W., Chen, P., Pan, Y., Lu, L., Ning, X., Liu, J., Wei, J., Chen, M., Zhao, P., & Ou, C. (2022) · Advanced Science · doi:10.1002/advs.202204509 · Cited by 38 · see citing works

Hydrogen Sulfide Attenuates the Recruitment of CD11b+Gr-1+ Myeloid Cells and Regulates Bax/Bcl-2 Signaling in Myocardial Ischemia Injury

Zhang, Y., Li, H., Zhao, G., Sun, A., Zong, C., Li, Z., Zhu, H., Zou, Y., Yang, X., & Ge, J. (2014) · Scientific Reports · doi:10.1038/srep04774 · Cited by 38 · see citing works

Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA

Arndt, S., Baeza-Garza, C. D., Logan, A., Rosa, T., Wedmann, R., Prime, T. A., Martin, J. L., Saeb‐Parsy, K., Krieg, T., Filipović, M. R., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784678 · Cited by 38 · see citing works

Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

Yli-Karjanmaa, M., Clausen, B. H., Degn, M., Novrup, H. G., Ellman, D. G., Jensen, P. T., Szymkowski, D. E., Stensballe, A., Meyer, M., Brambilla, R., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00781 · Cited by 37 · see citing works

Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis

Zayachkivska, O., Havryluk, O., Hrycevych, N., Bula, N., Grushka, O., & Wallace, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110688 · Cited by 34 · see citing works

Hydrogen Sulfide Regulates Macrophage Function in Cardiovascular Diseases

Zhang, H., Du, J., Huang, Y., Tang, C., & Jin, H. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0075 · Cited by 34 · see citing works

Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells

Chen, B., Wang, P., Jin, Q., & Tang, X. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00923a · Cited by 32 · see citing works

Pro-Resolving Ligands Orchestrate Phagocytosis

Decker, C., Sadhu, S., & Fredman, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660865 · Cited by 30 · see citing works

Inflammation resolution in environmental pulmonary health and morbidity

Marzec, J. M., & Nadadur, S. S. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116070 · Cited by 29 · see citing works

Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging

Pacitti, D., Scotton, C. J., Kumar, V., Khan, H. Z., Wark, P. A. B., Torregrossa, R., Hansbro, P. M., & Whiteman, M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0039 · Cited by 25 · see citing works

Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy

Shaaban, A. A., & El‐Agamy, D. S. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1393-0 · Cited by 24 · see citing works

Complex Pathophysiology of Acute Kidney Injury (AKI) in Aging: Epigenetic Regulation, Matrix Remodeling, and the Healing Effects of H2S

Gupta, S., Mandal, S., Banerjee, K., Almarshood, H., Pushpakumar, S. B., & Sen, U. (2024) · Biomolecules · doi:10.3390/biom14091165 · Cited by 21 · see citing works

A cancer cell-specific benzoxadiazole-based fluorescent probe for hydrogen sulfide detection in mitochondria

Fortibui, M. M., Yoon, D. W., Lim, J.-Y., Lee, S., Choi, M.-S., Heo, J. S., Kim, J., & Kim, J. (2021) · Dalton Transactions · doi:10.1039/d0dt03653f · Cited by 20 · see citing works

Endothelium-Mimicking Bilayer Vascular Grafts with Dual-Releasing of NO/H2S for Anti-Inflammation and Anticalcification

Wang, L., Liang, F., Shang, Y., Liu, X., Yin, M., Shen, J., & Yuan, J. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c15176 · Cited by 19 · see citing works

Hydrogen sulfide depletion contributes to microvascular remodeling in obesity

Candela, J., Velmurugan, G. V., & White, C. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00062.2016 · Cited by 19 · see citing works

A simple fluorophore-imine ensemble for colorimetric and fluorescent detection of CN− and HS− in aqueous solution

Lakshmi, P. R., Kumar, P., & Elango, K. P. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117974 · Cited by 19 · see citing works

Lipopolysaccharide regulates biosynthesis of cystathionine γ-lyase and hydrogen sulfide through toll-like receptor-4/p38 and toll-like receptor-4/NF-κB pathways in macrophages

Zheng, Y., Luo, N., Mu, D., Jiang, P., Liu, R., Sun, H., Xiong, S., Liu, X., Wang, L., & Chu, Y. (2013) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-013-9659-4 · Cited by 19 · see citing works

Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells

Sulen, A., Gullaksen, S., Bader, L., McClymont, D. W., Skavland, J., Gavasso, S., & Gjertsen, B. T. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.018 · Cited by 17 · see citing works

Triggered emission for rapid detection of hydrogen sulfide chaperoned by large Stokes shift

Biswas, B., Venkateswarulu, M., Gaur, P., Sharma, Y., Sinha, S., & Ghosh, S. (2018) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2018.11.011 · Cited by 17 · see citing works

Clinical Use of Hydrogen Sulfide to Protect Against Intimal Hyperplasia

Macabrey, D., Longchamp, A., Déglise, S., & Allagnat, F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.876639 · Cited by 16 · see citing works

Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease

Bechelli, C., Macabrey, D., Déglise, S., & Allagnat, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129955 · Cited by 16 · see citing works

H2S confers colonoprotection against TNBS-induced colitis by HO-1 upregulation in rats

Kupai, K., Almási, N., Kósa, M., Nemcsók, J., Murlasits, Z., Török, S., Al-Awar, A., Baráth, Z., Pósa, A., & Varga, C. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0382-8 · Cited by 14 · see citing works

Label-Free Time-of-Flight Secondary Ion Mass Spectrometry Imaging of Sulfur-Producing Enzymes inside Microglia Cells following Exposure to Silver Nanowires

Leo, B. F., Fearn, S., Gonzalez‐Carter, D., Theodorou, I. G., Ruenraroengsak, P., Goode, A. E., McPhail, D. S., Dexter, D. T., Shaffer, M. S. P., Chung, K. F., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b01704 · Cited by 12 · see citing works

A novel mitochondria‐targeting fluorescent probe for hydrogen sulfide in living cells

Shi, W., Pan, M., Qiang, H., Qiu, Q., Huang, W., Lin, H., Qian, H., & Ge, L. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12948 · Cited by 11 · see citing works

Searching for Novel Sources of Hydrogen Sulfide Donors: Chemical Profiling of Polycarpa aurata Extract and Evaluation of the Anti-Inflammatory Effects

Casertano, M., Esposito, E., Bello, I., Indolfi, C., Putra, M. Y., Mannelli, L. D. C., Ghelardini, C., Menna, M., Sorrentino, R., Cirino, G., et al. (2023) · Marine Drugs · doi:10.3390/md21120641 · Cited by 10 · see citing works

Imaging and Targeting Coronary Artery Inflammation

West, H. W., & Antoniades, C. A. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8128 · Cited by 10 · see citing works

Production of endogenous hydrogen sulfide in human gingival tissue

Chun-mei, J., Wu, C., Guo-Liang, M., Gu, Y., Ning, C., & Ji, Y. H. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.11.016 · Cited by 10 · see citing works

Hydrogen Sulfide Confers Lung Protection During Mechanical Ventilation via Cyclooxygenase 2, 15-deoxy Δ12,14-Prostaglandin J2, and Peroxisome Proliferator-Activated Receptor Gamma

Spassov, S. G., Faller, S., Hummel, M., Helo, K., Ihle, A., Ryter, S. W., Strosing, K. M., & Hoetzel, A. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002440 · Cited by 8 · see citing works

Toward More GI-Friendly Anti-Inflammatory Medications

Wallace, J. L., Nucci, G. D., & Sulaieva, O. (2015) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-015-0064-9 · Cited by 7 · see citing works

At the Molecular Level through Photophysical Studies: Structural Implications on the Reactivity of Dual-Site Sensitive Positional Isomers Toward a Gasotransmitter (H2S)

Venkateswarulu, M., Gaur, P., Sinha, S., Pramanik, A., & Ghosh, S. (2015) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b05459 · Cited by 7 · see citing works

Interaction between hydrogen sulfide, nitric oxide, and carbon monoxide pathways in the bovine isolated retina

Chitnis, M. K., Bush, L., Belford, R., Robinson, J., Opere, C. A., Ohia, S. E., & Mbye, Y. F. N. (2019) · AIMS neuroscience · doi:10.3934/neuroscience.2019.3.104 · Cited by 7 · see citing works

Multiple Roles of H2S in Inflammation: A New Class of Therapeutics?

Li, L., Atan, M. S. B. M., & Moore, P. K. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1550-3_3 · Cited by 6 · see citing works

S-sulfhydration: Novel insights into the antioxidant and antiinflammation in age-related diseases

Liu, F., Li, L., Yuan, L., Yang, J., Tang, X., Liu, J., Liu, S., Chen, Y., Lu, Y., Cheng, J., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.038 · Cited by 5 · see citing works

Colorimetric Chemosensor for Sulfide Anion Detection Based on Symmetrical Nitrovanillin Azine

Lestari, D., Wahyuningsih, T. D., & Purwono, B. (2022) · Indonesian Journal of Chemistry · doi:10.22146/ijc.71259 · Cited by 5 · see citing works

The Effect of a Fast-Releasing Hydrogen Sulfide Donor on Vascularization of Subcutaneous Scaffolds in Immunocompetent and Immunocompromised Mice

Smink, A. M., Najdahmadi, A., Alexander, M., Li, S., Rodriquez, S., van Goor, H., Hillebrands, J., Botvinick, E. L., Lakey, J. R. T., & de Vos, P. (2020) · Biomolecules · doi:10.3390/biom10050722 · Cited by 5 · see citing works

Non-Invasive Monitoring of Oxygen Tension and Oxygen Transport Inside Subcutaneous Devices After H 2 S Treatment

Najdahmadi, A., Smink, A. M., de Vos, P., Lakey, J. R. T., & Botvinick, E. L. (2020) · Cell Transplantation · doi:10.1177/0963689719893936 · Cited by 4 · see citing works

One-step synthesis of a pH switched pyrene-based fluorescent probe for ratiometric detection of HS − in real water samples

Magesh, K., Singh, S., Wu, S., & Velmathi, S. (2023) · Analytical Methods · doi:10.1039/d3ay00987d · Cited by 4 · see citing works

Toxicological insights into hydrogen sulfide biology in Caenorhabditis elegans : detection, metabolism, and functional outcomes

Yang, B., Aschner, M., & Lu, R. (2025) · Critical Reviews in Toxicology · doi:10.1080/10408444.2025.2543396 · Cited by 3 · see citing works

Hydrogen Sulfide (H2S)-Donating Formyl Peptide Receptor 2 (FPR2) Agonists: Design, Synthesis, and Biological Evaluation in Primary Mouse Microglia Culture

Brunetti, L., Francavilla, F., Niso, M., Frydrych, J. K., Trojan, E., Schepetkin, I. A., Kirpotina, L. N., Grygier, B., Łukowicz, K., Quinn, M. T., et al. (2025) · Antioxidants · doi:10.3390/antiox14070827 · Cited by 3 · see citing works

Fluorescent-colorimetric selective and sensitive detection of sulfide anions by salicylaldehyde-2,4-dinitrophenylhydrazone: biological, environmental and logic gate application

Sahu, D., Roy, R. K., Pandey, A., Dutta, S., Kumar, D., Sharma, V., Mahata, K. P., & Patra, G. K. (2025) · New Journal of Chemistry · doi:10.1039/d5nj02931g · Cited by 3 · see citing works

Hydrogen Sulfide: Its Production, Release and Functions

Flannigan, K. L., & Wallace, J. L. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1550-3_5 · Cited by 3 · see citing works

A turn-on colorimetric dual-response fluorescent probe for rapid detecting and its application in bio-imaging and real water samples

Zhang, C., Li, X., Jiang, Y., Zhang, Y.-N., Xie, Y.-X., Li, Y.-Z., & Liu, C. (2022) · Optical Materials · doi:10.1016/j.optmat.2022.112625 · Cited by 3 · see citing works

A Dinuclear Iron(II) Persulfide Complex Reacts with O 2 to Give Sulfite: Relevance to Persulfide Dioxygenases

Ballot, J. G., Siegler, M. A., Guo, Y., Michel, S. L. J., & Goldberg, D. P. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c19572 · Cited by 2 · see citing works

Potential Therapeutic Role of Hydrogen Sulfide-Releasing Molecule GYY4137 in a Rat Model of Acute Compartment Syndrome.

Haddara, M. (2015) · Scholarship@Western (Western University) · Cited by 2 · see citing works

A turn-on fluorescent nanosensor for H2S detection and imaging in inflammatory cells and mice

Liu, X., Lei, H., Hu, Y., Fan, X., Zhang, Y., Xie, L., Huang, J., & Cai, Q. (2023) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2023.122739 · Cited by 2 · see citing works

Trends in development of gi-safe anti-inflammatory drugs

Sulaieva, O., & Wallace, J. L. (2017) · Clinical Medicine (Russian Journal) · doi:10.18821/0023-2149-2017-95-3-222-227 · Cited by 2 · see citing works

Waterborne cadmium exposure provokes mucosal damage and inflammatory response in crayfish midgut via multiple types of signaling mediators

Wei, K., Feng, J., & Zhou, W. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743642 · Cited by 1 · see citing works

Synthesis of two AIE polymers and their sensing performance to S2− in aqueous solution

Guo, X., Cheng, B., Tao, F., Li, X., & Cui, Y. (2023) · Journal of Polymer Research · doi:10.1007/s10965-023-03801-8 · Cited by 1 · see citing works

Efeitos antipruriginosos do sulfeto de hidrogênio (exógeno e endógeno) sobre o prurido agudo e crônico em pele de camundongos.

Rodrigues, L. (2018) · doi:10.11606/t.42.2018.tde-08102018-154445

A kén-hidrogén protektív hatásmechanizmusainak vizsgálata TNBS-indukált patkány colitis modellben

Török, S. (2022) · doi:10.14232/phd.11508

Use of a Near Infrared Probe to Assess Intracellular Hydrogen Sulfide Production

Mesfin, F. M., Zeng, L., Manohar, K., Hunter, C., Shelley, W. C., Brokaw, J. P., Joseph, S., Lee, J., Markel, T. A., & Liu, J. (2025) · Journal of Surgical Research · doi:10.1016/j.jss.2025.11.008

An imidazole-based Schiff-base chemosensor for selective, sensitive and reversible optical detection of Ni 2+ ions in aqueous media: analytical and biological application

Sahu, D., Pandey, A., Patra, D., Sahu, A., Manna, A. K., Patra, S. G., Thakur, S. S., & Patra, G. K. (2026) · RSC Advances · doi:10.1039/d6ra07629g

VISCERAL PAIN RESPONSES TO COLORECTAL DISTENTION IN RATS THAT HAVE RECOVERED FROM A BOUT OF COLITIS

Sessenwein, J. L. (2013) · MacSphere (McMaster University) · doi:10.71548/16976

Construction of an in vivo NIR fluorescent probe for revealing the correlation between inflammation and mitochondrial hydrogen sulfide and viscosity

Cui, Y., Hu, G., Wu, T., Yang, J., Nie, Y., & Zhou, Y. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106107 · Cited by 28 · see citing works

Construction of an effective near-infrared fluorescence “turn-on” probe for hydrogen sulfide detection and imaging in living inflammatory cell and zebrafish models

Chen, S., Liu, T., Yuan, X., & Zhou, L. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.124863 · Cited by 1 · see citing works

A novel fluorescent probe for in vivo H₂S monitoring in inflammatory arthritis

Wang, Y., Gao, Y., Zhou, J., Jiang, Y., Wang, Y., Zhang, C., Meng, Q., & Zhang, Z. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.127007 · Cited by 2 · see citing works

A novel fluorescent probe for hydrogen sulfide imaging in living inflammatory models

Shi, X.-A., Jiang, Y., Tang, P. S., Zhang, X.-R., Wang, G., Peng, H., Wang, P., Xu, L., Han, Q.-Q., & Ye, Y. (2026) · Analytical Methods · doi:10.1039/d5ay01252j · Cited by 1 · see citing works

Intravital Microscopic Methods to Evaluate Anti-inflammatory Effects and Signaling Mechanisms Evoked by Hydrogen Sulfide

Zuidema, M. Y., & Korthuis, R. J. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.11.022 · Cited by 20 · see citing works