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Cited by 402

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

Open access
Kawasaki, Noritaka, Asada, Rie, Saito, Atsushi, Kanemoto, Soshi, Imaizumi, Kazunori·2012·Scientific Reports
DOI 10.1038/srep00799
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Abstract

Adipose tissue plays a central role in maintaining metabolic homeostasis under normal conditions. Metabolic diseases such as obesity and type 2 diabetes are often accompanied by chronic inflammation and adipose tissue dysfunction. In this study, we observed that endoplasmic reticulum (ER) stress and the inflammatory response occurred in adipose tissue of mice fed a high-fat diet for a period of 16 weeks. After 16 weeks of feeding, ER stress markers increased and chronic inflammation occurred in adipose tissue. We found that ER stress is induced by free fatty acid (FFA)-mediated reactive oxygen species (ROS) generation and up-regulated gene expression of inflammatory cytokines in 3T3-L1 adipocytes. Oral administration to obese mice of chemical chaperons, which alleviate ER stress, improved chronic inflammation in adipose tissue, followed by the suppression of increased body weight and improved insulin signaling. These results indicate that ER stress plays important pathophysiological roles in obesity-induced adipose tissue dysfunction.

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Metadata

Authors
Kawasaki, N., Asada, R., Saito, A., Kanemoto, S., & Imaizumi, K.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2012-11-12
Volume
2
Issue
1
Pages
799-799
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep00799
OpenAlex
W1988973837
Cited by
402
References
11
FWCI
14.86
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. https://app.cochat.ai/papers/10.1038/srep00799
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Kawasaki, N., Asada, R., Saito, A., Kanemoto, S., & Imaizumi, K. (2012). Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Scientific Reports. https://doi.org/10.1038/srep00799

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.