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Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor
Open accessAbstract
A sensitive and selective field-effect transistor (FET) biosensor is demonstrated using vertically-oriented graphene (VG) sheets labeled with gold nanoparticle (NP)-antibody conjugates. VG sheets are directly grown on the sensor electrode using a plasma-enhanced chemical vapor deposition (PECVD) method and function as the sensing channel. The protein detection is accomplished through measuring changes in the electrical signal from the FET sensor upon the antibody-antigen binding. The novel biosensor with unique graphene morphology shows high sensitivity (down to ~2 ng/ml or 13 pM) and selectivity towards specific proteins. The PECVD growth of VG presents a one-step and reliable approach to prepare graphene-based electronic biosensors.
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Cites
Graphene-based wireless bacteria detection on tooth enamel
Mannoor, M. S., Tao, H., Clayton, J. D., Sengupta, A., Kaplan, D. L., Naik, R. R., Verma, N., Omenetto, F. G., & McAlpine, M. C. (2012) · Nature Communications · doi:10.1038/ncomms1767 · Cited by 1,014
Cited by
Malhotra, B. D., & Ali, M. A. (2018) · Nanomaterials for Biosensors · doi:10.1016/b978-0-323-44923-6.00001-7 · Cited by 319
Mao, S., Wen, Z., Ci, S., Guo, X., Ostrikov, K. K., & Chen, J. (2015) · Small · doi:10.1002/smll.201401598 · Cited by 298
Self-citationLee, J. S., Shin, K.-Y., Cheong, O. J., Kim, J. H., & Jang, J. (2015) · Scientific Reports · doi:10.1038/srep07887 · Cited by 199
Ultrasensitive and Stretchable Strain Sensors Based on Mazelike Vertical Graphene Network
Wu, S., Peng, S., Han, Z. J., Zhu, H., & Wang, C. H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b15848 · Cited by 144
Flexible nanoporous tunable electrical double layer biosensors for sweat diagnostics
Munje, R. D., Muthukumar, S., Panneer Selvam, A., & Prasad, S. (2015) · Scientific Reports · doi:10.1038/srep14586 · Cited by 138
Metadata
- Authors
- Mao, S., Yu, K., Chang, J., Steeber, D. A., Ocola, L. E., & Chen, J.
- Venue
- Scientific Reports
- Published
- 2013-04-22
- Volume
- 3
- Issue
- 1
- Pages
- 1696-1696
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2010479193
- Cited by
- 204
- References
- 1
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mao, S., Yu, K., Chang, J., Steeber, D. A., Ocola, L. E., & Chen, J. (2013). Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor. Scientific Reports. https://doi.org/10.1038/srep01696
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